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International Journal of Radiation Biology Volume 65, 1994 - Issue 4
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Original Article

Clonogen Content of Intestinal Crypts: Its Deduction Using a Microcolony Assay on Whole Mount Preparations and Its Dependence on Radiation Dose

S.A. Roberts Cancer Research Campaign Biomathematics and Computing Unit, Christie Hospital, Withington, Manchester, M20 9BX, UK
&
C.S. Potten Cancer Research Campaign Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital, Withington, Manchester, M20 9BX, UK
Pages 477-481 | Received 10 Aug 1993, Accepted 16 Dec 1993, Published online: 03 Jul 2009

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Kunzhong Zhang, Liangjie Yin, Mei Zhang, Mark Daniel Parker, Henry J. Binder, Peter Salzman, Lurong Zhang, Paul Okunieff & Sadasivan Vidyasagar. (2011) Radiation decreases murine small intestinal HCO3− secretion. International Journal of Radiation Biology 87:8, pages 878-888.
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Anna Chiara Piscaglia, Marialuisa Novi, Mariachiara Campanale & Antonio Gasbarrini. (2008) Stem cell‐based therapy in gastroenterology and hepatology. Minimally Invasive Therapy & Allied Technologies 17:2, pages 100-118.
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W. B. CAI, S. A. ROBERTS, E. BOWLEY, J. H. HENDRY and C. S. POTTEN. (1997) Differential survival of murine small and large intestinal crypts following ionizing radiation. International Journal of Radiation Biology 71:2, pages 145-155.
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W.B. CAI, S.A. ROBERTS and C.S. POTTEN. (1997) The number of clonogenic cells in crypts in three regions of murine large intestine. International Journal of Radiation Biology 71:5, pages 573-579.
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Articles from other publishers (22)

Brian J. Leibowitz, Guangyi ZhaoLiang Wei, Hang Ruan, Michael Epperly, Lujia ChenXinghua Lu, Joel S. GreenbergerLin Zhang & Jian Yu. (2021) Interferon b drives intestinal regeneration after radiation. Science Advances 7:41.
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Ziwen Wang, Zelin Chen, Zhongyong Jiang, Peng Luo, Lang Liu, Yu Huang, Huilan Wang, Yu Wang, Lei Long, Xu Tan, Dengqun Liu, Taotao Jin, Yawei Wang, Yang Wang, Fengying Liao, Chi Zhang, Long Chen, Yibo Gan, Yunsheng Liu, Fan Yang, Chunji Huang, Hongming Miao, Jieping Chen, Tianmin Cheng, Xiaobing Fu & Chunmeng Shi. (2019) Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents. Nature Communications 10:1.
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Z Liu, H Tian, J Jiang, Y Yang, S Tan, X Lin, H Liu & B Wu. (2016) β-Arrestin-2 modulates radiation-induced intestinal crypt progenitor/stem cell injury. Cell Death & Differentiation 23:9, pages 1529-1541.
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Brian J. Leibowitz, Liang Wei, Lin Zhang, Xiaochun Ping, Michael Epperly, Joel Greenberger, Tao Cheng & Jian Yu. (2014) Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice. Nature Communications 5:1.
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Catherine Legraverend & Philippe Jay. (2013) Random chromosome segregation in mouse intestinal epithelial stem cells. Chromosome Research 21:3, pages 213-224.
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Catherine Booth, Gregory Tudor, Julie Tudor, Barry P. Katz & Thomas J. MacVittie. (2012) Acute Gastrointestinal Syndrome in High-Dose Irradiated Mice. Health Physics 103:4, pages 383-399.
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Alda Vidrich, Jenny M. Buzan, Brooks Brodrick, Chibuzo Ilo, Leigh Bradley, Kirstin Skaar Fendig, Thomas Sturgill & Steven M. Cohn. (2009) Fibroblast growth factor receptor-3 regulates Paneth cell lineage allocation and accrual of epithelial stem cells during murine intestinal development. American Journal of Physiology-Gastrointestinal and Liver Physiology 297:1, pages G168-G178.
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A. R. Clarke & V. Meniel. 2007. Cancer Stem Cells. Cancer Stem Cells 99 108 .
Melissa Wong & Adnan Rizvi. 2006. Tissue Stem Cells. Tissue Stem Cells 89 115 .
Alda Vidrich, Jenny M. Buzan, Sarah A. De La Rue & Steven M. Cohn. 2006. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 307 343 .
Alda Vidrich, Jenny M. Buzan, Sean Barnes, Brian K. Reuter, Kirstin Skaar, Chibuzo Ilo, Fabio Cominelli, Theresa Pizarro & Steven M. Cohn. (2005) Altered Epithelial Cell Lineage Allocation and Global Expansion of the Crypt Epithelial Stem Cell Population Are Associated with Ileitis in SAMP1/YitFc Mice. The American Journal of Pathology 166:4, pages 1055-1067.
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Adnan Z. Rizvi & Melissa H. Wong. (2009) Epithelial Stem Cells and Their Niche: There's No Place Like Home. STEM CELLS 23:2, pages 150-165.
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S. A. Roberts, J. H. Hendry & C. S. Potten. (2003) Intestinal crypt clonogens: a new interpretation of radiation survival curve shape and clonogenic cell number. Cell Proliferation 36:4, pages 215-231.
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A.C Piscaglia, C Di Campli, G Gasbarrini & A Gasbarrini. (2003) Stem cells: new tools in gastroenterology and hepatology. Digestive and Liver Disease 35:7, pages 507-514.
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Courtney W. Houchen, Mark A. Sturmoski, Shrikant Anant, Richard M. Breyer & William F. Stenson. (2003) Prosurvival and antiapoptotic effects of PGE 2 in radiation injury are mediated by EP 2 receptor in intestine . American Journal of Physiology-Gastrointestinal and Liver Physiology 284:3, pages G490-G498.
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Ian T. Johnson. (2009) Mechanisms and anticarcinogenic effects of diet-related apoptosis in the intestinal mucosa. Nutrition Research Reviews 14:02, pages 229.
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H. D. Suit. (2001) Endothelial Cells and Radiation Gastrointestinal Syndrome. Science 294:5546, pages 1411a-1411.
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Owen J Sansom & Alan R Clarke. (2000) P53 null mice: damaging the hypothesis?. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 452:2, pages 149-162.
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Simon P. Bach, Andrew G. Renehan & Christopher S. Potten. (2000) Stem cells: the intestinal stem cell as a paradigm. Carcinogenesis 21:3, pages 469-476.
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Simon P. Bach, Rebecca Chinery, Sarah T. O'Dwyer, Christopher S. Potten, Robert J. Coffey & Alastair J.M. Watson. (2000) Pyrrolidinedithiocarbamate increases the therapeutic index of 5-fluorouracil in a mouse model. Gastroenterology 118:1, pages 81-89.
Crossref
C. S. Potten. 1999. Fundamentals for the Assessment of Risks from Environmental Radiation. Fundamentals for the Assessment of Risks from Environmental Radiation 317 326 .
K. Martin, C. S. Potten, S. A. Roberts & T. B. L. Kirkwood. (1998) Altered stem cell regeneration in irradiated intestinal crypts of senescent mice. Journal of Cell Science 111:16, pages 2297-2303.
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