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Original Article

DNA Double-strand Break Measurement in Mammalian Cells by Pulsed-field Gel Electrophoresis: An Approach Using Restriction Enzymes and Gene Probing

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Pages 623-630 | Received 15 Sep 1993, Accepted 18 Jan 1994, Published online: 03 Jul 2009

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Read on this site (8)

Ghazi Alsbeih, Williams Brock & Michael Story. (2014) Misrepair of DNA double-strand breaks in patient with unidentified chromosomal fragility syndrome and family history of radiosensitivity. International Journal of Radiation Biology 90:1, pages 53-59.
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Nirmal Bhogal, Farid Jalali & Robert G. Bristow. (2009) Microscopic imaging of DNA repair foci in irradiated normal tissues. International Journal of Radiation Biology 85:9, pages 732-746.
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K. M. PRISE, G. AHNSTRÖM, M. BELLI, J. CARLSSON, D. FRANKENBERG, J. KIEFER, M. LOÖBRICH, B. D. MICHAEL, J. NYGREN, G. SIMONE & B. STENERLÖW. (1998) A review of dsb induction data for varying quality radiations. International Journal of Radiation Biology 74:2, pages 173-184.
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F. HUTCHINSON. (1996) Formation of two double-strand breaks in the same DNA molecule by a single high-energy photon or ionizing particle. International Journal of Radiation Biology 70:5, pages 505-512.
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M. LOBRICH, P. K. COOPER and B. RYDBERG. (1996) Non-random distribution of DNA double-strand breaks induced by particle irradiation. International Journal of Radiation Biology 70:5, pages 493-503.
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D. LATZ, W. C. DEWEY, M. FLENTJE, F. LOHR, F. WENZ and K. J. WEBER. (1996) Migration patterns in pulsed-field electrophoresis of DNA restriction fragments from log-phase mammalian cells after irradiation and incubation for repair. International Journal of Radiation Biology 70:6, pages 637-646.
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J. Dahm-Daphi & E. Dikomey. (1995) Separation of DNA Fragments Induced by Ionizing Irradiation Using a Graded-field Gel Electrophoresis. International Journal of Radiation Biology 67:2, pages 161-168.
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Articles from other publishers (17)

Ghazi Alsbeih, Najla Al-Harbi, Sheikh Ismail & Michael Story. (2021) Impaired DNA Repair Fidelity in a Breast Cancer Patient With Adverse Reactions to Radiotherapy. Frontiers in Public Health 9.
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Kelly J. McKelvey, Amanda L. Hudson, Michael Back, Tom Eade & Connie I. Diakos. (2018) Radiation, inflammation and the immune response in cancer. Mammalian Genome 29:11-12, pages 843-865.
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Ying Liang, Qibin Fu, Xudong Wang, Feng Liu, Gen Yang, Chunxiong Luo, Qi Ouyang & Yugang Wang. (2017) Relative biological effectiveness for photons: implication of complex DNA double-strand breaks as critical lesions. Physics in Medicine and Biology 62:6, pages 2153-2175.
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M Nenoi, B Wang & G Vares. (2014) In vivo radioadaptive response. Human & Experimental Toxicology 34:3, pages 272-283.
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L A Tobin, C Robert, A P Rapoport, I Gojo, M R Baer, A E Tomkinson & F V Rassool. (2012) Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias. Oncogene 32:14, pages 1784-1793.
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Stephen Barnard, Simon Bouffler & Kai Rothkamm. (2013) The shape of the radiation dose response for DNA double-strand break induction and repair. Genome Integrity 4:1, pages 1.
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W. Li, R. Jones, H. Spaeth & A. J. Steckl. (2010) Dose effects in electron beam irradiation of DNA-complex thin films. Applied Physics Letters 97:6.
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Vasilissa Manova, Kostadin Gecheff & Lubomir Stoilov. (2006) Efficient repair of bleomycin-induced double-strand breaks in barley ribosomal genes. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 601:1-2, pages 179-190.
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G Esposito, M Belli, G Simone, E Sorrentino & M A. Tabocchini. (2006) A 244CM IRRADIATOR FOR PROTRACTED EXPOSURE OF CULTURED MAMMALIAN CELLS WITH ALPHA PARTICLES. Health Physics 90:1, pages 66-73.
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Yoshihiro Higuchi. (2003) Chromosomal DNA fragmentation in apoptosis and necrosis induced by oxidative stress. Biochemical Pharmacology 66:8, pages 1527-1535.
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Vasilissa I. Manova & Lubomir M. Stoilov. (2003) Induction and recovery of double-strand breaks in barley ribosomal DNA. DNA Repair 2:9, pages 983-990.
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R A El-Awady, E Dikomey & J Dahm-Daphi. (2003) Radiosensitivity of human tumour cells is correlated with the induction but not with the repair of DNA double-strand breaks. British Journal of Cancer 89:3, pages 593-601.
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Maria-Antonella Tabocchini, Kai Rothkamm, Claudia Signoretti, Jana Risse, Orazio Sapora & Markus Löbrich. (2000) Formation and repair of DNA double-strand breaks in γ-irradiated K562 cells undergoing erythroid differentiation. Mutation Research/DNA Repair 461:1, pages 71-82.
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Markus L�brich, Martin K�hne, Jana Wetzel & Kai Rothkamm. (2000) Joining of correct and incorrect DNA double-strand break ends in normal human and ataxia telangiectasia fibroblasts. Genes, Chromosomes and Cancer 27:1, pages 59-68.
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Kai Rothkamm & Markus Löbrich. (1999) Misrejoining of DNA double-strand breaks in primary and transformed human and rodent cells: a comparison between the HPRT region and other genomic locations. Mutation Research/DNA Repair 433:3, pages 193-205.
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M Löbrich. (1998) Induction and repair of DNA double-strand breaks in human fibroblasts after particle irradiation. Advances in Space Research 22:4, pages 551-560.
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Peggy L. Olive. 1998. DNA Damage and Repair. DNA Damage and Repair 539 557 .

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