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Original Article

Radiation-induced Genomic Instability

Pages 603-609 | Received 26 Jul 1994, Accepted 28 Jul 1994, Published online: 03 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Manuela Buonanno, Géraldine Gonon, Badri N. Pandey & Edouard I. Azzam. (2023) The intercellular communications mediating radiation-induced bystander effects and their relevance to environmental, occupational, and therapeutic exposures. International Journal of Radiation Biology 99:6, pages 964-982.
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Munira Kadhim, Seda Tuncay Cagatay & Eman Mohammed Elbakrawy. (2022) Non-targeted effects of radiation: a personal perspective on the role of exosomes in an evolving paradigm. International Journal of Radiation Biology 98:3, pages 410-420.
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Volodymyr A. Vinnikov, Nataliya A. Maznyk & David Lloyd. (2010) Delayed chromosomal instability in lymphocytes of cancer patients after radiotherapy. International Journal of Radiation Biology 86:4, pages 271-282.
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I. TESTARD, B. DUTRILLAUX and L. SABATIER. (1997) Chromosomal aberrations induced in human lymphocytes by high-LET irradiation. International Journal of Radiation Biology 72:4, pages 423-433.
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Andrew J. Grosovsky, Karyn K. Parks, Cynthia R. Giver & Stephen L. Nelson. (1996) Clonal Analysis of Delayed Karyotypic Abnormalities and Gene Mutations in Radiation-Induced Genetic Instability. Molecular and Cellular Biology 16:11, pages 6252-6262.
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M. JAMALI. (1996) Increased micronucleus frequency in the progeny of irradiated Chinese hamster cells. International Journal of Radiation Biology 69:3, pages 301-307.
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K. Holmberg, A.E. Meijer, G. Auer & BO Lambert. (1995) Delayed Chromosomal Instability in Human T-lymphocyte Clones Exposed to Ionizing Radiation. International Journal of Radiation Biology 68:3, pages 245-255.
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Leila Rouhi, Sirisha M. Cheedipudi, Benjamin Cathcart, Priyatansh Gurha & Ali J. Marian. (2023) Cytosolic DNA sensing protein pathway is activated in human hearts with dilated cardiomyopathy. The Journal of Cardiovascular Aging 3:3.
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Leon P. Bignold. 2020. Principles of Tumors. Principles of Tumors 375 388 .
S. Shohreh Alavi, Sima Taghizadeh Dabbagh, Mahya Abbasi & Ramin Mehrdad. (2016) Radiation Protection Knowledge, Attitude and Practice (RP-KAP) as Predictors of Job Stress Among Radiation Workers in Tehran Province, Iran. Iranian Red Crescent Medical Journal 18:10.
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Shubhankar Suman, Santosh Kumar, Bo-Hyun Moon, Steve J. Strawn, Hemang Thakor, Ziling Fan, Jerry W. Shay, Albert J. FornaceJr.Jr. & Kamal Datta. (2016) Relative Biological Effectiveness of Energetic Heavy Ions for Intestinal Tumorigenesis Shows Male Preponderance and Radiation Type and Energy Dependence in APC1638N/+ Mice. International Journal of Radiation Oncology*Biology*Physics 95:1, pages 131-138.
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G. Massenkeil, P. Zschieschang, G. Thiel, P. G. Hemmati, V. Budach, B. Dörken, J. Pross & R. Arnold. (2015) Frequent induction of chromosomal aberrations in in vivo skin fibroblasts after allogeneic stem cell transplantation: hints to chromosomal instability after irradiation. Radiation Oncology 10:1.
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A. Sundaresan, K. Marriott, J. Mao, S. Bhuiyan & P. Denkins. (2015) The Effects of Benzofuran-2-Carboxylic Acid Derivatives as Countermeasures in Immune Modulation and Cancer Cell Inhibition. Microgravity Science and Technology 27:3, pages 129-140.
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Leon P. Bignold. 2015. Principles of Tumors. Principles of Tumors 309 338 .
Dmytro Grygoryev, Cristian Dan, Stacey Gauny, Bradley Eckelmann, Anna P. Ohlrich, Marissa Connolly, Michael Lasarev, Gianfranco Grossi, Amy Kronenberg & Mitchell S. Turker. (2014) Autosomal Mutants of Proton-Exposed Kidney Cells Display Frequent Loss of Heterozygosity on Nonselected Chromosomes. Radiation Research 181:5, pages 452-463.
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Kamal Datta, Shubhankar Suman, Bhaskar V. S. Kallakury & Albert J. Fornace. (2013) Heavy Ion Radiation Exposure Triggered Higher Intestinal Tumor Frequency and Greater β-Catenin Activation than γ Radiation in APCMin/+ Mice. PLoS ONE 8:3, pages e59295.
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Jae Min Shin, Tae Hoon Lee, Sang-Heum Park, Sang Goo Kang, Yeon Seon Lee, Suk Ja Park, Mi Gyeong Ku, Suck-Ho Lee, Il-Kwun Chung, Hyun Jong Choi, Jong Ho Moon, Sang Woo Cha, Young Deok Cho & Sun-Joo Kim. (2013) A Survey of the Radiation Exposure Protection of Health Care Providers during Endoscopic Retrograde Cholangiopancreatography in Korea. Gut and Liver 7:1, pages 100-105.
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Byoung Kwan SonKyu Taek LeeJae Seon KimSeung Ok Lee. (2011) Lack of Radiation Protection for Endoscopists Performing Endoscopic Retrograde Cholangiopancreatography. The Korean Journal of Gastroenterology 58:2, pages 93.
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Jaroslaw Dziegielewski, Wilfried Goetz & Janet E. Baulch. (2009) Heavy ions, radioprotectors and genomic instability: implications for human space exploration. Radiation and Environmental Biophysics 49:3, pages 303-316.
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Ilaria Postiglione, Angela Chiaviello & Giuseppe Palumbo. (2009) Twilight effects of low doses of ionizing radiation on cellular systems: a bird’s eye view on current concepts and research. Medical Oncology 27:2, pages 495-509.
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Kanokporn Noy Rithidech, Wisa Supanpaiboon, Louise Honikel & Elbert B. Whorton. (2009) Induction of genomic instability after an acute whole-body exposure of mice to 56Fe ions. Advances in Space Research 44:8, pages 895-906.
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Rosalie Bertell, Lynn Howard Ehrle & Inge Schmitz-Feuerhake. (2016) Pediatric CT Research Elevates Public Health Concerns: Low-Dose Radiation Issues are Highly Politicized. International Journal of Health Services 37:3, pages 419-439.
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Christine E. Hellweg, Andrea Arenz & Christa Baumstark-Khan. (2007) Assessment of space environmental factors by cytotoxicity bioassays. Acta Astronautica 60:4-7, pages 525-533.
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Ivana Icevic, Visnja Bogdanovic, Dragan Zikic, Slavica Solajic, Gordana Bogdanovic & Aleksandar Djordjevic. (2007) The influence of fullerenol on the cell number, cell area and colony forming unit ability in irradiated human erythroleukemic cell line. Hemijska industrija Chemical Industry 61:3, pages 167-170.
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Visnja Bogdanovic, Karmen Stankov, Aleksandra Nikolic, Ivana Icevic, Slavica Solajic, Gordana Bogdanovic & Aleksandar Djordjevic. (2007) The influence of fullerenol on antioxidative enzyme activity in irradiated human erythroleukemic cell line (K562). Hemijska industrija Chemical Industry 61:3, pages 164-166.
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V. N. Kalaev & A. K. Butorina. (2006) Cytogenetic Effect of Radiation in Seed of Oak (Quercus robur L.) Trees Growing on Sites Contaminated by Chernobyl Fallout. Silvae Genetica 55:1-6, pages 93-101.
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Carmel Mothersill & C.B. Seymour. (2006) Radiation-induced bystander effects and the DNA paradigm: An “out of field” perspective. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 597:1-2, pages 5-10.
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Colin J. Martin. 2006. Wiley Encyclopedia of Biomedical Engineering. Wiley Encyclopedia of Biomedical Engineering.
P Uma Devi & M Satyamitra. (2005) Tracing radiation induced genomic instability in vivo in the haemopoietic cells from fetus to adult mouse . The British Journal of Radiology 78:934, pages 928-933.
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Rebecca E. Rugo & Robert H. Schiestl. (2004) Increases in Oxidative Stress in the Progeny of X-Irradiated Cells. Radiation Research 162:4, pages 416-425.
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Antone L. Brooks. (2003) Developing a scientific basis for radiation risk estimates: major goal of the DOE Low Dose Radiation Research Program. International Congress Series 1258, pages 287-295.
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Antone L. Brooks. (2003) DEVELOPING A SCIENTIFIC BASIS FOR RADIATION RISK ESTIMATES: GOAL OF THE DOE LOW DOSE RESEARCH PROGRAM. Health Physics 85:1, pages 85-93.
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Jeffrey L. Schwartz, Robert Jordan, Helen H. Evans, Marek Lenarczyk & Howard Liber. (2003) The TP53 Dependence of Radiation-Induced Chromosome Instability in Human Lymphoblastoid Cells. Radiation Research 159:6, pages 730-736.
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Tomonori Miyazawa, Hiroki Sato, Katsuyoshi Hatakeyama, Tomoyuki Kitagawa & Ryo Kominami. (2005) Allelic Losses in Mouse Skin Tumors Induced by γ‐Irradiation of p53 Heterozygotes . Japanese Journal of Cancer Research 93:9, pages 994-999.
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R. E. Rugo, M. B. Secretan & R. H. Schiestl. (2002) X Radiation Causes a Persistent Induction of Reactive Oxygen Species and a Delayed Reinduction of TP53 in Normal Human Diploid Fibroblasts. Radiation Research 158:2, pages 210-219.
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M. Durante. (2002) Radiation protection in space. La Rivista del Nuovo Cimento 25:8, pages 1-70.
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Ross P Phillipson, Simon E Tobi, James A Morris & Trevor J McMillan. (2002) UV-A induces persistent genomic instability in human keratinocytes through an oxidative stress mechanism. Free Radical Biology and Medicine 32:5, pages 474-480.
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Edward L. Loechler, Bryan Henry & Kwang-Young Seo. 2002. The Molecular Basis of Human Cancer. The Molecular Basis of Human Cancer 203 222 .
Jeffrey L Schwartz, Robert Jordan & Helen H Evans. (2001) Characteristics of chromosome instability in the human lymphoblast cell line WTK1. Cancer Genetics and Cytogenetics 129:2, pages 124-130.
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L. Abramsson-Zetterberg & J. Grawé. (2001) Extended exposure of adult and fetal mice to 50 Hz magnetic field does not increase the incidence of micronuclei in erythrocytes. Bioelectromagnetics 22:5, pages 351-357.
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Richard J. Brennan & Robert H. Schiestl. (2001) Persistent Genomic Instability in the Yeast Saccharomyces cerevisiae Induced by Ionizing Radiation and DNA-Damaging Agents . Radiation Research 155:6, pages 768-777.
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Detlef Bartkowiak, Stephanie Högner, Wilhelm Nothdurft & Erwin M Röttinger. (2001) Cell cycle and growth response of CHO cells to X-irradiation: Threshold-free repair at low doses. International Journal of Radiation Oncology*Biology*Physics 50:1, pages 221-227.
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Eleanor A. Blakely. (2000) Biological Effects of Cosmic Radiation: Deterministic and Stochastic. Health Physics 79:5, pages 495-506.
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Masataka Taga, Kazunori Shiraishi, Tsutomu Shimura, Norio Uematsu, Mitsuo Oshimura & Ohtsura Niwa. (2005) Increased Frequencies of Gene and Chromosome Mutations after X‐Irradiation in Mouse Embryonal Carcinoma Cells Transfected with the bcl‐2 Gene. Japanese Journal of Cancer Research 91:10, pages 994-1000.
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D Averbeck. (2000) Mécanismes de réparation et mutagenèse radio-induite chez les eucaryotes supérieurs. Cancer/Radiothérapie 4:5, pages 335-354.
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Christina Voelkel-Johnson, Dale J. Voeks, Norman M. Greenberg, Roberto Barrios, Frideriki Maggouta, David T. Kurtz, David A. Schwartz, Gina M. Keller, Thomas Papenbrock, Gary A. Clawson & James S. Norris. (2000) Genomic instability-based transgenic models of prostate cancer. Carcinogenesis 21:8, pages 1623-1627.
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Christina Voelkel-Johnson, Dale J. Voeks, Norman M. Greenberg, Roberto Barrios, Frideriki Maggouta, David T. Kurtz, David A. Schwartz, Gina M. Keller, Thomas Papenbrock, Gary A. Clawson & James S. Norris. (2000) Genomic instability-based transgenic models of prostate cancer. Carcinogenesis 21:8, pages 1623-1627.
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E.V. Domracheva, N.B. Rivkind, E.A. Aseeva, T.N. Obukhova, L.V. D’achenko & A.I. Vorobiov. (2000) Stable and unstable aberrations in lymphocytes of Chernobyl accident clearance workers carrying rogue cells. Applied Radiation and Isotopes 52:5, pages 1153-1159.
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Isabelle Testard & Laure Sabatier. (1998) Is delayed genomic instability specifically induced by high-LET particles?. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 146:1-4, pages 518-527.
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Bo Lambert, Kerstin Holmberg, Peter Hackman & Anders Wennborg. (1998) Radiation induced chromosomal instability in human T-lymphocytes. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 405:2, pages 161-170.
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Rosemary M. Caron, Hatsumi Nagasawa, Yongjia Yu, Tracy Pfenning, Helen Vetrovs & John B. Little. (1997) Evidence for a role for genomic instability in radiation-induced mutagenesis. Radiation Oncology Investigations 5:3, pages 119-123.
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John P. Murname. (1996) Role of induced genetic instability in the mutagenic effects of chemicals and radiation. Mutation Research/Genetic Toxicology 367:1, pages 11-23.
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