25
Views
48
CrossRef citations to date
0
Altmetric
Original Article

DNA Double-strand Break Induction and Rejoining as Determinants of Human Tumour Cell Radiosensitivity. A Pulsed-field Gel Electrophoresis Study

, &
Pages 7-18 | Received 22 Feb 1994, Accepted 31 Aug 1994, Published online: 03 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

D. M. Smith & G. P. Raaphorst. (2003) Adaptive responses in human glioma cells assessed by clonogenic survival and DNA strand break analysis. International Journal of Radiation Biology 79:5, pages 333-339.
Read now
Spiros Vamvakas, Esther H. Vock & Werner K. Lutz. (1997) On the Role of DNA Double-Strand Breaks in Toxicity and Carcinogenesis. Critical Reviews in Toxicology 27:2, pages 155-174.
Read now
N. C. WATSON, Y.-M. DI, M. S. ORR, F. A. FORNARI JR, J. K. RANDOLPH, K. J. MAGNET, P. T. JAIN and D. A. GEWIRTZ. (1997) Influence of ionizing radiation on proliferation, c-myc expression and the induction of apoptotic cell death in two breast tumour cell lines differing in p53 status. International Journal of Radiation Biology 72:5, pages 547-559.
Read now
N. FORAY. (1996) Dose-rate effect on radiation-induced DNA double-strand breaks in the human fibroblast HF19 cell line. International Journal of Radiation Biology 69:2, pages 241-249.
Read now
E. C. WOUDSTRA. (1996) Chromatin structure and cellular radiosensitivity: a comparison of two human tumour cell lines. International Journal of Radiation Biology 70:6, pages 693-703.
Read now
T. Orta, J.J. Eady, J.H. Peacock & G.G. Steel. (1995) Glutathione Manipulation and the Radiosensitivity of Human Tumour and Fibroblast Cell Lines. International Journal of Radiation Biology 68:4, pages 413-419.
Read now

Articles from other publishers (40)

Seiya Takano, Yuta Shibamoto, Zhen Wang, Takuhito Kondo, Shingo Hashimoto, Tatsuya Kawai & Akio Hiwatashi. (2023) Optimal timing of a γH2AX analysis to predict cellular lethal damage in cultured tumor cell lines after exposure to diagnostic and therapeutic radiation doses. Journal of Radiation Research 64:2, pages 317-327.
Crossref
Megumi Fujiwara, Nana Sato & Ken Okamoto. (2022) Hypoxanthine Reduces Radiation Damage in Vascular Endothelial Cells and Mouse Skin by Enhancing ATP Production via the Salvage Pathway. Radiation Research 197:6.
Crossref
Lisa Herr, Igor Shuryak, Thomas Friedrich, Michael Scholz, Marco Durante & David J. Brenner. (2015) New Insight into Quantitative Modeling of DNA Double-Strand Break Rejoining. Radiation Research 184:3, pages 280.
Crossref
Pedro Carlos Lara, Jesús Joaquín López-Peñalver, Virgínea de Araújo Farias, M. Carmen Ruiz-Ruiz, Francisco Javier Oliver & José Mariano Ruiz de Almodóvar. (2015) Direct and bystander radiation effects: A biophysical model and clinical perspectives. Cancer Letters 356:1, pages 5-16.
Crossref
JIANGUO LI, YAN WANG, LIQING DU, CHANG XU, JIA CAO, QIN WANG, QIANG LIU & FEIYUE FAN. (2014) Nested PCR for mtDNA-4977-bp deletion and comet assay for DNA damage - a combined method for radiosensitivity evaluation of tumor cells. Oncology Letters 7:4, pages 1083-1087.
Crossref
A-C Heuskin, C Michiels & S Lucas. (2013) Toward computer simulation of high-LET in vitro survival curves . Physics in Medicine and Biology 58:18, pages 6495-6510.
Crossref
Ekram M. Saleh, Raafat A. El-awady, Noha Anis & Nahla El-sharkawy. (2012) Induction and repair of DNA double-strand breaks using constant-field gel electrophoresis and apoptosis as predictive markers for sensitivity of cancer cells to cisplatin. Biomedicine & Pharmacotherapy 66:7, pages 554-562.
Crossref
Chizuru Tsuruoka. (2011) Difference in Biological Effectiveness Due to The Endpoints and Radiation Quality. Biological Sciences in Space 25:1, pages 13-17.
Crossref
Christophe E. Redon, Jennifer S. Dickey, Asako J. Nakamura, Olga A. Martin & William M. Bonner. 2011. Molecular Determinants of Radiation Response. Molecular Determinants of Radiation Response 3 33 .
Britta C. Kaminski, Gerhard G. Grabenbauer, Carl N. Sprung, Rolf Sauer & Luitpold V.R. Distel. (2006) Inter-relation of apoptosis and DNA double-strand breaks in patients with multiple primary cancers. European Journal of Cancer Prevention 15:3, pages 274-282.
Crossref
Joanna D. Friesner, Bo Liu, Kevin Culligan & Anne B. Britt. (2005) Ionizing Radiation–dependent γ-H2AX Focus Formation Requires Ataxia Telangiectasia Mutated and Ataxia Telangiectasia Mutated and Rad3-related. Molecular Biology of the Cell 16:5, pages 2566-2576.
Crossref
Nicole Chavaudra, Jean Bourhis & Nicolas Foray. (2004) Quantified relationship between cellular radiosensitivity, DNA repair defects and chromatin relaxation: a study of 19 human tumour cell lines from different origin. Radiotherapy and Oncology 73:3, pages 373-382.
Crossref
Abdelkarim S. Allal, Thilo Kähne, Alexandra K. Reverdin, Hans Lippert, Werner Schlegel & Marc‐André Reymond. (2004) Radioresistance‐related proteins in rectal cancer. PROTEOMICS 4:8, pages 2261-2269.
Crossref
L Bohm. (2004) Cellular radiosensitivity: do separate predictive parameters apply for fibroblasts and for human tumour cells?. British Journal of Cancer 90:2, pages 554-555.
Crossref
Jochen Dahm-Daphi & Petra Hubbe. 2004. Life Sciences and Radiation. Life Sciences and Radiation 121 137 .
R A El-Awady, E Dikomey & J Dahm-Daphi. (2003) Radiosensitivity of human tumour cells is correlated with the induction but not with the repair of DNA double-strand breaks. British Journal of Cancer 89:3, pages 593-601.
Crossref
ALEXANDRA J. COLQUHOUN, GEORGE D.D. JONES, MANAR A.L. MONEEF, KAREN J. BOWMAN, ROGER C. KOCKELBERGH, R. PAUL SYMONDS, WILL P. STEWARD & J. KILIAN MELLON. (2003) Improving and Predicting Radiosensitivity in Muscle Invasive Bladder Cancer. Journal of Urology 169:6, pages 1983-1992.
Crossref
Seiichi WADA, Hidemitsu KURAHAYASHI, Yasuhiko KOBAYASHI, Tomoo FUNAYAMA, Kazuo YAMAMOTO, Masahiro NATSUHORI & Nobuhiko ITO. (2003) The Relationship between Cellular Radiosensitivity and Radiation-Induced DNA Damage Measured by the Comet Assay. Journal of Veterinary Medical Science 65:4, pages 471-477.
Crossref
Björn E. Cedervall & Trevor J. McMillan. (2002) The Fraction of DNA Released on Pulsed-Field Gel Electrophoresis Gels may Differ Significantly between Genomes at Low Levels of Double-Strand Breaks. Radiation Research 158:2, pages 247-249.
Crossref
Jochen Lips & Bernd Kaina. (2001) DNA double-strand breaks trigger apoptosis in p53-deficient fibroblasts. Carcinogenesis 22:4, pages 579-585.
Crossref
Trevor J McMillan, Simon Tobi, Santiago Mateos & Catherine Lemon. (2001) The use of DNA double-strand break quantification in radiotherapy. International Journal of Radiation Oncology*Biology*Physics 49:2, pages 373-377.
Crossref
Masao Suzuki, Yoko Kase, Hiroshi Yamaguchi, Tatsuaki Kanai & Koichi Ando. (2000) Relative biological effectiveness for cell-killing effect on various human cell lines irradiated with heavy-ion medical accelerator in Chiba (HIMAC) carbon-ion beams. International Journal of Radiation Oncology*Biology*Physics 48:1, pages 241-250.
Crossref
M. E. Price, V. J. McKelvey-Martin, T. Robson, D. G. Hirst & S. R. McKeown. (2000) Induction and Rejoining of DNA Double-Strand Breaks in Bladder Tumor Cells. Radiation Research 153:6, pages 788-794.
Crossref
Ekkehard Dikomey, Ingo Brammer, Jørgen Johansen, Søren M. Bentzen & Jens Overgaard. (2000) Relationship between DNA double-strand breaks, cell killing, and fibrosis studied in confluent skin fibroblasts derived from breast cancer patients. International Journal of Radiation Oncology*Biology*Physics 46:2, pages 481-490.
Crossref
M Widel, S Jędruś, S Owczarek, M Konopacka, B Lubecka & Z Kolosza. (1999) The increment of micronucleus frequency in cervical carcinoma during irradiation in vivo and its prognostic value for tumour radiocurability. British Journal of Cancer 80:10, pages 1599-1607.
Crossref
Kai Rothkamm & Markus Löbrich. (1999) Misrejoining of DNA double-strand breaks in primary and transformed human and rodent cells: a comparison between the HPRT region and other genomic locations. Mutation Research/DNA Repair 433:3, pages 193-205.
Crossref
F Sirzén, A Nilsson, B Zhivotovsky & R Lewensohn. (1999) DNA-dependent protein kinase content and activity in lung carcinoma cell lines: correlation with intrinsic radiosensitivity. European Journal of Cancer 35:1, pages 111-116.
Crossref
Anya G Polischouk, Björn Cedervall, Siv Ljungquist, Jenny Flygare, Dennis Hellgren, Reidar Grénman & Rolf Lewensohn. (1999) DNA double-strand break repair, DNA-PK, and DNA ligases in two human squamous carcinoma cell lines with different radiosensitivity. International Journal of Radiation Oncology*Biology*Physics 43:1, pages 191-198.
Crossref
Birgitte Stausbøl-Grøn & Jens Overgaard. (1999) Relationship between tumour cell in vitro radiosensitivity and clinical outcome after curative radiotherapy for squamous cell carcinoma of the head and neck. Radiotherapy and Oncology 50:1, pages 47-55.
Crossref
S N Powell, J Mills & T J McMillan. (1998) Radiosensitive human tumour cell lines show misrepair of DNA termini.. The British Journal of Radiology 71:851, pages 1178-1184.
Crossref
Santiago Mateos, G.Gordon Steel & Trevor J. McMillan. (1998) Differences between a human bladder carcinoma cell line and its radiosensitive clone in the formation of radiation-induced DNA double-strand breaks in different chromatin substrates. Mutation Research/DNA Repair 409:2, pages 73-80.
Crossref
T Girinsky & MM Cosset. (1998) Les tests de radiosensibilité tumorale: état des lieux en 1998. Cancer/Radiothérapie 2:5, pages 530-533.
Crossref
Pascale Varlet, Nathalie Bidon, Georges Noël, Gilbert DeMurcia, Jean Salamero & Dietrich Averbeck. (1998) Fragmentation radio-induite de l'ADN évaluée par immunomarquage anti poly(ADP-ribose) dans les CHO. Étalonnage par électrophorèse en champ pulsé. Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie 321:4, pages 313-318.
Crossref
N. Foray, C.F. Arlett & E.P. Malaise. (1997) Radiation-induced DNA double-strand breaks and the radiosensitivity of human cells: A closer look. Biochimie 79:9-10, pages 567-575.
Crossref
A.T. Gordon & T.J. McMillan. (1997) A role for molecular radiobiology in radiotherapy?. Clinical Oncology 9:2, pages 70-78.
Crossref
Corinne M. Gajdusek, Hua Tian, Susan London, Dadong Zhou, Janet Rasey & Marc R. Mayberg. (1996) Gamma radiation effect on vascular smooth muscle cells in culture. International Journal of Radiation Oncology*Biology*Physics 36:4, pages 821-828.
Crossref
P. Virsik-Peuckert, M. Rave-Fränk & H. Schmidberger. (1996) Further studies on the possible relationship between radiation-induced reciprocal translocations and intrinsic radiosensitivity of human tumor cells. Radiotherapy and Oncology 40:2, pages 111-119.
Crossref
M.I. Núñez, T.J. McMillan, M.T. Valenzuela, J.M.Ruiz de Almodóvar & V. Pedraza. (1996) Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells. Radiotherapy and Oncology 39:2, pages 155-165.
Crossref
Elies C. Woudstra, Jeanette F. Brunsting, Judith M. Roesink, Antonius W.T. Konings & Harm H. Kampinga. (1996) Radiation induced DNA damage and damage repair in three human tumour cell lines. Mutation Research/DNA Repair 362:1, pages 51-59.
Crossref
N. Foray, C.F. Arlett & E.P. Malaise. (1995) Dose-rate effect on induction and repair rate of radiation-induced DNA double-strand breaks in a normal and an ataxia telangiectasia human fibroblast cell line. Biochimie 77:11, pages 900-905.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.