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International Journal of Radiation Biology Volume 67, 1995 - Issue 2
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Original Article

Does Tirapazamine (SR-4233) Have Any Cytotoxic or Sensitizing Effect on Three Human Tumour Cell Lines at Clinically Relevant Partial Oxygen Pressure?

E. Lartigau Laboratoire de Radiobiologie Cellulaire, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94800, Villejuif, France
&
M. Guichard Laboratoire de Radiobiologie Cellulaire, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94800, Villejuif, France
Pages 211-216 | Received 01 Jun 1994, Accepted 26 Sep 1994, Published online: 03 Jul 2009

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Read on this site (2)

William A. Denny. (2004) Tumor-activated Prodrugs—A New Approach to Cancer Therapy. Cancer Investigation 22:4, pages 604-619.
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William A Denny & William R Wilson. (2000) Tirapazamine: a bioreductive anticancer drug that exploits tumour hypoxia. Expert Opinion on Investigational Drugs 9:12, pages 2889-2901.
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Articles from other publishers (14)

Nuria Vilaplana-Lopera, Maxym Besh & Eui Jung Moon. (2021) Targeting Hypoxia: Revival of Old Remedies. Biomolecules 11:11, pages 1604.
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Ishna N. Mistry, Matthew Thomas, Ewen D.D. Calder, Stuart J. Conway & Ester M. Hammond. (2017) Clinical Advances of Hypoxia-Activated Prodrugs in Combination With Radiation Therapy. International Journal of Radiation Oncology*Biology*Physics 98:5, pages 1183-1196.
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Nabila Kazmi, M.A. Hossain & Roger M. Phillips. (2012) A Hybrid Cellular Automaton Model of Solid Tumor Growth and Bioreductive Drug Transport. IEEE/ACM Transactions on Computational Biology and Bioinformatics 9:6, pages 1595-1606.
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N. Kazmi, M.A. Hossain, R.M. Phillips, M.A. Al-Mamun & R. Bass. (2012) Avascular tumour growth dynamics and the constraints of protein binding for drug transportation. Journal of Theoretical Biology 313, pages 142-152.
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N. Kazmi, M. A. Hossain & R. Phillips. (2011) A hybrid cellular automaton model of bioreductive drug transportation with protein binding. A hybrid cellular automaton model of bioreductive drug transportation with protein binding.
Bo Hong, Vivian W. Y. Lui, Edwin P. Hui, Margaret H. L. Ng, Suk-Hang Cheng, Fion L. Sung, Chi-Man Tsang, Sai-Wah Tsao & Anthony Tak-Cheung Chan. (2009) Hypoxia-targeting by tirapazamine (TPZ) induces preferential growth inhibition of nasopharyngeal carcinoma cells with Chk1/2 activation. Investigational New Drugs 29:3, pages 401-410.
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N. Kazmi, M. A. Hossain & R. M. Phillips. 2011. 5th International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB 2011). 5th International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB 2011) 125 132 .
Tanguy Y Seiwert, Joseph K Salama & Everett E Vokes. (2007) The concurrent chemoradiation paradigm—general principles. Nature Clinical Practice Oncology 4:2, pages 86-100.
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Rachel L. Cowen, Kaye J. Williams, Edwin C. Chinje, Mohammed Jaffar, Freda C. D. Sheppard, Brian A. Telfer, Natasha S. Wind & Ian J. Stratford. (2004) Hypoxia Targeted Gene Therapy to Increase the Efficacy of Tirapazamine as an Adjuvant to Radiotherapy. Cancer Research 64:4, pages 1396-1402.
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Donald J. AbrahamWilliam A. Denny. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 51 105 .
E. Lartigau, S. Stern & M. Guichard. (2000) Survie in vitro « oxygène dépendantede deux lignées humaines après irradiation associée à la tirapazamine (SR-4233) et au cisplatine. Cancer/Radiothérapie 4:3, pages 217-222.
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Eric Lartigau & Marcelle Guichard. 1999. Antiangiogenic Agents in Cancer Therapy. Antiangiogenic Agents in Cancer Therapy 23 35 .
E Lartigau. (1998) Radiosensibilisateurs des cellules hypoxiques : passé, présent et avenir. Cancer/Radiothérapie 2:6, pages 775-780.
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E Lartigau, A Lusinchi, P Weeger, P Wibault, B Luboinski, F Eschwege & M Guichard. (1998) Variations in tumour oxygen tension (pO2) during accelerated radiotherapy of head and neck carcinoma. European Journal of Cancer 34:6, pages 856-861.
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