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International Journal of Radiation Biology Volume 70, 1996 - Issue 6
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Research Article

P53 deficiency produces fewer regenerating spermatogenic tubules after irradiation

J. H. HENDRY, A. ADEEKO, C. S. POTTEN and I. D. MORRIS CRC Departments of Experimental Radiation Oncology and Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester M20 4BX, UK. Department of Pharmacology, Physiology and Toxicology, School of Biological Sciences, University of Manchester, Manchester, M13 9PT, UK.
Pages 677-682 | Published online: 03 Jul 2009

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Chamutal Bornstein, Ran Brosh, Alina Molchadsky, Shalom Madar, Ira Kogan-Sakin, Ido Goldstein, Deepavali Chakravarti, Elsa R. Flores, Naomi Goldfinger, Rachel Sarig & Varda Rotter. (2011) SPATA18, a Spermatogenesis-Associated Gene, Is a Novel Transcriptional Target of p53 and p63. Molecular and Cellular Biology 31:8, pages 1679-1689.
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Articles from other publishers (22)

Craig M. Brackett, Kellee F. Greene, Alyssa R. Aldrich, Nicholas H. Trageser, Srabani Pal, Ivan Molodtsov, Bojidar M. Kandar, Lyudmila G. Burdelya, Scott I. Abrams & Andrei V. Gudkov. (2021) Signaling through TLR5 mitigates lethal radiation damage by neutrophil-dependent release of MMP-9. Cell Death Discovery 7:1.
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J. C. Bloom, A. R. Loehr, J. C. Schimenti & R. S. Weiss. (2019) Germline genome protection: implications for gamete quality and germ cell tumorigenesis. Andrology.
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Yi Zheng, Qijing Lei, Aldo Jongejan, Callista L. Mulder, Saskia K.M. van Daalen, Sebastiaan Mastenbroek, Grace Hwang, Philip W. Jordan, Sjoerd Repping & Geert Hamer. (2018) The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells. DNA Repair 70, pages 55-66.
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M. S. Dai, S. J. Hall, M. M. Vantangoli Policelli, K. Boekelheide & D. J. Spade. (2017) Spontaneous testicular atrophy occurs despite normal spermatogonial proliferation in a Tp53 knockout rat . Andrology 5:6, pages 1141-1152.
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Henri-Baptiste Marjault & Isabelle Allemand. (2016) Consequences of irradiation on adult spermatogenesis: Between infertility and hereditary risk. Mutation Research/Reviews in Mutation Research 770, pages 340-348.
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Kei Ishii, Masamichi Ishiai, Hiroko Morimoto, Mito Kanatsu-Shinohara, Ohtsura Niwa, Minoru Takata & Takashi Shinohara. (2014) The Trp53-Trp53inp1-Tnfrsf10b Pathway Regulates the Radiation Response of Mouse Spermatogonial Stem Cells. Stem Cell Reports 3:4, pages 676-689.
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Y.N. Lou, W.J. Liu, C.L. Wang, L. Huang, S.Y. Jin, Y.Q. Lin & Y.C. Zheng. (2014) Histological evaluation and Prdm9 expression level in the testis of sterile male cattle-yaks. Livestock Science 160, pages 208-213.
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Flavio Maina & Rosanna Dono. 2008. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy 189 202 .
Akira Kaji, Yiguo Zhang, Masaaki Nomura, Ann M. Bode, Wei‐Ya Ma, Qing‐Bai She & Zigang Dong. (2003) Pifithrin‐α promotes p53‐mediated apoptosis in JB6 cells. Molecular Carcinogenesis 37:3, pages 138-148.
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Andrei V. Gudkov & Elena A. Komarova. (2003) The role of p53 in determining sensitivity to radiotherapy. Nature Reviews Cancer 3:2, pages 117-129.
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Paul P.W. van Buul & Annemarie van Duijn-Goedhart. (2002) Enhanced recovery of radiation-induced translocations from spermatogonial stem cells of p53 null mice. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 508:1-2, pages 29-32.
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Grant A. Haines, Jolyon H. Hendry, C. Paul Daniel & Ian D. Morris. (2002) Germ Cell and Dose-Dependent DNA Damage Measured by the Comet Assay in Murine Spermatozoaa after Testicular X-Irradiation1. Biology of Reproduction 67:3, pages 854-861.
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Elena A. Komarova & Andrei V. Gudkov. (2001) Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors 2 2Abbreviations: CP, cyclophosphamide; PFT, pifithrin-α or p53 inhibitor; HT, hyperthermia; HS, heat shock; HO, hypoxia; and HIF-1, hypoxia inducible factor.. Biochemical Pharmacology 62:6, pages 657-667.
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Anjali K. Gupta, Vincent J. Bakanauskas, W. Gillies McKenna, Eric J. Bernhard & Ruth J. Muschel. 2001. Regulators and Effectors of Small GTPases, Part G. Regulators and Effectors of Small GTPases, Part G 284 290 .
M. E. Embree & K. Boekelheide. 2000. Testis, Epididymis and Technologies in the Year 2000. Testis, Epididymis and Technologies in the Year 2000 141 163 .
Isabelle Allemand, Anny Anglo, Anne-Yvonne Jeantet, Italina Cerutti & Evelyne May. (1999) Testicular wild-type p53 expression in transgenic mice induces spermiogenesis alterations ranging from differentiation defects to apoptosis. Oncogene 18:47, pages 6521-6530.
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Pavel G. KomarovElena A. KomarovaRoman V. KondratovKonstantin Christov-TselkovJohn S. CoonMikhail V. ChernovAndrei V. Gudkov. (1999) A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy. Science 285:5434, pages 1733-1737.
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J. Martin Brown & Bradly G. Wouters. 1999. Apoptosis and Cancer Chemotherapy. Apoptosis and Cancer Chemotherapy 1 19 .
Tim L. Beumer & Dirk G. De Rooij. 1999. Male Sterility and Motility Disorders. Male Sterility and Motility Disorders 215 224 .
Abid Sattar, Stephen C. Robson, Hitendra R. H. Patel, Brian Angus & Frederick C. Campbell. (1999) Expression of growth regulatory genes in a SCID mouse-human model of intestinal epithelial regeneration. The Journal of Pathology 187:2, pages 229-236.
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Dirk G de Rooij & J Anton Grootegoed. (1998) Spermatogonial stem cells. Current Opinion in Cell Biology 10:6, pages 694-701.
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Teresa Odorisio, Tristan A. Rodriguez, Edward P. Evans, Alan R. Clarke & Paul S. Burgoyne. (1998) The meiotic checkpoint monitoring sypapsis eliminates spermatocytes via p53-independent apoptosis. Nature Genetics 18:3, pages 257-261.
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