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Research Article

Withaferin A: a new radiosensitizer from the Indian medicinal plant Withania somnifera

Pages 193-197 | Published online: 03 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Bianca Hamman, Angela Chinhengo, Antonio Serafin, Vikash Sewram & John Akudugu. (2018) Radiomodifying effects of Centella asiatica and Withania somnifera. Journal of Herbs, Spices & Medicinal Plants 24:3, pages 221-228.
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Shaik Abdul Hussain, Narender Raju Panjagari, R. R. B. Singh & G. R. Patil. (2015) Potential Herbs and Herbal Nutraceuticals: Food Applications and Their Interactions with Food Components. Critical Reviews in Food Science and Nutrition 55:1, pages 94-122.
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M.K. Kaul, Arun Kumar, Ashok Ahuja, B.A. Mir, K.A. Suri & G.N. Qazi. (2009) Production dynamics of Withaferin A in Withania somnifera (L.) Dunal complex. Natural Product Research 23:14, pages 1304-1311.
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SilviaD. Stan, Yan Zeng & ShivendraV. Singh. (2008) Ayurvedic Medicine Constituent Withaferin A Causes G2 and M Phase Cell Cycle Arrest in Human Breast Cancer Cells. Nutrition and Cancer 60:sup1, pages 51-60.
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Articles from other publishers (51)

Smriti Ojha, Shalini Yadav, Ajeet, Babita Aggarwal, Saurabh Kumar Gupta & Sudhanshu Mishra. (2023) Considering the Conception of Nanotechnology Integrated on Herbal Formulation for the Management of Cancer. Letters in Drug Design & Discovery 20:10, pages 1437-1457.
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Sabah Nisar, Tariq Masoodi, Kirti S. Prabhu, Shilpa Kuttikrishnan, Lubna Zarif, Summaiya Khatoon, Shahid Ali, Shahab Uddin, Ammira Al-Shabeeb Akil, Mayank Singh, Muzafar A. Macha & Ajaz A. Bhat. (2022) Natural products as chemo-radiation therapy sensitizers in cancers. Biomedicine & Pharmacotherapy 154, pages 113610.
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Tahira Sultana, Mohammad K. Okla, Madiha Ahmed, Nosheen Akhtar, Abdulrahman Al-Hashimi, Hamada Abdelgawad & Ihsan-ul- Haq. (2021) Withaferin A: From Ancient Remedy to Potential Drug Candidate. Molecules 26:24, pages 7696.
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Jerome Lacombe, Titouan Cretignier, Laetitia Meli, E. M. Kithsiri Wijeratne, Jean-Luc Veuthey, Muriel Cuendet, A. A. Leslie Gunatilaka & Frederic Zenhausern. (2020) Withanolide D Enhances Radiosensitivity of Human Cancer Cells by Inhibiting DNA Damage Non-homologous End Joining Repair Pathway. Frontiers in Oncology 9.
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Preetismita Borah & Bimal Krishna Banik. 2020. Green Approaches in Medicinal Chemistry for Sustainable Drug Design. Green Approaches in Medicinal Chemistry for Sustainable Drug Design 759 776 .
Rinku Dutta, Roukiah Khalil, Ryan Green, Shyam S Mohapatra & Subhra Mohapatra. (2019) Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology. International Journal of Molecular Sciences 20:21, pages 5310.
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Marco Calvaruso, Gaia Pucci, Rosa Musso, Valentina Bravatà, Francesco P. Cammarata, Giorgio Russo, Giusi I. Forte & Luigi Minafra. (2019) Nutraceutical Compounds as Sensitizers for Cancer Treatment in Radiation Therapy. International Journal of Molecular Sciences 20:21, pages 5267.
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Iram Fatima, Sobia Kanwal & Tariq Mahmood. (2019) Natural Products Mediated Targeting of Virally Infected Cancer. Dose-Response 17:1, pages 155932581881322.
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Steffi Witter, Raiker Witter, Raivo Vilu & Ago Samoson. (2018) Medical Plants and Nutraceuticals for Amyloid-β Fibrillation Inhibition. Journal of Alzheimer's Disease Reports 2:1, pages 239-252.
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Jasdeep Dhami, Edwin Chang & Sanjiv S. Gambhir. (2016) Withaferin A and its potential role in glioblastoma (GBM). Journal of Neuro-Oncology 131:2, pages 201-211.
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Genji Imokawa. 2017. Science of Ashwagandha: Preventive and Therapeutic Potentials. Science of Ashwagandha: Preventive and Therapeutic Potentials 121 146 .
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Mohammad Bokaeian, Barat Ali Fakheri, Nafise Mahdi Nejad, Hemadollah Zarei, Saeide Saeidi & Taher Mohasseli. (2015) The Effect of Withania somnifera Extract on Drug Resistant Strains of Escherichia coli. International Journal of Infection 2:2.
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Sharmistha Gupta & Pankaj K. Sahu. (2015) WITHDRAWN: In vitro micro propagation of Withania somnifera (L.) Dunal. Saudi Journal of Biological Sciences.
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Amritpal Saroya. 2014. Herbal Drugs as Therapeutic Agents. Herbal Drugs as Therapeutic Agents 20 27 .
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Shailendra Kapoor. (2012) Withania somnifera and its emerging anti-neoplastic effects. Inflammopharmacology 22:1, pages 67-67.
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Marie L. Antony, Joomin Lee, Eun-Ryeong Hahm, Su-Hyeong Kim, Adam I. Marcus, Vandana Kumari, Xinhua Ji, Zhen Yang, Courtney L. Vowell, Peter Wipf, Guy T. Uechi, Nathan A. Yates, Guillermo Romero, Saumendra N. Sarkar & Shivendra V. Singh. (2014) Growth Arrest by the Antitumor Steroidal Lactone Withaferin A in Human Breast Cancer Cells Is Associated with Down-regulation and Covalent Binding at Cysteine 303 of β-Tubulin. Journal of Biological Chemistry 289:3, pages 1852-1865.
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Wim Vanden Berghe, Linde Sabbe, Mary Kaileh, Guy Haegeman & Karen Heyninck. (2012) Molecular insight in the multifunctional activities of Withaferin A. Biochemical Pharmacology 84:10, pages 1282-1291.
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Thomas Efferth & Henry Johannes Greten. (2012) In Silico Analysis of Microarray-Based Gene Expression Profiles Predicts Tumor Cell Response to Withanolides. Microarrays 1:1, pages 44-63.
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Kiran B. Aithal, Sunil Kumar, B. Nageshwar Rao, Nayanabhirama Udupa & Satish Bola Sadashiva Rao. (2011) Tumor Growth Inhibitory Effect of Juglone and Its Radiation Sensitizing Potential. Integrative Cancer Therapies 11:1, pages 68-80.
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Hiroaki Nakajima, Yuki Wakabayashi, Kazumasa Wakamatsu & Genji Imokawa. (2011) An Extract of Withania somnifera Attenuates Endothelin‐1‐stimulated Pigmentation in Human Epidermal Equivalents through the Interruption of PKC Activity Within Melanocytes . Phytotherapy Research 25:9, pages 1398-1411.
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M. Akram, E. Mohiuddin, Abdul Hannan & Khan Usmanghani. (2011) Withania somnifera (L.) Dunal(Pharmacology Activity). Pharmacognosy Journal 2:18, pages 77-78.
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Wipob Suttana, Samlee Mankhetkorn, Wilart Poompimon, Ajay Palagani, Sergey Zhokhov, Sarah Gerlo, Guy Haegeman & Wim Vanden Berghe. (2010) Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. Molecular Cancer 9:1.
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Guruprasad Kalthur Uma Devi Pathirissery. (2010) Enhancement of the Response of B16F1 Melanoma to Fractionated Radiotherapy and Prolongation of Survival by Withaferin A and/or Hyperthermia. Integrative Cancer Therapies 9:4, pages 370-377.
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I.A. Arif, M.A. Bakir, H.A. Khan, A.H. Al Farhan, A.A. Al Homaidan, A.H. Bahkali, M. Al Sadoon & M. Shobrak. (2010) Application of RAPD for molecular characterization of plant species of medicinal value from an arid environment. Genetics and Molecular Research 9:4, pages 2191-2198.
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Ravikumar Aalinkeel, Zihua Hu, Bindukumar B. Nair, Donald E. Sykes, Jessica L. Reynolds, Supriya D. Mahajan & Stanley A. Schwartz. (2010) Genomic Analysis Highlights the Role of the JAK-STAT Signaling in the Anti-Proliferative Effects of Dietary Flavonoid—‘Ashwagandha’ in Prostate Cancer Cells. Evidence-Based Complementary and Alternative Medicine 7:2, pages 177-187.
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Khaula Shirin, Saima Imad, Sheraz Shafiq & Kaneez Fatima. (2010) Determination of major and trace elements in the indigenous medicinal plant Withania somnifera and their possible correlation with therapeutic activity. Journal of Saudi Chemical Society 14:1, pages 97-100.
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Ashok D.B. Vaidya, Ashok J. Amonkar, Narendra S. Bhatt & Purvish M. Parikh. 2010. Alternative and Complementary Therapies for Cancer. Alternative and Complementary Therapies for Cancer 31 82 .
Mohammad Hossein Mirjalili, Seyyed Mohammad Fakhr-Tabatabaei, Houshang Alizadeh, Alireza Ghassempour & Fateme Mirzajani. (2009) Genetic and Withaferin A Analysis of Iranian Natural Populations of Withania Somnifera and W. Coagulans by RAPD and HPTLC . Natural Product Communications 4:3, pages 1934578X0900400.
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Guruprasad KalthurSrinivas Mutalik & Uma Devi Pathirissery. (2009) Effect of Withaferin A on the Development and Decay of Thermotolerance in B16F1 Melanoma: A Preliminary Study. Integrative Cancer Therapies 8:1, pages 93-97.
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Silvia D. Stan, Eun-Ryeong Hahm, Renaud Warin & Shivendra V. Singh. (2008) Withaferin A Causes FOXO3a- and Bim-Dependent Apoptosis and Inhibits Growth of Human Breast Cancer Cells In vivo . Cancer Research 68:18, pages 7661-7669.
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R. Prasad, M. Sharma, S. Chatterjee, G. Chauhan, S. Tripathi, A. Das, S. Kamal, A. K. S. Rawat, K. K. Bhutani, M. K. Rai, P. Pushpangdan & A. Varma. 2008. Mycorrhiza. Mycorrhiza 655 678 .
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Huanjie Yang, Guoqing Shi & Q. Ping Dou. (2007) The Tumor Proteasome Is a Primary Target for the Natural Anticancer Compound Withaferin A Isolated from “Indian Winter Cherry”. Molecular Pharmacology 71:2, pages 426-437.
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Haruyo Ichikawa, Yasunari Takada, Shishir Shishodia, Bolleddula Jayaprakasam, Muraleedharan G. Nair & Bharat B. Aggarwal. (2006) Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB–regulated gene expression. Molecular Cancer Therapeutics 5:6, pages 1434-1445.
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Ganesh Chandra Jagetia & Venkatasubbaiah Ashoka Kumar Venkatesha. (2005) Enhancement of Radiation Effect by <i>Aphanamixis polystachya</i> in Mice Transplanted with Ehrlich Ascites Carcinoma. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 28:1, pages 69-77.
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Royce Mohan, Hans Hammers, Paola Bargagna-mohan, Xiaoguo Zhan, Christopher Herbstritt, Antonio Ruiz, Li Zhang, Art Hanson, Barry Conner, John Rougas & Victor Pribluda. (2004) Withaferin A is a potent inhibitor of angiogenesis. Angiogenesis 7:2, pages 115-122.
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Ganesh Chandra Jagetia & Manjeshwar Shrinath Baliga. (2003) Treatment with Alstonia scholaris Enhances Radiosensitivity In vitro and In vivo . Cancer Biotherapy and Radiopharmaceuticals 18:6, pages 917-929.
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E.M. Abdel-Magied, H.A. Abdel-Rahman & F.M. Harraz. (2001) The effect of aqueous extracts of Cynomorium coccineum and Withania somnifera on testicular development in immature Wistar rats. Journal of Ethnopharmacology 75:1, pages 1-4.
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M S Negi, A Singh & M Lakshmikumaran. (2000) Genetic variation and relationship among and within Withania species as revealed by AFLP markers . Genome 43:6, pages 975-980.
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A Ganasoundari, S M Zare & P U Devi. (1997) Modification of bone marrow radiosensensitivity by medicinal plant extracts.. The British Journal of Radiology 70:834, pages 599-602.
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