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Research Article

Tocotrienols inhibit growth of ZR-75–1 breast cancer cells

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Pages s95-s103 | Published online: 08 Dec 2010

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Read on this site (3)

Jen-Kit Tan, Sue-Mian Then, Musalmah Mazlan, Rahman Jamal & Wan Zurinah Wan Ngah. (2016) Vitamin E, γ-tocotrienol, Protects Against Buthionine Sulfoximine-Induced Cell Death by Scavenging Free Radicals in SH-SY5Y Neuroblastoma Cells. Nutrition and Cancer 68:3, pages 507-517.
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Wong Weng-Yew, Kanga Rani Selvaduray, Cheng Hwee Ming & Kalanithi Nesaretnam. (2009) Suppression of Tumor Growth by Palm Tocotrienols Via the Attenuation of Angiogenesis. Nutrition and Cancer 61:3, pages 367-373.
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Sanchita P. Ghosh, Shilpa Kulkarni, Kevin Hieber, Raymond Toles, Lyudmila Romanyukha, Tzu-Cheg Kao, Martin Hauer-Jensen & K. Sree kumar. (2009) Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector. International Journal of Radiation Biology 85:7, pages 598-606.
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Articles from other publishers (34)

A. Marisa Ribeiro, Berta N. Estevinho & Fernando Rocha. (2021) The progress and application of vitamin E encapsulation – A review. Food Hydrocolloids 121, pages 106998.
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Maya Idriss, Mohammad Hassan Hodroj, Rajaa Fakhoury & Sandra Rizk. (2020) Beta-Tocotrienol Exhibits More Cytotoxic Effects than Gamma-Tocotrienol on Breast Cancer Cells by Promoting Apoptosis via a P53-Independent PI3-Kinase Dependent Pathway. Biomolecules 10:4, pages 577.
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Sitti Rahma Abdul Hafid & Ammu Kutty Radhakrishnan. (2019) Palm Tocotrienol-Adjuvanted Dendritic Cells Decrease Expression of the SATB1 Gene in Murine Breast Cancer Cells and Tissues. Vaccines 7:4, pages 198.
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Anthony F. Fransway, Paulina J. Fransway, Donald V. Belsito & James A. Yiannias. (2019) Paraben Toxicology. Dermatitis 30:1, pages 32-45.
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Nor Nor Azman, Jo Goon, Siti Abdul Ghani, Zalina Hamid & Wan Wan Ngah. (2018) Comparing Palm Oil, Tocotrienol-Rich Fraction and α-Tocopherol Supplementation on the Antioxidant Levels of Older Adults. Antioxidants 7:6, pages 74.
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Bethsebie Lalduhsaki Sailo, Kishore Banik, Ganesan Padmavathi, Monisha Javadi, Devivasha Bordoloi & Ajaikumar B. Kunnumakkara. (2018) Tocotrienols: The promising analogues of vitamin E for cancer therapeutics. Pharmacological Research 130, pages 259-272.
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Madhu M. Kanchi, Muthu K. Shanmugam, Grishma Rane, Gautam Sethi & Alan P. Kumar. (2017) Tocotrienols: the unsaturated sidekick shifting new paradigms in vitamin E therapeutics. Drug Discovery Today 22:12, pages 1765-1781.
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Doryn Meam-Yee Tan, Ju-Yen Fu, Fu-Shun Wong, Hui-Meng Er, Yu-Sui Chen & Kalanithi Nesaretnam. (2017) Tumor regression and modulation of gene expression via tumor-targeted tocotrienol niosomes. Nanomedicine 12:20, pages 2487-2502.
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Sibyl N. Swift, Roli L. Pessu, Kushal Chakraborty, Vilmar Villa, Eric Lombardini & Sanchita P. Ghosh. (2014) Acute Toxicity of Subcutaneously Administered Vitamin E Isomers Delta- and Gamma-Tocotrienol in Mice. International Journal of Toxicology 33:6, pages 450-458.
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Valentina Viola, Silvia Ciffolilli, Silvia Legnaioli, Marta Piroddi, Michele Betti, Francesco Mazzini, Elisa Pierpaoli, Mauro Provinciali & Francesco Galli. (2013) Mitochondrial-dependent anticancer activity of δ-tocotrienol and its synthetic derivatives in HER-2/neu overexpressing breast adenocarcinoma cells. BioFactors 39:4, pages 485-493.
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Ammu Kutty Radhakrishnan, Dashayini Mahalingam, Kanga Rani Selvaduray & Kalanithi Nesaretnam. (2013) Supplementation with Natural Forms of Vitamin E Augments Antigen-Specific TH1-Type Immune Response to Tetanus Toxoid. BioMed Research International 2013, pages 1-8.
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Abhita Malaviya & Paul W. Sylvester. (2013) Mechanisms Mediating the Effects of γ -Tocotrienol When Used in Combination with PPAR γ Agonists or Antagonists on MCF-7 and MDA-MB-231 Breast Cancer Cells . International Journal of Breast Cancer 2013, pages 1-17.
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Dennis M. Peffley & Patricia Hentosh. 2012. Natural compounds as inducers of cell death. Natural compounds as inducers of cell death 373 400 .
Lim T. K.T. K. Lim. 2012. Edible Medicinal and Non-Medicinal Plants. Edible Medicinal and Non-Medicinal Plants 335 392 .
Siok-Fong Chin, Johari Ibahim, Suzana Makpol, Noor Aini Abdul Hamid, Azian Abdul Latiff, Zaiton Zakaria, Musalmah Mazlan, Yasmin Anum Mohd Yusof, Aminuddin Abdul Karim & Wan Zurinah Wan Ngah. (2011) Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study. Nutrition & Metabolism 8:1.
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D Mahalingam, A K Radhakrishnan, Z Amom, N Ibrahim & K Nesaretnam. (2010) Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers. European Journal of Clinical Nutrition 65:1, pages 63-69.
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Sitti Rahma Abdul Hafid, Ammu Kutty Radhakrishnan & Kalanithi Nesaretnam. (2010) Tocotrienols are good adjuvants for developing cancer vaccines. BMC Cancer 10:1.
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Kalanithi Nesaretnam, Kanga Rani Selvaduray, Ghazali Abdul Razak, Sheela Devi Veerasenan & Patricia A Gomez. (2010) Effectiveness of tocotrienol-rich fraction combined with tamoxifen in the management of women with early breast cancer: a pilot clinical trial. Breast Cancer Research 12:5.
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Raffaella Comitato, Guido Leoni, Raffaella Canali, Roberto Ambra, Kalanithi Nesaretnam & Fabio Virgili. (2010) Tocotrienols activity in MCF-7 breast cancer cells: Involvement of ERβ signal transduction. Molecular Nutrition & Food Research 54:5, pages 669-678.
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Jean Ne Cheong & Chin Ping Tan. (2010) Palm‐based functional lipid nanodispersions: Preparation, characterization and stability evaluation. European Journal of Lipid Science and Technology 112:5, pages 557-564.
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Jihyeung Ju, Sonia C. Picinich, Zhihong Yang, Yang Zhao, Nanjoo Suh, Ah-Ng Kong & Chung S. Yang. (2010) Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis 31:4, pages 533-542.
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Suman Verma, Michelle M Tabb & Bruce Blumberg. (2009) Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells. BMC Cancer 9:1.
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Mun‐Li Yam, Sitti Rahma Abdul Hafid, Hwee‐Ming Cheng & Kalanithi Nesaretnam. (2009) Tocotrienols Suppress Proinflammatory Markers and Cyclooxygenase‐2 Expression in RAW264.7 Macrophages. Lipids 44:9, pages 787-797.
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Kalanithi Nesaretnam. (2008) Multitargeted therapy of cancer by tocotrienols. Cancer Letters 269:2, pages 388-395.
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Constantina Constantinou, Andreas Papas & Andreas I. Constantinou. (2008) Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs. International Journal of Cancer 123:4, pages 739-752.
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Kalanithi Nesaretnam, Teoh Hoon Koon, Kanga Rani Selvaduray, Richard S. Bruno & Emily Ho. (2008) Modulation of cell growth and apoptosis response in human prostate cancer cells supplemented with tocotrienols. European Journal of Lipid Science and Technology 110:1, pages 23-31.
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Kalanithi Nesaretnam, Wong Weng Yew & Mohd Basri Wahid. (2007) Tocotrienols and cancer: Beyond antioxidant activity. European Journal of Lipid Science and Technology 109:4, pages 445-452.
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Kwang Seok Ahn, Gautam Sethi, Koyamangalath Krishnan & Bharat B. Aggarwal. (2007) γ-Tocotrienol Inhibits Nuclear Factor-κB Signaling Pathway through Inhibition of Receptor-interacting Protein and TAK1 Leading to Suppression of Antiapoptotic Gene Products and Potentiation of Apoptosis. Journal of Biological Chemistry 282:1, pages 809-820.
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Janmejai K. Srivastava & Sanjay Gupta. (2006) Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells. Biochemical and Biophysical Research Communications 346:2, pages 447-453.
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HUANBIAO MO & CHARLES E. ELSON. 2006. Nutritional Oncology. Nutritional Oncology 629 644 .
KALANITHI NESARETNAM, ROBERTO AMBRA, KANGA RANI SELVADURAY, AMMU RADHAKRISHNAN, RAFFAELLA CANALI & FABIO VIRGILI. (2004) Tocotrienol-Rich Fraction from Palm Oil and Gene Expression in Human Breast Cancer Cells. Annals of the New York Academy of Sciences 1031:1, pages 143-157.
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Kalanithi Nesaretnam, Roberto Ambra, Kanga Rani Selvaduray, Ammu Radhakrishnan, Karin Reimann, Ghazali Razak & Fabio Virgili. (2004) Tocotrienol-rich fraction from palm oil affects gene expression in tumors resulting from MCF-7 cell inoculation in athymic mice. Lipids 39:5, pages 459-467.
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J Iqbal, M Minhajuddin & Z H Beg. (2003) Suppression of 7,12-dimethylbenz[α]anthracene-induced carcinogenesis and hypercholesterolaemia in rats by tocotrienol-rich fraction isolated from rice bran oil. European Journal of Cancer Prevention 12:6, pages 447-453.
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Dawn C. Schwenke. (2002) Does lack of tocopherols and tocotrienols put women at increased risk of breast cancer?. The Journal of Nutritional Biochemistry 13:1, pages 2-20.
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