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Studies in Humans

Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial

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Pages 82-89 | Received 22 Jun 2016, Accepted 11 Jul 2016, Published online: 05 Aug 2016

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Rudy Wouters, Stephan Theis, Linda Mertens, Monique Steegmans, Bart Levecke & Anne Franck. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry 1 11 .
Maísa Miranda Araújo & Patrícia Borges Botelho. (2022) Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence. Frontiers in Nutrition 9.
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Fernanda Cosme, António Inês & Alice Vilela. (2022) Consumer’s acceptability and health consciousness of probiotic and prebiotic of non-dairy products. Food Research International 151, pages 110842.
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Simone Pyle. 2022. Comprehensive Gut Microbiota. Comprehensive Gut Microbiota 271 288 .
Okan Arıhan. 2022. Novel Drug Targets With Traditional Herbal Medicines. Novel Drug Targets With Traditional Herbal Medicines 131 139 .
Iris Rijnaarts, Nicole de Roos, Erwin G. Zoetendal, Nicole de Wit & Ben J. M. Witteman. (2021) Development and validation of the FiberScreen: A short questionnaire to screen fibre intake in adults. Journal of Human Nutrition and Dietetics 34:6, pages 969-980.
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Satish S.C. RaoDarren M. Brenner. (2021) Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review. American Journal of Gastroenterology 116:6, pages 1156-1181.
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欢 熊. (2021) Effect of Inulin Prebiotics on Constipation during Pregnancy. Advances in Clinical Medicine 11:10, pages 4519-4522.
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Shuli Man, Taohua Liu, Yuan Yao, Yingying Lu, Long Ma & Fuping Lu. (2021) Friend or foe? The roles of inulin-type fructans. Carbohydrate Polymers 252, pages 117155.
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Dawei Ni, Wei Xu & Wanmeng Mu. 2021. Novel enzymes for functional carbohydrates production. Novel enzymes for functional carbohydrates production 199 222 .
Aayushi Kadam, Deepak Kadam, Kanchanlata Tungare & Heena Shah. 2021. Nutrition, Food and Diet in Ageing and Longevity. Nutrition, Food and Diet in Ageing and Longevity 85 108 .
Bisma Malik & Reiaz Ul Rehman. 2021. Medicinal and Aromatic Plants. Medicinal and Aromatic Plants 373 390 .
Maliha Naseer, Shiva Poola, Suleyman Uraz & Veysel Tahan. (2020) Therapeutic Effects of Prebiotics on Constipation: A Schematic Review. Current Clinical Pharmacology 15:3, pages 207-215.
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Dawei Ni, Ziwei Chen, Wei Xu, Wenli Zhang & Wanmeng Mu. (2020) Efficient production of inulin and oligosaccharides using thermostable inulosucrase from Lactobacillus jensenii. International Journal of Biological Macromolecules 165, pages 1250-1257.
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Su-Jin Jung, Mi-Ra Oh, Soo-Hyun Park & Soo-Wan Chae. (2020) Effects of rice-based and wheat-based diets on bowel movements in young Korean women with functional constipation. European Journal of Clinical Nutrition 74:11, pages 1565-1575.
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Xue Cheng, Junping Zheng, Aizhen Lin, Hui Xia, Zhigang Zhang, Qinghua Gao, Wenliang Lv & Hongtao Liu. (2020) A review: Roles of carbohydrates in human diseases through regulation of imbalanced intestinal microbiota. Journal of Functional Foods 74, pages 104197.
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Oana Lelia Pop, Dan Cristian Vodnar, Zorita Diaconeasa, Magdalena Istrati, Adriana Bințințan, Vasile Virgil Bințințan, Ramona Suharoschi & Rosita Gabbianelli. (2020) An Overview of Gut Microbiota and Colon Diseases with a Focus on Adenomatous Colon Polyps. International Journal of Molecular Sciences 21:19, pages 7359.
Crossref
Andrea García Contreras, Edgar Vásquez Garibay, Carmen Sánchez Ramírez, Mary Fafutis Morris & Vidal Delgado Rizo. (2020) Lactobacillus reuteri DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial. Nutrients 12:10, pages 2971.
Crossref
Paweł Glibowski, Michał Skrzypek, Magdalena Ćwiklińska, Monika Drozd & Aleksandra Kowalska. (2020) Chemical stability of fructans in apple beverages and their influence on chronic constipation. Food & Function 11:5, pages 3860-3866.
Crossref
Hamed Ebrahimzadeh Leylabadlo, Reza Ghotaslou, Hossein Samadi Kafil, Mohammad Mehdi Feizabadi, Seyed Yaghoub Moaddab, Safar Farajnia, Elham Sheykhsaran, Sarvin Sanaie, Dariush Shanehbandi & Hossein Bannazadeh Baghi. (2019) Non-alcoholic fatty liver diseases: from role of gut microbiota to microbial-based therapies. European Journal of Clinical Microbiology & Infectious Diseases 39:4, pages 613-627.
Crossref
K.S. SwansonW.M. de VosE.C. MartensJ.A. GilbertR.S. MenonA. Soto-VacaJ. HautvastP.D. MeyerK. BorewiczE.E. VaughanJ.L. Slavin. (2020) Effect of fructans, prebiotics and fibres on the human gut microbiome assessed by 16S rRNA-based approaches: a review. Beneficial Microbes 11:2, pages 101-129.
Crossref
Eamonn M.M. Quigley. (2020) Nutraceuticals as modulators of gut microbiota: Role in therapy. British Journal of Pharmacology 177:6, pages 1351-1362.
Crossref
Quentin Le Bastard, Guillaume Chapelet, François Javaudin, Didier Lepelletier, Eric Batard & Emmanuel Montassier. (2019) The effects of inulin on gut microbial composition: a systematic review of evidence from human studies. European Journal of Clinical Microbiology & Infectious Diseases 39:3, pages 403-413.
Crossref
欢 熊. (2020) Research Progress on Physiological Function of Probiotics Inulin. Hans Journal of Food and Nutrition Science 09:03, pages 229-235.
Crossref
Eva Ivanišová, Beáta Drevková, Marián Tokár, Margarita Terentjeva, Tomáš Krajčovič & Miroslava Kačániová. (2019) Physicochemical and sensory evaluation of biscuits enriched with chicory fiber. Food Science and Technology International 26:1, pages 38-43.
Crossref
Anthony W. Watson, David Houghton, Peter J. Avery, Christopher Stewart, Elaine E. Vaughan, P. Diederick Meyer, Minse J.J. de Bos Kuil, Peter J.M. Weijs & Kirsten Brandt. (2019) Changes in stool frequency following chicory inulin consumption, and effects on stool consistency, quality of life and composition of gut microbiota. Food Hydrocolloids 96, pages 688-698.
Crossref
Mary Ellen Sanders, Daniel J. Merenstein, Gregor Reid, Glenn R. Gibson & Robert A. Rastall. (2019) Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nature Reviews Gastroenterology & Hepatology 16:10, pages 605-616.
Crossref
Christopher J. Martoni, Malkanthi Evans, Cheryl‐Emiliane T. Chow, Luisa S. Chan & Gregory Leyer. (2019) Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial. Journal of Digestive Diseases 20:9, pages 435-446.
Crossref
Nitin Gupta, Ashok Kumar Jangid, Deep Pooja & Hitesh Kulhari. (2019) Inulin: A novel and stretchy polysaccharide tool for biomedical and nutritional applications. International Journal of Biological Macromolecules 132, pages 852-863.
Crossref
Teng-Gen Hu, Peng Wen, Hui-Zhan Fu, Guang-Yue Lin, Sen-Tai Liao & Yu-Xiao Zou. (2019) Protective effect of mulberry ( Morus atropurpurea ) fruit against diphenoxylate-induced constipation in mice through the modulation of gut microbiota . Food & Function 10:3, pages 1513-1528.
Crossref
Jan De Vries, Cindy Le Bourgot, Wim Calame & Frédérique Respondek. (2019) Effects of β-Fructans Fiber on Bowel Function: A Systematic Review and Meta-Analysis. Nutrients 11:1, pages 91.
Crossref
红伟 郝. (2019) Studies of Inulin on Intestinal Health. Hans Journal of Food and Nutrition Science 08:03, pages 175-179.
Crossref
Johnson W. McRorieJr.Jr.. 2019. Dietary Interventions in Gastrointestinal Diseases. Dietary Interventions in Gastrointestinal Diseases 19 32 .
Ruiting Han, Junli Ma & Houkai Li. (2018) Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota. Frontiers of Medicine 12:6, pages 645-657.
Crossref
Hong Yun Zhang, Li Na Yang, Dan Shi Zhu & He Liu. (2018) An Efficient Method for Decoloration of Inulin from Jerusalem Artichoke by Macroporous Resin. Key Engineering Materials 789, pages 92-97.
Crossref
Pan Zhou, Yongsheng Wang, Shuang Li, Yang Zhao, Kai Deng, Dandan Chao, Chao Jin, Yong Zhuo, Lianqiang Che, Jian Li, Yan Lin, Shengyu Xu, Bin Feng, Zhengfeng Fang & De Wu. (2018) Effects of prebiotic inulin addition to low- or high-fat diet on maternal metabolic status and neonatal traits of offspring in a pregnant sow model. Journal of Functional Foods 48, pages 125-133.
Crossref
Linsheng Huang, Qi Zhu, Xiao Qu & Huanlong Qin. (2018) Microbial treatment in chronic constipation. Science China Life Sciences 61:7, pages 744-752.
Crossref
M. Hasan Mohajeri, Robert J. M. Brummer, Robert A. Rastall, Rinse K. Weersma, Hermie J. M. Harmsen, Marijke Faas & Manfred Eggersdorfer. (2018) The role of the microbiome for human health: from basic science to clinical applications. European Journal of Nutrition 57:S1, pages 1-14.
Crossref
Bryan Tungland. 2018. Human Microbiota in Health and Disease. Human Microbiota in Health and Disease 155 196 .
Stephan Theis. 2018. Foods, Nutrients and Food Ingredients with Authorised EU Health Claims. Foods, Nutrients and Food Ingredients with Authorised EU Health Claims 147 158 .
Mark L. DreherMark L. Dreher. 2018. Dietary Patterns and Whole Plant Foods in Aging and Disease. Dietary Patterns and Whole Plant Foods in Aging and Disease 145 164 .
Mark L. DreherMark L. Dreher. 2018. Dietary Fiber in Health and Disease. Dietary Fiber in Health and Disease 95 115 .
Randal Buddington, Cavita Kapadia, Franka Neumer & Stephan Theis. (2017) Oligofructose Provides Laxation for Irregularity Associated with Low Fiber Intake. Nutrients 9:12, pages 1372.
Crossref
Pan Zhou, Yang Zhao, Pan Zhang, Yan Li, Taotao Gui, Jun Wang, Chao Jin, Lianqiang Che, Jian Li, Yan Lin, Shengyu Xu, Bin Feng, Zhengfeng Fang & De Wu. (2017) Microbial Mechanistic Insight into the Role of Inulin in Improving Maternal Health in a Pregnant Sow Model. Frontiers in Microbiology 8.
Crossref
Sandrine Paule Claus. (2017) Inulin prebiotic: is it all about bifidobacteria?. Gut 66:11, pages 1883-1884.
Crossref
Doris Vandeputte, Gwen Falony, Sara Vieira-Silva, Jun Wang, Manuela Sailer, Stephan Theis, Kristin Verbeke & Jeroen Raes. (2017) Prebiotic inulin-type fructans induce specific changes in the human gut microbiota. Gut 66:11, pages 1968-1974.
Crossref
Junli Ma, Qihang Zhou & Houkai Li. (2017) Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanisms and Therapy. Nutrients 9:10, pages 1124.
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