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International Journal of Food Sciences and Nutrition Volume 68, 2017 - Issue 1
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Comprehensive Review

Mediterranean diet and nonalcoholic fatty liver disease: molecular mechanisms of protection

Justyna GodosIntegrated Cancer Registry of Catania-Messina-Siracusa-Enna, Azienda Universitario Ospedaliera Policlinico “Vittorio Emanuale”, Catania, Italy; Correspondence[email protected]
,
Alessandro FedericoHepato-Gastroenterology Division, Second University of Naples, Napoli, Italy;
,
Marcello DallioHepato-Gastroenterology Division, Second University of Naples, Napoli, Italy;
&
Francesca ScazzinaHuman Nutrition Unit, Department of Food Science, University of Parma, Parma, Italy
Pages 18-27 | Received 08 Jul 2016, Accepted 14 Jul 2016, Published online: 02 Aug 2016

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Enoch Cobbina & Fatemeh Akhlaghi. (2017) Non-alcoholic fatty liver disease (NAFLD) – pathogenesis, classification, and effect on drug metabolizing enzymes and transporters. Drug Metabolism Reviews 49:2, pages 197-211.
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Marco Poeta & Pietro Vajro. (2017) Mediterranean diet to prevent/treat nonalcoholic fatty liver disease in children: A promising approach. Nutrition 43-44, pages 98-99.
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Prasanthi Jegatheesan & Jean‐Pascal De Bandt. (2017) Fructose and NAFLD: The Multifaceted Aspects of  Fructose Metabolism. Nutrients 9:3, pages 230.
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Salamah Alwahsh, Benjamin Dwyer, Shareen Forbes, David van Thiel, Philip Starkey Lewis & Giuliano Ramadori. (2017) Insulin Production and Resistance in Different Models of Diet-Induced Obesity and Metabolic Syndrome. International Journal of Molecular Sciences 18:2, pages 285.
Crossref
Mark Benedict & Xuchen Zhang. (2017) Non-alcoholic fatty liver disease: An expanded review. World Journal of Hepatology 9:16, pages 715.
Crossref
Wei Jiang, Mei-Hua Guo & Xin Hai. (2016) Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat. World Journal of Gastroenterology 22:46, pages 10180.
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