791
Views
52
CrossRef citations to date
0
Altmetric
Studies in Humans

Lactobacillus helveticus-fermented milk containing lactononadecapeptide (NIPPLTQTPVVVPPFLQPE) improves cognitive function in healthy middle-aged adults: a randomised, double-blind, placebo-controlled trial

, , , &
Pages 369-376 | Received 29 May 2017, Accepted 07 Aug 2017, Published online: 18 Aug 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Fatma Elif Eroğlu & Nevin Sanlier. (2023) Effect of fermented foods on some neurological diseases, microbiota, behaviors: mini review. Critical Reviews in Food Science and Nutrition 63:26, pages 8066-8082.
Read now

Articles from other publishers (51)

Shuai Guo, Yaru Sun, Ting Wu, Lai-Yu Kwok, Zhihong Sun, Jicheng Wang & Heping Zhang. (2024) Co-fermented milk beverage has better stability and contains more health-promoting amino acid metabolites than single-strain-fermented milk beverage over one-month storage. Food Chemistry 430, pages 136840.
Crossref
Lihong Cheng, Mitsuru Tanaka, Atsuko Yoshino, Yuki Nagasato, Fuyuko Takata, Shinya Dohgu & Toshiro Matsui. (2023) A memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration. Scientific Reports 13:1.
Crossref
Nanyang Liu, Di Yang, Jiahui Sun & Yapeng Li. (2023) Probiotic supplements are effective in people with cognitive impairment: a meta-analysis of randomized controlled trials. Nutrition Reviews 81:9, pages 1091-1104.
Crossref
Tianqi Li, Auriel A. Willette, Qian Wang, Amy Pollpeter, Brittany A. Larsen, Parvin Mohammadiarvejeh & Mohammad Fili. (2023) Alzheimer’s Disease Genetic Influences Impact the Associations between Diet and Resting-State Functional Connectivity: A Study from the UK Biobank. Nutrients 15:15, pages 3390.
Crossref
Ales Bartos, Josefina Weinerova & Sofia Diondet. (2023) Effects of human probiotics on memory and psychological and physical measures in community-dwelling older adults with normal and mildly impaired cognition: results of a bi-center, double-blind, randomized, and placebo-controlled clinical trial (CleverAge biota). Frontiers in Aging Neuroscience 15.
Crossref
Neeraja Recharla, Jihee Choi, Pradeep Puligundla, Seon-Joo Park & Hae-Jeung Lee. (2023) Impact of probiotics on cognition and constipation in the elderly: A meta-analysis. Heliyon 9:7, pages e18306.
Crossref
Ami Thakkar, Amisha Vora, Ginpreet Kaur & Jamal Akhtar. (2023) Dysbiosis and Alzheimer’s disease: role of probiotics, prebiotics and synbiotics. Naunyn-Schmiedeberg's Archives of Pharmacology.
Crossref
Kobika Chelladhurai, Mutamed Ayyash, Mark S. Turner & Afaf Kamal-Eldin. (2023) Lactobacillus helveticus: Health effects, current applications, and future trends in dairy fermentation. Trends in Food Science & Technology 136, pages 159-168.
Crossref
Sunil Meena, B Keerthi Reddy & Dinesh Chandra Rai. (2023) Fermented food products for gastrointestinal health and related diseases. Journal of Dairy, Veterinary & Animal Research 12:1, pages 35-41.
Crossref
Patrycja Cichońska, Ewa Kowalska & Małgorzata Ziarno. (2023) The Survival of Psychobiotics in Fermented Food and the Gastrointestinal Tract: A Review. Microorganisms 11:4, pages 996.
Crossref
Victor E. Vera-Santander, Ricardo H. Hernández-Figueroa, María T. Jiménez-Munguía, Emma Mani-López & Aurelio López-Malo. (2023) Health Benefits of Consuming Foods with Bacterial Probiotics, Postbiotics, and Their Metabolites: A Review. Molecules 28:3, pages 1230.
Crossref
Gargi Dey. 2023. Lactic Acid Bacteria as Cell Factories. Lactic Acid Bacteria as Cell Factories 401 412 .
Cássia Pereira Barros, Erick A. Esmerino, Roberto Laureano Melo & Adriano Gomes da Cruz. 2023. Probiotic Foods and Beverages. Probiotic Foods and Beverages 243 262 .
Shaoqi Shi, Qi Zhang, Yue Sang, Shaoyang Ge, Qi Wang, Ran Wang & Jingjing He. (2022) Probiotic Bifidobacterium longum BB68S Improves Cognitive Functions in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 15:1, pages 51.
Crossref
Hale İnci Öztürk, Aysun Oraç & Nihat Akın. (2022) Characterization of bioactive peptides derived from goatskin Tulum cheese of the Ereğli region at different stages of ripening. Food Research International 162, pages 112124.
Crossref
Le Zhao, Dan Li, Xiaofen Qi, Kaifang Guan, Haoran Chen, Rongchun Wang & Ying Ma. (2022) Potential of food-derived bioactive peptides in alleviation and prevention of Alzheimer's disease. Food & Function 13:21, pages 10851-10869.
Crossref
Fabiana Galland, Juliana Santos de Espindola, Daniel Saraiva Lopes, Milena Ferreira Taccola & Maria Teresa Bertoldo Pacheco. (2022) Food-derived bioactive peptides: Mechanisms of action underlying inflammation and oxidative stress in the central nervous system. Food Chemistry Advances 1, pages 100087.
Crossref
Parvin Oroojzadeh, Saber Yari Bostanabad & Hajie Lotfi. (2022) Psychobiotics: the Influence of Gut Microbiota on the Gut-Brain Axis in Neurological Disorders. Journal of Molecular Neuroscience 72:9, pages 1952-1964.
Crossref
Yvonne Suzy Handajani, Yuda Turana, Yogiara Yogiara, Sagita Pratiwi Sugiyono, Vincent Lamadong, Nelly Tina Widjaja, Geovannie Audrey Moniqe Christianto & Antonius Suwanto. (2022) Effects of Tempeh Probiotics on Elderly With Cognitive Impairment. Frontiers in Aging Neuroscience 14.
Crossref
Maria Dobielska, Natalia Karina Bartosik, Kamil A. Zyzik, Edward Kowalczyk & Michał Seweryn Karbownik. (2022) Mechanisms of Cognitive Impairment in Depression. May Probiotics Help?. Frontiers in Psychiatry 13.
Crossref
Muganti Rajah Kumar, Nor Farahin Azizi, Swee Keong Yeap, Janna Ong Abdullah, Melati Khalid, Abdul Rahman Omar, Mohd. Azuraidi Osman, Adam Thean Chor Leow, Sharifah Alawieyah Syed Mortadza & Noorjahan Banu Alitheen. (2022) Clinical and Preclinical Studies of Fermented Foods and Their Effects on Alzheimer’s Disease. Antioxidants 11:5, pages 883.
Crossref
Michał Seweryn Karbownik, Łukasz Mokros, Maria Dobielska, Mateusz Kowalczyk & Edward Kowalczyk. (2022) Association Between Consumption of Fermented Food and Food-Derived Prebiotics With Cognitive Performance, Depressive, and Anxiety Symptoms in Psychiatrically Healthy Medical Students Under Psychological Stress: A Prospective Cohort Study. Frontiers in Nutrition 9.
Crossref
Melania Casertano, Vincenzo Fogliano & Danilo Ercolini. (2022) Psychobiotics, gut microbiota and fermented foods can help preserving mental health. Food Research International 152, pages 110892.
Crossref
Charlotte Le Morvan de Sequeira, Charlotte Hengstberger, Paul Enck & Isabelle Mack. (2022) Effect of Probiotics on Psychiatric Symptoms and Central Nervous System Functions in Human Health and Disease: A Systematic Review and Meta-Analysis. Nutrients 14:3, pages 621.
Crossref
Kazuhito OhsawaHidehiko Yokogoshi. (2022) Study of the Cognitive Function of Lactononadecapeptide and Its Application in Foodラクトノナデカペプチドの認知機能に対する作用の研究とその応用. Nippon Eiyo Shokuryo Gakkaishi 75:6, pages 305-309.
Crossref
Maria Elieidy Gomes de Oliveira. 2022. Probiotics for Human Nutrition in Health and Disease. Probiotics for Human Nutrition in Health and Disease 373 410 .
Mrinal Samtiya, Tejpal Dhewa & Anil Kumar Puniya. 2022. Microbiome-Gut-Brain Axis. Microbiome-Gut-Brain Axis 237 259 .
Simone Baldi, Tiziana Mundula, Giulia Nannini & Amedeo Amedei. (2021) Microbiota shaping — the effects of probiotics, prebiotics, and fecal microbiota transplant on cognitive functions: A systematic review. World Journal of Gastroenterology 27:39, pages 6715-6732.
Crossref
Shuguang Wang, Dongxiao Sun-Waterhouse, Geoffrey Ivan Neil Waterhouse, Lin Zheng, Guowan Su & Mouming Zhao. (2021) Effects of food-derived bioactive peptides on cognitive deficits and memory decline in neurodegenerative diseases: A review. Trends in Food Science & Technology 116, pages 712-732.
Crossref
Jessica Eastwood, Gemma Walton, Saskia Van Hemert, Claire Williams & Daniel Lamport. (2021) The effect of probiotics on cognitive function across the human lifespan: A systematic review. Neuroscience & Biobehavioral Reviews 128, pages 311-327.
Crossref
Naohisa Shobako. (2021) Hypotensive peptides derived from plant proteins. Peptides 142, pages 170573.
Crossref
Agata Białecka-Dębek, Dominika Granda, Maria Karolina Szmidt & Dorota Zielińska. (2021) Gut Microbiota, Probiotic Interventions, and Cognitive Function in the Elderly: A Review of Current Knowledge. Nutrients 13:8, pages 2514.
Crossref
Yantyati Widyastuti, Andi Febrisiantosa & Flavio Tidona. (2021) Health-Promoting Properties of Lactobacilli in Fermented Dairy Products. Frontiers in Microbiology 12.
Crossref
H.İ. Öztürk & N. Akın. (2021) Effect of ripening time on peptide dynamics and bioactive peptide composition in Tulum cheese. Journal of Dairy Science 104:4, pages 3832-3852.
Crossref
Hafiz Arbab Sakandar & Heping Zhang. (2021) Trends in Probiotic(s)-Fermented milks and their in vivo functionality: A review. Trends in Food Science & Technology 110, pages 55-65.
Crossref
Masaki Sasai, Megumi Kato, Kazuhito Ohsawa, Koichi Sashihara, Yasunori Nakamura & Toshiyuki Kaneko. (2021) Effects of a single dose of tablets containing lactononadecapeptide on cognitive function in healthy adults: a randomized, double-blind, cross-over, placebo-controlled trial. Bioscience, Biotechnology, and Biochemistry 85:4, pages 948-956.
Crossref
Mariano Del Toro-Barbosa, Alejandra Hurtado-Romero, Luis Eduardo Garcia-Amezquita & Tomás García-Cayuela. (2020) Psychobiotics: Mechanisms of Action, Evaluation Methods and Effectiveness in Applications with Food Products. Nutrients 12:12, pages 3896.
Crossref
Hiroyuki Suzuki, Daichi Yamashiro, Susumu Ogawa, Momoko Kobayashi, Daisuke Cho, Ai Iizuka, Masako Tsukamoto-Yasui, Michihiro Takada, Muneki Isokawa, Kenji Nagao & Yoshinori Fujiwara. (2020) Intake of Seven Essential Amino Acids Improves Cognitive Function and Psychological and Social Function in Middle-Aged and Older Adults: A Double-Blind, Randomized, Placebo-Controlled Trial. Frontiers in Nutrition 7.
Crossref
Wolfgang Marx, Andrew Scholey, Joseph Firth, Nathan M. D’Cunha, Melissa Lane, Meghan Hockey, Melanie M. Ashton, John F. Cryan, Adrienne O’Neil, Nenad Naumovski, Michael Berk, Olivia M. Dean & Felice Jacka. (2020) Prebiotics, probiotics, fermented foods and cognitive outcomes: A meta-analysis of randomized controlled trials. Neuroscience & Biobehavioral Reviews 118, pages 472-484.
Crossref
Katie Louise Tooley. (2020) Effects of the Human Gut Microbiota on Cognitive Performance, Brain Structure and Function: A Narrative Review. Nutrients 12:10, pages 3009.
Crossref
Jinzhong Xiao, Noriko Katsumata, Francois Bernier, Kazuya Ohno, Yuki Yamauchi, Toshitaka Odamaki, Kenji Yoshikawa, Kumie Ito & Toshiyuki Kaneko. (2020) Probiotic Bifidobacterium breve in Improving Cognitive Functions of Older Adults with Suspected Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Alzheimer's Disease 77:1, pages 139-147.
Crossref
Gitishree Das, Spiros Paramithiotis, Bhagavathi Sundaram Sivamaruthi, Christofora Hanny Wijaya, Sigit Suharta, Nevin Sanlier, Han-Seung Shin & Jayanta Kumar Patra. (2020) Traditional fermented foods with anti-aging effect: A concentric review. Food Research International 134, pages 109269.
Crossref
JunLi Liu, ChunYang Yu, RunLe Li, KunMei Liu, GuoEn Jin, RiLi Ge, Feng Tang & Sen Cui. (2020) High-altitude Tibetan fermented milk ameliorated cognitive dysfunction by modified gut microbiota in Alzheimer's disease transgenic mice. Food & Function 11:6, pages 5308-5319.
Crossref
Takashi Ichinose, Hiroyasu Murasawa, Tomoko Ishijima, Shinji Okada, Keiko Abe, Saki Matsumoto, Toshiro Matsui & Shigeki Furuya. (2020) Tyr-Trp administration facilitates brain norepinephrine metabolism and ameliorates a short-term memory deficit in a mouse model of Alzheimer’s disease. PLOS ONE 15:5, pages e0232233.
Crossref
Liesbeth C. de Goeij, Ondine van de Rest, Edith J. M. Feskens, Lisette C. P. G. M. de Groot & Elske M. Brouwer-Brolsma. (2020) Associations between the Intake of Different Types of Dairy and Cognitive Performance in Dutch Older Adults: The B-PROOF Study. Nutrients 12:2, pages 468.
Crossref
Shin Jie Yong, Tommy Tong, Jactty Chew & Wei Ling Lim. (2020) Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential. Frontiers in Neuroscience 13.
Crossref
Marcel van de Wouw, Marcus Boehme, Timothy G. Dinan & John F. Cryan. (2019) Monocyte mobilisation, microbiota & mental illness. Brain, Behavior, and Immunity 81, pages 74-91.
Crossref
Shigeru Katayama & Soichiro Nakamura. (2018) Emerging roles of bioactive peptides on brain health promotion. International Journal of Food Science & Technology 54:6, pages 1949-1955.
Crossref
Masahiro Kita, Keiko Kobayashi, Kuniaki Obara, Takashi Koikeda, Satoshi Umeda & Yasuhisa Ano. (2019) Supplementation With Whey Peptide Rich in β-Lactolin Improves Cognitive Performance in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Frontiers in Neuroscience 13.
Crossref
Bhagavathi Sivamaruthi, Periyanaina Kesika & Chaiyavat Chaiyasut. (2018) Impact of Fermented Foods on Human Cognitive Function—A Review of Outcome of Clinical Trials. Scientia Pharmaceutica 86:2, pages 22.
Crossref
Alan Logan & Susan Prescott. (2017) Astrofood, Priorities and Pandemics: Reflections of an Ultra-Processed Breakfast Program and Contemporary Dysbiotic Drift. Challenges 8:2, pages 24.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.