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Review Article

Vitamin D in health and disease: a literature review

Pages 161-172 | Accepted 12 Jan 2013, Published online: 20 Jan 2016

Keep up to date with the latest research on this topic with citation updates for this article.

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Martyna Lis, Natalia Niedziela, Maria Nowak-Kiczmer, Katarzyna Kubicka-Bączyk & Monika Adamczyk-Sowa. (2021) Calcium-phosphate homeostasis in secondary progressive multiple sclerosis patients during mitoxantrone therapy. Neurological Research 43:12, pages 1050-1055.
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Jelena Djurovic, Gorana Stamenkovic, Jelena Todorovic, Natasa Aleksic & Oliver Stojkovic. (2020) Polymorphisms and haplotypes in VDR gene are associated with female idiopathic infertility. Human Fertility 23:2, pages 101-110.
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I Raafat Rowida, KA Eshra, RM El-Sharaby, RAE Eissa, SM Saied, I Amer & S El Sharawy. (2020) Apa1 (rs7975232) SNP in the vitamin D receptor is linked to hepatocellular carcinoma in hepatitis C virus cirrhosis. British Journal of Biomedical Science 77:2, pages 53-57.
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Anna Maria Zicari, Arianna Cafarotti, Francesca Occasi, Valeria Lollobrigida, Marcella Nebbioso, Irene Pecorella, Giovanna De Castro, Alberto Spalice, Lorenzo Loffredo, Maria Pia Villa & Marzia Duse. (2017) Vitamin D levels in children affected by vernal keratoconjunctivitis. Current Medical Research and Opinion 33:2, pages 269-274.
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Andrew Blann. (2017) British Journal of Biomedical Science in 2016. What have we learned?. British Journal of Biomedical Science 74:1, pages 1-7.
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Marina Parra, Laura Foj & Xavier Filella. (2016) Automated measurement of 25-OH Vitamin D on the LUMIPULSE® G1200: analytical verification and method comparison. British Journal of Biomedical Science 73:3, pages 104-109.
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Andrew Blann. (2016) The rolling evolution of biomedical science as an essential tool in modern clinical practice. British Journal of Biomedical Science 73:1, pages 1-3.
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Articles from other publishers (85)

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Indumathi. K. PS. Sibyl. (2023) Vitamin D and its Influence on Oral Health: A Literature Review. Research Journal of Pharmacy and Technology, pages 2507-2512.
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Florin Mircea Iliescu, Paulina Pruszkowska‐Przybylska, Aneta Sitek & Elżbieta Żądzińska. (2023) The effect of skin color variation on 25( OH ) D concentration in P olish children . American Journal of Biological Anthropology 180:4, pages 733-744.
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Susana Rojo-Tolosa, Noelia Márquez-Pete, José María Gálvez-Navas, Laura Elena Pineda-Lancheros, Andrea Fernández-Alonso, Cristina Membrive-Jiménez, María Carmen Ramírez-Tortosa, Cristina Pérez-Ramírez & Alberto Jiménez-Morales. (2023) Single Nucleotide Polymorphisms in the Vitamin D Metabolic Pathway and Their Relationship with High Blood Pressure Risk. International Journal of Molecular Sciences 24:6, pages 5974.
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Rosa S Wong, Keith T S Tung, Ray T W Mak, Wing Cheong Leung, Jason C Yam, Gilbert T Chua, Genevieve P G Fung, Macro H K Ho, Ian C K Wong & Patrick Ip. (2022) Vitamin D concentrations during pregnancy and in cord blood: a systematic review and meta-analysis. Nutrition Reviews 80:12, pages 2225-2236.
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Lei Zhang, Jinting Liu, Ziyan Dai, Jia Wang, Mengyang Wu, Ruicong Su & Di Zhang. (2022) Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species. Frontiers in Nutrition 9.
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Zuoxiang Dong, Changjiang Fan, Wenshuai Deng & Peng Sun. (2022) Porous gelatin microsphere-based scaffolds containing MC3T3-E1 cells and calcitriol for the repair of skull defect. Biomaterials Advances 138, pages 212964.
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François Parant, Justin Bouloy, Julie Haesebaert, Lamia Bendim’red, Karine Goldet, Philippe Vanhems, Laetitia Henaff, Thomas Gilbert, Charlotte Cuerq, Emilie Blond, Muriel Bost & Marc Bonnefoy. (2022) Vitamin D and COVID-19 Severity in Hospitalized Older Patients: Potential Benefit of Prehospital Vitamin D Supplementation. Nutrients 14:8, pages 1641.
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Iman Akhlaghipour, Amir Reza Bina, Mohammad Reza Mogharrabi, Ali Fanoodi, Amir Reza Ebrahimian, Soroush Khojasteh Kaffash, Atefeh Babazadeh Baghan, Mohammad Erfan Khorashadizadeh, Negin Taghehchian & Meysam Moghbeli. (2022) Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population. Human Genomics 16:1.
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Ievgeniia Burlaka. (2022) Approach to correction of apoptotic disorders in children with early diabetic nephropathy ‎. Journal Of Advanced Pharmacy Education And Research 12:2, pages 104-109.
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Gerald Litwack. 2022. Human Biochemistry. Human Biochemistry 703 747 .
Selçuk Kaplan, Ahmet Türk, Hasan Aydın, Mehmet Erten & Pınar Kırıcı. (2021) Vitamin D improves oxidative stress and histopathological damage in rat ovaries caused by hyperthyroidism. Journal of Obstetrics and Gynaecology Research 47:10, pages 3551-3560.
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Huilin Song, Xingchen Wang, Siyu Hou, Yuqi Zhang, Xi Luo, Tengfei Li & Shunli Ji. (2021) Economical irregular silica as an effective dispersive solid-phase extraction sorbent for the quantification of calcitriol in soft capsules. Journal of Pharmaceutical and Biomedical Analysis 203, pages 114227.
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Alice Blufstein, Christian Behm, Barbara Kubin, Johannes Gahn, Xiaohui Rausch‐Fan, Andreas Moritz & Oleh Andrukhov. (2021) Effect of vitamin D 3 on the osteogenic differentiation of human periodontal ligament stromal cells under inflammatory conditions . Journal of Periodontal Research 56:3, pages 579-588.
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Young-Ju Jin, Chang-Myeon Song, Bum-Jung Park & Hyo-Geun Choi. (2021) Analyses of the Association between Thyroid Cancer and Osteoporosis/Fracture Histories: A Cross-Sectional Study Using KoGES HEXA Data. International Journal of Environmental Research and Public Health 18:9, pages 4732.
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Shaniya Ahmad, Shweta Arora, Salman Khan, Mohd Mohsin, Anant Mohan, Kailash Manda & Mansoor Ali Syed. (2021) Vitamin D and its therapeutic relevance in pulmonary diseases. The Journal of Nutritional Biochemistry 90, pages 108571.
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Mohammad Hassan Meshkibaf, Somayeh Mousazadeh, Mahsa Maleknia & Mohammad Ali Takhshid. (2021) Association of vitamin D deficiency with vitamin D binding protein (DBP) and CYP2R1 polymorphisms in Iranian population. Meta Gene 27, pages 100824.
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Andrés Díaz-López, Indira Paz-Graniel, Ramón Alonso-Sanz, Carolina Marqués Baldero, César Mateos Gil & Victoria Arija Val. (2021) Vitamin D deficiency in primary health care users at risk in Spain. Nutrición Hospitalaria.
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Ko Igarashi, Yoshihiro Yui, Kenta Watanabe, Jun Kumai, Yasuko Nishizawa, Chisato Miyaura, Masaki Inada & Satoru Sasagawa. (2020) Molecular evidence of IGFBP-3 dependent and independent VD3 action and its nonlinear response on IGFBP-3 induction in prostate cancer cells. BMC Cancer 20:1.
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Buthaina E. Alathari, Aji A. Sabta, Chinnappan A. Kalpana & Karani Santhanakrishnan Vimaleswaran. (2020) Vitamin D pathway-related gene polymorphisms and their association with metabolic diseases: A literature review. Journal of Diabetes & Metabolic Disorders 19:2, pages 1701-1729.
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Gayle C. Windham, Michelle Pearl, Victor Poon, Kimberly Berger, Jasmine W. Soriano, Darryl Eyles, Kristen Lyall, Martin Kharrazi & Lisa A. Croen. (2020) Maternal Vitamin D Levels During Pregnancy in Association With Autism Spectrum Disorders ( ASD ) or Intellectual Disability ( ID ) in Offspring; Exploring Non‐linear Patterns and Demographic Sub‐groups . Autism Research 13:12, pages 2216-2229.
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Krisna Moorthi Periyasamy, Uma Devi Ranganathan, Srikanth Prasad Tripathy & Ramalingam Bethunaickan. (2020) Vitamin D – A host directed autophagy mediated therapy for tuberculosis. Molecular Immunology 127, pages 238-244.
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Miranda Muhvić-Urek, Ema Saltović, Alen Braut & Daniela Kovačević Pavičić. (2020) Association between Vitamin D and Candida-Associated Denture Stomatitis. Dentistry Journal 8:4, pages 121.
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Marwa El‐Zeftawy, Samar Abd‐El Mohsen Ali, Sally Salah & Hani S. Hafez. (2020) The functional nutritional and regulatory activities of calcium supplementation from eggshell for obesity disorders management. Journal of Food Biochemistry 44:8.
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Kristen Heitman, Marcia Nahikian-Nelms & Kristen Roberts. (2020) Assessment of Calcium and Vitamin D Intake in an Outpatient Gastroenterology and Hepatology Clinic. Topics in Clinical Nutrition 35:3, pages 200-209.
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Oleh Andrukhov, Alice Blufstein, Christian Behm, Andreas Moritz & Xiaohui Rausch-Fan. (2020) Vitamin D3 and Dental Mesenchymal Stromal Cells. Applied Sciences 10:13, pages 4527.
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Dmitriy N. Shurpik, Yulia I. Aleksandrova, Pavel V. Zelenikhin, Evgenia V. Subakaeva, Peter J. Cragg & Ivan I. Stoikov. (2020) Towards new nanoporous biomaterials: self-assembly of sulfopillar[5]arenes with vitamin D 3 into supramolecular polymers . Organic & Biomolecular Chemistry 18:22, pages 4210-4216.
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Aaron H. Wasserman, Manigandan Venkatesan & Aitor Aguirre. (2020) Bioactive Lipid Signaling in Cardiovascular Disease, Development, and Regeneration. Cells 9:6, pages 1391.
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Andrea Stucchi, Ferruccio Conte, Andrea Galassi, Paola Ciceri & Mario Cozzolino. 2020. Molecular Nutrition. Molecular Nutrition 409 425 .
Sirajudeen, Shah & Al Menhali. (2019) A Narrative Role of Vitamin D and Its Receptor: With Current Evidence on the Gastric Tissues. International Journal of Molecular Sciences 20:15, pages 3832.
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Raúl Vicente Olmedo-Martín, Inmaculada González-Molero, Gabriel Olveira, Víctor Amo-Trillo & Miguel Jiménez-Pérez. (2019) Vitamin D in Inflammatory Bowel Disease: Biological, Clinical and Therapeutic Aspects. Current Drug Metabolism 20:5, pages 390-398.
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Gayle C. Windham, Michelle Pearl, Meredith C. Anderson, Victor Poon, Darryl Eyles, Karen L. Jones, Kristen Lyall, Martin Kharrazi & Lisa A. Croen. (2019) Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case–control study in california. Autism Research 12:6, pages 989-998.
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Maged M. Yassin, Abed El-Raoof D. Masoud & Mohammed M. Yasin. (2019) Serum vitamin D status in type 2 diabetic patients from Gaza Strip. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 13:3, pages 1865-1870.
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Yi Hao & Yueling Chen. (2019) Vitamin D levels and vitamin D receptor variants are associated with chronic heart failure in Chinese patients. Journal of Clinical Laboratory Analysis 33:4, pages e22847.
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M. Bičíková, L. Máčová, D. Ostatníková & L. Hanzlíková. (2019) Vitamin D in autistic children and healthy controls. Physiological Research, pages 317-320.
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Phoebe E. Mayne & Thomas H.J. Burne. (2019) Vitamin D in Synaptic Plasticity, Cognitive Function, and Neuropsychiatric Illness. Trends in Neurosciences 42:4, pages 293-306.
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Vasilios Tzilas, Evangelos Bouros, Ilianna Barbayianni, Thodoris Karampitsakos, Sofia Kourtidou, Maria Ntassiou, Ioanna Ninou, Vassilis Aidinis, Demosthenes Bouros & Argyris Tzouvelekis. (2019) Vitamin D prevents experimental lung fibrosis and predicts survival in patients with idiopathic pulmonary fibrosis. Pulmonary Pharmacology & Therapeutics 55, pages 17-24.
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Ali Sazci, Nihal Uren, Halil Atilla Idrisoglu & Emel Ergul. (2018) The rs2228570 Variant of the Vitamin D Receptor Gene is Associated with Essential Tremor. Neuroscience Bulletin 35:2, pages 362-364.
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Norman Ramirez, Jose L. Ortiz-Fullana, Norma Arciniegas, Altagracia Fullana, Pablo Valentin, Juan Carlos Orengo, Ivan Iriarte & Simon Carlo. (2018) Vitamin D levels and fracture risk among Hispanic children. European Journal of Orthopaedic Surgery & Traumatology 29:3, pages 531-536.
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Pedro Teixeira, Ana C. Santos, João Casalta-Lopes, Marco Almeida, Jorge Loureiro, Vera Ermida, Jorge Caldas & Carlos Fontes-Ribeiro. (2019) Prevalence of vitamin D deficiency amongst soccer athletes and effects of 8 weeks supplementation. The Journal of Sports Medicine and Physical Fitness 59:4.
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L. Pashova-Stoyanova & A. Tolekova. (2019) Effects of vitamin D on the renin-angiotensin system. Trakia Journal of Sciences 17:3, pages 277-282.
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Farideh Razi, Marzieh Arshadi Meshkani, Fariba Zarrabi, Maryam Sadr, Saeedeh Asgarbeik, Fatemeh Bandarian, Katayoon Forouzanfar & Mahsa Mohammad Amoli. (2019) Haplotypes in vitamin D receptor gene encode risk in diabetic nephropathy. Gene 683, pages 149-152.
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Babikir Kheiri, Ahmed Abdalla, Mohammed Osman, Sahar Ahmed, Mustafa Hassan & Ghassan Bachuwa. (2018) Vitamin D deficiency and risk of cardiovascular diseases: a narrative review. Clinical Hypertension 24:1.
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S. Mays. (2018) The epidemiology of rickets in the 17th–19th centuries: Some contributions from documentary sources and their value to palaeopathologists. International Journal of Paleopathology 23, pages 88-95.
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AlJohara M. AlQuaiz, Ambreen Kazi, Mona Fouda & Nada Alyousefi. (2018) Age and gender differences in the prevalence and correlates of vitamin D deficiency. Archives of Osteoporosis 13:1.
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S. Mays, T. Prowse, M. George & M. Brickley. (2018) Latitude, urbanization, age, and sex as risk factors for vitamin D deficiency disease in the Roman Empire. American Journal of Physical Anthropology 167:3, pages 484-496.
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Courtney PremerIvonne H. Schulman. (2018) Have We Been Measuring the Wrong Form of Vitamin D?. Circulation Research 123:8, pages 934-935.
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Dora Castiglione, Armando Platania, Alessandra Conti, Mariagiovanna Falla, Maurizio D’Urso & Marina Marranzano. (2018) Dietary Micronutrient and Mineral Intake in the Mediterranean Healthy Eating, Ageing, and Lifestyle (MEAL) Study. Antioxidants 7:7, pages 79.
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Chiara Ricca, Alessia Aillon, Loredana Bergandi, Daniela Alotto, Carlotta Castagnoli & Francesca Silvagno. (2018) Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health. International Journal of Molecular Sciences 19:6, pages 1672.
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Nikita Meghani, Pal Patel, Krupa Kansara, Shivendu Ranjan, Nandita Dasgupta, Chidambaram Ramalingam & Ashutosh Kumar. (2018) Formulation of vitamin D encapsulated cinnamon oil nanoemulsion: Its potential anti-cancerous activity in human alveolar carcinoma cells. Colloids and Surfaces B: Biointerfaces 166, pages 349-357.
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Ali AlJama, Mohammed AlKhalifah, Ibrahim Abdulla Al-Dabbous & Ghada Alqudaihi. (2018) Vitamin D deficiency in sickle cell disease patients in the Eastern Province of Saudi Arabia. Annals of Saudi Medicine 38:2, pages 130-136.
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Songcheng Yu, Xing Li, Yan Wang, Zhenxing Mao, Chongjian Wang, Yue Ba & Wenjie Li. (2018) Maternal transmission disequilibrium of rs2248359 in type 2 diabetes mellitus families and its association with vitamin D level in offspring. Scientific Reports 8:1.
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Caroline Himbert, Jennifer Ose, Mahmoud Delphan & Cornelia M. Ulrich. (2017) A systematic review of the interrelation between diet- and surgery-induced weight loss and vitamin D status. Nutrition Research 38, pages 13-26.
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Ma’an Abdullah Al-Barry, Alia M Albalawi, Mohammed Abu Sayf, Abdulrahman Badawi, Sibtain Afzal, Muhammad Latif, Mohammed I. Samman & Sulman Basit. (2016) Sequence analysis of four vitamin D family genes (VDR, CYP24A1, CYP27B1 and CYP2R1) in Vogt-Koyanagi-Harada (VKH) patients: identification of a potentially pathogenic variant in CYP2R1. BMC Ophthalmology 16:1.
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Andre Valcour, Claudia Zierold, Angela L. Podgorski, Gregory T. Olson, John V. Wall, Hector F. DeLuca & Fabrizio Bonelli. (2016) A novel, fully-automated, chemiluminescent assay for the detection of 1,25-dihydroxyvitamin D in biological samples. The Journal of Steroid Biochemistry and Molecular Biology 164, pages 120-126.
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