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Molecular Membrane Biology Volume 20, 2003 - Issue 3
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Research Article

Substrate recognition by the mammalian proton-dependent amino acid transporter PAT1

Michael Boll Molecular Nutrition Unit Technical University of Munich Hochfeldweg 2 D-85350 Freising-Weihenstephan
,
Martin Foltz Molecular Nutrition Unit Technical University of Munich Hochfeldweg 2 D-85350 Freising-Weihenstephan
,
Catriona M. H. Anderson School of Cell and Molecular Biosciences, Medical School University of Newcastle upon Tyne NE2 4HH Newcastle upon Tyne
,
Carmen Oechsler Molecular Nutrition Unit Technical University of Munich Hochfeldweg 2 D-85350 Freising-Weihenstephan
,
Gabor Kottra Molecular Nutrition Unit Technical University of Munich Hochfeldweg 2 D-85350 Freising-Weihenstephan
,
David T. Thwaites School of Cell and Molecular Biosciences, Medical School University of Newcastle upon Tyne NE2 4HH Newcastle upon Tyne
&
Hannelore Daniel Molecular Nutrition Unit Technical University of Munich Hochfeldweg 2 D-85350 Freising-Weihenstephan
 show all
Pages 261-269 | Published online: 09 Jul 2009

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Seiji Miyauchi, Emily L. Abbot, Lina Zhuang, Radhika Subramanian, Vadivel Ganapathy & David T. Thwaites. (2005) Isolation and function of the amino acid transporter PAT1 (slc36a1) from rabbit and discrimination between transport via PAT1 and system IMINO in renal brush-border membrane vesicles. Molecular Membrane Biology 22:6, pages 549-559.
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Articles from other publishers (52)

Tessa H. de Bie, Michiel G. J. Balvers, Ric C. H. de Vos, Renger F. Witkamp & Maarten A. Jongsma. (2022) The influence of a tomato food matrix on the bioavailability and plasma kinetics of oral gamma-aminobutyric acid (GABA) and its precursor glutamate in healthy men. Food & Function 13:16, pages 8399-8410.
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Robin Roychaudhuri & Solomon H. Snyder. (2022) Mammalian D‐cysteine: A novel regulator of neural progenitor cell proliferation. BioEssays 44:7, pages 2200002.
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Üner Kolukisaoglu. (2020) d-Amino Acids in Plants: Sources, Metabolism, and Functions. International Journal of Molecular Sciences 21:15, pages 5421.
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Javier G. Luengo, María-Dolores Muñoz, Iris Álvarez-Merz, Antonio S. Herranz, José C. González, Rafael Martín del Río, Jesús M. Hernández-Guijo & José M. Solís. (2019) Intracellular accumulation of amino acids increases synaptic potentials in rat hippocampal slices. Amino Acids 51:9, pages 1337-1351.
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Stefan Bröer & Stephen J. Fairweather. 2011. Comprehensive Physiology. Comprehensive Physiology 343 373 .
Xin Ji, Lingling Zhao, Hongjie Luo, Xiangxiang Zhang, Yaping Jin & Wei Liu. (2017) Amino acids suppress the expression of PAT 1 on lysosomes via inducing the cleavage of a targeting signal . FEBS Letters 591:15, pages 2279-2289.
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Israel Zelikovic. 2016. Pediatric Nephrology. Pediatric Nephrology 1155 1200 .
M.K. Nøhr, R.V. Juul, Z.I. Thale, R. Holm, M. Kreilgaard & C.U. Nielsen. (2015) Is oral absorption of vigabatrin carrier-mediated?. European Journal of Pharmaceutical Sciences 69, pages 10-18.
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Martha Kampp Nøhr, Sidsel Frølund, René Holm & Carsten Uhd Nielsen. (2014) Pharmacokinetic aspects of the anti-epileptic drug substance vigabatrin: focus on transporter interactions. Therapeutic Delivery 5:8, pages 927-942.
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Martha Kampp Nøhr, René Holm, Zia Irene Thale & Carsten Uhd Nielsen. (2014) Intestinal absorption of the antiepileptic drug substance vigabatrin in Göttingen mini-pigs is unaffected by co-administration of amino acids. International Journal of Pharmaceutics 466:1-2, pages 18-20.
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Sahar Roshanbin, Sofie V. Hellsten, Atieh Tafreshiha, Yinan Zhu, Amanda Raine & Robert Fredriksson. (2014) PAT4 is abundantly expressed in excitatory and inhibitory neurons as well as epithelial cells. Brain Research 1557, pages 12-25.
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Valerie Voigt, Linda Laug, Katja Zebisch, Iris Thondorf, Fritz Markwardt & Matthias Brandsch. (2013) Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). Journal of Pharmacy and Pharmacology 65:4, pages 582-590.
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Katja Zebisch & Matthias Brandsch. (2012) Transport of l-proline by the proton-coupled amino acid transporter PAT2 in differentiated 3T3-L1 cells. Amino Acids 44:2, pages 373-381.
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Yurong Lai. 2013. Transporters in Drug Discovery and Development. Transporters in Drug Discovery and Development 1 146 .
S. Frølund, M.K. Nøhr, R. Holm, B. Brodin & C.U. Nielsen. (2013) Potential involvement of the proton-coupled amino acid transporter PAT1 (SLC36A1) in the delivery of pharmaceutical agents. Journal of Drug Delivery Science and Technology 23:4, pages 293-306.
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David T Thwaites & Catriona MH Anderson. (2011) The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport. British Journal of Pharmacology 164:7, pages 1802-1816.
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Iris Thondorf, Valerie Voigt, Sarah Schäfer, Sabine Gebauer, Katja Zebisch, Linda Laug & Matthias Brandsch. (2011) Three-dimensional quantitative structure–activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1). Bioorganic & Medicinal Chemistry 19:21, pages 6409-6418.
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Sidsel Frølund, Nicolas Rapin & Carsten Uhd Nielsen. (2011) Gaboxadol has affinity for the proton-coupled amino acid transporter 1, SLC36A1 (hPAT1)—A modelling approach to determine IC50 values of the three ionic species of gaboxadol. European Journal of Pharmaceutical Sciences 42:3, pages 192-198.
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Samyuktha Muralidharan Pillai & David Meredith. (2011) SLC36A4 (hPAT4) Is a High Affinity Amino Acid Transporter When Expressed in Xenopus laevis Oocytes. Journal of Biological Chemistry 286:4, pages 2455-2460.
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Noel Edwards, Catriona M.H. Anderson, Kelly M. Gatfield, Mark P. Jevons, Vadivel Ganapathy & David T. Thwaites. (2011) Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochimica et Biophysica Acta (BBA) - Biomembranes 1808:1, pages 260-270.
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S Frølund, R Holm, B Brodin & CU Nielsen. (2010) The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics. British Journal of Pharmacology 161:3, pages 589-600.
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S Frølund, OC Marquez, M Larsen, B Brodin & CU Nielsen. (2010) δ‐Aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1). British Journal of Pharmacology 159:6, pages 1339-1353.
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Dmitri Y. Boudko. 2010. Epithelial Transport Physiology. Epithelial Transport Physiology 379 472 .
Amy M. Evans, Karlygash G. Aimanova & Sarjeet S. Gill. (2009) Characterization of a blood-meal-responsive proton-dependent amino acid transporter in the disease vector, Aedes aegypti . Journal of Experimental Biology 212:20, pages 3263-3271.
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Madlen Dorn, Matthias Weiwad, Fritz Markwardt, Linda Laug, Rainer Rudolph, Matthias Brandsch & Eva Bosse-Doenecke. (2009) Identification of a Disulfide Bridge Essential for Transport Function of the Human Proton-coupled Amino Acid Transporter hPAT1. Journal of Biological Chemistry 284:33, pages 22123-22132.
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Madlen Dorn, Michael Jaehme, Matthias Weiwad, Fritz Markwardt, Rainer Rudolph, Matthias Brandsch & Eva Bosse-Doenecke. (2009) The role of N -glycosylation in transport function and surface targeting of the human solute carrier PAT1 . FEBS Letters 583:10, pages 1631-1636.
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Mie Larsen, Birger Brodin Larsen, Bente Frølund & Carsten Uhd Nielsen. (2008) Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: Characterization of conditions for affinity and transport experiments in Caco-2 cells. European Journal of Pharmaceutical Sciences 35:1-2, pages 86-95.
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Stefan Bröer. (2008) Apical Transporters for Neutral Amino Acids: Physiology and Pathophysiology. Physiology 23:2, pages 95-103.
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Stefan Bröer. (2008) Amino Acid Transport Across Mammalian Intestinal and Renal Epithelia. Physiological Reviews 88:1, pages 249-286.
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David T. Thwaites & Catriona M. H. Anderson. (2007) H + -coupled nutrient, micronutrient and drug transporters in the mammalian small intestine . Experimental Physiology 92:4, pages 603-619.
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David T. Thwaites & Catriona M.H. Anderson. (2007) Deciphering the mechanisms of intestinal imino (and amino) acid transport: The redemption of SLC36A1. Biochimica et Biophysica Acta (BBA) - Biomembranes 1768:2, pages 179-197.
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Raquel Martín-Venegas, M. José Rodríguez-Lagunas, Pierre-André Geraert & Ruth Ferrer. (2007) Monocarboxylate Transporter 1 Mediates DL-2-Hydroxy-(4-Methylthio)Butanoic Acid Transport across the Apical Membrane of Caco-2 Cell Monolayers. The Journal of Nutrition 137:1, pages 49-54.
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P. Morin, C. Sagné & B. Gasnier. 2007. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology 439 459 .
M. Brandsch. (2006) Transport of L-proline, L-proline-containing peptides and related drugs at mammalian epithelial cell membranes. Amino Acids 31:2, pages 119-136.
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L. Metzner, K. Neubert & M. Brandsch. (2006) Substrate specificity of the amino acid transporter PAT1. Amino Acids 31:2, pages 111-117.
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Linda Metzner & Matthias Brandsch. (2006) Influence of a proton gradient on the transport kinetics of the H+/amino acid cotransporter PAT1 in Caco-2 cells. European Journal of Pharmaceutics and Biopharmaceutics 63:3, pages 360-364.
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C. Inigo, A. Barber & M. P. Lostao. (2006) Na+ and pH dependence of proline and beta-alanine absorption in rat small intestine. Acta Physiologica 186:4, pages 271-278.
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Emily L Abbot, Danielle S Grenade, David J Kennedy, Kelly M Gatfield & David T Thwaites. (2006) Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H + -coupled amino-acid transporter hPAT1 . British Journal of Pharmacology 147:3, pages 298-306.
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Angelika Bröer, Juleen A. Cavanaugh, John E. J. Rasko & Stefan Bröer. (2005) The molecular basis of neutral aminoacidurias. Pflügers Archiv - European Journal of Physiology 451:4, pages 511-517.
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Linda Metzner, Gabor Kottra, Klaus Neubert, Hannelore Daniel & Matthias Brandsch. (2005) Serotonin, l ‐tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1 . The FASEB Journal 19:11, pages 1468-1473.
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Catriona M.H. Anderson & David T. Thwaites. (2005) Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1). Journal of Cellular Physiology 204:2, pages 604-613.
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Martin FOLTZ, Manuela MERTL, Veronika DIETZ, Michael BOLL, Gabor KOTTRA & Hannelore DANIEL. (2005) Kinetics of bidirectional H+ and substrate transport by the proton-dependent amino acid symporter PAT1. Biochemical Journal 386:3, pages 607-616.
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David J Kennedy, Kelly M Gatfield, John P Winpenny, Vadivel Ganapathy & David T Thwaites. (2005) Substrate specificity and functional characterisation of the H + /amino acid transporter rat PAT2 (Slc36a2) . British Journal of Pharmacology 144:1, pages 28-41.
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Martin Foltz, Michael Boll, Ladislav Raschka, Gabor Kottra & Hannelore Daniel. (2004) A novel bifunctionality: PAT1 and PAT2 mediate electrogenic proton/amino acid and electroneutral proton/fatty acid symport. The FASEB Journal 18:14, pages 1758-1760.
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Catriona M.H. Anderson, Danielle S. Grenade, Michael Boll, Martin Foltz, Katherine A. Wake, David J. Kennedy, Lars K. Munck, Seiji Miyauchi, Peter M. Taylor, Frederick Charles Campbell, Bjarne G. Munck, Hannelore Daniel, Vadivel Ganapathy & David T. Thwaites. (2004) H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat. Gastroenterology 127:5, pages 1410-1422.
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Martin Foltz, Carmen Oechsler, Michael Boll, Gabor Kottra & Hannelore Daniel. (2004) Substrate specificity and transport mode of the proton‐dependent amino acid transporter mPAT2. European Journal of Biochemistry 271:16, pages 3340-3347.
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Linda Metzner, Jutta Kalbitz & Matthias Brandsch. (2004) Transport of Pharmacologically Active Proline Derivatives by the Human Proton-Coupled Amino Acid Transporter hPAT1. Journal of Pharmacology and Experimental Therapeutics 309:1, pages 28-35.
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Isabel Rubio-Aliaga, Michael Boll, Daniela M. Vogt Weisenhorn, Martin Foltz, Gabor Kottra & Hannelore Daniel. (2004) The Proton/Amino Acid Cotransporter PAT2 Is Expressed in Neurons with a Different Subcellular Localization than Its Paralog PAT1. Journal of Biological Chemistry 279:4, pages 2754-2760.
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