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Molecular Membrane Biology Volume 21, 2004 - Issue 1
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Original Paper

Functional expression and characterization of a purine nucleobase transporter gene from Leishmania major

Marco A. Sanchez* Department of Molecular Microbiology and Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, OR, 97201, PortlandCorrespondencee-mail: [email protected]
,
Rob Tryon Department of Molecular Microbiology and Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, OR, 97201, Portland
,
Steven Pierce Department of Molecular Microbiology and Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, OR, 97201, Portland
,
Gayatri Vasudevan Department of Molecular Microbiology and Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, OR, 97201, Portland
&
Scott M. Landfear Department of Molecular Microbiology and Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, OR, 97201, Portland
Pages 11-18 | Received 20 Feb 2003, Published online: 09 Jul 2009

Citations (32)

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Gozde Deveci, Mohd Kamil, Umit Kina, Binnur Aydogan Temel & Ahmed S. I. Aly. (2023) Genetic disruption of nucleoside transporter 4 reveals its critical roles in malaria parasite sporozoite functions. Pathogens and Global Health 117:3, pages 284-292.
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Rebba C. Boswell-Casteel & Franklin A. Hays. (2017) Equilibrative nucleoside transporters—A review. Nucleosides, Nucleotides & Nucleic Acids 36:1, pages 7-30.
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Articles from other publishers (30)

Mustafa M. Aldfer, Tahani A. AlSiari, Hamza A. A. Elati, Manal J. Natto, Ibrahim A. Alfayez, Gustavo D. Campagnaro, Bashiru Sani, Richard J. S. Burchmore, George Diallinas & Harry P. De Koning. (2022) Nucleoside Transport and Nucleobase Uptake Null Mutants in Leishmania mexicana for the Routine Expression and Characterization of Purine and Pyrimidine Transporters. International Journal of Molecular Sciences 23:15, pages 8139.
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Bindu Ambaru, Ganesh Muthu Gangadharan, Hosahalli S. Subramanya & Chhitar M. Gupta. (2022) Profilin is involved in G1 to S phase progression and mitotic spindle orientation during Leishmania donovani cell division cycle. PLOS ONE 17:3, pages e0265692.
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Gustavo D. Campagnaro & Harry P. Koning. (2020) Purine and pyrimidine transporters of pathogenic protozoa – conduits for therapeutic agents. Medicinal Research Reviews 40:5, pages 1679-1714.
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Anargyros Doukas, Ekaterini Karena, Maria Botou, Konstantinos Papakostas, Amalia Papadaki, Olympia Tziouvara, Evaggelia Xingi, Stathis Frillingos & Haralabia Boleti. (2019) Heterologous expression of the mammalian sodium-nucleobase transporter rSNBT1 in Leishmania tarentolae. Biochimica et Biophysica Acta (BBA) - Biomembranes 1861:9, pages 1546-1557.
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Kashika Arora & Ambak Kumar Rai. (2018) Dependence of Leishmania parasite on host derived ATP: an overview of extracellular nucleotide metabolism in parasite. Journal of Parasitic Diseases 43:1, pages 1-13.
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Scott M. Landfear. 2018. Drug Resistance in Leishmania Parasites. Drug Resistance in Leishmania Parasites 273 294 .
Snezhana AkpunarlievaRichard Burchmore. (2017) The role of membrane transporters in Leishmania virulence . Emerging Topics in Life Sciences 1:6, pages 601-611.
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Khalid J.H. Alzahrani, Juma A.M. Ali, Anthonius A. Eze, Wan Limm Looi, Daniel N.A. Tagoe, Darren J. Creek, Michael P. Barrett & Harry P. de Koning. (2017) Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy. International Journal for Parasitology: Drugs and Drug Resistance 7:2, pages 206-226.
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Paul Dean, Peter Major, Sirintra Nakjang, Robert P. Hirt & T. Martin Embley. (2014) Transport proteins of parasitic protists and their role in nutrient salvage. Frontiers in Plant Science 5.
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Jean-François Ritt, Frédéric Raymond, Philippe Leprohon, Danielle Légaré, Jacques Corbeil & Marc Ouellette. (2013) Gene Amplification and Point Mutations in Pyrimidine Metabolic Genes in 5-Fluorouracil Resistant Leishmania infantum. PLoS Neglected Tropical Diseases 7:11, pages e2564.
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Cassandra S. Arendt. (2013) Crithidia fasciculata adenosine transporter 1 (CfAT1), a novel high-affinity equilibrative nucleoside transporter specific for adenosine. Molecular and Biochemical Parasitology 191:2, pages 75-79.
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Scott M. Landfear. 2013. Drug Resistance in Leishmania Parasites. Drug Resistance in Leishmania Parasites 259 284 .
Jan M. Boitz, Buddy Ullman, Armando Jardim & Nicola S. Carter. (2012) Purine salvage in Leishmania: complex or simple by design?. Trends in Parasitology 28:8, pages 345-352.
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Martin Blume, Marion Hliscs, Dayana Rodriguez‐Contreras, Marco Sanchez, Scott Landfear, Richard Lucius, Kai Matuschewski & and Nishith Gupta. (2010) A constitutive pan‐hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs . The FASEB Journal 25:4, pages 1218-1229.
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Nicola S. Carter, Phillip A. Yates, Sarah K. Gessford, Sean R. Galagan, Scott M. Landfear & Buddy Ullman. (2010) Adaptive responses to purine starvation in Leishmania donovani. Molecular Microbiology, pages no-no.
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Mohamad Hamdi, Marco A Sanchez, Lauren C Beene, Qianyong Liu, Scott M Landfear, Barry P Rosen & Zijuan Liu. (2009) Arsenic transport by zebrafish aquaglyceroporins. BMC Molecular Biology 10:1.
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Raquel Valdés, Shirin Arastu-Kapur, Scott M. Landfear & Ujwal Shinde. (2009) An ab Initio Structural Model of a Nucleoside Permease Predicts Functionally Important Residues. Journal of Biological Chemistry 284:28, pages 19067-19076.
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Diana Ortiz, Marco A. Sanchez, Hans P. Koch, H. Peter Larsson & Scott M. Landfear. (2009) An Acid-activated Nucleobase Transporter from Leishmania major. Journal of Biological Chemistry 284:24, pages 16164-16169.
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I. Papageorgiou, H.P. De Koning, K. Soteriadou & G. Diallinas. (2008) Kinetic and mutational analysis of the Trypanosoma brucei NBT1 nucleobase transporter expressed in Saccharomyces cerevisiae reveals structural similarities between ENT and MFS transporters. International Journal for Parasitology 38:6, pages 641-653.
Crossref
Scott M.. 2008. Drug Targets in Kinetoplastid Parasites. Drug Targets in Kinetoplastid Parasites 22 32 .
Nicola S. Carter, Phillip Yates, Cassandra S. Arendt, Jan M. Boitz & Buddy Ullman. 2008. Drug Targets in Kinetoplastid Parasites. Drug Targets in Kinetoplastid Parasites 141 154 .
Diana Ortiz, Marco A. Sanchez, Steven Pierce, Timo Herrmann, Nicola Kimblin, H. G. Archie Bouwer & Scott M. Landfear. (2007) Molecular genetic analysis of purine nucleobase transport in Leishmania major. Molecular Microbiology 64:5, pages 1228-1243.
Crossref
Wei Liu, Jan M. Boitz, Jon Galazka, Cassandra S. Arendt, Nicola S. Carter & Buddy Ullman. (2006) Functional characterization of nucleoside transporter gene replacements in Leishmania donovani. Molecular and Biochemical Parasitology 150:2, pages 300-307.
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Raquel Valdés, Wei Liu, Buddy Ullman & Scott M. Landfear. (2006) Comprehensive Examination of Charged Intramembrane Residues in a Nucleoside Transporter. Journal of Biological Chemistry 281:32, pages 22647-22655.
Crossref
Harry P. de Koning, Daniel J. Bridges & Richard J.S. Burchmore. (2005) Purine and pyrimidine transport in pathogenic protozoa: From biology to therapy. FEMS Microbiology Reviews 29:5, pages 987-1020.
Crossref
Mohammed I. Al-Salabi & Harry P. de Koning. (2005) Purine Nucleobase Transport in Amastigotes of Leishmania mexicana : Involvement in Allopurinol Uptake . Antimicrobial Agents and Chemotherapy 49:9, pages 3682-3689.
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J. A. Kloepfer, R. E. Mielke & J. L. Nadeau. (2005) Uptake of CdSe and CdSe/ZnS Quantum Dots into Bacteria via Purine-Dependent Mechanisms. Applied and Environmental Microbiology 71:5, pages 2548-2557.
Crossref
Wei Liu, Cassandra S. Arendt, Sarah K. Gessford, Dziwe Ntaba, Nicola S. Carter & Buddy Ullman. (2005) Identification and characterization of purine nucleoside transporters from Crithidia fasciculata. Molecular and Biochemical Parasitology 140:1, pages 1-12.
Crossref
Marco A. Sanchez, Scott Drutman, Marleen van Ampting, Keith Matthews & Scott M. Landfear. (2004) A novel purine nucleoside transporter whose expression is up-regulated in the short stumpy form of the Trypanosoma brucei life cycle. Molecular and Biochemical Parasitology 136:2, pages 265-272.
Crossref
Scott M. Landfear, Buddy Ullman, Nicola S. Carter & Marco A. Sanchez. (2004) Nucleoside and Nucleobase Transporters in Parasitic Protozoa. Eukaryotic Cell 3:2, pages 245-254.
Crossref

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