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Molecular Membrane Biology Volume 24, 2007 - Issue 5-6
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Original Article

A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity

Andrei R. Manolescu Department of Physiology, University of Alberta, Edmonton, Alberta, Canada
,
Robert Augustin Washington University, Obstetrics/Gynecology, Washington University School of Medicine, St. Louis, Missouri, USA
,
Kelle Moley Washington University, Obstetrics/Gynecology, Washington University School of Medicine, St. Louis, Missouri, USA
&
Chris Cheeseman Department of Physiology, University of Alberta, Edmonton, Alberta, CanadaCorrespondence[email protected]
Pages 455-463 | Received 28 Nov 2006, Published online: 09 Jul 2009

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Douglas J Stewart, Valerie Langlois & Damien Noone. (2019) Hyperuricemia and Hypertension: Links and Risks. Integrated Blood Pressure Control 12, pages 43-62.
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Wentong Long & Chris I Cheeseman. (2015) Structure of, and functional insight into the GLUT family of membrane transporters. Cell Health and Cytoskeleton 7, pages 167-183.
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Brian J. DeBoschMonique R. HeitmeierAllyson L. MayerCassandra B. HigginsJan R. CrowleyThomas E. KraftMaggie ChiElizabeth P. NewberryZhouji ChenBrian N. FinckNicholas O. DavidsonKevin E. YarasheskiPaul W. HruzKelle H. Moley. (2016) Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Science Signaling 9:416.
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Li-Qing ChenLily S. CheungLiang Feng, Widmar Tanner & Wolf B. Frommer. (2015) Transport of Sugars. Annual Review of Biochemistry 84:1, pages 865-894.
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Asim K. MandalDavid B. Mount. (2015) The Molecular Physiology of Uric Acid Homeostasis. Annual Review of Physiology 77:1, pages 323-345.
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Olivier-Mohamad Soueidan, Brendan J. Trayner, Tina N. Grant, Jeff R. Henderson, Frank Wuest, F. G. West & Chris I. Cheeseman. (2015) New fluorinated fructose analogs as selective probes of the hexose transporter protein GLUT5. Organic & Biomolecular Chemistry 13:23, pages 6511-6521.
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D. Tyler McQuade, Matthew B. Plutschack & Peter H. Seeberger. (2013) Passive fructose transporters in disease: a molecular overview of their structural specificity. Organic & Biomolecular Chemistry 11:30, pages 4909.
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Mark A. Sarzynski, Peter Jacobson, Tuomo Rankinen, Björn Carlsson, Lars Sjöström, Claude Bouchard & Lena M. S. Carlsson. (2012) Changes in Uric Acid Levels following Bariatric Surgery Are Not Associated with SLC2A9 Variants in the Swedish Obese Subjects Study. PLoS ONE 7:12, pages e51658.
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Anthony M. Reginato, David B. Mount, Irene Yang & Hyon K. Choi. (2012) The genetics of hyperuricaemia and gout. Nature Reviews Rheumatology 8:10, pages 610-621.
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Samuel K. McBrayer, Javelin C. Cheng, Seema Singhal, Nancy L. Krett, Steven T. Rosen & Mala Shanmugam. (2012) Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy. Blood 119:20, pages 4686-4697.
Crossref
Anthony J. Cura & Anthony Carruthers. 2011. Comprehensive Physiology. Comprehensive Physiology 863 914 .
Philip L Riches. 2012. Gout & Other Crystal Arthropathies. Gout & Other Crystal Arthropathies 85 93 .
SPH Alexander, A Mathie & JA Peters. (2011) TRANSPORTERS. British Journal of Pharmacology 164:s1.
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Isabel Soares-Silva, Joana Sá-Pessoa, Vassilios Myrianthopoulos, Emmanuel Mikros, Margarida Casal & George Diallinas. (2011) A substrate translocation trajectory in a cytoplasm-facing topological model of the monocarboxylate/H+ symporter Jen1p. Molecular Microbiology 81:3, pages 805-817.
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Gaëlle Boudry, Elmer S David, Véronique Douard, Iona M Monteiro, Isabelle Le Huërou-Luron & Ronaldo P Ferraris. (2010) Role of Intestinal Transporters in Neonatal Nutrition: Carbohydrates, Proteins, Lipids, Minerals, and Vitamins. Journal of Pediatric Gastroenterology & Nutrition 51:4, pages 380-401.
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Christina M. Naula, Flora M. Logan, Pui Ee Wong, Michael P. Barrett & Richard J. Burchmore. (2010) A Glucose Transporter Can Mediate Ribose Uptake. Journal of Biological Chemistry 285:39, pages 29721-29728.
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Alexander So & Bernard Thorens. (2010) Uric acid transport and disease. Journal of Clinical Investigation 120:6, pages 1791-1799.
Crossref
Kimberley M. MellorRebecca H. RitchieAmy J. DavidoffLea M.D. Delbridge. (2010) Elevated dietary sugar and the heart: experimental models and myocardial remodeling. Canadian Journal of Physiology and Pharmacology 88:5, pages 525-540.
Crossref
Hyon K Choi, Yanyan Zhu & David B Mount. (2010) Genetics of gout. Current Opinion in Rheumatology 22:2, pages 144-151.
Crossref
Avner Schlessinger, Pär Matsson, James E. Shima, Ursula Pieper, Sook Wah Yee, Libusha Kelly, Leonard Apeltsin, Robert M. Stroud, Thomas E. Ferrin, Kathleen M. Giacomini & Andrej Sali. (2010) Comparison of human solute carriers. Protein Science 19:3, pages 412-428.
Crossref
Robert Augustin. (2010) The protein family of glucose transport facilitators: It's not only about glucose after all. IUBMB Life, pages NA-NA.
Crossref
Sarah A. Evans, Manuel Doblado, Maggie M. Chi, John A. Corbett & Kelle H. Moley. (2009) Facilitative Glucose Transporter 9 Expression Affects Glucose Sensing in Pancreatic β-Cells. Endocrinology 150:12, pages 5302-5310.
Crossref
Scott H. Purcell & Kelle H. Moley. (2009) Glucose transporters in gametes and preimplantation embryos. Trends in Endocrinology & Metabolism 20:10, pages 483-489.
Crossref
P. L. Riches, A. F. Wright & S. H. Ralston. (2009) Recent insights into the pathogenesis of hyperuricaemia and gout. Human Molecular Genetics 18:R2, pages R177-R184.
Crossref
Anthony Carruthers, Julie DeZutter, Amit Ganguly & Sherin U. Devaskar. (2009) Will the original glucose transporter isoform please stand up!. American Journal of Physiology-Endocrinology and Metabolism 297:4, pages E836-E848.
Crossref
Manuel Doblado & Kelle H. Moley. (2009) Facilitative glucose transporter 9, a unique hexose and urate transporter. American Journal of Physiology-Endocrinology and Metabolism 297:4, pages E831-E835.
Crossref
Stéphanie Bibert, Solange Kharoubi Hess, Dmitri Firsov, Bernard Thorens, Käthi Geering, Jean-Daniel Horisberger & Olivier Bonny. (2009) Mouse GLUT9: evidences for a urate uniporter. American Journal of Physiology-Renal Physiology 297:3, pages F612-F619.
Crossref
Chris Cheeseman. (2009) Solute carrier family 2, member 9 and uric acid homeostasis. Current Opinion in Nephrology and Hypertension 18:5, pages 428-432.
Crossref
Sung Tae Kim & Kelle H. Moley. (2009) Regulation of Facilitative Glucose Transporters and AKT/MAPK/PRKAA Signaling via Estradiol and Progesterone in the Mouse Uterine Epithelium1. Biology of Reproduction 81:1, pages 188-198.
Crossref
Y. Izumi & C.F. Zorumski. (2009) Glial–neuronal interactions underlying fructose utilization in rat hippocampal slices. Neuroscience 161:3, pages 847-854.
Crossref
Antonina Frolova, Lauren Flessner, Maggie Chi, Sung Tae Kim, Nastaran Foyouzi-Yousefi & Kelle H. Moley. (2009) Facilitative Glucose Transporter Type 1 Is Differentially Regulated by Progesterone and Estrogen in Murine and Human Endometrial Stromal Cells. Endocrinology 150:3, pages 1512-1520.
Crossref
Leonid Livshits, Andreas Caduff, Mark S. Talary, Hans U. Lutz, Yoshihito Hayashi, Alexander Puzenko, Andrey Shendrik & Yuri Feldman. (2009) The Role of GLUT1 in the Sugar-Induced Dielectric Response of Human Erythrocytes. The Journal of Physical Chemistry B 113:7, pages 2212-2220.
Crossref
RA Stein. (2008) The genetic basis of uric acid variance. Clinical Genetics 74:5, pages 410-413.
Crossref
Patrick F. McArdle, Afshin Parsa, Yen-Pei C. Chang, Matthew R. Weir, Jeffery R. O'Connell, Braxton D. Mitchell & Alan R. Shuldiner. (2008) Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish. Arthritis & Rheumatism 58:9, pages 2874-2881.
Crossref
Veronique Vitart, Igor Rudan, Caroline Hayward, Nicola K Gray, James Floyd, Colin NA Palmer, Sara A Knott, Ivana Kolcic, Ozren Polasek, Juergen Graessler, James F Wilson, Anthony Marinaki, Philip L Riches, Xinhua Shu, Branka Janicijevic, Nina Smolej-Narancic, Barbara Gorgoni, Joanne Morgan, Susan Campbell, Zrinka Biloglav, Lovorka Barac-Lauc, Marijana Pericic, Irena Martinovic Klaric, Lina Zgaga, Tatjana Skaric-Juric, Sarah H Wild, William A Richardson, Peter Hohenstein, Charley H Kimber, Albert Tenesa, Louise A Donnelly, Lynette D Fairbanks, Martin Aringer, Paul M McKeigue, Stuart H Ralston, Andrew D Morris, Pavao Rudan, Nicholas D Hastie, Harry Campbell & Alan F Wright. (2008) SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nature Genetics 40:4, pages 437-442.
Crossref

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