Advanced search
Publication Cover
Molecular Membrane Biology Volume 25, 2008 - Issue 2
Journal homepage
525
Views
24
CrossRef citations to date
0
Altmetric
Original

Functional characterization of residues within the carnitine/acylcarnitine translocase RX2PANAAXF distinct motif

J. Ramon De Lucas Departamento de Microbiología y Parasitología, Facultad de Farmacia, Campus Universitario, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
,
J. Ramon De Lucas Departamento de Microbiología y Parasitología, Facultad de Farmacia, Campus Universitario, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
,
Cesare Indiveri Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Bari, Italy; Department of Cellular Biology, University of Calabria, Arcavacata di Rende, Italy
,
J. Ramon De Lucas Departamento de Microbiología y Parasitología, Facultad de Farmacia, Campus Universitario, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
,
Cesare Indiveri Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Bari, Italy; Department of Cellular Biology, University of Calabria, Arcavacata di Rende, Italy
,
Annamaria Tonazzi Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Bari, Italy; CNR Institute of Biomembranes and Bioenergetics, Bari, Italy
,
Patricia Perez Departamento de Microbiología y Parasitología, Facultad de Farmacia, Campus Universitario, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
,
Nicola Giangregorio Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Bari, Italy; CNR Institute of Biomembranes and Bioenergetics, Bari, Italy
,
Vito Iacobazzi Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Bari, Italy; CNR Institute of Biomembranes and Bioenergetics, Bari, Italy
&
Dr Ferdinando Palmieri Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Bari, Italy; CNR Institute of Biomembranes and Bioenergetics, Bari, ItalyCorrespondence[email protected]
 show all
Pages 152-163 | Received 09 May 2007, Published online: 09 Jul 2009

Citations (24)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Magnus Monné, Ferdinando Palmieri & Edmund R. S. Kunji. (2013) The substrate specificity of mitochondrial carriers: Mutagenesis revisited. Molecular Membrane Biology 30:2, pages 149-159.
Read now

Articles from other publishers (23)

Eugenia Messina, Camilla Pires de Souza, Claudia Cappella, Simona Nicole Barile, Pasquale Scarcia, Isabella Pisano, Luigi Palmieri, Jean-Marc Nicaud & Gennaro Agrimi. (2023) Genetic inactivation of the Carnitine/Acetyl-Carnitine mitochondrial carrier of Yarrowia lipolytica leads to enhanced odd-chain fatty acid production. Microbial Cell Factories 22:1.
Crossref
Andrea Pasquadibisceglie, Virginia Quadrotta & Fabio Polticelli. (2023) In Silico Analysis of the Structural Dynamics and Substrate Recognition Determinants of the Human Mitochondrial Carnitine/Acylcarnitine SLC25A20 Transporter. International Journal of Molecular Sciences 24:4, pages 3946.
Crossref
Michele Galluccio, Lara Console, Lorena Pochini, Mariafrancesca Scalise, Nicola Giangregorio & Cesare Indiveri. (2022) Strategies for Successful Over-Expression of Human Membrane Transport Systems Using Bacterial Hosts: Future Perspectives. International Journal of Molecular Sciences 23:7, pages 3823.
Crossref
Annamaria Tonazzi, Nicola Giangregorio, Lara Console, Ferdinando Palmieri & Cesare Indiveri. (2021) The Mitochondrial Carnitine Acyl-carnitine Carrier (SLC25A20): Molecular Mechanisms of Transport, Role in Redox Sensing and Interaction with Drugs. Biomolecules 11:4, pages 521.
Crossref
Ferdinando Palmieri, Pasquale Scarcia & Magnus Monné. (2020) Diseases Caused by Mutations in Mitochondrial Carrier Genes SLC25: A Review. Biomolecules 10:4, pages 655.
Crossref
Nicola Giangregorio, Annamaria Tonazzi, Lara Console, Mario Prejanò, Tiziana Marino, Nino Russo & Cesare Indiveri. (2020) Effect of Copper on the Mitochondrial Carnitine/Acylcarnitine Carrier Via Interaction with Cys136 and Cys155. Possible Implications in Pathophysiology. Molecules 25:4, pages 820.
Crossref
Nicola Giangregorio, Annamaria Tonazzi, Lara Console, Mariella Pistillo, Vito Scalera & Cesare Indiveri. (2019) Tryptophan 224 of the rat mitochondrial carnitine/acylcarnitine carrier is crucial for the antiport mechanism. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1860:9, pages 708-716.
Crossref
Nicola Giangregorio, Annamaria Tonazzi, Lara Console, Imma Lorusso, Annalisa De Palma & Cesare Indiveri. (2016) The mitochondrial carnitine/acylcarnitine carrier is regulated by hydrogen sulfide via interaction with C136 and C155. Biochimica et Biophysica Acta (BBA) - General Subjects 1860:1, pages 20-27.
Crossref
Nicola Giangregorio, Lara Console, Annamaria Tonazzi, Ferdinando Palmieri & Cesare Indiveri. (2014) Identification of Amino Acid Residues Underlying the Antiport Mechanism of the Mitochondrial Carnitine/Acylcarnitine Carrier by Site-Directed Mutagenesis and Chemical Labeling. Biochemistry 53:44, pages 6924-6933.
Crossref
Lara Console, Nicola Giangregorio, Cesare Indiveri & Annamaria Tonazzi. (2014) Carnitine/acylcarnitine translocase and carnitine palmitoyltransferase 2 form a complex in the inner mitochondrial membrane. Molecular and Cellular Biochemistry 394:1-2, pages 307-314.
Crossref
Michel Flipphi, Nathalie Oestreicher, Valérie Nicolas, Audrey Guitton & Christian Vélot. (2014) The Aspergillus nidulans acuL gene encodes a mitochondrial carrier required for the utilization of carbon sources that are metabolized via the TCA cycle. Fungal Genetics and Biology 68, pages 9-22.
Crossref
Magnus Monné & Ferdinando Palmieri. 2014. Exchangers. Exchangers 289 320 .
Annamaria Tonazzi, Lara Console & Cesare Indiveri. (2013) Inhibition of mitochondrial carnitine/acylcarnitine transporter by H2O2: Molecular mechanism and possible implication in pathophysiology. Chemico-Biological Interactions 203:2, pages 423-429.
Crossref
Vito Iacobazzi, Vittoria Infantino & Ferdinando Palmieri. (2013) Transcriptional Regulation of the Mitochondrial Citrate and Carnitine/Acylcarnitine Transporters: Two Genes Involved in Fatty Acid Biosynthesis and β-oxidation. Biology 2:1, pages 284-303.
Crossref
Gennaro Agrimi, Annamaria Russo, Ciro Leonardo Pierri & Ferdinando Palmieri. (2012) The peroxisomal NAD+ carrier of Arabidopsis thaliana transports coenzyme A and its derivatives. Journal of Bioenergetics and Biomembranes 44:3, pages 333-340.
Crossref
Annamaria Tonazzi, Lara Console, Nicola Giangregorio, Cesare Indiveri & Ferdinando Palmieri. (2012) Identification by site-directed mutagenesis of a hydrophobic binding site of the mitochondrial carnitine/acylcarnitine carrier involved in the interaction with acyl groups. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1817:5, pages 697-704.
Crossref
Marion Babot, Corinne Blancard, Ludovic Pelosi, Guy J.-M. Lauquin & Véronique Trézéguet. (2012) The Transmembrane Prolines of the Mitochondrial ADP/ATP Carrier Are Involved in Nucleotide Binding and Transport and Its Biogenesis. Journal of Biological Chemistry 287:13, pages 10368-10378.
Crossref
Cesare Indiveri, Vito Iacobazzi, Annamaria Tonazzi, Nicola Giangregorio, Vittoria Infantino, Paolo Convertini, Lara Console & Ferdinando Palmieri. (2011) The mitochondrial carnitine/acylcarnitine carrier: Function, structure and physiopathology. Molecular Aspects of Medicine 32:4-6, pages 223-233.
Crossref
Nicola Giangregorio, Annamaria Tonazzi, Lara Console, Cesare Indiveri & Ferdinando Palmieri. (2010) Site-directed mutagenesis of charged amino acids of the human mitochondrial carnitine/acylcarnitine carrier: Insight into the molecular mechanism of transport. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1797:6-7, pages 839-845.
Crossref
Ferdinando Palmieri & Ciro Leonardo Pierri. (2010) Structure and function of mitochondrial carriers - Role of the transmembrane helix P and G residues in the gating and transport mechanism. FEBS Letters 584:9, pages 1931-1939.
Crossref
Annamaria Tonazzi, Nicola Giangregorio, Cesare Indiveri & Ferdinando Palmieri. (2009) Site-directed mutagenesis of the His residues of the rat mitochondrial carnitine/acylcarnitine carrier: Implications for the role of His-29 in the transport pathway. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1787:8, pages 1009-1015.
Crossref
Alessandra Tessa, Giuseppe Fiermonte, Carlo Dionisi-Vici, Eleonora Paradies, Matthias R. Baumgartner, Yin-Hsiu Chien, Carmela Loguercio, Helene Ogier de Baulny, Marie-Cecile Nassogne, Manuel Schiff, Federica Deodato, Giancarlo Parenti, S. Lane Rutledge, M. Antonia Vilaseca, Mariarosa A.B. Melone, Gioacchino Scarano, Luiz Aldamiz-Echevarría, Guy Besley, John Walter, Eugenia Martinez-Hernandez, Jose M. Hernandez, Ciro L. Pierri, Ferdinando Palmieri & Filippo M. Santorelli. (2009) Identification of novel mutations in the SLC25A15 gene in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome: A clinical, molecular, and functional study . Human Mutation 30:5, pages 741-748.
Crossref
Ferdinando Palmieri. (2008) Diseases caused by defects of mitochondrial carriers: A review. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1777:7-8, pages 564-578.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.