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Molecular Membrane Biology Volume 25, 2008 - Issue 2
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Original

Functional characterization of residues within the carnitine/acylcarnitine translocase RX2PANAAXF distinct motif

J. Ramon De Lucas Departamento de Microbiología y Parasitología, Facultad de Farmacia, Campus Universitario, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
,
J. Ramon De Lucas Departamento de Microbiología y Parasitología, Facultad de Farmacia, Campus Universitario, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
,
Cesare Indiveri Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Bari, Italy; Department of Cellular Biology, University of Calabria, Arcavacata di Rende, Italy
,
J. Ramon De Lucas Departamento de Microbiología y Parasitología, Facultad de Farmacia, Campus Universitario, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
,
Cesare Indiveri Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Bari, Italy; Department of Cellular Biology, University of Calabria, Arcavacata di Rende, Italy
,
Annamaria Tonazzi Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Bari, Italy; CNR Institute of Biomembranes and Bioenergetics, Bari, Italy
,
Patricia Perez Departamento de Microbiología y Parasitología, Facultad de Farmacia, Campus Universitario, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
,
Nicola Giangregorio Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Bari, Italy; CNR Institute of Biomembranes and Bioenergetics, Bari, Italy
,
Vito Iacobazzi Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Bari, Italy; CNR Institute of Biomembranes and Bioenergetics, Bari, Italy
&
Dr Ferdinando Palmieri Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Bari, Italy; CNR Institute of Biomembranes and Bioenergetics, Bari, ItalyCorrespondence[email protected]
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Pages 152-163 | Received 09 May 2007, Published online: 09 Jul 2009

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Magnus Monné, Ferdinando Palmieri & Edmund R. S. Kunji. (2013) The substrate specificity of mitochondrial carriers: Mutagenesis revisited. Molecular Membrane Biology 30:2, pages 149-159.
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Articles from other publishers (23)

Eugenia Messina, Camilla Pires de Souza, Claudia Cappella, Simona Nicole Barile, Pasquale Scarcia, Isabella Pisano, Luigi Palmieri, Jean-Marc Nicaud & Gennaro Agrimi. (2023) Genetic inactivation of the Carnitine/Acetyl-Carnitine mitochondrial carrier of Yarrowia lipolytica leads to enhanced odd-chain fatty acid production. Microbial Cell Factories 22:1.
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Andrea Pasquadibisceglie, Virginia Quadrotta & Fabio Polticelli. (2023) In Silico Analysis of the Structural Dynamics and Substrate Recognition Determinants of the Human Mitochondrial Carnitine/Acylcarnitine SLC25A20 Transporter. International Journal of Molecular Sciences 24:4, pages 3946.
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Michele Galluccio, Lara Console, Lorena Pochini, Mariafrancesca Scalise, Nicola Giangregorio & Cesare Indiveri. (2022) Strategies for Successful Over-Expression of Human Membrane Transport Systems Using Bacterial Hosts: Future Perspectives. International Journal of Molecular Sciences 23:7, pages 3823.
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Annamaria Tonazzi, Nicola Giangregorio, Lara Console, Ferdinando Palmieri & Cesare Indiveri. (2021) The Mitochondrial Carnitine Acyl-carnitine Carrier (SLC25A20): Molecular Mechanisms of Transport, Role in Redox Sensing and Interaction with Drugs. Biomolecules 11:4, pages 521.
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Ferdinando Palmieri, Pasquale Scarcia & Magnus Monné. (2020) Diseases Caused by Mutations in Mitochondrial Carrier Genes SLC25: A Review. Biomolecules 10:4, pages 655.
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Nicola Giangregorio, Annamaria Tonazzi, Lara Console, Mario Prejanò, Tiziana Marino, Nino Russo & Cesare Indiveri. (2020) Effect of Copper on the Mitochondrial Carnitine/Acylcarnitine Carrier Via Interaction with Cys136 and Cys155. Possible Implications in Pathophysiology. Molecules 25:4, pages 820.
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Nicola Giangregorio, Annamaria Tonazzi, Lara Console, Mariella Pistillo, Vito Scalera & Cesare Indiveri. (2019) Tryptophan 224 of the rat mitochondrial carnitine/acylcarnitine carrier is crucial for the antiport mechanism. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1860:9, pages 708-716.
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Nicola Giangregorio, Annamaria Tonazzi, Lara Console, Imma Lorusso, Annalisa De Palma & Cesare Indiveri. (2016) The mitochondrial carnitine/acylcarnitine carrier is regulated by hydrogen sulfide via interaction with C136 and C155. Biochimica et Biophysica Acta (BBA) - General Subjects 1860:1, pages 20-27.
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Nicola Giangregorio, Lara Console, Annamaria Tonazzi, Ferdinando Palmieri & Cesare Indiveri. (2014) Identification of Amino Acid Residues Underlying the Antiport Mechanism of the Mitochondrial Carnitine/Acylcarnitine Carrier by Site-Directed Mutagenesis and Chemical Labeling. Biochemistry 53:44, pages 6924-6933.
Crossref
Lara Console, Nicola Giangregorio, Cesare Indiveri & Annamaria Tonazzi. (2014) Carnitine/acylcarnitine translocase and carnitine palmitoyltransferase 2 form a complex in the inner mitochondrial membrane. Molecular and Cellular Biochemistry 394:1-2, pages 307-314.
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Michel Flipphi, Nathalie Oestreicher, Valérie Nicolas, Audrey Guitton & Christian Vélot. (2014) The Aspergillus nidulans acuL gene encodes a mitochondrial carrier required for the utilization of carbon sources that are metabolized via the TCA cycle. Fungal Genetics and Biology 68, pages 9-22.
Crossref
Magnus Monné & Ferdinando Palmieri. 2014. Exchangers. Exchangers 289 320 .
Annamaria Tonazzi, Lara Console & Cesare Indiveri. (2013) Inhibition of mitochondrial carnitine/acylcarnitine transporter by H2O2: Molecular mechanism and possible implication in pathophysiology. Chemico-Biological Interactions 203:2, pages 423-429.
Crossref
Vito Iacobazzi, Vittoria Infantino & Ferdinando Palmieri. (2013) Transcriptional Regulation of the Mitochondrial Citrate and Carnitine/Acylcarnitine Transporters: Two Genes Involved in Fatty Acid Biosynthesis and β-oxidation. Biology 2:1, pages 284-303.
Crossref
Gennaro Agrimi, Annamaria Russo, Ciro Leonardo Pierri & Ferdinando Palmieri. (2012) The peroxisomal NAD+ carrier of Arabidopsis thaliana transports coenzyme A and its derivatives. Journal of Bioenergetics and Biomembranes 44:3, pages 333-340.
Crossref
Annamaria Tonazzi, Lara Console, Nicola Giangregorio, Cesare Indiveri & Ferdinando Palmieri. (2012) Identification by site-directed mutagenesis of a hydrophobic binding site of the mitochondrial carnitine/acylcarnitine carrier involved in the interaction with acyl groups. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1817:5, pages 697-704.
Crossref
Marion Babot, Corinne Blancard, Ludovic Pelosi, Guy J.-M. Lauquin & Véronique Trézéguet. (2012) The Transmembrane Prolines of the Mitochondrial ADP/ATP Carrier Are Involved in Nucleotide Binding and Transport and Its Biogenesis. Journal of Biological Chemistry 287:13, pages 10368-10378.
Crossref
Cesare Indiveri, Vito Iacobazzi, Annamaria Tonazzi, Nicola Giangregorio, Vittoria Infantino, Paolo Convertini, Lara Console & Ferdinando Palmieri. (2011) The mitochondrial carnitine/acylcarnitine carrier: Function, structure and physiopathology. Molecular Aspects of Medicine 32:4-6, pages 223-233.
Crossref
Nicola Giangregorio, Annamaria Tonazzi, Lara Console, Cesare Indiveri & Ferdinando Palmieri. (2010) Site-directed mutagenesis of charged amino acids of the human mitochondrial carnitine/acylcarnitine carrier: Insight into the molecular mechanism of transport. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1797:6-7, pages 839-845.
Crossref
Ferdinando Palmieri & Ciro Leonardo Pierri. (2010) Structure and function of mitochondrial carriers - Role of the transmembrane helix P and G residues in the gating and transport mechanism. FEBS Letters 584:9, pages 1931-1939.
Crossref
Annamaria Tonazzi, Nicola Giangregorio, Cesare Indiveri & Ferdinando Palmieri. (2009) Site-directed mutagenesis of the His residues of the rat mitochondrial carnitine/acylcarnitine carrier: Implications for the role of His-29 in the transport pathway. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1787:8, pages 1009-1015.
Crossref
Alessandra Tessa, Giuseppe Fiermonte, Carlo Dionisi-Vici, Eleonora Paradies, Matthias R. Baumgartner, Yin-Hsiu Chien, Carmela Loguercio, Helene Ogier de Baulny, Marie-Cecile Nassogne, Manuel Schiff, Federica Deodato, Giancarlo Parenti, S. Lane Rutledge, M. Antonia Vilaseca, Mariarosa A.B. Melone, Gioacchino Scarano, Luiz Aldamiz-Echevarría, Guy Besley, John Walter, Eugenia Martinez-Hernandez, Jose M. Hernandez, Ciro L. Pierri, Ferdinando Palmieri & Filippo M. Santorelli. (2009) Identification of novel mutations in the SLC25A15 gene in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome: A clinical, molecular, and functional study . Human Mutation 30:5, pages 741-748.
Crossref
Ferdinando Palmieri. (2008) Diseases caused by defects of mitochondrial carriers: A review. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1777:7-8, pages 564-578.
Crossref

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