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Molecular Membrane Biology Volume 33, 2016 - Issue 1-2
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Molecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation

Sherry S. AgabitiDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA;
,
Yilan LiangDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA;
&
Andrew J. WiemerDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA; ;Institute for Systems Genomics, University of Connecticut, Storrs, CT, USACorrespondence[email protected]
Pages 1-11 | Received 03 Feb 2016, Accepted 29 Jun 2016, Published online: 18 Aug 2016

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Annalisa Marcuzzi, Elisa Piscianz, Liza Vecchi Brumatti & Alberto Tommasini. (2017) Mevalonate kinase deficiency: therapeutic targets, treatments, and outcomes. Expert Opinion on Orphan Drugs 5:6, pages 515-524.
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Articles from other publishers (12)

Molly E. Muehlebach & Sarah A. Holstein. (2023) Geranylgeranyl diphosphate synthase: Role in human health, disease and potential therapeutic target. Clinical and Translational Medicine 13:1.
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Liping ZhuFangbo LiuQiang HaoTian FengZeshuai ChenShengquan LuoRui XiaoMengxiang SunTing ZhangXiaohang FanXianqin ZengJianguo HePing YuanJinming LiuMatthieu RuizJocelyn Dupuis & Qinghua Hu. (2021) Dietary Geranylgeranyl Pyrophosphate Counteracts the Benefits of Statin Therapy in Experimental Pulmonary Hypertension. Circulation 143:18, pages 1775-1792.
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Gökçen Boran, Sepideh Tavakoli, Ingo Dierking, Ali Reza Kamali & Duygu Ege. (2020) Synergistic effect of graphene oxide and zoledronic acid for osteoporosis and cancer treatment. Scientific Reports 10:1.
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Nazmul H. Bhuiyan, Michelle L. Varney, Deep S. Bhattacharya, William M. Payne, Aaron M. Mohs, Sarah A. Holstein & David F. Wiemer. (2019) ω-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors. Bioorganic & Medicinal Chemistry Letters 29:19, pages 126633.
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Sherry S. Agabiti, Jin Li, Willie Dong, Michael M. Poe & Andrew J. Wiemer. (2019) Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition. Cell Death & Disease 10:10.
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Staci L. Haney, Yashpal S. Chhonker, Michelle L. Varney, Geoffrey Talmon, Daryl J. Murry & Sarah A. Holstein. (2018) Preclinical investigation of a potent geranylgeranyl diphosphate synthase inhibitor. Investigational New Drugs 36:5, pages 810-818.
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Yashpal S. Chhonker, Staci L. Haney, Robert A. Matthiesen, David F. Wiemer, Sarah A. Holstein & Daryl J. Murry. (2018) Quantitative determination of a potent geranylgeranyl diphosphate synthase inhibitor using LC–MS/MS: Derivatization and application. Journal of Pharmaceutical and Biomedical Analysis 153, pages 22-28.
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Łukasz Joachimiak, Aleksandra Marchwicka, Edyta Gendaszewska-Darmach & Katarzyna M. Błażewska. (2018) Synthesis and Biological Evaluation of Imidazole-Bearing α-Phosphonocarboxylates as Inhibitors of Rab Geranylgeranyl Transferase (RGGT). ChemMedChem 13:8, pages 842-851.
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Robert A. Matthiesen, Michelle L. Varney, Pauline C. Xu, Alex S. Rier, David F. Wiemer & Sarah A. Holstein. (2018) α-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors. Bioorganic & Medicinal Chemistry 26:2, pages 376-385.
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Aleksandra Kaźmierczak, Damian Kusy, Sanna P. Niinivehmas, Joanna Gmach, Łukasz Joachimiak, Olli T. Pentikäinen, Edyta Gendaszewska-Darmach & Katarzyna M. Błażewska. (2017) Identification of the Privileged Position in the Imidazo[1,2- a ]pyridine Ring of Phosphonocarboxylates for Development of Rab Geranylgeranyl Transferase (RGGT) Inhibitors . Journal of Medicinal Chemistry 60:21, pages 8781-8800.
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Staci Haney, Veronica Wills, David Wiemer & Sarah Holstein. (2017) Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors. Molecules 22:6, pages 886.
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Sherry S Agabiti, Jin Li & Andrew J Wiemer. (2017) Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation. Cell Death & Disease 8:3, pages e2678-e2678.
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