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Original Article

Curcumin inhibits oxidative stress-induced TRPM2 channel activation, calcium ion entry and apoptosis values in SH-SY5Y neuroblastoma cells: Involvement of transfection procedure

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Pages 76-88 | Received 01 Dec 2016, Accepted 20 Feb 2017, Published online: 01 Jun 2017

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Read on this site (4)

Zübeyir Huyut, Bünyamin Uçar, Fikret Altındağ, Kenan Yıldızhan & Mehmet Tahir Huyut. (2023) Effect of curcumin on lipid profile, fibrosis, and apoptosis in liver tissue in abemaciclib-administered rats. Drug and Chemical Toxicology 46:6, pages 1138-1146.
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Orhan Akpınar, Ahmet Özşimşek, Mustafa Güzel & Mustafa Nazıroğlu. (2020) Clostridium botulinum neurotoxin A induces apoptosis and mitochondrial oxidative stress via activation of TRPM2 channel signaling pathway in neuroblastoma and glioblastoma tumor cells. Journal of Receptors and Signal Transduction 40:6, pages 620-632.
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Ahmet KOÇAK, Anıl GÜLCÜ & İshak Suat ÖVEY. (2023) Apoptosis Induction Through Increased TRPV1 Activation by Synergic Effect of Melatonin and Doxorubicin in Human Osteosarcoma and Chondrosarcoma Cell Linesİnsan Osteosarkoma ve Kondrosarkoma Hücre Hatlarında Melatonin ve Doksorubisinin Sinerjik Etkisi Yoluyla Artan TRPV1 Etkinliği Üzerinden Apopitoz Uyarımı. Acta Medica Alanya 7:2, pages 145-152.
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Ishak Suat Ovey, Ahmet Ozsimsek, Halil Aziz Velioglu, Ozlem Altay, Adil Mardinoglu & Burak Yulug. (2023) EGb 761 reduces Ca2+ influx and apoptosis after pentylenetetrazole treatment in a neuroblastoma cell line. Frontiers in Cellular Neuroscience 17.
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Jiaxin Zhou, Wenfen Zhang, Zhiwen Cao, Shaoyan Lian, Jieying Li, Jiaying Nie, Ying Huang, Ke Zhao, Jiang He & Chaoqun Liu. (2023) Association of Selenium Levels with Neurodegenerative Disease: A Systemic Review and Meta-Analysis. Nutrients 15:17, pages 3706.
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Taral Patel, Małgorzata Skorupa, Magdalena Skonieczna, Roman Turczyn & Katarzyna Krukiewicz. (2023) Surface grafting of poly-L-lysine via diazonium chemistry to enhance cell adhesion to biomedical electrodes. Bioelectrochemistry 152, pages 108465.
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Alper Ertuğrul, Dilek Özkaya & Mustafa Nazıroğlu. (2023) Curcumin attenuates hydroxychloroquine-mediated apoptosis and oxidative stress via the inhibition of TRPM2 channel signalling pathways in a retinal pigment epithelium cell line. Graefe's Archive for Clinical and Experimental Ophthalmology.
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Zübeyir Huyut, Bünyamin Uçar, Kenan Yıldızhan & Fikret Altındağ. (2022) The protective effect of curcumin on cardiac markers and fibrosis in abemaciclib‐induced cardiac damage in rats. Journal of Biochemical and Molecular Toxicology 37:1.
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Ahmi Öz, Ramazan Çinar & Mustafa Naziroğlu. (2022) TRPV1 stimulation increased oxidative neurotoxicity and apoptosis in the glia cell membrane but not in the perinuclear area: An evidence of TRPV1 subtype. Metabolic Brain Disease 37:7, pages 2291-2304.
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Delphine Ji, Zheng-wei Luo, Andrea Ovcjak, Rahmah Alanazi, Mei-Hua Bao, Zhong-Ping Feng & Hong-Shuo Sun. (2021) Role of TRPM2 in brain tumours and potential as a drug target. Acta Pharmacologica Sinica 43:4, pages 759-770.
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Carmen Costas & Lilian R.F. Faro. (2022) Do Naturally Occurring Antioxidants Protect Against Neurodegeneration of the Dopaminergic System? A Systematic Revision in Animal Models of Parkinson's Disease. Current Neuropharmacology 20:2, pages 432-459.
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Delphine Ji, Andrea Fleig, F. David Horgen, Zhong-Ping Feng & Hong-Shuo Sun. (2022) Modulators of TRPM7 and its potential as a drug target for brain tumours. Cell Calcium 101, pages 102521.
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Aya AlabdaliMarwah KzarSasikala ChinnappanMogana RShaik Ibrahim KhalivullaRahman HBasma M. Abd Razik. (2021) Antioxidant activity of Curcumin. Research Journal of Pharmacy and Technology, pages 6741-6746.
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Lisa Strother, Gareth B. Miles, Alison R. Holiday, Ying Cheng & Gayle H. Doherty. (2021) Long-term culture of SH-SY5Y neuroblastoma cells in the absence of neurotrophins: A novel model of neuronal ageing. Journal of Neuroscience Methods 362, pages 109301.
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Mustafa Güzel, Mustafa Nazıroğlu, Orhan Akpınar & Ramazan Çınar. (2021) Interferon Gamma-Mediated Oxidative Stress Induces Apoptosis, Neuroinflammation, Zinc Ion Influx, and TRPM2 Channel Activation in Neuronal Cell Line: Modulator Role of Curcumin. Inflammation 44:5, pages 1878-1894.
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Eunus S. Ali, Grigori Y. Rychkov & Greg J. Barritt. (2021) TRPM2 Non-Selective Cation Channels in Liver Injury Mediated by Reactive Oxygen Species. Antioxidants 10:8, pages 1243.
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María Luisa Mendoza-Magaña, Hugo Alejandro Espinoza-Gutiérrez, Sendar Daniel Nery-Flores, Abraham Alberto Ramírez-Mendoza, Cesar Ricardo Cortez-Álvarez, Robert de Mario Bonnet-Lemus & Mario Alberto Ramírez-Herrera. (2021) Curcumin Decreases Hippocampal Neurodegeneration and Nitro-Oxidative Damage to Plasma Proteins and Lipids Caused by Short-Term Exposure to Ozone. Molecules 26:13, pages 4075.
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Hamit Hakan Armağan & Mustafa Nazıroğlu. (2020) Curcumin Attenuates Hypoxia-Induced Oxidative Neurotoxicity, Apoptosis, Calcium, and Zinc Ion Influxes in a Neuronal Cell Line: Involvement of TRPM2 Channel. Neurotoxicity Research 39:3, pages 618-633.
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Dilek Özkaya, Xinhua Shu & Mustafa Nazıroğlu. (2021) Deletion of Mitochondrial Translocator Protein (TSPO) Gene Decreases Oxidative Retinal Pigment Epithelial Cell Death via Modulation of TRPM2 Channel. Biology 10:5, pages 382.
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Bo Huang, Xuecheng Sun & Aie Xu. (2021) MicroRNA-145-5p Protects Human Melanocytes Against Oxidative Damage by Targeting Transient Receptor Potential Melastatin 2 (TRPM2). Journal of Biomaterials and Tissue Engineering 11:4, pages 736-742.
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Kemal Ertilav, Mustafa Nazıroğlu, Zeki Serdar Ataizi & Kenan Yıldızhan. (2020) Melatonin and Selenium Suppress Docetaxel-Induced TRPV1 Activation, Neuropathic Pain and Oxidative Neurotoxicity in Mice. Biological Trace Element Research 199:4, pages 1469-1487.
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Peilin Yu, Xiaobo Cai, Yan Liang, Mingxiang Wang & Wei Yang. (2020) Roles of NAD+ and Its Metabolites Regulated Calcium Channels in Cancer. Molecules 25:20, pages 4826.
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Han-A Park & Amy C. Ellis. (2020) Dietary Antioxidants and Parkinson’s Disease. Antioxidants 9:7, pages 570.
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Mustafa Nazıroğlu, Ahmi Öz & Kenan Yıldızhan. (2020) Selenium and Neurological Diseases: Focus on Peripheral Pain and TRP Channels. Current Neuropharmacology 18:6, pages 501-517.
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Birol Özkal & İshak Suat Övey. (2020) Selenium enhances TRPA1 channel-mediated activity of temozolomide in SH-SY5Y neuroblastoma cells. Child's Nervous System 36:6, pages 1283-1292.
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Yener Akyuva & Mustafa Nazıroğlu. (2020) Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel. Scientific Reports 10:1.
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A. Öz & Ö. Çelik. (2019) P.827 Have the TRP channels a role in MPP+ neurotoxicity?. European Neuropsychopharmacology 29, pages S550-S551.
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Sinem Gökçe Kütük, Gökçen Gökçe, Mustafa Kütük, Hacer Esra Gürses Cila & Mustafa Nazıroğlu. (2019) Curcumin enhances cisplatin-induced human laryngeal squamous cancer cell death through activation of TRPM2 channel and mitochondrial oxidative stress. Scientific Reports 9:1.
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Mustafa Nazıroğlu, Bilal Çiğ, Yener Yazğan, Gerburg K. Schwaerzer, Franziska Theilig & László Pecze. (2019) Albumin evokes Ca2+-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin. Scientific Reports 9:1.
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Jamshid Tabeshpour, Sara Banaeeyeh, Farhad Eisvand, Thozhukat Sathyapalan, Mahmoud Hashemzaei & Amirhossein Sahebkar. (2019) Effects of curcumin on ion channels and pumps: A review. IUBMB Life 71:7, pages 812-820.
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Shameemah Abrahams, William L. Haylett, Glynis Johnson, Jonathan A. Carr & Soraya Bardien. (2019) Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review. Neuroscience 406, pages 1-21.
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Yasin Öztürk, Caner Günaydın, Fatma Yalçın, Mustafa Nazıroğlu & Nady Braidy. (2019) Resveratrol Enhances Apoptotic and Oxidant Effects of Paclitaxel through TRPM2 Channel Activation in DBTRG Glioblastoma Cells. Oxidative Medicine and Cellular Longevity 2019, pages 1-13.
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Alexander V. Zholos, Olesia F. Moroz & Maksim V. Storozhuk. (2019) Curcuminoids and Novel Opportunities for the Treatment of Alzheimer's Disease: Which Molecules are Actually Effective?. Current Molecular Pharmacology 12:1, pages 12-26.
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Pan Kang, Weigang Zhang, Xuguang Chen, Xiuli Yi, Pu Song, Yuqian Chang, Shaolong Zhang, Tianwen Gao, Chunying Li & Shuli Li. (2018) TRPM2 mediates mitochondria-dependent apoptosis of melanocytes under oxidative stress. Free Radical Biology and Medicine 126, pages 259-268.
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