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Research Article

The paramyxovirus fusion protein forms an extremely stable core trimer: structural parallels to influenza virus haemagglutinin and HIV-1 gp41

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Pages 11-19 | Published online: 09 Jul 2009

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Satinder S. Rawat, Mathias Viard, Stephen A. Gallo, Alan Rein, Robert Blumenthal & Anu Puri. (2003) Modulation of entry of enveloped viruses by cholesterol and sphingolipids (Review). Molecular Membrane Biology 20:3, pages 243-254.
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Everett Clinton Smith & Rebecca Ellis Dutch. (2010) Side Chain Packing below the Fusion Peptide Strongly Modulates Triggering of the Hendra Virus F Protein. Journal of Virology 84:20, pages 10928-10932.
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Paul A. Rota, Bettina Bankamp & William J. Bellini. 2010. Topley & Wilson's Microbiology and Microbial Infections. Topley & Wilson's Microbiology and Microbial Infections.
Scott A. Miller, Sharon Tollefson, James E. CroweJr.Jr., John V. Williams & David W. Wright. (2007) Examination of a Fusogenic Hexameric Core from Human Metapneumovirus and Identification of a Potent Synthetic Peptide Inhibitor from the Heptad Repeat 1 Region. Journal of Virology 81:1, pages 141-149.
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Zhiyong Lou, Yanhui Xu, Kehui Xiang, Nan Su, Lan Qin, Xu Li, George F. Gao, Mark Bartlam & Zihe Rao. (2006) Crystal structures of Nipah and Hendra virus fusion core proteins. The FEBS Journal 273:19, pages 4538-4547.
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Jieqing Zhu, Xiuli Jiang, Yueyong Liu, Po Tien & George F. Gao. (2005) Design and Characterization of Viral Polypeptide Inhibitors Targeting Newcastle Disease Virus Fusion. Journal of Molecular Biology 354:3, pages 601-613.
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Ling Ni, Linqing Zhao, Yuan Qian, Jieqing Zhu, Zhibo Jin, Yu Wai Chen, Po Tien & George F Gao. (2005) Design and Characterization of Human Respiratory Syncytial Virus Entry Inhibitors. Antiviral Therapy 10:7, pages 833-840.
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Yanhui Xu, David K. Cole, Zhiyong Lou, Yiwei Liu, Lan Qin, Xu Li, Zhihong Bai, Fang Yuan, Zihe Rao & George F. Gao. (2004) Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein. Protein Expression and Purification 38:1, pages 116-122.
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Kehu Yuan, Ling Yi, Jian Chen, Xiuxia Qu, Tingting Qing, Xi Rao, Pengfei Jiang, Jianhe Hu, Zikai Xiong, Yuchun Nie, Xuanling Shi, Wei Wang, Chen Ling, Xiaolei Yin, Keqiang Fan, Luhua Lai, Mingxiao Ding & Hongkui Deng. (2004) Suppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoprotein. Biochemical and Biophysical Research Communications 319:3, pages 746-752.
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Jieqing Zhu, Gengfu Xiao, Yanhui Xu, Fang Yuan, Congyi Zheng, Yueyong Liu, Huimin Yan, David K Cole, John I Bell, Zihe Rao, Po Tien & George F Gao. (2004) Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors. Biochemical and Biophysical Research Communications 319:1, pages 283-288.
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Yanhui Xu, Shan Gao, David K. Cole, Junjie Zhu, Nan Su, Hui Wang, George F. Gao & Zihe Rao. (2004) Basis for fusion inhibition by peptides: analysis of the heptad repeat regions of the fusion proteins from Nipah and Hendra viruses, newly emergent zoonotic paramyxoviruses. Biochemical and Biophysical Research Communications 315:3, pages 664-670.
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Yueyong Liu, Jieqing Zhu, Ming-Guang Feng, Po Tien & George F Gao. (2004) Six-helix bundle assembly and analysis of the central core of mumps virus fusion protein. Archives of Biochemistry and Biophysics 421:1, pages 143-148.
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Enxiu Wang, Xiao’ou Sun, Yuan Qian, Linqing Zhao, Po Tien & George F Gao. (2003) Both heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusion. Biochemical and Biophysical Research Communications 302:3, pages 469-475.
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Jieqing Zhu, Catherine W.-H Zhang, Yipeng Qi, Po Tien & George F Gao. (2002) The fusion protein core of measles virus forms stable coiled-coil trimer. Biochemical and Biophysical Research Communications 299:5, pages 897-902.
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Katharine N. Bossart, Lin-Fa Wang, Michael N. Flora, Kaw Bing Chua, Sai Kit Lam, Bryan T. Eaton & Christopher C. Broder. (2002) Membrane Fusion Tropism and Heterotypic Functional Activities of the Nipah Virus and Hendra Virus Envelope Glycoproteins . Journal of Virology 76:22, pages 11186-11198.
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James M. Hogle. (2002) Poliovirus Cell Entry: Common Structural Themes in Viral Cell Entry Pathways. Annual Review of Microbiology 56:1, pages 677-702.
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Dale Christiansen, Emmanuel R. De Sousa, Bruce Loveland, Peter Kyriakou, Marc Lanteri, Fabian T. Wild & Denis Gerlier. (2002) A CD46CD[55–46] chimeric receptor, eight short consensus repeats long, acts as an inhibitor of both CD46 (MCP)- and CD150 (SLAM)-mediated cell–cell fusion induced by CD46-using measles virus. Journal of General Virology 83:5, pages 1147-1155.
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Winfried Weissenhorn. 2002. Structure-Function Relationships of Human Pathogenic Viruses. Structure-Function Relationships of Human Pathogenic Viruses 25 54 .
Maurice R Hilleman. (2001) Current overview of the pathogenesis and prophylaxis of measles with focus on practical implications. Vaccine 20:5-6, pages 651-665.
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Katharine N Bossart, Lin-Fa Wang, Bryan T Eaton & Christopher C Broder. (2001) Functional Expression and Membrane Fusion Tropism of the Envelope Glycoproteins of Hendra Virus. Virology 290:1, pages 121-135.
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Jennifer A. Schwartz, Erik K. Lium & Saul J. Silverstein. (2001) Herpes Simplex Virus Type 1 Entry Is Inhibited by the Cobalt Chelate Complex CTC-96. Journal of Virology 75:9, pages 4117-4128.
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Rebecca Ellis Dutch, Ryan N. Hagglund, Margaret A. Nagel, Reay G. Paterson & Robert A. Lamb. (2001) Paramyxovirus Fusion (F) Protein: A Conformational Change on Cleavage Activation. Virology 281:1, pages 138-150.
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Suxiang Tong, Fia Yi, Anne Martin, Qizhi Yao, Min Li & Richard W. Compans. (2001) Three Membrane-Proximal Amino Acids in the Human Parainfluenza Type 2 (HPIV 2) F Protein Are Critical for Fusogenic Activity. Virology 280:1, pages 52-61.
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Genfa Zhou, Marc Ferrer, Rajiv Chopra, Tarun M. Kapoor, Tim Strassmaier, Winfried Weissenhorn, John J. Skehel, Dan Oprian, Stuart L. Schreiber, Stephen C. Harrison & Don C. Wiley. (2000) The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core. Bioorganic & Medicinal Chemistry 8:9, pages 2219-2227.
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James A. McNew, Thomas Weber, Francesco Parlati, Robert J. Johnston, Thomas J. Melia, Thomas H. Söllner & James E. Rothman. (2000) Close Is Not Enough. The Journal of Cell Biology 150:1, pages 105-118.
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John J. SkehelDon C. Wiley. (2000) Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin. Annual Review of Biochemistry 69:1, pages 531-569.
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Suxiang Tong & Richard W. Compans. (2000) Oligomerization, Secretion, and Biological Function of an Anchor-Free Parainfluenza Virus Type 2 (PI2) Fusion Protein. Virology 270:2, pages 368-376.
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