Advanced search
Publication Cover
Molecular Membrane Biology Volume 23, 2006 - Issue 5
Journal homepage
298
Views
27
CrossRef citations to date
0
Altmetric
Original

Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor

Nora L. Sullivan Department of Biochemistry, University of Cambridge, Cambridge, UK
,
Nora L. Sullivan Department of Biochemistry, University of Cambridge, Cambridge, UK
,
Andrew J. Thompson Department of Biochemistry, University of Cambridge, Cambridge, UK
,
Kerry L. Price Department of Biochemistry, University of Cambridge, Cambridge, UK
&
Sarah C. R. Lummis Department of Biochemistry, University of Cambridge, Cambridge, UKCorrespondence[email protected]
Pages 442-451 | Received 10 Mar 2006, Published online: 09 Jul 2009

Citations (27)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Francesca De Rienzo, Arménio J. Moura Barbosa, Marta A.S. Perez, Pedro A. Fernandes, Maria J. Ramos & Maria Cristina Menziani. (2012) The extracellular subunit interface of the 5-HT3 receptors: a computational alanine scanning mutagenesis study. Journal of Biomolecular Structure and Dynamics 30:3, pages 280-298.
Read now

Articles from other publishers (26)

Eric Gibbs & Sudha Chakrapani. 2021. Macromolecular Protein Complexes III: Structure and Function. Macromolecular Protein Complexes III: Structure and Function 373 408 .
Eleftherios Zarkadas, Hong Zhang, Wensheng Cai, Gregory Effantin, Jonathan Perot, Jacques Neyton, Christophe Chipot, Guy Schoehn, Francois Dehez & Hugues Nury. (2020) The Binding of Palonosetron and Other Antiemetic Drugs to the Serotonin 5-HT3 Receptor. Structure 28:10, pages 1131-1140.e4.
Crossref
Lucy Kate Ladefoged, Lachlan Munro, Anders J. Pedersen, Sarah C. R. Lummis, Benny Bang-Andersen, Thomas Balle, Birgit Schiøtt & Anders S. Kristensen. (2018) Modeling and Mutational Analysis of the Binding Mode for the Multimodal Antidepressant Drug Vortioxetine to the Human 5-HT 3A Receptor . Molecular Pharmacology 94:6, pages 1421-1434.
Crossref
Marc-David Ruepp, Hao Wei, Michele Leuenberger, Martin Lochner & Andrew J. Thompson. (2017) The binding orientations of structurally-related ligands can differ; A cautionary note. Neuropharmacology 119, pages 48-61.
Crossref
Danilo Di Maio, Balasubramanian Chandramouli & Giuseppe Brancato. (2015) Pathways and Barriers for Ion Translocation through the 5-HT3A Receptor Channel. PLOS ONE 10:10, pages e0140258.
Crossref
Sarah Lummis. 2015. Handbook of Ion Channels. Handbook of Ion Channels 331 344 .
Jeremías Corradi & Cecilia Bouzat. (2014) Unraveling Mechanisms Underlying Partial Agonism in 5-HT 3 A Receptors . The Journal of Neuroscience 34:50, pages 16865-16876.
Crossref
Marta Del Cadia, Francesca De Rienzo, David A. Weston, Andrew J. Thompson, Maria Cristina Menziani & Sarah C.R. Lummis. (2013) Exploring a potential palonosetron allosteric binding site in the 5-HT3 receptor. Bioorganic & Medicinal Chemistry 21:23, pages 7523-7528.
Crossref
Marta Del Cadia, Francesca De Rienzo & Maria Cristina Menziani. (2013) Approaching the 5-HT3 receptor heterogeneity by computational studies of the transmembrane and intracellular domains. Journal of Computer-Aided Molecular Design 27:6, pages 491-509.
Crossref
Sarah C.R. Lummis. (2012) 5-HT3 Receptors. Journal of Biological Chemistry 287:48, pages 40239-40245.
Crossref
Timothy F. Miles, Kiowa S. Bower, Henry A. Lester & Dennis A. Dougherty. (2012) A Coupled Array of Noncovalent Interactions Impacts the Function of the 5-HT 3 A Serotonin Receptor in an Agonist-Specific Way . ACS Chemical Neuroscience 3:10, pages 753-760.
Crossref
Janna L. Kozuska & Isabelle M. Paulsen. (2012) The Cys-loop pentameric ligand-gated ion channel receptors: 50 years on. Canadian Journal of Physiology and Pharmacology 90:6, pages 771-782.
Crossref
A. J. Thompson, K. L. Price & S. C. R. Lummis. (2011) Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5-HT 3 AB receptors . The Journal of Physiology 589:17, pages 4243-4257.
Crossref
Andrew J. Thompson, Henry A. Lester & Sarah C. R. Lummis. (2010) The structural basis of function in Cys-loop receptors. Quarterly Reviews of Biophysics 43:4, pages 449-499.
Crossref
Arménio J. Moura Barbosa, Francesca De Rienzo, Maria J. Ramos & Maria Cristina Menziani. (2010) Computational analysis of ligand recognition sites of homo- and heteropentameric 5-HT3 receptors. European Journal of Medicinal Chemistry 45:11, pages 4746-4760.
Crossref
Heather L. Nyce, Spencer T. Stober, Cameron F. Abrams & Michael M. White. (2010) Mapping Spatial Relationships between Residues in the Ligand-Binding Domain of the 5-Ht3 Receptor Using a Molecular Ruler. Biophysical Journal 98:9, pages 1847-1855.
Crossref
Bon Nyeo Koo, Mi Kyeong Kim, Jay Yang & Kyeong Tae Min. (2009) The role of residues in binding loop A in desflurane and propofol modulation of recombinant 5-HT3A receptor. Neuroscience Letters 465:2, pages 147-150.
Crossref
Eszter Hazai, Prasad Joshi, Edward C. Skoviak, Asha Suryanarayanan, Marvin K. Schulte & Zsolt Bikadi. (2009) A comprehensive study on the 5-hydroxytryptamine3A receptor binding of agonists serotonin and m-chlorophenylbiguanidine. Bioorganic & Medicinal Chemistry 17:16, pages 5796-5805.
Crossref
Elena MorelliSandra GemmaRoberta BudriesiGiuseppe CampianiEttore NovellinoCaterina FattorussoBruno CatalanottiSalvatore Sanna CocconeSindu RosGiuseppe BorrelliMarco PersicoIsabella FioriniVito NacciPierfranco IoanAlberto ChiariniMichel HamonAlfredo CagnottoTiziana MenniniClaudia FracassoMilena ColovicSilvio CacciaStefania Butini. (2009) Specific Targeting of Peripheral Serotonin 5-HT 3 Receptors. Synthesis, Biological Investigation, and Structure−Activity Relationships . Journal of Medicinal Chemistry 52:11, pages 3548-3562.
Crossref
Nicholas M. Barnes, Tim G. Hales, Sarah C.R. Lummis & John A. Peters. (2009) The 5-HT3 receptor – the relationship between structure and function. Neuropharmacology 56:1, pages 273-284.
Crossref
A.J. Thompson, M. Lochner & S.C.R. Lummis. (2008) Loop B Is a Major Structural Component of the 5-HT3 Receptor. Biophysical Journal 95:12, pages 5728-5736.
Crossref
Kerry L. Price, Kiowa S. Bower, Andrew J. Thompson, Henry A. Lester, Dennis A. Dougherty & Sarah C. R. Lummis. (2008) A Hydrogen Bond in Loop A Is Critical for the Binding and Function of the 5-HT 3 Receptor . Biochemistry 47:24, pages 6370-6377.
Crossref
Kiowa S. Bower, Kerry L. Price, Laura E.C. Sturdee, Mariza Dayrell, Dennis A. Dougherty & Sarah C.R. Lummis. (2008) 5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function. European Journal of Pharmacology 580:3, pages 291-297.
Crossref
Manuel Criado, José Mulet, Mar Castillo, Marcos Aldea, Salvador Sala & Francisco Sala. (2007) Interactions between loop 5 and β-strand β6' are involved in α7 nicotinic acetylcholine receptors channel gating. Journal of Neurochemistry 0:0, pages 071027034430001-???.
Crossref
A J Thompson, M Lochner & S C R Lummis. (2007) The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT 3 receptors . British Journal of Pharmacology 151:5, pages 666-677.
Crossref
Claire L. Padgett, Ariele P. Hanek, Henry A. Lester, Dennis A. Dougherty & Sarah C. R. Lummis. (2007) Unnatural Amino Acid Mutagenesis of the GABA A Receptor Binding Site Residues Reveals a Novel Cation–π Interaction between GABA and β 2 Tyr97 . The Journal of Neuroscience 27:4, pages 886-892.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.