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Original

Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3

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Pages 53-64 | Received 20 Mar 2006, Published online: 09 Jul 2009

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Balázs Vaskó, Viktória Juhász, Beáta Tóth, Anita Kurunczi, Zsolt Fekete, Joseph Krisjanis Zolnerciks, Emese Kis, Rémi Magnan, Axel Bidon-Chanal Badia, Marçal Pastor-Anglada, Eszter Hazai, Zsolt Bikadi, Ferenc Fülöp & Peter Krajcsi. (2019) Inhibitor selectivity of CNTs and ENTs. Xenobiotica 49:7, pages 840-851.
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Articles from other publishers (28)

Elena Puris, Gert Fricker & Mikko Gynther. (2023) The Role of Solute Carrier Transporters in Efficient Anticancer Drug Delivery and Therapy. Pharmaceutics 15:2, pages 364.
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Rajgopal Govindarajan, Antonio López Quiñones & Joanne Wang. 2022. Drug Transporters. Drug Transporters 165 187 .
Nicholas J. Wright & Seok-Yong Lee. (2020) Toward a Molecular Basis of Cellular Nucleoside Transport in Humans. Chemical Reviews 121:9, pages 5336-5358.
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Yanxia Zhou, Lianghuan Liao, Chen Wang, Jialu Li, Pengliang Chi, Qingjie Xiao, Qingting Liu, Li Guo, Linfeng Sun & Dong Deng. (2020) Cryo-EM structure of the human concentrative nucleoside transporter CNT3. PLOS Biology 18:8, pages e3000790.
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Lijie Sun, Hao Xie, Jean C. Ingram, Ryan J. Hope, Stephen A. Baldwin & Simon G. Patching. (2017) Retraction of “Characterization of the Escherichia coli Concentrative Nucleoside Transporter NupC Using Computational, Biochemical, and Biophysical Methods” . Biochemistry 57:28, pages 4237-4237.
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Sylvia Y. M. Yao & James D. Young. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 5002 5010 .
Ras Mulinta, Sylvia Y.M. Yao, Amy M.L. Ng, Carol E. Cass & James D. Young. (2017) Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance. Journal of Biological Chemistry 292:23, pages 9505-9522.
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C. Arimany-Nardi, A. Claudio-Montero, A. Viel-Oliva, P. Schmidtke, C. Estarellas, X. Barril, A. Bidon-Chanal & M. Pastor-Anglada. (2017) Identification and Characterization of a Secondary Sodium-Binding Site and the Main Selectivity Determinants in the Human Concentrative Nucleoside Transporter 3. Molecular Pharmaceutics 14:6, pages 1980-1987.
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Justine M. Grixti, Steve O'Hagan, Philip J. Day & Douglas B. Kell. (2017) Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine. Frontiers in Pharmacology 8.
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Sylvia Y. M. Yao & James D. Young. 2017. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 9 .
James D. Young. (2016) The SLC28 (CNT) and SLC29 (ENT) nucleoside transporter families: a 30-year collaborative odyssey. Biochemical Society Transactions 44:3, pages 869-876.
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Marçal Pastor-Anglada & Sandra Pérez-Torras. (2015) Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets. Frontiers in Pharmacology 6.
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Horace T. B. Ho & Joanne Wang. 2014. Drug Transporters. Drug Transporters 107 126 .
Eve-Irene Lepist, Vijaya L. Damaraju, Jing Zhang, Wendy P. Gati, Sylvia Y.M. Yao, Kyla M. Smith, Edward Karpinski, James D. Young, Kwan H. Leung & Carol E. Cass. (2013) Transport of A 1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1 . Drug Metabolism and Disposition 41:4, pages 916-922.
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James D. Young, Sylvia Y.M. Yao, Jocelyn M. Baldwin, Carol E. Cass & Stephen A. Baldwin. (2013) The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Molecular Aspects of Medicine 34:2-3, pages 529-547.
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Pedro Cano‐Soldado & Marçal Pastor‐Anglada. (2011) Transporters that translocate nucleosides and structural similar drugs: structural requirements for substrate recognition. Medicinal Research Reviews 32:2, pages 428-457.
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Pedro Cano-SoldadoEdurne Gorraitz, Ekaitz Errasti-MurugarrenF. Javier CasadoM. Pilar Lostao & Marçal Pastor-Anglada. (2012) Functional analysis of the human concentrative nucleoside transporter-1 variant hCNT1S546P provides insight into the sodium-binding pocket. American Journal of Physiology-Cell Physiology 302:1, pages C257-C266.
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Edurne Gorraitz, Marçal Pastor-Anglada & Maria Pilar Lostao. (2010) Effects of Na+ and H+ on steady-state and presteady-state currents of the human concentrative nucleoside transporter 3 (hCNT3). Pflügers Archiv - European Journal of Physiology 460:3, pages 617-632.
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Dominique Deville-Bonne, Chahrazade El Amri, Philippe Meyer, Yuxing Chen, Luigi A. Agrofoglio & Joël Janin. (2010) Human and viral nucleoside/nucleotide kinases involved in antiviral drug activation: Structural and catalytic properties. Antiviral Research 86:1, pages 101-120.
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Zsuzsanna Hamari, Sotiris Amillis, Christine Drevet, Angeliki Apostolaki, Csaba Vágvölgyi, George Diallinas & Claudio Scazzocchio. (2009) Convergent evolution and orphan genes in the Fur4p-like family and characterization of a general nucleoside transporter in Aspergillus nidulans . Molecular Microbiology 73:1, pages 43-57.
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Danielle E. Johnson, Hui-wang Ai, Peter Wong, James D. Young, Robert E. Campbell & Joseph R. Casey. (2009) Red Fluorescent Protein pH Biosensor to Detect Concentrative Nucleoside Transport. Journal of Biological Chemistry 284:31, pages 20499-20511.
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Melissa D. Slugoski, Amy M.L. Ng, Sylvia Y.M. Yao, Colin C. Lin, Ras Mulinta, Carol E. Cass, Stephen A. Baldwin & James D. Young. (2009) Substituted Cysteine Accessibility Method Analysis of Human Concentrative Nucleoside Transporter hCNT3 Reveals a Novel Discontinuous Region of Functional Importance within the CNT Family Motif (G/A)XKX3NEFVA(Y/M/F). Journal of Biological Chemistry 284:25, pages 17281-17292.
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Melissa D. Slugoski, Kyla M. Smith, Amy M.L. Ng, Sylvia Y.M. Yao, Edward Karpinski, Carol E. Cass, Stephen A. Baldwin & James D. Young. (2009) Conserved Glutamate Residues Glu-343 and Glu-519 Provide Mechanistic Insights into Cation/Nucleoside Cotransport by Human Concentrative Nucleoside Transporter hCNT3. Journal of Biological Chemistry 284:25, pages 17266-17280.
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Adam N. Elwi, Vijaya L. Damaraju, Michelle L. Kuzma, Stephen A. Baldwin, James D. Young, Michael B. Sawyer & Carol E. Cass. (2008) Human concentrative nucleoside transporter 3 is a determinant of fludarabine transportability and cytotoxicity in human renal proximal tubule cell cultures. Cancer Chemotherapy and Pharmacology 63:2, pages 289-301.
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Melissa D. Slugoski, Kyla M. Smith, Ras Mulinta, Amy M.L. Ng, Sylvia Y.M. Yao, Ellen L. Morrison, Queenie O.T. Lee, Jing Zhang, Edward Karpinski, Carol E. Cass, Stephen A. Baldwin & James D. Young. (2008) A Conformationally Mobile Cysteine Residue (Cys-561) Modulates Na+ and H+ Activation of Human CNT3. Journal of Biological Chemistry 283:36, pages 24922-24934.
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Melissa D. Slugoski, Amy M.L. Ng, Sylvia Y.M. Yao, Kyla M. Smith, Colin C. Lin, Jing Zhang, Edward Karpinski, Carol E. Cass, Stephen A. Baldwin & James D. Young. (2008) A Proton-mediated Conformational Shift Identifies a Mobile Pore-lining Cysteine Residue (Cys-561) in Human Concentrative Nucleoside Transporter 3. Journal of Biological Chemistry 283:13, pages 8496-8507.
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Detlev Boison. (2008) The adenosine kinase hypothesis of epileptogenesis. Progress in Neurobiology 84:3, pages 249-262.
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Sylvia Y.M. Yao, Amy M.L. Ng, Melissa D. Slugoski, Kyla M. Smith, Ras Mulinta, Edward Karpinski, Carol E. Cass, Stephen A. Baldwin & James D. Young. (2007) Conserved Glutamate Residues Are Critically Involved in Na+/Nucleoside Cotransport by Human Concentrative Nucleoside Transporter 1 (hCNT1). Journal of Biological Chemistry 282:42, pages 30607-30617.
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