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Articles

Homoharringtonine: A New Treatment Option for Myeloid Leukemia

Pages 259-270 | Published online: 29 Nov 2013

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Yanjing Tang, Chengjuan Luo, Shuhong Shen, Huiliang Xue, Ci Pan, Wenting Hu, Xiaoxiao Chen, Jiaoyang Cai, Jing Chen & Jingyan Tang. (2021) The efficacy and safety of a homoharringtonine-based protocol for children with acute myeloid leukemia: A retrospective study in China. Pediatric Hematology and Oncology 38:2, pages 97-107.
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Dong Liu, Jing Xing, Fei Xiong, Fang Yang & Ning Gu. (2017) Preparation and in vivo safety evaluations of antileukemic homoharringtonine-loaded PEGylated liposomes. Drug Development and Industrial Pharmacy 43:4, pages 652-660.
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Camilla Stapnes, Bjørn Tore Gjertsen, Håkon Reikvam & Øystein Bruserud. (2009) Targeted therapy in acute myeloid leukaemia: current status and future directions. Expert Opinion on Investigational Drugs 18:4, pages 433-455.
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Nadine Darwiche, Sara El-Banna & Hala Gali-Muhtasib. (2007) Cell cycle modulatory and apoptotic effects of plant-derived anticancer drugs in clinical use or development. Expert Opinion on Drug Discovery 2:3, pages 361-379.
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Yin-Jun Lou, Wen-Bin Qian & Jie Jin. (2007) Homoharringtonine induces apoptosis and growth arrest in human myeloma cells. Leukemia & Lymphoma 48:7, pages 1400-1406.
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Articles from other publishers (32)

Chiao-Hui Hsieh, Chen-Tsung Huang, Yi-Sheng Cheng, Chun-Hua Hsu, Wen-Ming Hsu, Yun-Hsien Chung, Yen-Lin Liu, Tsai-Shan Yang, Chia-Yu Chien, Yu-Hsuan Lee, Hsuan-Cheng Huang & Hsueh-Fen Juan. (2023) Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma. Biomedicine & Pharmacotherapy 166, pages 115429.
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Yiqing Li, Ting Tang, Jie Xiao, Boqi Li, Wenjuan Yang, Shuangfeng Xie, Yumo Du, Kezhi Huang & Danian Nie. (2022) Comparative efficacy and safety of eleven induction chemotherapy regimens for young adult patients with newly diagnosed acute myeloid leukemia: a network meta-analysis. Annals of Hematology 101:7, pages 1509-1522.
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Kishor Mazumder, Asma Aktar, Priyanka Roy, Biswajit Biswas, Md. Emran Hossain, Kishore Kumar Sarkar, Sitesh Chandra Bachar, Firoj Ahmed, A. S. M. Monjur-Al-Hossain & Koichi Fukase. (2022) A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship. Molecules 27:9, pages 3036.
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Mounir Tilaoui, Hassan Ait Mouse & Abdelmajid Zyad. (2021) Update and New Insights on Future Cancer Drug Candidates From Plant-Based Alkaloids. Frontiers in Pharmacology 12.
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Shuai Guo, Xue Bai, Sai Shi, Yawen Deng, Xianjiang Kang & Hailong An. (2021) TMEM16A, a Homoharringtonine Receptor, as a Potential Endogenic Target for Lung Cancer Treatment. International Journal of Molecular Sciences 22:20, pages 10930.
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Tahani Maher, Raha Ahmad Raus, Djabir Daddiouaissa, Farah Ahmad, Noor Suhana Adzhar, Elda Surhaida Latif, Ferid Abdulhafiz & Arifullah Mohammed. (2021) Medicinal Plants with Anti-Leukemic Effects: A Review. Molecules 26:9, pages 2741.
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Thomas P. Howard, Elaine M. Oberlick, Matthew G. Rees, Taylor E. Arnoff, Minh-Tam Pham, Lisa Brenan, Mariana DoCarmo, Andrew L. Hong, Guillaume Kugener, Hsien-Chao Chou, Yiannis Drosos, Kaeli M. Mathias, Pilar Ramos, Brinton Seashore-Ludlow, Andrew O. Giacomelli, Xiaofeng Wang, Burgess B. FreemanIIIIII, Kaley Blankenship, Lauren Hoffmann, Hong L. Tiv, Prafulla C. Gokhale, Cory M. Johannessen, Elizabeth A. Stewart, Stuart L. Schreiber, William C. Hahn & Charles W.M. Roberts. (2020) Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine. Clinical Cancer Research 26:18, pages 4995-5006.
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Xiaoxiao Chen, Yanjing Tang, Jing Chen, Ru Chen, Longjun Gu, Huiliang Xue, Ci Pan, Jingyan Tang & Shuhong Shen. (2019) Homoharringtonine is a safe and effective substitute for anthracyclines in children younger than 2 years old with acute myeloid leukemia. Frontiers of Medicine 13:3, pages 378-387.
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Rahul V. Patel, Bhupendra M. Mistry, Riyaz Syed, Nikhil M. Parekh & Han-Seung Shin. (2019) Pyrrolo[1,2-a]azepines Coupled with Benzothiazole and Fluorinated Aryl Thiourea Scaffolds as Promising Antioxidant and Anticancer Agents. Anti-Cancer Agents in Medicinal Chemistry 19:15, pages 1855-1862.
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Ping Chen, Xiaofang Wen, Bin Wang, Diyu Hou, Hong Zou, Qin Yuan, Hui Yang, Jieqiong Xie & Huifang Huang. (2018) PI3K/Akt inhibitor LY294002 potentiates homoharringtonine antimyeloma activity in myeloma cells adhered to stromal cells and in SCID mouse xenograft. Annals of Hematology 97:5, pages 865-875.
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Chi-Yu He, Jie Fu, Jia-Wen Shou, Zhen-Xiong Zhao, Long Ren, Yan Wang & Jian-Dong Jiang. (2017) In Vitro Study of the Metabolic Characteristics of Eight Isoquinoline Alkaloids from Natural Plants in Rat Gut Microbiota. Molecules 22:6, pages 932.
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Joëlle Pérard-Viret, Laith Quteishat, Rana Alsalim, Jacques Royer & Françoise Dumas. 2017. 205 352 .
Shaohua Liang, Pengcheng Meng & Yadong Wang. (2014) Physicochemical Property and Fatty Acid Profile of Cephalotaxus fortunei Nut Oils. Journal of the American Oil Chemists' Society 91:7, pages 1121-1130.
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Amany Belal. (2014) Design, Synthesis and Anticancer Activity Evaluation of Some Novel Pyrrolo[1,2- a ]azepine Derivatives . Archiv der Pharmazie 347:7, pages 515-522.
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XIA REN, YUBAO ZHANG, CUILING LI, HENGXIAO WANG, ZHENG JIANG, ZHIYONG ZHANG, QIANG GUO, GUANHUA SONG, KEHONG BI & GUOSHENG JIANG. (2013) Enhancement of baicalin by hexamethylene bisacetamide on the induction of apoptosis contributes to simultaneous activation of the intrinsic and extrinsic apoptotic pathways in human leukemia cells. Oncology Reports 30:5, pages 2071-2080.
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HUI CAO, YIZHI CHENG, LIANGSHUN YOU, JIEJING QIAN & WENBIN QIAN. (2013) Homoharringtonine and SAHA synergistically enhance apoptosis in human acute myeloid leukemia cells through upregulation of TRAIL and death receptors. Molecular Medicine Reports 7:6, pages 1838-1844.
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Kuo‐Hsiung Lee, Hideji Itokawa, Toshiyuki Akiyama & Susan L. Morris‐Natschke. 2012. Natural Products in Chemical Biology. Natural Products in Chemical Biology 351 388 .
Bin-Tao Huang, Qing-Chun Zeng, Jessica Yu, Xiao-Li Liu, Zhen Xiao & Hong-Qian Zhu. (2011) High-dose homoharringtonine versus standard-dose daunorubicin is effective and safe as induction and post-induction chemotherapy for elderly patients with acute myeloid leukemia: a multicenter experience from China. Medical Oncology 29:1, pages 251-259.
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Hajer Abdelkafi & Bastien Nay. (2012) Natural products from Cephalotaxus sp.: chemical diversity and synthetic aspects. Natural Product Reports 29:8, pages 845.
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JingYan Tang, Yin Liu, Jing Chen, Huiliang Xue, Ci Pan & LongJun Gu. (2011) Homoharringtonine as a backbone drug for the treatment of newly diagnosed pediatric acute myeloid leukemia: a report from a single institution in China. International Journal of Hematology 93:5, pages 610-617.
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Li Pan, Heebyung Chai & A. Douglas Kinghorn. (2010) The continuing search for antitumor agents from higher plants. Phytochemistry Letters 3:1, pages 1-8.
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Jianmin Wang, Shuqing Lü, Jianmin Yang, Xianmin Song, Li Chen, Chongmei Huang, Jun Hou & Weiping Zhang. (2009) A homoharringtonine-based induction regimen for the treatment of elderly patients with acute myeloid leukemia: a single center experience from China. Journal of Hematology & Oncology 2:1.
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Hai-tao Meng, Lu Li, Hui Liu, Ying Wang, Gong-chu Li & Wen-bin Qian. (2009) Homoharringtonine acts synergistically with SG235-TRAIL, a conditionally replicating adenovirus, in human leukemia cell lines. Acta Pharmacologica Sinica 30:11, pages 1529-1536.
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Y Chen, Y Hu, S Michaels, D Segal, D Brown & S Li. (2009) Inhibitory effects of omacetaxine on leukemic stem cells and BCR-ABL-induced chronic myeloid leukemia and acute lymphoblastic leukemia in mice. Leukemia 23:8, pages 1446-1454.
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Byung-Sik Kim & Jin-Hyun Kim. (2010) Characterization of solvent induced crystalline and amorphous homoharringtonine. Korean Journal of Chemical Engineering 26:4, pages 1090-1093.
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Li Pan, Esperanza J. Carcache de Blanco & A. Douglas Kinghorn. 2009. Plant-derived Natural Products. Plant-derived Natural Products 547 567 .
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Tadhg P. BegleyKuo‐Hsiung Lee, Hideji Itokawa, Toshiyuki Akiyama & Susan L. Morris‐Natschke. 2007. Wiley Encyclopedia of Chemical Biology. Wiley Encyclopedia of Chemical Biology 1 22 .
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Byung-Sik Kim & Jin-Hyun Kim. (2008) Purification of homoharringtonine and removal of residual solvents by spray drying. Korean Journal of Chemical Engineering 25:1, pages 108-111.
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Xiudi Yang, Chunmei Yang, Keding Shao, Xingnong Ye, Haitao Meng, Yuhong Zhou & Wenbin Qian. (2007) Refractory multiple myeloma treated with homoharringtonine: report of two cases. Annals of Hematology 86:12, pages 919-921.
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Thomas Efferth, Paul C.H. Li, Venkata S. Badireenath Konkimalla & Bernd Kaina. (2007) From traditional Chinese medicine to rational cancer therapy. Trends in Molecular Medicine 13:8, pages 353-361.
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