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Lymphoproliferative Disease

Effectiveness of pegaspargase, gemcitabine, and oxaliplatin (P-GEMOX) chemotherapy combined with radiotherapy in newly diagnosed, stage IE to IIE, nasal-type, extranodal natural killer/T-cell lymphoma

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Akhil Rajendra, Manju Sengar, V.N. Avinash Bonda, Hasmukh Jain, Lingaraj Nayak, Jayashree Thorat, Tanuja Shet, Sridhar Epari, Siddharth Laskar, Archi Aggarwal, V. Rangarajan, Sumeet Gujral, Bhausaheb Bagal, Sangeeta Kakoti & Omkar Salvi. (2023) Outcomes and prognostic factors of patients with Extranodal NK T cell lymphoma (ENKTL). Leukemia & Lymphoma 0:0, pages 1-13.
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Benjamin J. Lee, Jean Doh, Alexandre Chan, Deepa Jeyakumar & Susan O’Brien. (2022) Increased incidence of Pegaspargase-induced hypertriglyceridemia and associated pancreatitis observed in the Hispanic adult patient population. Leukemia & Lymphoma 63:12, pages 2992-2995.
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Yi Chen, Luting Luo, Xiaoyun Zheng, Haiying Fu, Xiaozhu Yang, Wanling Huang, Lushan Chen, Zhihong Zheng, Jing Zheng, Ting Yang, Tingbo Liu & Jianda Hu. (2020) Clinical characteristics and survival of extranodal natural killer/T-cell lymphoma: a single-center 12-year retrospective analysis. Leukemia & Lymphoma 61:14, pages 3306-3318.
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Liqiang Wei, Jia Cong, Lei Yang, Jin Ye, Xin Li, Na Yao, Jing Yang, Xueying Cui, Yiping Wu, Jing Ding & Jingwen Wang. (2020) Treatment outcomes and prognostic analysis of elderly patients with extranodal natural killer/T-cell lymphoma, nasal type: a retrospective analysis. Leukemia & Lymphoma 61:12, pages 2962-2968.
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Liqiang Wei, Jingwen Wang, Jin Ye, Lei Yang, Jia Cong, Xin Li, Yiping Wu, Xueying Cui, Jing Ding, Na Yao & Jing Yang. (2020) Long-term outcomes of patients treated with an EPOCHL regimen as first-line chemotherapy for newly diagnosed extranodal natural killer/T-cell lymphoma: a retrospective single-center study. Leukemia & Lymphoma 61:2, pages 337-343.
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Eric Tse, Rex Au-Yeung & Yok-Lam Kwong. (2019) Recent advances in the diagnosis and treatment of natural killer/T-cell lymphomas. Expert Review of Hematology 12:11, pages 927-935.
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Sadia Sikder, Vrinda Gote, Meshal Alshamrani, Jeff Sicotte & Dhananjay Pal. (2019) Long-term delivery of protein and peptide therapeutics for cancer therapies. Expert Opinion on Drug Delivery 16:10, pages 1113-1131.
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Vadim S. Pokrovsky & Denis Vinnikov. (2017) L-Asparaginase for newly diagnosed extra-nodal NK/T-cell lymphoma: systematic review and meta-analysis. Expert Review of Anticancer Therapy 17:8, pages 759-768.
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Articles from other publishers (36)

Judith Porte, Christophe Hennequin, Daphné Krizch, Laetitia Vercellino, Sophie Guillerm, Catherine Thieblemont & Laurent Quéro. (2023) Extranodal nasal-type NK/T lymphoma treated with chemotherapy and radiotherapy: case series from a European tertiary referral center and review of the literature. Strahlentherapie und Onkologie.
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Jing Tian, Miaowang Hao, Qiang Liu, Fang Xiao, Yuanchun Li, Meiying Qi, Jing Gao, Li Liu & Dandan Yin. (2022) Efficacy and safety of PD‐1 inhibitor alone or combined with chemotherapy in patients with relapsed or refractory extranodal natural Killer/T cell lymphoma: A retrospective study. Hematological Oncology 41:3, pages 396-406.
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Cheng-qi Shen, Guo-qian He, Zhi Wan, Chao Lin, Xue Yang, Xiao-xi Lu, Yi-ping Zhu, Ju Gao & Xia Guo. (2023) “Sandwich” protocol based on modified SMILE regimen for children with newly extranodal NK/T cell lymphoma, nasal type: a single-arm, single-center clinical study. Annals of Hematology.
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Philipp Berning, Norbert Schmitz, Maud Ngoya, Hervé Finel, Ariane Boumendil, Fengrong Wang, Xiao-Jun Huang, Olivier Hermine, Laure Philippe, Lucile Couronné, Arnaud Jaccard, Daihong Liu, Depei Wu, Hans Christian Reinhardt, Yves Chalandon, Eva Wagner-Drouet, Mi Kwon, Xi Zhang, Ben Carpenter, Ibrahim Yakoub-Agha, Gerald Wulf, Javier López-Jiménez, Jaime Sanz, Hélène Labussière-Wallet, Avichai Shimoni, Peter Dreger, Anna Sureda, Won Seog Kim & Bertram Glass. (2023) Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma: an international collaborative analysis. Leukemia 37:7, pages 1511-1520.
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Tianxiao Gao, Jieye Huang, Haofan Yin, Jiajia Huang, Jinye Xie, Ti Zhou, Wei Fan, Xia Yang, Guoquan Gao & Zhiming Li. (2023) Inhibition of extranodal NK/T-cell lymphoma by Chiauranib through an AIF-dependent pathway and its synergy with L-asparaginase. Cell Death & Disease 14:5.
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Sammara Chaubard, Amira Marouf, David Lavergne, François Lemonnier, Julien Rossignol, Aline Clavert, Rémy Gressin, Guillaume Cartron, Agathe Waultier‐Rascalou, Jacques Vargaftig, Gilles Salles, Emmanuel Bachy, Hervé Ghesquières, Olivier Tournilhac, Adrien Chauchet, Steven Le Gouill, Gandhi Damaj, Luc‐Matthieu Fornecker, David Sibon, Lucie Obéric, Jean‐Marie Michot, Philippe Gaulard, Olivier Hermine, Lucile Couronné & Arnaud Jaccard. (2023) Efficacy of a short sandwich protocol, methotrexate, gemcitabine, L‐asparaginase and dexamethasone chemotherapy combined with radiotherapy, in localised newly diagnosed NK /T‐cell lymphoma: A French retrospective study . British Journal of Haematology 201:4, pages 673-681.
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Jia‐Xin Liu, Xin Liu, Yong Yang, Wei‐Ping Liu, Ying Wang, Xia He, Li‐Ling Zhang, Bao‐Lin Qu, Li‐Ting Qian, Xiao‐Rong Hou, Xue‐Ying Qiao, Hua Wang, Gao‐Feng Li, Yuan Zhu, Jian‐Zhong Cao, Jun‐Xin Wu, Tao Wu, Su‐Yu Zhu, Mei Shi, Hui‐Lai Zhang, Hang Su, Yu‐Jing Zhang, Jun Zhu, Shu‐Nan Qi, Ye‐Xiong Li & Yu‐Qin Song. (2023) Clinical characteristics, treatment, and survival of 30 patients with gastrointestinal natural killer/T‐cell lymphoma. Cancer Reports 6:5.
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Wanchun Wu, Xi Chen, Na Li, Qian Luo & Liqun Zou. (2022) A neutrophil/lymphocyte Ratio as a Significant Predictor for Patients with low-risk and early-stage Extranodal NK-T-cell Lymphoma. Indian Journal of Hematology and Blood Transfusion 39:2, pages 228-236.
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Wanchun Wu, Kexin Ren, Xi Chen, Na Li, Huijie Zhou, Ming Jiang, Youhui Yu & Liqun Zou. (2023) A controlling nutritional status score is an independent predictor for patients with newly diagnosed nasal‐type extranodal NK /T‐cell lymphoma based on asparaginase‐containing regimens . Cancer Medicine 12:8, pages 9439-9448.
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Zheng Yan, Shuna Yao, Zhizhong Wang, Wenping Zhou, Zhihua Yao & Yanyan Liu. (2023) Treatment of extranodal NK/T-cell lymphoma: From past to future. Frontiers in Immunology 14.
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Eric Tse, Wei-Li Zhao, Jie Xiong & Yok-Lam Kwong. (2022) How we treat NK/T-cell lymphomas. Journal of Hematology & Oncology 15:1.
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Luís Alberto de Pádua Covas Lage, Pedro Paulo Faust Machado, Cadiele Oliana Reichert, Eliana Miranda, Hebert Fabrício Culler, Sheila Aparecida Coelho da Siqueira, Renata de Oliveira Costa, Dênis Ricardo Miyashiro, José Antônio Sanches, Vanderson Rocha, Carlos Sérgio Chiattone & Juliana Pereira. (2022) High-dose extended-field radiotherapy plus chemotherapy improved survival in extranodal NK/T-cell lymphoma in a real-life setting: results from the multicenter T-Cell Brazil Project. Scientific Reports 12:1.
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Wanchun Wu, Xi Chen, Na Li, Qian Luo & Liqun Zou. (2022) First-line LVDP (l-asparaginase, etoposide, dexamethasone, and cisplatin) regimen combined with radiotherapy is effective for early-stage extranodal natural killer/T-cell lymphoma, nasal type. Annals of Hematology 101:7, pages 1557-1565.
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Xinhua Wang, Lei Zhang, Xiangli Liu, Xin Li, Ling Li, Xiaorui Fu, Zhenchang Sun, Jingjing Wu, Xudong Zhang, Jiaqin Yan, Yu Chang, Feifei Nan, Zhiyuan Zhou, Xiaolong Wu, Li Tian, Minrui Ma, Zhaoming Li, Hui Yu, Linan Zhu, Yingjun Wang, Cunzhen Shi, Xiaoyan Feng, Jiwei Li, Mengjie Ding, Jieming Zhang, Meng Dong, Hongwei Xue, Jinghua Wang, Liqun Zou, Liping Su, Jianqiu Wu, Lihong Liu, Huizheng Bao, Liling Zhang, Yanzhen Guo, Shuxia Guo, Yi Lu, Ken H. Young, Wencai Li & Mingzhi Zhang. (2022) Efficacy and Safety of a Pegasparaginase-Based Chemotherapy Regimen vs an L-asparaginase–Based Chemotherapy Regimen for Newly Diagnosed Advanced Extranodal Natural Killer/T-Cell Lymphoma. JAMA Oncology 8:7, pages 1035.
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John C. Reneau, Polina Shindiapina, Zachary Braunstein, Youssef Youssef, Miguel Ruiz, Saira Farid, Walter Hanel & Jonathan E. Brammer. (2022) Extranodal Natural Killer/T-Cell Lymphomas: Current Approaches and Future Directions. Journal of Clinical Medicine 11:10, pages 2699.
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Jing Yang, Pengfei Li, Yingshi Piao, Xindi Liu, Liqiang Wei, Wei Sang, Luo Zhang & Liang Wang. (2022) CD56-Negative Extranodal Natural Killer/T-Cell Lymphoma: A Retrospective Study in 443 Patients Treated by Chemotherapy With or Without Asparaginase. Frontiers in Immunology 13.
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Eric Tse & Yok-Lam Kwong. (2022) Recent Advances in the Diagnosis and Treatment of Natural Killer Cell Malignancies. Cancers 14:3, pages 597.
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Yuchen Zhang, Shuyun Ma, Jun Cai, Yu Yang, Hongmei Jing, Yuerong Shuang, Zhigang Peng, Bingzong Li, Panpan Liu, Zhongjun Xia, Yi Xia, Yan Gao, Daoguang Chen, Jianyang Lin, Qihui Li, Shenghua Xu, Qingyuan Xu, Han Zhang, Huiqiang Huang & Qingqing Cai. (2021) Sequential P‐GEMOX and radiotherapy for early‐stage extranodal natural killer/ T‐ cell lymphoma: A multicenter study . American Journal of Hematology 96:11, pages 1481-1490.
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Ayan Kusari, Philip E. LeBoit & Anna Haemel. (2021) Widespread Erythematous Plaques With Prominent Telangiectases. JAMA Dermatology 157:11, pages 1376.
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Adam J.S. McCartan, David W. Curran & Randall J. Mrsny. (2021) Evaluating parameters affecting drug fate at the intramuscular injection site. Journal of Controlled Release 336, pages 322-335.
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Peter Mallal, Benhur Ammanuel, Rohen White, Chris Kennedy & Chan Yoon Cheah. (2021) Simultaneous intraocular and cutaneous extranodal NK/T‐cell lymphoma refractory to multiple therapies including pembrolizumab. Clinical Case Reports 9:5.
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Seok Jin Kim, Ritsuro Suzuki, Arnaud Jaccard, Soon Thye Lim & Won Seog Kim. 2021. The Peripheral T‐Cell Lymphomas. The Peripheral T‐Cell Lymphomas 159 173 .
Lei Zhang, Yan Wang, Xin Li, Ling Li, Xinhua Wang, Zhenchang Sun, Jingjing Wu, Xiaorui Fu, Xudong Zhang, Hui Yu, Guannan Wang, Yu Chang, Jiaqin Yan, Zhiyuan Zhou, Xiaolong Wu, Feifei Nan, Wencai Li & Mingzhi Zhang. (2020) Radiotherapy vs sequential pegaspargase, gemcitabine, cisplatin and dexamethasone and radiotherapy in newly diagnosed early natural killer/T‐cell lymphoma: A randomized, controlled, open‐label, multicenter study. International Journal of Cancer 148:6, pages 1470-1477.
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Gregory M. Orlowski, Alice J. Tan, Eric Evan-Browning & Mark J. Scharf. (2020) Primary cutaneous nasal-type NK/T-cell lymphoma presenting as purpuric nodules on the lower leg. JAAD Case Reports 6:10, pages 1075-1078.
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Seong Hyun Jeong. (2020) Extranodal NK/T cell lymphoma. BLOOD RESEARCH 55:S1, pages S63-S71.
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Pamela B. Allen & Mary Jo Lechowicz. (2019) Management of NK/T-Cell Lymphoma, Nasal Type. Journal of Oncology Practice 15:10, pages 513-520.
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Eric Tse & Yok-Lam Kwong. (2019) NK/T-cell lymphomas. Best Practice & Research Clinical Haematology 32:3, pages 253-261.
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Xiaoying Quan, Chunzhi Wu, Lei Lei, Xiaoyan Chen & Bin Ye. (2019) The prognostic potential of pretreatment C-reactive protein to albumin ratio in stage IE/IIE extranodal natural killer/T-cell lymphoma*. Oncology and Translational Medicine 5:4, pages 162-169.
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Shu Tian, Ruichen Li, Tian Wang, Shengzi Wang, Rong Tao, Xichun Hu & Hao Ding. (2019) Gemcitabine, dexamethasone, and cisplatin (GDP) chemotherapy with sandwiched radiotherapy in the treatment of newly diagnosed stage IE/IIE extranodal natural killer/T‐cell lymphoma, nasal type. Cancer Medicine 8:7, pages 3349-3358.
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Xiaoying Quan. (2019) The combined prognostic value of pretreatment neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio in stage IE/IIE extranodal natural killer/T-cell lymphoma. Oncology and Translational Medicine 5:3, pages 137-146.
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Peiling Zhang, Chen Zeng, Jiali Cheng, Jing Zhou, Jia Gu, Xia Mao, Wei Zhang, Yang Cao, Hui Luo, Bin Xu, Qinlu Li, Min Xiao & Jianfeng Zhou. (2019) Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases. Open Forum Infectious Diseases 6:5.
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Yan Zhang, Wei Zhang, Jian Li, Minghui Duan, Bing Han, Tienan Zhu, Junling Zhuang, Huacong Cai, Xinxin Cao, Miao Chen & Daobin Zhou. (2018) Gemcitabine, cisplatin, and dexamethasone (GDP) in combination with methotrexate and pegaspargase is active in newly diagnosed peripheral T cell lymphoma patients: a phase 2, single-center, open-label study in China. Annals of Hematology 98:1, pages 143-150.
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Xiu-Wen Deng, Jun-Xin Wu, Tao Wu, Su-Yu Zhu, Mei Shi, Hang Su, Ying Wang, Xia He, Li-Ming Xu, Zhi-Yong Yuan, Li-Ling Zhang, Gang Wu, Bao-Lin Qu, Li-Ting Qian, Xiao-Rong Hou, Fu-Quan Zhang, Yu-Jing Zhang, Yuan Zhu, Jian-Zhong Cao, Sheng-Min Lan, Mei Dong, Shu-Nan Qi, Yong Yang & Ye-Xiong Li. (2018) Radiotherapy is essential after complete response to asparaginase-containing chemotherapy in early-stage extranodal nasal-type NK/T-cell lymphoma: A multicenter study from the China Lymphoma Collaborative Group (CLCG). Radiotherapy and Oncology 129:1, pages 3-9.
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Xiaoying Quan, Pinjia Wang, Lei Lei, Xiaoyan Chen, Chunzhi Wu, Bin Ye & Zhihui Zhang. (2018) Analysis of clinical efficacy of P-Gemox regimen sandwich radiotherapy, P-Gemox regimen sequential radiotherapy, and radiotherapy alone treatment for extranodal natural killer/T-cell lymphoma*. Oncology and Translational Medicine 4:5, pages 185-195.
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