Advanced search
Publication Cover
Hematology Volume 23, 2018 - Issue 10
Submit an article Journal homepage
7,663
Views
63
CrossRef citations to date
0
Altmetric
Hematological Malignancy: Acute Leukemia

Roles of the bone marrow niche in hematopoiesis, leukemogenesis, and chemotherapy resistance in acute myeloid leukemia

Andi WangDepartment of Hematology, South Campus Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaView further author information
&
Hua ZhongDepartment of Hematology, South Campus Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
View further author information
Pages 729-739 | Published online: 14 Jun 2018

Citations (63)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Nadia ElMenshawy, Farha EL-Chennawi, Ahmed Darwish, Asmaa Foda, Doaa Atita & Mohamed Eissa. (2023) CD44, CD90 and CD96 expression in immune thrombocytopenia purpura (ITP) patients. Journal of Immunoassay and Immunochemistry 44:4, pages 326-337.
Read now
Hassan Rafieemehr, Masumeh Maleki Behzad, Saeed Azandeh, Niloofar Farshchi, Mohammad Ghasemi Dehcheshmeh & Najmaldin Saki. (2021) Chemo/radiotherapy-Induced Bone Marrow Niche Alterations. Cancer Investigation 39:2, pages 180-194.
Read now

Articles from other publishers (61)

Niyati Seshagiri Sharma & Bibha Choudhary. (2023) Good Cop, Bad Cop: Profiling the Immune Landscape in Multiple Myeloma. Biomolecules 13:11, pages 1629.
Crossref
Noémie Ravalet, Hélène Guermouche, Pierre Hirsch, Frédéric Picou, Amélie Foucault, Nathalie Gallay, Jean-Alain Martignoles, Jenny Beaud, Ludovic Suner, Caroline Deswarte, Sébastien Lachot, Emmanuelle Rault, Laëtitia Largeaud, Valérie Gissot, Marie-Christine Béné, Emmanuel Gyan, François Delhommeau & Olivier Herault. (2023) Modulation of bone marrow and peripheral blood cytokine levels by age and clonal hematopoiesis in healthy individuals. Clinical Immunology 255, pages 109730.
Crossref
Thao M. Nguyen, Manasi Jambhrunkar, Sook S. Wong, David M. Ross, Paul Joyce, John W. Finnie, Jim Manavis, Kristen Bremmell, Melissa R. Pitman & Clive A. Prestidge. (2023) Targeting Acute Myeloid Leukemia Using Sphingosine Kinase 1 Inhibitor-Loaded Liposomes. Molecular Pharmaceutics 20:8, pages 3937-3946.
Crossref
Annachiara Dozzo, Aoife Galvin, Jae-Won Shin, Santo Scalia, Caitriona M. O’Driscoll & Katie B. Ryan. (2022) Modelling acute myeloid leukemia (AML): What’s new? A transition from the classical to the modern. Drug Delivery and Translational Research 13:8, pages 2110-2141.
Crossref
Chen Tian, Yueyang Li, Junqi Si, Junnan Kang, Zehui Chen, Rexidan Nuermaimaiti, Yafei Wang, Yong Yu, Zhigang Zhao, Xiaofang Wang, Yizhuo Zhang, Haifeng Zhao, Hongliang Yang, Mingjian James You, Guoguang Zheng & Lina Wang. (2023) Knockdown of let‐7b in leukemia associated macrophages inhibit acute myeloid leukemia progression. Hematological Oncology 41:3, pages 510-519.
Crossref
Daniela Damiani & Mario Tiribelli. (2023) Checkpoint Inhibitors in Acute Myeloid Leukemia. Biomedicines 11:6, pages 1724.
Crossref
Yanitsa Davidkova, Milan Jagurinoski, Gueorgui Balatzenko & Margarita Guenova. 2023. Leukemia - From Biology to Clinic. Leukemia - From Biology to Clinic.
Nicholas R. Anderson, Vipul Sheth, Hui Li, Mason W. Harris, Shaowei Qiu, David K. Crossman, Harish Kumar, Puneet Agarwal, Takashi Nagasawa, Andrew J. Paterson, Robert S. Welner & Ravi Bhatia. (2022) Microenvironmental CXCL12 deletion enhances Flt3-ITD acute myeloid leukemia stem cell response to therapy by reducing p38 MAPK signaling. Leukemia 37:3, pages 560-570.
Crossref
Jiajia Xin, Huijie Zhang, Dandan Yin, Ning An, Yaozhen Chen, Jinmei Xu, Jing Zhang, Zhixin Liu, Yongsheng Liu, Wen Yin, Mingkai Li & Xingbin Hu. (2023) A novel coumarin derivative DBH2 inhibits proliferation and induces apoptosis of chronic myeloid leukemia cells. Genes & Diseases 10:2, pages 596-607.
Crossref
Wolf‐Karsten Hofmann, Andreas Trumpp & Carsten Müller‐Tidow. (2022) Therapy resistance mechanisms in hematological malignancies. International Journal of Cancer 152:3, pages 340-347.
Crossref
Jennifer N. Saultz & Jeffrey W. Tyner. (2023) Chasing leukemia differentiation through induction therapy, relapse and transplantation. Blood Reviews 57, pages 101000.
Crossref
Ian M. Bouligny, Keri R. Maher & Steven Grant. (2023) Mechanisms of myeloid leukemogenesis: Current perspectives and therapeutic objectives. Blood Reviews 57, pages 100996.
Crossref
Daniela Damiani & Mario Tiribelli. (2022) Present and Future Role of Immune Targets in Acute Myeloid Leukemia. Cancers 15:1, pages 253.
Crossref
Mingying Li, Jingjing Ye, Yuan Xia, Meng Li, Guosheng Li, Xiang Hu, Xiuhua Su, Dongmei Wang, Xin Zhao, Fei Lu, Jingxin Li, Daoxin Ma, Tao Sun & Chunyan Ji. (2022) METTL3 mediates chemoresistance by enhancing AML homing and engraftment via ITGA4. Leukemia 36:11, pages 2586-2595.
Crossref
Jonas B. Lang, Michèle C. Buck, Jennifer Rivière, Oumaima Stambouli, Ken Sachenbacher, Purva Choudhary, Hendrik Dietz, Bernd Giebel, Florian Bassermann, Robert A. J. Oostendorp, Katharina S. Götze & Judith S. Hecker. (2022) Comparative analysis of extracellular vesicle isolation methods from human AML bone marrow cells and AML cell lines. Frontiers in Oncology 12.
Crossref
Debora Capelli, Diego Menotti, Alessandro Fiorentini, Francesco Saraceni & Attilio Olivieri. (2022) Overcoming Resistance: FLT3 Inhibitors Past, Present, Future and the Challenge of Cure. Cancers 14:17, pages 4315.
Crossref
Alessandro Allegra, Alessandro Tonacci, Laura Giordano, Caterina Musolino & Sebastiano Gangemi. (2022) Targeting Redox Regulation as a Therapeutic Opportunity against Acute Leukemia: Pro-Oxidant Strategy or Antioxidant Approach?. Antioxidants 11:9, pages 1696.
Crossref
Yulieth Ximena Torres-Llanos & Alba Lucia Combita-Rojas. (2022) Relation between tumor micro-environment and epigenetic alterations in hematological malignancies. Advances in Cancer Biology - Metastasis 4, pages 100024.
Crossref
Georgios Petros Barakos & Eleftheria Hatzimichael. (2022) Microenvironmental Features Driving Immune Evasion in Myelodysplastic Syndromes and Acute Myeloid Leukemia. Diseases 10:2, pages 33.
Crossref
Saravanan Ganesan, Vikram Mathews & Neha Vyas. (2021) Microenvironment and drug resistance in acute myeloid leukemia: Do we know enough?. International Journal of Cancer 150:9, pages 1401-1411.
Crossref
Tianyuan Ci, Wentao Zhang, Yingyu Qiao, Huangjuan Li, Jing Zang, Hongjun Li, Nianping Feng & Zhen Gu. (2022) Delivery strategies in treatments of leukemia. Chemical Society Reviews 51:6, pages 2121-2144.
Crossref
Yashar Mesbahi, Toby N. Trahair, Richard B. Lock & Patrick Connerty. (2022) Exploring the Metabolic Landscape of AML: From Haematopoietic Stem Cells to Myeloblasts and Leukaemic Stem Cells. Frontiers in Oncology 12.
Crossref
Driti Ashok, Laura Polcik, Svenja Dannewitz Prosseda & Tanja Nicole Hartmann. (2022) Insights Into Bone Marrow Niche Stability: An Adhesion and Metabolism Route. Frontiers in Cell and Developmental Biology 9.
Crossref
JinFang Zhang, XiaoLi Liu, ChangXin Yin & Sa Zong. (2022) hnRNPK/Beclin1 signaling regulates autophagy to promote imatinib resistance in Philadelphia chromosome-positive acute lymphoblastic leukemia cells. Experimental Hematology.
Crossref
Shuichiro Okamoto, Kei Miyano, Keisuke Kitakaze, Hitomi Kato, Akira Yamauchi, Mizuho Kajikawa, Momoe Itsumi, Chikage Kawai & Futoshi Kuribayashi. (2022) Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling–independent manner. Biochemical and Biophysical Research Communications 587, pages 78-84.
Crossref
Gregory P. Van Stavern, Loreley D. Smith & Hayley R. James. 2022. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology 7409 7447 .
Berna Bou-Tayeh, Vladimir Laletin, Nassim Salem, Sylvaine Just-Landi, Joanna Fares, Raphael Leblanc, Marielle Balzano, Yann M. Kerdiles, Ghislain Bidaut, Olivier Hérault, Daniel Olive, Michel Aurrand-Lions, Thierry Walzer, Jacques A. Nunès & Cyril Fauriat. (2021) Chronic IL-15 Stimulation and Impaired mTOR Signaling and Metabolism in Natural Killer Cells During Acute Myeloid Leukemia. Frontiers in Immunology 12.
Crossref
Débora Bifano Pimenta, Vanessa Araujo Varela, Tarcila Santos Datoguia, Victória Bulcão Caraciolo, Gabriel Herculano Lopes & Welbert Oliveira Pereira. (2021) The Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia. Frontiers in Cell and Developmental Biology 9.
Crossref
Yanmei Yang, Haiping He, Jigang He, Xuezhong Gu, Peng Hu, Rongxia Zuo & Yalian Sa. (2021) Hyperleukocytic Acute Leukemia Circulating Exosomes Regulate HSCs and BM-MSCs. Journal of Healthcare Engineering 2021, pages 1-14.
Crossref
Yuliya Yakymiv, Stefania Augeri, Cristiano Bracci, Sara Marchisio, Semra Aydin, Stefano D’Ardia, Massimo Massaia, Enza Ferrero, Erika Ortolan & Ada Funaro. (2021) CD157 signaling promotes survival of acute myeloid leukemia cells and modulates sensitivity to cytarabine through regulation of anti-apoptotic Mcl-1. Scientific Reports 11:1.
Crossref
Seyed Mohammadreza Bolandi, Mahdi Pakjoo, Peyman Beigi, Mohammad Kiani, Ali Allahgholipour, Negar Goudarzi, Jamshid S. Khorashad & Anna M. Eiring. (2021) A Role for the Bone Marrow Microenvironment in Drug Resistance of Acute Myeloid Leukemia. Cells 10:11, pages 2833.
Crossref
Celia A. Soto, Cristina Lo Celso, Louise E. Purton & Benjamin J. Frisch. (2021) From the niche to malignant hematopoiesis and back: reciprocal interactions between leukemia and the bone marrow microenvironment. JBMR Plus 5:10.
Crossref
Natalia-Del Pilar Vanegas, Paola Fernanda Ruiz-Aparicio, Gloria Inés Uribe, Adriana Linares-Ballesteros & Jean-Paul Vernot. (2021) Leukemia-Induced Cellular Senescence and Stemness Alterations in Mesenchymal Stem Cells Are Reversible upon Withdrawal of B-Cell Acute Lymphoblastic Leukemia Cells. International Journal of Molecular Sciences 22:15, pages 8166.
Crossref
Sunil K. Joshi, Tamilla Nechiporuk, Daniel Bottomly, Paul D. Piehowski, Julie A. Reisz, Janét Pittsenbarger, Andy Kaempf, Sara J.C. Gosline, Yi-Ting Wang, Joshua R. Hansen, Marina A. Gritsenko, Chelsea Hutchinson, Karl K. Weitz, Jamie Moon, Francesca Cendali, Thomas L. Fillmore, Chia-Feng Tsai, Athena A. Schepmoes, Tujin Shi, Osama A. Arshad, Jason E. McDermott, Ozgun Babur, Kevin Watanabe-Smith, Emek Demir, Angelo D'Alessandro, Tao Liu, Cristina E. Tognon, Jeffrey W. Tyner, Shannon K. McWeeney, Karin D. Rodland, Brian J. Druker & Elie Traer. (2021) The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance. Cancer Cell 39:7, pages 999-1014.e8.
Crossref
Vincent Kuek, Anastasia M. Hughes, Rishi S. Kotecha & Laurence C. Cheung. (2021) Therapeutic Targeting of the Leukaemia Microenvironment. International Journal of Molecular Sciences 22:13, pages 6888.
Crossref
Daniel Arthur Corpuz Fisher, Jared Scott Fowles, Amy Zhou & Stephen Tracy Oh. (2021) Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms. Frontiers in Immunology 12.
Crossref
Zehui Chen, Yaxin Zheng, Yaling Yang, Junnan Kang, M. James You & Chen Tian. (2021) Abnormal bone marrow microenvironment: the “harbor” of acute lymphoblastic leukemia cells. Blood Science 3:2, pages 29-34.
Crossref
Hae-Ri LeeSeung-Jip YangHyun-Kyung ChoiJin-A KimIl-Hoan Oh. (2021) The Chromatin Remodeling Complex CHD1 Regulates the Primitive State of Mesenchymal Stromal Cells to Control Their Stem Cell Supporting Activity. Stem Cells and Development 30:7, pages 363-373.
Crossref
Fernanda Marconi Roversi, Maura Lima Pereira Bueno, Fernando Viera Pericole & Sara Teresinha Olalla Saad. (2021) Hematopoietic Cell Kinase (HCK) Is a Player of the Crosstalk Between Hematopoietic Cells and Bone Marrow Niche Through CXCL12/CXCR4 Axis. Frontiers in Cell and Developmental Biology 9.
Crossref
Selda Ayhan, Emirhan Nemutlu, Duygu Uçkan Çetinkaya, Sedef Kır & Rıza Köksal Özgül. (2021) Characterization of human bone marrow niches with metabolome and transcriptome profiling. Journal of Cell Science 134:6.
Crossref
Takanori Yamaguchi, Eiji Kawamoto, Arong Gaowa, Eun Jeong Park & Motomu Shimaoka. (2021) Remodeling of Bone Marrow Niches and Roles of Exosomes in Leukemia. International Journal of Molecular Sciences 22:4, pages 1881.
Crossref
Armando Vilchis-Ordoñez, Dalia Ramírez-Ramírez & Rosana Pelayo. (2021) The triad inflammation-microenvironment-tumor initiating cells in leukemia progression. Current Opinion in Physiology 19, pages 211-218.
Crossref
Gregory P. Van Stavern, Loreley D. Smith & Hayley R. James. 2020. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology 1 40 .
Wen Ju, Wenyi Lu, Lan Ding, Yurong Bao, Fei Hong, Yuting Chen, Hui Gao, Xiaoqi Xu, Guozhang Wang, Weiwei Wang, Xi Zhang, Chunling Fu, Kunming Qi, Zhenyu Li, Kailin Xu, Jianlin Qiao & Lingyu Zeng. (2020) PEDF promotes the repair of bone marrow endothelial cell injury and accelerates hematopoietic reconstruction after bone marrow transplantation. Journal of Biomedical Science 27:1.
Crossref
D.G.J. Cucchi, R.W.J. Groen, J.J.W.M. Janssen & J. Cloos. (2020) Ex vivo cultures and drug testing of primary acute myeloid leukemia samples: Current techniques and implications for experimental design and outcome. Drug Resistance Updates 53, pages 100730.
Crossref
Carmelo Gurnari, Simona Pagliuca & Valeria Visconte. (2020) Deciphering the Therapeutic Resistance in Acute Myeloid Leukemia. International Journal of Molecular Sciences 21:22, pages 8505.
Crossref
Chengyun Pan, Ping Liu, Dan Ma, Siyu Zhang, Ming Ni, Qin Fang & Jishi Wang. (2020) Bone marrow mesenchymal stem cells in microenvironment transform into cancer-associated fibroblasts to promote the progression of B-cell acute lymphoblastic leukemia. Biomedicine & Pharmacotherapy 130, pages 110610.
Crossref
Konstantinos D. Kokkaliaris & David T. Scadden. (2020) Cell interactions in the bone marrow microenvironment affecting myeloid malignancies. Blood Advances 4:15, pages 3795-3803.
Crossref
Yongfeng Chen, Yong Liang, Xingjing Luo & Qiongying Hu. (2020) Oxidative resistance of leukemic stem cells and oxidative damage to hematopoietic stem cells under pro-oxidative therapy. Cell Death & Disease 11:4.
Crossref
Shuang-long Li, Yong-liang Zhu, Yi Zhang, Shu-han Liu, Xiang-die Wang & Xiang-jun Qiu. (2020) Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application. International Journal of Analytical Chemistry 2020, pages 1-7.
Crossref
E. E. Ladikou, H. Sivaloganathan, A. Pepper & T. Chevassut. (2020) Acute Myeloid Leukaemia in Its Niche: the Bone Marrow Microenvironment in Acute Myeloid Leukaemia. Current Oncology Reports 22:3.
Crossref
Farah Kouzi, Kazem Zibara, Jerome Bourgeais, Frederic Picou, Nathalie Gallay, Julie Brossaud, Hassan Dakik, Benjamin Roux, Sophie Hamard, Louis-Romee Le Nail, Rita Hleihel, Amelie Foucault, Noemie Ravalet, Florence Rouleux-Bonnin, Fabrice Gouilleux, Frederic Mazurier, Marie C. Bene, Haidar Akl, Emmanuel Gyan, Jorge Domenech, Marwan El-Sabban & Olivier Herault. (2019) Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells. Oncogene 39:6, pages 1198-1212.
Crossref
Yin Sun, Hongxiang Wang & Chibao Luo. (2020) MiR-100 regulates cell viability and apoptosis by targeting ATM in pediatric acute myeloid leukemia. Biochemical and Biophysical Research Communications 522:4, pages 855-861.
Crossref
Anuvrat Sircar, Sayan Chowdhury, Amber Hart, William Bell, Satishkumar Singh, Lalit Sehgal & Narendranath Epperla. (2020) Impact and Intricacies of Bone Marrow Microenvironment in B-cell Lymphomas: From Biology to Therapy. International Journal of Molecular Sciences 21:3, pages 904.
Crossref
Paraskevi Vgenopoulou & Stavroula Kousteni. 2020. Encyclopedia of Bone Biology. Encyclopedia of Bone Biology 225 235 .
Yuliya Yakymiv, Stefania Augeri, Giulia Fissolo, Silvia Peola, Cristiano Bracci, Monica Binaschi, Daniela Bellarosa, Andrea Pellacani, Enza Ferrero, Erika Ortolan & Ada Funaro. (2019) CD157: From Myeloid Cell Differentiation Marker to Therapeutic Target in Acute Myeloid Leukemia. Cells 8:12, pages 1580.
Crossref
Nithya Mudgapalli, Palanisamy Nallasamy, Haritha Chava, Srinivas Chava, Anup S. Pathania, Venugopal Gunda, Santhi Gorantla, Manoj K. Pandey, Subash C. Gupta & Kishore B. Challagundla. (2019) The role of exosomes and MYC in therapy resistance of acute myeloid leukemia: Challenges and opportunities. Molecular Aspects of Medicine 70, pages 21-32.
Crossref
Kedong Song, Qian Kong, Liying Li, Yiwei Wang, Roxanne Parungao, Shuangshuang Zheng, Yi Nie, Zeren Jiao, Hongfei Wang & Tianqing Liu. (2019) In Vitro Fabrication and Biocompatibility Assay of a Biomimetic Osteoblastic Niche. Applied Biochemistry and Biotechnology 189:2, pages 471-484.
Crossref
Peter Valent, Irina Sadovnik, Gregor Eisenwort, Karin Bauer, Harald Herrmann, Karoline V. Gleixner, Axel Schulenburg, Werner Rabitsch, Wolfgang R. Sperr & Dominik Wolf. (2019) Immunotherapy-Based Targeting and Elimination of Leukemic Stem Cells in AML and CML. International Journal of Molecular Sciences 20:17, pages 4233.
Crossref
Carmelo Gurnari, Giulia Falconi, Eleonora De Bellis, Maria Teresa Voso & Emiliano Fabiani. (2019) The Role of Forkhead Box Proteins in Acute Myeloid Leukemia. Cancers 11:6, pages 865.
Crossref
Alicja Gruszka, Debora Valli, Cecilia Restelli & Myriam Alcalay. (2019) Adhesion Deregulation in Acute Myeloid Leukaemia. Cells 8:1, pages 66.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.