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Article

The effect of hydrogel injection on cardiac function and myocardial mechanics in a computational post-infarction model

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Pages 1185-1195 | Received 18 Jul 2011, Accepted 09 Jan 2012, Published online: 22 Mar 2012

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Mazin S. Sirry, Neil H. Davies, Karen Kadner, Laura Dubuis, Muhammad G. Saleh, Ernesta M. Meintjes, Bruce S. Spottiswoode, Peter Zilla & Thomas Franz. (2015) Micro-structurally detailed model of a therapeutic hydrogel injectate in a rat biventricular cardiac geometry for computational simulations. Computer Methods in Biomechanics and Biomedical Engineering 18:3, pages 325-331.
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Ricardo Avendaño, Dan Midgett, Inga Melvinsdottir, Stephanie L. Thorn, Selen Uman, Zachary Pickell, Shin Rong Lee, Zhao Liu, Marina Mamarian, James S. Duncan, Francis G. Spinale, Jason A. Burdick & Albert J. Sinusas. (2023) Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model. Journal of Applied Physiology 135:2, pages 405-420.
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Y. D. Motchon, Kevin L. Sack, M. S. Sirry, M. Kruger, E. Pauwels, D. Van Loo, A. De Muynck, L. Van Hoorebeke, Neil H. Davies & Thomas Franz. (2023) Effect of biomaterial stiffness on cardiac mechanics in a biventricular infarcted rat heart model with microstructural representation of in situ intramyocardial injectate. International Journal for Numerical Methods in Biomedical Engineering 39:5.
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Shuqin Wang, Yuejun Yao, Tong Zhou, Jieqi Xie, Jie Ding, Wangbei Cao, Liyin Shen, Yang Zhu & Changyou Gao. (2022) Preservation of cardiac functions post myocardial infarction in vivo by a phenylboric acid-grafted hyaluronic hydrogel with anti-oxidation and accelerated degradation under oxidative microenvironment. Composites Part B: Engineering 238, pages 109941.
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D.E. Midgett, S.L. Thorn, S.S. Ahn, S. Uman, R. Avendano, I. Melvinsdottir, T. Lysyy, J.S. Kim, J.S. Duncan, J.D. Humphrey, X. Papademetris, J.A. Burdick & A.J. Sinusas. (2022) CineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogel. Journal of Molecular and Cellular Cardiology 166, pages 74-90.
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Martin Philipp Dieterle, Ayman Husari, Thorsten Steinberg, Xiaoling Wang, Imke Ramminger & Pascal Tomakidi. (2021) From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues. Biomolecules 11:6, pages 824.
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Renee Miller, David Marlevi, Will Zhang, Marc Hirschvogel, Myrianthi Hadjicharalambous, Adela Capilnasiu, Maximilian Balmus, Sandra Hager, Javiera Jilberto, Mia Bonini, Anna Wittgenstein, Yunus Ahmed & David Nordsletten. 2021. Modeling Biomaterials. Modeling Biomaterials 141 239 .
Yiling Fan, William Ronan, Irvin Teh, Jurgen E. Schneider, Claudia E. Varela, William Whyte, Peter McHugh, Sean Leen & Ellen Roche. (2019) A comparison of two quasi‐static computational models for assessment of intra‐myocardial injection as a therapeutic strategy for heart failure. International Journal for Numerical Methods in Biomedical Engineering 35:9.
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Malebogo Ngoepe, Andreas Passos, Stavroula Balabani, Jesse King, Anastasia Lynn, Jasanth Moodley, Liam Swanson, Deon Bezuidenhout, Neil H. Davies & Thomas Franz. (2019) A Preliminary Computational Investigation Into the Flow of PEG in Rat Myocardial Tissue for Regenerative Therapy. Frontiers in Cardiovascular Medicine 6.
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Mathias Peirlinck, Kevin L. Sack, Pieter De Backer, Pedro Morais, Patrick Segers, Thomas Franz & Matthieu De Beule. (2019) Kinematic boundary conditions substantially impact in silico ventricular function. International Journal for Numerical Methods in Biomedical Engineering 35:1, pages e3151.
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Tamer Abdalrahman, Laura Dubuis, Jason Green, Neil Davies & Thomas Franz. (2017) Cellular mechanosensitivity to substrate stiffness decreases with increasing dissimilarity to cell stiffness. Biomechanics and Modeling in Mechanobiology 16:6, pages 2063-2075.
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Fulufhelo Nemavhola. (2017) Fibrotic infarction on the LV free wall may alter the mechanics of healthy septal wall during passive filling. Bio-Medical Materials and Engineering 28:6, pages 579-599.
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Peter Wise, Neil H. Davies, Mazin S. Sirry, Jeroen Kortsmit, Laura Dubuis, Chen-Ket Chai, Frank P.T. Baaijens & Thomas Franz. (2016) Excessive volume of hydrogel injectates may compromise the efficacy for the treatment of acute myocardial infarction. International Journal for Numerical Methods in Biomedical Engineering 32:12, pages e02772.
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Kevin L. Sack, Neil H. Davies, Julius M. Guccione & Thomas Franz. (2016) Personalised computational cardiology: Patient-specific modelling in cardiac mechanics and biomaterial injection therapies for myocardial infarction. Heart Failure Reviews 21:6, pages 815-826.
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Andrew P. Voorhees & Hai‐Chao Han. 2011. Comprehensive Physiology. Comprehensive Physiology 1623 1644 .
Remya Komeri, Finosh Gnanaprakasam Thankam & Jayabalan Muthu. (2015) Influence of matrix and bulk behaviour of an injectable hydrogel on the survival of encapsulated cardiac cells. RSC Advances 5:40, pages 31439-31449.
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Elena Tous Kichula, Hua Wang, Shauna M. Dorsey, Spencer E. Szczesny, Dawn M. Elliott, Jason A. Burdick & Jonathan F. Wenk. (2013) Experimental and Computational Investigation of Altered Mechanical Properties in Myocardium after Hydrogel Injection. Annals of Biomedical Engineering 42:7, pages 1546-1556.
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D. Legner, S. Skatulla, J. MBewu, R. R. Rama, B. D. Reddy, C. SansourN. H. Davies & T. Franz. (2014) Studying the influence of hydrogel injections into the infarcted left ventricle using the element-free Galerkin method. International Journal for Numerical Methods in Biomedical Engineering 30:3, pages 416-429.
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