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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 6, 2003 - Issue 2
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Research Article

Prolonged Treatment with l-Lysine and l-Arginine Reduces Stress-induced Anxiety in an Elevated Plus Maze

Pages 125-128 | Published online: 05 Sep 2013

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L.M.S.S. Maia, A. Amancio-dos-Santos, D. Duda-de-Oliveira, M.K.C. Angelim, P.C.P. Germano, S.F. Santos & R.C.A. Guedes. (2009) L-Arginine administration during rat brain development facilitates spreading depression propagation: evidence for a dose- and nutrition-dependent effect. Nutritional Neuroscience 12:2, pages 73-80.
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Jezova Daniela, Makatsori Aikaterini, Smriga Miro, Morinaga Yasushi & Duncko Roman. (2005) Subchronic treatment with amino acid mixture of L-lysine and L-arginine modifies neuroendocrine activation during psychosocial stress in subjects with high trait anxiety. Nutritional Neuroscience 8:3, pages 155-160.
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Saksit Srinongkote, Miro Smriga, Kazuki Nakagawa & Yasuhiko Toride. (2003) A Diet Fortified with l-lysine and l-arginine Reduces Plasma Cortisol and Blocks Anxiogenic Response to Transportation in Pigs. Nutritional Neuroscience 6:5, pages 283-289.
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Articles from other publishers (15)

Khurshid Jalal, Faisal Khan, Shazia Nawaz, Rushda Afroz, Kanwal Khan, Sadia Basharat Ali, Liangliang Hao, Saeed Ahmad Khan, Mohsin Kazi, Reaz Uddin & Darakhshan Jabeen Haleem. (2022) Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study. Biomedicine & Pharmacotherapy 152, pages 113235.
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Artur Pałasz, Itiana Castro Menezes & John J. Worthington. (2021) The role of brain gaseous neurotransmitters in anxiety. Pharmacological Reports 73:2, pages 357-371.
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Pei Lingpeng, Song Jingzhu, Liu Wei, Wu Enqi & Ling Yaqin. (2021) Effect of water extracts from Cynanchum thesioides (Freyn) K. Schum. on visceral hypersensitivity and gut microbiota profile in maternally separated rats. Journal of Ethnopharmacology 264, pages 113352.
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Rochelin Dalangin, Anna Kim & Robert E. Campbell. (2020) The Role of Amino Acids in Neurotransmission and Fluorescent Tools for Their Detection. International Journal of Molecular Sciences 21:17, pages 6197.
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Elżbieta Żmudzka, Kinga Sałaciak, Jacek Sapa & Karolina Pytka. (2018) Serotonin receptors in depression and anxiety: Insights from animal studies. Life Sciences 210, pages 106-124.
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Yeseung Lee, Adnan Khan, Seri Hong, Sun Ha Jee & Youngja H. Park. (2017) A metabolomic study on high-risk stroke patients determines low levels of serum lysine metabolites: a retrospective cohort study. Molecular BioSystems 13:6, pages 1109-1120.
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K. Gulati, N. Rai & A. Ray. 2017. Anxiety. Anxiety 169 192 .
Oscar Martínez-Alvarez. 2013. Marine Proteins and Peptides. Marine Proteins and Peptides 351 367 .
Taku Yamaguchi, Aki Tsujimatsu, Haruko Kumamoto, Takeshi Izumi, Yu Ohmura, Takayuki Yoshida & Mitsuhiro Yoshioka. (2012) Anxiolytic effects of yokukansan, a traditional Japanese medicine, via serotonin 5-HT1A receptors on anxiety-related behaviors in rats experienced aversive stress. Journal of Ethnopharmacology 143:2, pages 533-539.
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Ayanabha Chakraborti, Kavita Gulati & Arunabha Ray. (2008) Age related differences in stress-induced neurobehavioral responses in rats: Modulation by antioxidants and nitrergic agents. Behavioural Brain Research 194:1, pages 86-91.
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Erik Pålsson, Kim Fejgin, Caroline Wass, Jörgen A. Engel, Lennart Svensson & Daniel Klamer. (2007) The amino acid l-lysine blocks the disruptive effect of phencyclidine on prepulse inhibition in mice. Psychopharmacology 192:1, pages 9-15.
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Miro SMRIGA, Toshihiko ANDO, Masahisa AKUTSU, Yasushi FURUKAWA, Kiyoshi MIWA & Yasushi MORINAGA. (2007) Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans. Biomedical Research 28:2, pages 85-90.
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Saksit SRINONGKOTE, Miro SMRIGA & Yasuhiko TORIDE. (2004) Diet supplied with L-lysine and L-arginine during chronic stress of high stock density normalizes growth of broilers. Animal Science Journal 75:4, pages 339-343.
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Miro Smriga, Shibani Ghosh, Youssef Mouneimne, Peter L. Pellett & Nevin S. Scrimshaw. (2004) Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria. Proceedings of the National Academy of Sciences 101:22, pages 8285-8288.
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Miro Smriga & Kunio Torii. (2003) l -Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats . Proceedings of the National Academy of Sciences 100:26, pages 15370-15375.
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