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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 20, 2017 - Issue 6
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Original Articles

Neuroprotective effect of asiatic acid on rotenone-induced mitochondrial dysfunction and oxidative stress-mediated apoptosis in differentiated SH-SYS5Y cells

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Zarina Mushtaq, Muhammad Imran, Muzzamal Hussain, Farhan Saeed, Ali Imran, Maryam Umar, Mohamed A. Abdelgawad, Ahmed H. El-Ghorab, Awais Ahmed, Suliman A. Alsagaby, Mohamad Fawzi Mahomoodally & Entessar Al Jbawi. (2023) Asiatic acid: a review on its polypharmacological properties and therapeutic potential against various Maladies. International Journal of Food Properties 26:1, pages 1244-1263.
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D. Mahendran, P. B. Kavi Kishor, N. Geetha, T. Manish, S. V. Sahi & P. Venkatachalam. (2021) Efficient antibacterial/biofilm, anti-cancer and photocatalytic potential of titanium dioxide nanocatalysts green synthesised using Gloriosa superba rhizome extract. Journal of Experimental Nanoscience 16:1, pages 11-30.
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Articles from other publishers (47)

Hagera Dilnashin, Hareram Birla, Chetan Keswani, Saumitra Sen Singh, Walia Zahra, Aaina Singh Rathore, Richa Singh, Priyanka Kumari Keshri & Surya Pratap Singh. (2023) Neuroprotective Effects of Tinospora cordifolia via Reducing the Oxidative Stress and Mitochondrial Dysfunction against Rotenone-Induced PD Mice . ACS Chemical Neuroscience 14:17, pages 3077-3087.
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Vishwa Nath Shukla, Vikas, Abhishesh Kumar Mehata, Aseem Setia, Pooja Kumari, Sanjeev Kumar Mahto, Madaswamy S. Muthu & Sunil Kumar Mishra. (2023) Rational design of surface engineered albumin nanoparticles of asiatic acid for EGFR targeted delivery to lung cancer: formulation development and pharmacokinetics. Colloids and Surfaces A: Physicochemical and Engineering Aspects, pages 132188.
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Ahmed Sha Sulthana, Rengasamy Balakrishnan, Mani Renuka, Thangavel Mohankumar, Dharmar Manimaran, Kuppamuthu Arulkumar & Elangovan Namasivayam. (2023) PIASA, A Novel Peptide, Prevents SH-SY5Y Neuroblastoma Cells against Rotenone-induced Toxicity. Current Molecular Pharmacology 16:3, pages 393-410.
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Liuyun Ding, Tiantian Liu & Jin Ma. (2023) Neuroprotective mechanisms of Asiatic acid. Heliyon 9:5, pages e15853.
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Surjeet Verma, Motebang D.V. Nakin, Zesipho Makhosayafana & Namrita Lall. (2023) The Role of Aquatic Plants in Natural Products and Drug Discovery. Letters in Drug Design & Discovery 20:4, pages 386-407.
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Yulia Aleksandrova, Kirill Chaprov, Alexandra Podturkina, Oleg Ardashov, Ekaterina Yandulova, Konstantin Volcho, Nariman Salakhutdinov & Margarita Neganova. (2023) Monoterpenoid Epoxidiol Ameliorates the Pathological Phenotypes of the Rotenone-Induced Parkinson’s Disease Model by Alleviating Mitochondrial Dysfunction. International Journal of Molecular Sciences 24:6, pages 5842.
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Emmanuel Makinde, Linlin Ma, George D. Mellick & Yunjiang Feng. (2023) Mitochondrial Modulators: The Defender. Biomolecules 13:2, pages 226.
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Siva Prasad Panda, DSNBK Prasanth, Uma Sankar Gorla & Saikat Dewanjee. (2023) Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism. Ageing Research Reviews 83, pages 101783.
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Okon Godwin Okon. 2023. Herbal Medicine Phytochemistry. Herbal Medicine Phytochemistry 1 23 .
Constanza Morén, Nina Treder, Albert Martínez-Pinteño, Natàlia Rodríguez, Néstor Arbelo, Santiago Madero, Marta Gómez, Sergi Mas, Patricia Gassó & Eduard Parellada. (2022) Systematic Review of the Therapeutic Role of Apoptotic Inhibitors in Neurodegeneration and Their Potential Use in Schizophrenia. Antioxidants 11:11, pages 2275.
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Krishnan Raguvaran, Manickam Kalpana, Thulasiraman Manimegalai, Suresh Kalaivani, Palanisamy Devapriya, Nagarajan Siddharthan, Rengasamy Balakrishnan, Tamil Selvan Silambarasan & Rajan Maheswaran. (2022) Larvicidal, antioxidant and biotoxicity assessment of (2-(((2-ethyl-2 methylhexyl)oxy)carbonyl)benzoic acid isolated from Bacillus pumilus against Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus. Archives of Microbiology 204:10.
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Walia Zahra, Hareram Birla, Saumitra Sen Singh, Aaina Singh Rathore, Hagera Dilnashin, Richa Singh, Priyanka Kumari Keshri & Surya Pratap Singh. 2022. Neurodegenerative Diseases: Multifactorial Degenerative Processes, Biomarkers and Therapeutic Approaches (First Edition). Neurodegenerative Diseases: Multifactorial Degenerative Processes, Biomarkers and Therapeutic Approaches (First Edition) 199 217 .
Emmanuel Ayodeji Ayeni, Yuzhou Gong, Hao Yuan, Yikao Hu, Xiaolin Bai & Xun Liao. (2022) Medicinal Plants for Anti-neurodegenerative diseases in West Africa. Journal of Ethnopharmacology 285, pages 114468.
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Shuxin Li, Hongmin Zhang, Jing Chang, Dongming Li & Pengxiu Cao. (2021) Iron overload and mitochondrial dysfunction orchestrate pulmonary fibrosis. European Journal of Pharmacology 912, pages 174613.
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Swee Ching Tan, Subrat Kumar Bhattamisra, Dinesh Kumar Chellappan & Mayuren Candasamy. (2021) Actions and Therapeutic Potential of Madecassoside and Other Major Constituents of Centella asiatica: A Review. Applied Sciences 11:18, pages 8475.
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Jia Hui Wong, Anna M. Barron & Jafri Malin Abdullah. (2021) Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease. Frontiers in Pharmacology 12.
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Rengasamy Balakrishnan, Shofiul Azam, Duk-Yeon Cho, In Su-Kim & Dong-Kug Choi. (2021) Natural Phytochemicals as Novel Therapeutic Strategies to Prevent and Treat Parkinson’s Disease: Current Knowledge and Future Perspectives. Oxidative Medicine and Cellular Longevity 2021, pages 1-32.
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Cheng-Wei Lu, Tzu-Yu Lin, Tai-Long Pan, Pei-Wen Wang, Kuan-Ming Chiu, Ming-Yi Lee & Su-Jane Wang. (2021) Asiatic Acid Prevents Cognitive Deficits by Inhibiting Calpain Activation and Preserving Synaptic and Mitochondrial Function in Rats with Kainic Acid-Induced Seizure. Biomedicines 9:3, pages 284.
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Rui F. Simões, Rafaela Ferrão, Margarida R. Silva, Sonia L.C. Pinho, Lino Ferreira, Paulo J. Oliveira & Teresa Cunha-Oliveira. (2021) Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research. Food and Chemical Toxicology 149, pages 111967.
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Wei-Yi Hu, Xiao Xia Li, Yun Fei Diao, Jia-Jia Qi, Da-Li Wang, Jia-Bao Zhang, Bo-Xing Sun & Shuang Liang. (2020) Asiatic acid protects oocytes against in vitro aging-induced deterioration and improves subsequent embryonic development in pigs. Aging 13:3, pages 3353-3367.
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Prasad Arvind Thakurdesai. 2021. Nutraceuticals in Brain Health and Beyond. Nutraceuticals in Brain Health and Beyond 307 328 .
Farshad Abedi Torbati, Mahin Ramezani, Reza Dehghan, Mohammad Sadegh Amiri, Ali Tafazoli Moghadam, Neda Shakour, Sepideh Elyasi, Amirhossein Sahebkar & Seyed Ahmad Emami. 2021. Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health. Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health 451 499 .
Boju Sun, Lili Wu, You Wu, Chengfei Zhang, Lingling Qin, Misa Hayashi, Maya Kudo, Ming Gao & Tonghua Liu. (2020) Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review. Frontiers in Pharmacology 11.
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Muhammad T. Islam, Eunus S. Ali, Shaikh J. Uddin, Ishaq N. Khan, Manik C. Shill, João M. de Castro e Sousa, Marcus V.O. Barros de Alencar, Ana A.C. Melo-Cavalcante & Mohammad S. Mubarak. (2020) Anti-Cancer Effects of Asiatic Acid, a Triterpene from Centilla asiatica L: A Review. Anti-Cancer Agents in Medicinal Chemistry 20:5, pages 536-547.
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Mehdi Sharifi-Rad, Chintha Lankatillake, Daniel A. Dias, Anca Oana Docea, Mohamad Fawzi Mahomoodally, Devina Lobine, Paul L. Chazot, Begum Kurt, Tugba Boyunegmez Tumer, Ana Catarina Moreira, Farukh Sharopov, Miquel Martorell, Natália Martins, William C. Cho, Daniela Calina & Javad Sharifi-Rad. (2020) Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics. Journal of Clinical Medicine 9:4, pages 1061.
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Han Deng, Yi Jia, Dong Pan & ZeGang Ma. (2020) Berberine alleviates rotenone-induced cytotoxicity by antioxidation and activation of PI3K/Akt signaling pathway in SH-SY5Y cells. NeuroReport 31:1, pages 41-47.
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Kkot Byeol Kim, Seonah Lee & Jung Hee Kim. (2020) Neuroprotective effects of urolithin A on H 2 O 2 -induced oxidative stress-mediated apoptosis in SK-N-MC cells . Nutrition Research and Practice 14:1, pages 3.
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Xin Jiang, Pei-Chen Tang, Qin Chen, Xin Zhang, Yi-Yun Fan, Bo-Cheng Yu, Xin-Xia Gu, Ying Sun, Xiao-Qun Ge & Xiao-Ling Zhang. (2019) Cordycepin Exerts Neuroprotective Effects via an Anti-Apoptotic Mechanism based on the Mitochondrial Pathway in a Rotenone-Induced Parkinsonism Rat Model. CNS & Neurological Disorders - Drug Targets 18:8, pages 609-620.
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Dong Chen, Xiao-Ya Zhang, Jing Sun, Qi-Jie Cong, Wei-Xiong Chen, Hafiz Muhammad Ahsan, Jing Gao & Jin-Jun Qian. (2019) Asiatic Acid Protects Dopaminergic Neurons from Neuroinflammation by Suppressing Mitochondrial ROS Production. Biomolecules & Therapeutics 27:5, pages 442-449.
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Marcin Kruszewski, Katarzyna Sikorska, Sylwia Meczynska-Wielgosz, Agnieszka Grzelak, Monika Sramkova, Alena Gabelova & Lucyna Kapka-Skrzypczak. (2019) Comet assay in neural cells as a tool to monitor DNA damage induced by chemical or physical factors relevant to environmental and occupational exposure. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 845, pages 402990.
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Fiona Limanaqi, Francesca Biagioni, Carla Letizia Busceti, Larisa Ryskalin, Maico Polzella, Alessandro Frati & Francesco Fornai. (2019) Phytochemicals Bridging Autophagy Induction and Alpha-Synuclein Degradation in Parkinsonism. International Journal of Molecular Sciences 20:13, pages 3274.
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Venkatesan Manigandan, Jagatheesan Nataraj, Ramachandran Karthik, Thamilarasan Manivasagam, Ramachandran Saravanan, Arokyasamy Justin Thenmozhi, Musthafa Mohamed Essa & Gilles J. Guillemin. (2018) Low Molecular Weight Sulfated Chitosan: Neuroprotective Effect on Rotenone-Induced In Vitro Parkinson’s Disease. Neurotoxicity Research 35:3, pages 505-515.
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Afolabi C. Akinmoladun, Comfort Odunayo Oladejo, Sunday Solomon Josiah, Courage Dele Famusiwa, Olubukola Benedicta Ojo & M. Tolulope Olaleye. (2018) Catechin, quercetin and taxifolin improve redox and biochemical imbalances in rotenone-induced hepatocellular dysfunction: Relevance for therapy in pesticide-induced liver toxicity?. Pathophysiology 25:4, pages 365-371.
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Kkot Kim, SeonAh Lee, Inhae Kang & Jung-Hee Kim. (2018) Momordica charantia Ethanol Extract Attenuates H2O2-Induced Cell Death by Its Antioxidant and Anti-Apoptotic Properties in Human Neuroblastoma SK-N-MC Cells. Nutrients 10:10, pages 1368.
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Mohamed Fizur Nagoor Meeran, Sameer N. Goyal, Kapil Suchal, Charu Sharma, Chandragouda R. Patil & Shreesh K. Ojha. (2018) Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise. Frontiers in Pharmacology 9.
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Wanjing Huang, Fengjuan Gao, Fangyuan Hu, Jiancheng Huang, Min Wang, Ping Xu, Rong Zhang, Junyi Chen, Xinghuai Sun, Shenghai Zhang & Jihong Wu. (2018) Asiatic Acid Prevents Retinal Ganglion Cell Apoptosis in a Rat Model of Glaucoma. Frontiers in Neuroscience 12.
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Narudol Teerapattarakan, Hattaya Benya-aphikul, Rossarin Tansawat, Oraphan Wanakhachornkrai, Mayuree H. Tantisira & Ratchanee Rodsiri. (2018) Neuroprotective effect of a standardized extract of Centella asiatica ECa233 in rotenone-induced parkinsonism rats. Phytomedicine 44, pages 65-73.
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Huan-Cheng Wu, Qun-Liang Hu, Shi-Jun Zhang, Yan-Min Wang, Zhan-Kui Jin, Ling-Fu Lv, Sai Zhang, Zhen-Lin Liu, Hong-Lian Wu & Ou-Mei Cheng. (2018) Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant α-synuclein. Neural Regeneration Research 13:8, pages 1375.
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Ji-Hyun Park, Young Ho Seo, Jung-Hee Jang, Chul-Ho Jeong, Sooyeun Lee & Byoungduck Park. (2017) Asiatic acid attenuates methamphetamine-induced neuroinflammation and neurotoxicity through blocking of NF-kB/STAT3/ERK and mitochondria-mediated apoptosis pathway. Journal of Neuroinflammation 14:1.
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Francesca Pistollato, David Canovas-Jorda, Dimitra Zagoura & Anna Bal-Price. (2017) Nrf2 pathway activation upon rotenone treatment in human iPSC-derived neural stem cells undergoing differentiation towards neurons and astrocytes. Neurochemistry International 108, pages 457-471.
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Saurabh Kumar Jha, Niraj Kumar Jha, Dhiraj Kumar, Rashmi K. Ambasta & Pravir Kumar. (2017) Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863:5, pages 1132-1146.
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Jagatheesan Nataraj, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi & Musthafa Mohamed Essa. (2017) Neurotrophic Effect of Asiatic acid, a Triterpene of Centella asiatica Against Chronic 1-Methyl 4-Phenyl 1, 2, 3, 6-Tetrahydropyridine Hydrochloride/Probenecid Mouse Model of Parkinson’s disease: The Role of MAPK, PI3K-Akt-GSK3β and mTOR Signalling Pathways. Neurochemical Research 42:5, pages 1354-1365.
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Lin Chen, Li Cheng, Xinbing Wei, Zheng Yuan, Yanmei Wu, Shuaishuai Wang, Zhiping Ren, Xinyong Liu & Huiqing Liu. (2016) Tetramethylpyrazine Analogue CXC195 Protects Against Dopaminergic Neuronal Apoptosis via Activation of PI3K/Akt/GSK3β Signaling Pathway in 6-OHDA-Induced Parkinson’s Disease Mice. Neurochemical Research 42:4, pages 1141-1150.
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M. D. Pandareesh, M. K. Shrivash, H. N. Naveen Kumar, K. Misra & M. M. Srinivas Bharath. (2016) Curcumin Monoglucoside Shows Improved Bioavailability and Mitigates Rotenone Induced Neurotoxicity in Cell and Drosophila Models of Parkinson’s Disease. Neurochemical Research 41:11, pages 3113-3128.
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