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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 23, 2020 - Issue 4
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Articles

Palmitic acid triggers inflammatory responses in N42 cultured hypothalamic cells partially via ceramide synthesis but not via TLR4

Domenico SergiRowett Institute, University of Aberdeen, Foresterhill, AberdeenAB25 2ZD, UKCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3001-410X
ORCID Icon,
Amanda C. MorrisRowett Institute, University of Aberdeen, Foresterhill, AberdeenAB25 2ZD, UK
,
Darcy E. KahnRowett Institute, University of Aberdeen, Foresterhill, AberdeenAB25 2ZD, UK
,
Fiona H. McLeanRowett Institute, University of Aberdeen, Foresterhill, AberdeenAB25 2ZD, UKORCID Iconhttps://orcid.org/0000-0002-3058-1227
ORCID Icon,
Elizabeth A. HayInstitute of Medical Sciences, University of Aberdeen, Foresterhill, AberdeenAB25 2ZD, UK
,
Phil KubitzRowett Institute, University of Aberdeen, Foresterhill, AberdeenAB25 2ZD, UKORCID Iconhttps://orcid.org/0000-0002-5843-9759
ORCID Icon,
Alasdair MacKenzieInstitute of Medical Sciences, University of Aberdeen, Foresterhill, AberdeenAB25 2ZD, UK
,
Maria G. MartinoliCellular Neurobiology Group, Université du Québec, Trois-Rivières, Québec, G9A 5H7Canada
,
Janice E. DrewRowett Institute, University of Aberdeen, Foresterhill, AberdeenAB25 2ZD, UK
&
Lynda M. WilliamsRowett Institute, University of Aberdeen, Foresterhill, AberdeenAB25 2ZD, UK
 show all
Pages 321-334 | Published online: 21 Jul 2018

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Jesús Fernández-Felipe, Maria Valencia-Avezuela, Beatriz Merino, Beatriz Somoza, Victoria Cano, Ana B. Sanz-Martos, Laura M. Frago, Maria S. Fernández-Alfonso, Mariano Ruiz-Gayo & Julie A. Chowen. (2023) Effects of saturated versus unsaturated fatty acids on metabolism, gliosis, and hypothalamic leptin sensitivity in male mice. Nutritional Neuroscience 26:2, pages 173-186.
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Articles from other publishers (44)

Philipp Hammerschmidt, Sophie M. Steculorum, Cécile L. Bandet, Almudena Del Río-Martín, Lukas Steuernagel, Vivien Kohlhaas, Marvin Feldmann, Luis Varela, Adam Majcher, Marta Quatorze Correia, Rhena F. U. Klar, Corinna A. Bauder, Ecem Kaya, Marta Porniece, Nasim Biglari, Anna Sieben, Tamas L. Horvath, Thorsten Hornemann, Susanne Brodesser & Jens C. Brüning. (2023) CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice. Nature Communications 14:1.
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Annika Döding, Svenja Zimmermann, Ahmed Maghames, Michael Reimann, Judit Symmank, Maria Thürmer, Markus H. Gräler, Michael Wolf, Collin Jacobs, Andreas Koeberle, Bernd Sigusch & Ulrike Schulze-Späte. (2023) Immunometabolic capacities of nutritional fatty acids in regulation of inflammatory bone cell interaction and systemic impact of periodontal infection. Frontiers in Immunology 14.
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Michael J. Butler, Sabrina E. Mackey-Alfonso, Nashali Massa, Kedryn K. Baskin & Ruth M. Barrientos. (2023) Dietary fatty acids differentially impact phagocytosis, inflammatory gene expression, and mitochondrial respiration in microglial and neuronal cell models. Frontiers in Cellular Neuroscience 17.
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Domenico Sergi, Juana Maria Sanz, Stefano Lazzer, Gloria Brombo, Giovanni Zuliani, Gianni Biolo, Boštjan Šimunič, Rado Pišot, Edoardo Dalla Nora & Angelina Passaro. (2023) Interleukin-18 Is a Potential Biomarker Linking Dietary Fatty Acid Quality and Insulin Resistance: Results from a Cross-Sectional Study in Northern Italy. Nutrients 15:7, pages 1782.
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Stephanie M. Muscat, Michael J. Butler, Sabrina E. Mackey-Alfonso & Ruth M. Barrientos. (2023) Young adult and aged female rats are vulnerable to amygdala-dependent, but not hippocampus-dependent, memory impairment following short-term high-fat diet. Brain Research Bulletin 195, pages 145-156.
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Camilla P. Dias-Rocha, Julia C. B. Costa, Yamara S. Oliveira, Larissa B. Fassarella, Juliana Woyames, Georgia C. Atella, Gustavo R. C. Santos, Henrique M. G. Pereira, Carmen C. Pazos-Moura, Mariana M. Almeida & Isis H. Trevenzoli. (2023) Maternal high-fat diet decreases milk endocannabinoids with sex-specific changes in the cannabinoid and dopamine signaling and food preference in rat offspring. Frontiers in Endocrinology 14.
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Domenico Sergi, Enrico Zauli, Veronica Tisato, Paola Secchiero, Giorgio Zauli & Carlo Cervellati. (2023) Lipids at the Nexus between Cerebrovascular Disease and Vascular Dementia: The Impact of HDL-Cholesterol and Ceramides. International Journal of Molecular Sciences 24:5, pages 4403.
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Lucio Della Guardia & Roberto Codella. (2023) Exercise Restores Hypothalamic Health in Obesity by Reshaping the Inflammatory Network. Antioxidants 12:2, pages 297.
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Karina Sánchez‐Alegría & Clorinda Arias. (2022) Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage. Endocrinology, Diabetes & Metabolism 6:1.
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Philipp Hammerschmidt & Jens C. Brüning. (2022) Contribution of specific ceramides to obesity-associated metabolic diseases. Cellular and Molecular Life Sciences 79:8.
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Katarzyna Lipke, Adriana Kubis-Kubiak & Agnieszka Piwowar. (2022) Molecular Mechanism of Lipotoxicity as an Interesting Aspect in the Development of Pathological States—Current View of Knowledge. Cells 11:5, pages 844.
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Hu Zhang, Chao Zhao, Qiwei Liu, Ying Zhang, Kai Luo, Yuepu Pu & Lihong Yin. (2022) Dysregulation of fatty acid metabolism associated with esophageal inflammation of ICR mice induced by nitrosamines exposure. Environmental Pollution 297, pages 118680.
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Diego Julián Vesga-Jiménez, Cynthia Martin, George E. Barreto, Andrés Felipe Aristizábal-Pachón, Andrés Pinzón & Janneth González. (2022) Fatty Acids: An Insight into the Pathogenesis of Neurodegenerative Diseases and Therapeutic Potential. International Journal of Molecular Sciences 23:5, pages 2577.
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Guochao Chen, Wanqiao Zhang, Lingbo Kong, Chengxiang Wang, Xiaojing Lai, Xue Yu, Yuying Guo, Jun Wu & Qun Ma. (2022) Qiguiyin Decoction Improves Multidrug-Resistant Pseudomonas aeruginosa Infection in Rats by Regulating Inflammatory Cytokines and the TLR4/MyD88/NF-κB Signaling Pathway. BioMed Research International 2022, pages 1-11.
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Anup Bhusal, Md Habibur Rahman & Kyoungho Suk. (2021) Hypothalamic inflammation in metabolic disorders and aging. Cellular and Molecular Life Sciences 79:1.
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Calvin V. Lieu, Neruja Loganathan & Denise D. Belsham. (2021) Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the Hypothalamus. Cells 10:11, pages 3120.
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Christophe Magnan & Hervé Le Stunff. (2021) Role of hypothalamic de novo ceramides synthesis in obesity and associated metabolic disorders. Molecular Metabolism 53, pages 101298.
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Lili Sun, Hongmei Jia, Meng Yu, Yong Yang, Jiaojiao Li, Dong Tian, Hongwu Zhang & Zhongmei Zou. (2021) Salvia miltiorrhiza and Pueraria lobata, two eminent herbs in Xin-Ke-Shu, ameliorate myocardial ischemia partially by modulating the accumulation of free fatty acids in rats. Phytomedicine 89, pages 153620.
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Judit Symmank, Sophie Appel, Jana Asisa Bastian, Isabel Knaup, Jana Marciniak, Christoph-Ludwig Hennig, Annika Döding, Ulrike Schulze-Späte, Collin Jacobs & Michael Wolf. (2021) Hyperlipidemic Conditions Impact Force-Induced Inflammatory Response of Human Periodontal Ligament Fibroblasts Concomitantly Challenged with P. gingivalis-LPS. International Journal of Molecular Sciences 22:11, pages 6069.
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Domenico Sergi, Natalie Luscombe-Marsh, Nenad Naumovski, Mahinda Abeywardena & Nathan O'Callaghan. (2021) Palmitic Acid, but Not Lauric Acid, Induces Metabolic Inflammation, Mitochondrial Fragmentation, and a Drop in Mitochondrial Membrane Potential in Human Primary Myotubes. Frontiers in Nutrition 8.
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Valentina Ponzo, Marianna Pellegrini, Chiara D’Eusebio, Fabio Bioletto, Ilaria Goitre, Silvio Buscemi, Simone Frea, Ezio Ghigo & Simona Bo. (2021) Mediterranean Diet and SARS-COV-2 Infection: Is There Any Association? A Proof-of-Concept Study. Nutrients 13:5, pages 1721.
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Andressa Reginato, Alana Carolina Costa Veras, Mayara da Nóbrega Baqueiro, Carolina Panzarin, Beatriz Piatezzi Siqueira, Marciane Milanski, Patrícia Cristina Lisboa & Adriana Souza Torsoni. (2021) The Role of Fatty Acids in Ceramide Pathways and Their Influence on Hypothalamic Regulation of Energy Balance: A Systematic Review. International Journal of Molecular Sciences 22:10, pages 5357.
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Ping Lu, Hua-Juan Yan, Cui Yang, Wen-Cai Feng, Fei Hu, Yue-Ying Wu, Wei-Wen Sun, Mei-Mei Gao & Yue-Sheng Long. (2021) High fat suppresses SOD1 activity by reducing copper chaperone for SOD1 associated with neurodegeneration and memory decline. Life Sciences 272, pages 119243.
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Domenico Sergi, Natalie Luscombe-Marsh, Leonie K Heilbronn, Mark Birch-Machin, Nenad Naumovski, Lilla’ Lionetti, Christopher G Proud, Mahinda Y Abeywardena & Nathan O'Callaghan. (2021) The Inhibition of Metabolic Inflammation by EPA Is Associated with Enhanced Mitochondrial Fusion and Insulin Signaling in Human Primary Myotubes. The Journal of Nutrition 151:4, pages 810-819.
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Jimmy Beaulieu, Giulia Costa, Justine Renaud, Amélie Moitié, Hélène Glémet, Domenico Sergi & Maria-Grazia Martinoli. (2021) The Neuroinflammatory and Neurotoxic Potential of Palmitic Acid Is Mitigated by Oleic Acid in Microglial Cells and Microglial-Neuronal Co-cultures. Molecular Neurobiology.
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Andy Tran, Jim T. C. Chen & Denise D. Belsham. 2021. Glial-Neuronal Signaling in Neuroendocrine Systems. Glial-Neuronal Signaling in Neuroendocrine Systems 155 180 .
Manuel L. Montero, Jo‐Wen Liu, José Orozco, Carlos A. Casiano & Marino De Leon. (2020) Docosahexaenoic acid protection against palmitic acid‐induced lipotoxicity in NGF‐differentiated PC12 cells involves enhancement of autophagy and inhibition of apoptosis and necroptosis. Journal of Neurochemistry 155:5, pages 559-576.
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Amanda M Rampersaud, Caroline E Dunk, Stephen J Lye & Stephen J Renaud. (2020) Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1. Molecular Human Reproduction 26:11, pages 850-865.
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Bianca C. Field, Ruth Gordillo & Philipp E. Scherer. (2020) The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines. Frontiers in Endocrinology 11.
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Andressa Reginato, Beatriz Piatezzi Siqueira, Josiane Érica Miyamoto, Mariana Portovedo, Suleyma de Oliveira Costa, Thaís Fante, Hosana Gomes Rodrigues, Letícia Martins Ignácio‐Souza, Márcio Alberto Torsoni, Adriana Souza Torsoni, Hervé Le Stunff, Denise D. Belsham & Marciane Milanski. (2020) Acute effects of fatty acids on autophagy in NPY neurones. Journal of Neuroendocrinology 32:10.
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Michael J. Butler, Rachel M. Cole, Nicholas P. Deems, Martha A. Belury & Ruth M. Barrientos. (2020) Fatty food, fatty acids, and microglial priming in the adult and aged hippocampus and amygdala. Brain, Behavior, and Immunity 89, pages 145-158.
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Dejiang Pang, Chengcheng Yang, Qihui Luo, Chao Li, Wentao Liu, Lixia Li, Yuanfeng Zou, Bin Feng, Zhengli Chen & Chao Huang. (2020) Soy isoflavones improve the oxidative stress induced hypothalamic inflammation and apoptosis in high fat diet-induced obese male mice through PGC1-alpha pathway. Aging 12:9, pages 8710-8727.
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Arwa Alnahdi, Annie John & Haider Raza. (2019) N-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells. PLOS ONE 14:12, pages e0226696.
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Fiona H. McLean, Fiona M. Campbell, Domenico Sergi, Christine Grant, Amanda C. Morris, Elizabeth A. Hay, Alasdair MacKenzie, Claus D. Mayer, Rosamund F. Langston & Lynda M. Williams. (2019) Early and reversible changes to the hippocampal proteome in mice on a high-fat diet. Nutrition & Metabolism 16:1.
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Fiona H. McLean, Fiona M. Campbell, Rosamund F. Langston, Domenico Sergi, Cibell Resch, Christine Grant, Amanda C. Morris, Claus D. Mayer & Lynda M. Williams. (2019) A high-fat diet induces rapid changes in the mouse hypothalamic proteome. Nutrition & Metabolism 16:1.
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Domenico Sergi, Justine Renaud, Nicola Simola & Maria-Grazia Martinoli. (2019) Diabetes, a Contemporary Risk for Parkinson’s Disease: Epidemiological and Cellular Evidences. Frontiers in Aging Neuroscience 11.
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Domenico Sergi & Lynda M Williams. (2019) Potential relationship between dietary long-chain saturated fatty acids and hypothalamic dysfunction in obesity. Nutrition Reviews.
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Manuel Flores-León, Martha Pérez-Domínguez, Rodrigo González-Barrios & Clorinda Arias. (2019) Palmitic Acid-Induced NAD+ Depletion is Associated with the Reduced Function of SIRT1 and Increased Expression of BACE1 in Hippocampal Neurons. Neurochemical Research 44:7, pages 1745-1754.
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Domenico Sergi, Nenad Naumovski, Leonie Kaye Heilbronn, Mahinda Abeywardena, Nathan O’Callaghan, Lillà Lionetti & Natalie Luscombe-Marsh. (2019) Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet. Frontiers in Physiology 10.
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Jichang Seong, Jung Yun Kang, Ji Su Sun & Ki Woo Kim. (2019) Hypothalamic inflammation and obesity: a mechanistic review. Archives of Pharmacal Research 42:5, pages 383-392.
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Małgorzata Żendzian-Piotrowska, Bartłomiej Łukaszuk, Mateusz Maciejczyk, Lucyna Ostrowska, Anna Zalewska, Adrian Chabowski & Krzysztof Kurek. (2019) High-fat, high-protein, and high-carbohydrate diets affect sphingolipid profile in pancreatic steatosis in Wistar rats. Nutrition 60, pages 197-205.
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