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Original Articles

Antitumor activity of two gelsemine metabolites in rat liver microsomes

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Pages 731-739 | Received 18 Jan 2010, Accepted 11 May 2010, Published online: 13 Sep 2010

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Lin Zhang, Lan Du, Wen-Wen Lv, Qing-Chun Zhao, Wei Hua, Ye An, Tao Guo & Li-Jun Wu. (2013) Four new koumine metabolites in rat liver microsomes. Journal of Asian Natural Products Research 15:1, pages 46-52.
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Articles from other publishers (21)

Jiangyu Long, Mohuan Tang, Mengting Zuo, Wenbo Xu, Siyu Meng & Zhaoying Liu. (2023) The antianxiety effects of koumine and gelsemine, two main active components in the traditional Chinese herbal medicine Gelsemium : A comprehensive review . Brain‐X 1:4.
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Pan‐Pan Zhang, Jia‐Jun Liang, Qing‐Yu Lu, Xin Yin, Yong‐Qiang Zhou, Ting‐Ting Feng, Ying Zhou, Dong Chang & Xin Wei. (2023) New Monoterpenoid Indole Hybrids from Gelsemium elegans with Anti‐Inflammatory and Osteoclast Inhibitory Activities . Chemistry & Biodiversity.
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Lingjun Yang, Gang Zhou, Junming Chen & Sainan Zhang. (2023) Gelsemine relieves the neuropathic pain by down-regulating DPP4 level in rats. Neuroscience Letters 792, pages 136961.
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Guoquan You, Ruopeng Yang, Yingjie Wei, Wanyu Hu, Lili Gan, Cong Xie, Zhijie Zheng, Zhongqiu Liu, Rongxin Liao & Ling Ye. (2021) The detoxification effect of cytochrome P450 3A4 on gelsemine-induced toxicity. Toxicology Letters 353, pages 34-42.
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Hailing Lin, Hongqiang Qiu, Yu Cheng, Maobai Liu, Maohua Chen, Youxiong Que & Wancai Que. (2021) Gelsemium elegans Benth: Chemical Components, Pharmacological Effects, and Toxicity Mechanisms. Molecules 26:23, pages 7145.
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Pengfei Jin, Guanqun Zhan, Guijuan Zheng, Junjun Liu, Xiang Peng, Lang Huang, Biao Gao, Xinghua Yuan & Guangmin Yao. (2021) Gelstriamine A, a Triamino Monoterpene Indole Alkaloid with a Caged 6/5/7/6/6/5 Scaffold and Analgesic Alkaloids from Gelsemium elegans Stems . Journal of Natural Products 84:4, pages 1326-1334.
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Liping Chen, Hanbo Pan, Yujing Bai, Huiqin Li, Wen Yang, Zhi-Xiu Lin, Wei Cui & Yan-Fang Xian. (2020) Gelsemine, a natural alkaloid extracted from Gelsemium elegans Benth. alleviates neuroinflammation and cognitive impairments in Aβ oligomer-treated mice. Psychopharmacology 237:7, pages 2111-2124.
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Zi-Yuan Wang, Meng-Ting Zuo & Zhao-Ying Liu. (2019) The Metabolism and Disposition of Koumine, Gelsemine and Humantenmine from Gelsemium. Current Drug Metabolism 20:7, pages 583-591.
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Sha-Sha Liu, Kun Yang, Zhi-Liang Sun, Xiaofeng Zheng, Xia Bai & Zhao-Ying Liu. (2019) A novel two-dimensional liquid chromatography system for the simultaneous determination of three monoterpene indole alkaloids in biological matrices. Analytical and Bioanalytical Chemistry 411:17, pages 3857-3870.
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Daniele Nascimento Gouveia, Adriana Gibara Guimarães, Wagner Barbosa da Rocha Santos & Lucindo José Quintans-Júnior. (2019) Natural products as a perspective for cancer pain management: A systematic review. Phytomedicine 58, pages 152766.
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Lin Wang, Yanqing Wen & Fanhao Meng. (2018) Simultaneous determination of gelsemine and koumine in rat plasma by UPLC‐MS/MS and application to pharmacokinetic study after oral administration of Gelsemium elegans Benth extract . Biomedical Chromatography 32:6.
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Kun Yang, Ya-Jun Huang, Sa Xiao, Yan-Chun Liu, Zhi-Liang Sun, Yi-Song Liu, Qi Tang & Zhao-Ying Liu. (2018) Identification of gelsemine metabolites in rat liver S9 by high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry 32:1, pages 19-22.
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Cesar O Lara, Pablo Murath, Braulio Muñoz, Ana M Marileo, Loreto San Martín, Victoria P San Martín, Carlos F Burgos, Trinidad A Mariqueo, Luis G Aguayo, Jorge Fuentealba, Patricio Godoy, Leonardo Guzman & Gonzalo E Yévenes. (2016) Functional modulation of glycine receptors by the alkaloid gelsemine. British Journal of Pharmacology 173:14, pages 2263-2277.
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Stefan Diethelm & Erick M. Carreira. (2015) Total Synthesis of Gelsemoxonine through a Spirocyclopropane Isoxazolidine Ring Contraction. Journal of the American Chemical Society 137:18, pages 6084-6096.
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Lin Lin, Jing Zheng, Weiping Zhu & Ning Jia. (2014) Nephroprotective Effect of Gelsemine Against Cisplatin-Induced Toxicity is Mediated Via Attenuation of Oxidative Stress. Cell Biochemistry and Biophysics 71:2, pages 535-541.
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Shuangshuang Zhang, Shuping Hu, Xiangxiang Yang, Jiaqi Shen, Xiaoyong Zheng, Kexin Huang & Zheng Xiang. (2015) Development of a liquid chromatography with mass spectrometry method for the determination of gelsemine in rat plasma and tissue: Application to a pharmacokinetic and tissue distribution study. Journal of Separation Science 38:6, pages 936-942.
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Marta Marzotto, Debora Olioso, Maurizio Brizzi, Paola Tononi, Mirco Cristofoletti & Paolo Bellavite. (2014) Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-low doses of Gelsemium sempervirens. BMC Complementary and Alternative Medicine 14:1.
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Chada Raji Reddy, Paridala Kumaraswamy & Kiran K. Singarapu. (2014) Sequential Allylic Substitution/Pauson–Khand Reaction: A Strategy to Bicyclic Fused Cyclopentenones from MBH-Acetates of Acetylenic Aldehydes. The Journal of Organic Chemistry 79:17, pages 7880-7888.
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Gui-Lin Jin, Yan-Ping Su, Ming Liu, Ying Xu, Jian Yang, Kai-Jun Liao & Chang-Xi Yu. (2014) Medicinal plants of the genus Gelsemium (Gelsemiaceae, Gentianales)—A review of their phytochemistry, pharmacology, toxicology and traditional use. Journal of Ethnopharmacology 152:1, pages 33-52.
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Paolo Bellavite, Marta Marzotto, Debora Olioso, Elisabetta Moratti & Anita Conforti. (2014) High-dilution effects revisited. 2. Pharmacodynamic mechanisms. Homeopathy 103:1, pages 22-43.
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Shuang Liang, Chun-Yong He, László F. Szabó, Yi Feng, Xiao Lin & Yuan Wang. (2013) Gelsochalotine, a novel indole ring-degraded monoterpenoid indole alkaloid from Gelsemium elegans. Tetrahedron Letters 54:8, pages 887-890.
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