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Original Articles

Matrine inhibits matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells

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Pages 242-250 | Received 19 Sep 2010, Accepted 28 Dec 2010, Published online: 15 Mar 2011

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Yingda Lin, Fuming He, Ling Wu, Yuan Xu & Qiu Du. (2022) Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review. Drug Design, Development and Therapy 16, pages 533-569.
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Lingdi Ma, Zhichao Zhu, Lijia Jiang, Xiao Sun, Xuzhang Lu, Min Zhou, Sixuan Qian & Li Jianyong. (2015) Matrine suppresses cell growth of human chronic myeloid leukemia cells via its inhibition of the interleukin-6/Janus activated kinase/signal transducer and activator of transcription 3 signaling cohort. Leukemia & Lymphoma 56:10, pages 2923-2930.
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Articles from other publishers (33)

Chueh-Tan Chen, Chian-Feng Chen, Tung-Yi Lin, Wei-Jyun Hua, Kate Hua, Ching-Yao Tsai & Chung-Hua Hsu. (2023) Traditional Chinese medicine Kuan-Sin-Yin decoction inhibits cell mobility via downregulation of CCL2, CEACAM1 and PIK3R3 in hepatocellular carcinoma cells. Journal of Ethnopharmacology 317, pages 116834.
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Yaser E. Alqurashi, Hussein Riyadh Abdul Kareem Al-Hetty, Pushpamala Ramaiah, Alaa Hameed Fazaa, Abduladheem Turki Jalil, Fahad Alsaikhan, Jitendra Gupta, Andrés Alexis Ramírez-Coronel, Nahla A. Tayyib & Hu Peng. (2023) Harnessing function of EMT in hepatocellular carcinoma: From biological view to nanotechnological standpoint. Environmental Research 227, pages 115683.
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Yang Yang, Yu Lu, Tianduo Pei, Bao Guo, Jingquan Li, Hui Wang & Qian Ba. (2022) Compound kushen injection in cancer treatments: Efficacy, active ingredients, and mechanisms. Pharmacological Research - Modern Chinese Medicine 3, pages 100108.
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Guanglei Wang, Chengyu Ji, Chunling Wang, Zhonghui Liu, Aizhong Qu & Huaixin Wang. (2021) Matrine ameliorates the inflammatory response and lipid metabolism in vascular smooth muscle cells through the NF‑κB pathway. Experimental and Therapeutic Medicine 22:5.
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Fatma Tugce Guragac Dereli, Ali Guragac & Tarun Belwal. 2021. Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases. Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases 1 15 .
Amin Thawabteh, Salma Juma, Mariam Bader, Donia Karaman, Laura Scrano, Sabino Bufo & Rafik Karaman. (2019) The Biological Activity of Natural Alkaloids against Herbivores, Cancerous Cells and Pathogens. Toxins 11:11, pages 656.
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Shaza H. Aly, Ahmed M. Elissawy, Omayma A. Eldahshan, Mohamed A. Elshanawany, Thomas Efferth & Abdel Nasser B. Singab. (2019) The pharmacology of the genus Sophora (Fabaceae): An updated review. Phytomedicine 64, pages 153070.
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Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin & Jin Ye. (2019) Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells. Molecular Medicine Reports.
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Valentina Laghezza Masci, Stefano Bernardini, Lorenzo Modesti, Elisa Ovidi & Antonio Tiezzi. 2019. Medically Important Plant Biomes: Source of Secondary Metabolites. Medically Important Plant Biomes: Source of Secondary Metabolites 85 113 .
Priya Katyal & Shivani Sharma. 2019. Bioactive Natural Products for the Management of Cancer: from Bench to Bedside. Bioactive Natural Products for the Management of Cancer: from Bench to Bedside 37 60 .
Mingguang Zhou, Guojin Zhou, SunHong Hu & Lei Zhang. (2018) Tanshinone IIA suppress the proliferation of HNE-1 nasopharyngeal carcinoma an in vitro study. Saudi Journal of Biological Sciences 25:2, pages 267-272.
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Ruoming Fang, Renyi Wu, Qian Zuo, Ran Yin, Chengyue Zhang, Chao Wang, Yue Guo, Anne Yuqing Yang, Wenji Li, Lizhu Lin & Ah-Ng Kong. (2018) Sophora flavescens Containing-QYJD Formula Activates Nrf2 Anti-Oxidant Response, Blocks Cellular Transformation and Protects Against DSS-Induced Colitis in Mouse Model . The American Journal of Chinese Medicine 46:07, pages 1609-1623.
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Kyung-Hun Park, Jin-A Oh, Min-Kyoung Paik, Mi-Yeon Son, Jeongtaek Im & Sang-Gyun Han. (2017) Evaluation of Daphnia Magna Acute Toxicity and Preliminary Risk Assessment for Plant Extracts of Sophora, Neem and Derris. The Korean Journal of Pesticide Science 21:2, pages 107-113.
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Bing Hu, Hong-Mei An, Shuang-Shuang Wang, Jin-Jun Chen & Ling Xu. (2016) Preventive and Therapeutic Effects of Chinese Herbal Compounds against Hepatocellular Carcinoma. Molecules 21:2, pages 142.
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Jia-hong Wang, Wei Wei, Zhi-xing Guo, Ming Shi & Rong-ping Guo. (2015) Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma. Journal of Translational Medicine 13:1.
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Guan-Li Zhang, Ling Jiang, Qian Yan, Rong-Hui Liu & Lu Zhang. (2015) Anti-tumor effect of matrine combined with cisplatin on rat models of cervical cancer. Asian Pacific Journal of Tropical Medicine 8:12, pages 1055-1059.
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Kyung-Hun Park, Jin-A Oh, Min-Kyoung Paik, Mi-Yeon Son, Joung-Taek Lim, Jung-hwa Jin, Soonsung Hong, Nam-jun Cho, Sang-Gyun Han & Byung-Seok Kim. (2015) Evaluation of Fish Acute Toxicity and Preliminary Risk Assessment of Plant Extracts, Sophora, Neem and Derris. The Korean Journal of Pesticide Science 19:3, pages 255-263.
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BIN SUN & MIN XU. (2015) Matrine inhibits the migratory and invasive properties of nasopharyngeal carcinoma cells. Molecular Medicine Reports 11:6, pages 4158-4164.
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Bing Hu. (2015) Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside. World Journal of Hepatology 7:9, pages 1209.
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Yi Li, Zhen-Ni Zhang, Hong-Mou Zhao, Zhi-Chao Tong, Jie Yang, Hu Wang & Xiao-Jun Liang. (2014) Matrine inhibits the invasive properties of human osteosarcoma cells by downregulating the ERK-NF-κB pathway. Anti-Cancer Drugs 25:9, pages 1035-1043.
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Lianlian Song, Shu Sun, Longnan Jin, Lijuan Xue & Yaowen Fu. (2014) The extracts of Holotrichia diomphalia larvae inhibit proliferation and induce apoptosis of cancer cells in vitro and in vivo. Molecular & Cellular Toxicology 10:3, pages 251-259.
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Yan Liu, Yang Xu, Weidan Ji, Xiaoya Li, Bin Sun, Quangen Gao & Changqing Su. (2014) Anti-tumor activities of matrine and oxymatrine: literature review. Tumor Biology 35:6, pages 5111-5119.
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Guo-Gui Sun, Cui-Da Wei, Shao-Wu Jing & Wan-Ning Hu. (2014) Interactions between Filamin A and MMP-9 Regulate Proliferation and Invasion in Renal Cell Carcinoma. Asian Pacific Journal of Cancer Prevention 15:8, pages 3789-3795.
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G. G. Sun, Y. F. Lu, J. Zhang & W. N. Hu. (2014) Filamin A regulates MMP-9 expression and suppresses prostate cancer cell migration and invasion. Tumor Biology 35:4, pages 3819-3826.
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G. G. Sun, Y. F. Lu, Y. J. Cheng & W. N. Hu. (2013) Absent expression of FLNA is correlated with poor prognosis of nasopharyngeal cancer. Tumor Biology 35:4, pages 2967-2974.
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G. G. Sun, S. H. Sheng, S. W. Jing & W. N. Hu. (2013) An antiproliferative gene FLNA regulates migration and invasion of gastric carcinoma cell in vitro and its clinical significance. Tumor Biology 35:3, pages 2641-2648.
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Qing-Yu Zhang. (2014) Dihydromyricetin inhibits migration and invasion of hepatoma cells through regulation of MMP-9 expression. World Journal of Gastroenterology 20:29, pages 10082.
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Jin-A Oh, Jin-Hee Choi, Mi-Seon Choe, Jin-Hyo Kim, Min-Kyoung Paik, Kyung-Hun Park, Soon-Sung Hong, Je-Bong Lee & Doo-Ho Kim. (2013) Evaluation of Honeybee Acute Toxicity of Plant Extracts, Neem, Sophora and Derris. The Korean Journal of Pesticide Science 17:4, pages 473-477.
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Hyun Ho Noh, Jae Yun Lee, Jin Chan Kim, Oh Seok Jeong, Hye Sung Kim, Yong Hun Lee, Ji Hee Choi, Ae Son Om, Su Myeong Hong, Min Kyoung Paik, Doo Ho Kim & Kee Sung Kyung. (2013) Processing Factor of Matrine in Chilli Pepper. The Korean Journal of Pesticide Science 17:4, pages 244-248.
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CHENG CHANG, SHAO-PING LIU, CHUN-HUA FANG, REN-SHENG HE, ZHEN WANG, YOU-QING ZHU & SHAO-WEI JIANG. (2013) Effects of matrine on the proliferation of HT29 human colon cancer cells and its antitumor mechanism. Oncology Letters 6:3, pages 699-704.
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Aihua Zhang, Hui Sun & Xijun Wang. (2013) Recent advances in natural products from plants for treatment of liver diseases. European Journal of Medicinal Chemistry 63, pages 570-577.
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Min Xu, Lei Yang, Li-Zhi Hong, Xiao-Yuan Zhao & Hui-Ling Zhang. (2012) Direct protection of neurons and astrocytes by matrine via inhibition of the NF-κB signaling pathway contributes to neuroprotection against focal cerebral ischemia. Brain Research 1454, pages 48-64.
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Jin-Jian Lu, Jiao-Lin Bao, Xiu-Ping Chen, Min Huang & Yi-Tao Wang. (2012) Alkaloids Isolated from Natural Herbs as the Anticancer Agents. Evidence-Based Complementary and Alternative Medicine 2012, pages 1-12.
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