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Journal of Asian Natural Products Research Volume 13, 2011 - Issue 9
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Original Articles

Identification of the metabolites of baicalein in human plasma

Xiao-Yu Guo Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China
,
Lin Yang Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China; Center of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China
,
Ying Chen Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China
,
Qi-Fang Wang Shenyang Pharmaceutical University, Shenyang, 110016, China
,
Qi-Shi Sun Shenyang Pharmaceutical University, Shenyang, 110016, China
,
Yi-Xin Che Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China
&
Qing-Ming Che Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, ChinaCorrespondence[email protected]
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Pages 861-868 | Received 17 Mar 2011, Accepted 19 Jun 2011, Published online: 10 Aug 2011

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Hongjun Xia. (2021) Extensive metabolism of flavonoids relevant to their potential efficacy on Alzheimer’s disease. Drug Metabolism Reviews 53:4, pages 563-591.
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A K M Helal Morshed, Supti Paul, Arafat Hossain, Tuli Basak, Md. Sanower Hossain, Md. Mehedi Hasan, Md. Al Hasibuzzaman, Tanjim Ishraq Rahaman, Md. Abdur Rashid Mia, Pollob Shing, Md Sohel, Shabana Bibi, Dipta Dey, Partha Biswas, Md. Nazmul Hasan, Long Chiau Ming & Ching Siang Tan. (2023) Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives. Cancers 15:7, pages 2128.
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Shraddha Srivastava, Jose Mathew & Avinash chandra Pandey. (2023) Baicalein—A review on its molecular mechanism against breast cancer and delivery strategies. Medicinal Chemistry Research 32:4, pages 643-658.
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Hao Wang, Yantong Sun, Wei Guo, Jing Wang, Jingyi Gao, Wenwen Peng & Jingkai Gu. (2023) Identification and high-throughput quantification of baicalein and its metabolites in plasma and urine. Journal of Ethnopharmacology 301, pages 115853.
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Shubhangi Gupta, Harpal S Buttar, Ginpreet Kaur & Hardeep S Tuli. (2022) Baicalein: promising therapeutic applications with special reference to published patents. Pharmaceutical Patent Analyst 11:1, pages 23-32.
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Enrique Almanza-Aguilera, David Bars-Cortina, Fjorida Llaha & Raul Zamora-Ros. 2022. Biomarkers in Nutrition. Biomarkers in Nutrition 113 140 .
Enrique Almanza-Aguilera, David Bars-Cortina, Fjorida Llaha & Raul Zamora-Ros. 2022. Biomarkers in Nutrition. Biomarkers in Nutrition 1 28 .
De Xin Dang, Yan Jiao Li & In Ho Kim. (2021) Effects of dietary supplementation of enzymatic bio-conversion of Scutellaria baicalensis extract as an alternative to antibiotics on the growth performance, nutrient digestibility, fecal microbiota, fecal gas emission, blood hematology, and antioxidative indicators in growing pigs. Livestock Science 244, pages 104307.
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Linyi Lu, Guocan Zheng, Min Wang, Dandan Wang & Zhining Xia. (2021) Microwave-prepared mesoporous graphene as adsorbent and matrix of surface-assisted laser desorption/ionization mass spectrometry for the enrichment and rapid detection of polyphenols in biological samples. Talanta 222, pages 121365.
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Hardeep Singh Tuli, Vaishali Aggarwal, Jagjit Kaur, Diwakar Aggarwal, Gaurav Parashar, Nidarshana Chaturvedi Parashar, Muobarak Tuorkey, Ginpreet Kaur, Raj Savla, Katrin Sak & Manoj Kumar. (2020) Baicalein: A metabolite with promising antineoplastic activity. Life Sciences 259, pages 118183.
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Shi-Jun Yin, Ya-Li Wang, Hua Chen, Guang Hu, Guo-Can Zheng & Feng-Qing Yang. (2020) Investigation on the Metabolism of Curcumin and Baicalein in Zebrafish by Liquid Chromatography-tandem Mass Spectrometry Analysis. Current Pharmaceutical Analysis 16:8, pages 1052-1058.
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Robert Ancuceanu, Mihaela Dinu, Cristina Dinu-Pirvu, Valentina Anuţa & Vlad Negulescu. (2019) Pharmacokinetics of B-Ring Unsubstituted Flavones. Pharmaceutics 11:8, pages 370.
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Zhe Zhang, Guo Ma, Caifu Xue, Hong Sun, Ziteng Wang, Xiaoqiang Xiang & Weimin Cai. (2019) Establishment of rat liver microsome-hydrogel system for in vitro phase II metabolism and its application to study pharmacological effects of UGT substrates. Drug Metabolism and Pharmacokinetics 34:2, pages 141-147.
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Taomin Huang, Ya Xiong, Nianzu Chen, Donglei Wang, Yonghua Lai & Chunhui Deng. (2016) Highly selective enrichment of baicalin in rat plasma by boronic acid-functionalized core–shell magnetic microspheres: Validation and application to a pharmacokinetic study. Talanta 147, pages 501-509.
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Hong-Tai Chang, Chiang-Ting Chou, Daih-Huang Kuo, Pochuen Shieh, Chung-Ren Jan & Wei-Zhe Liang. (2015) The Mechanism of Ca 2+ Movement in the Involvement of Baicalein-Induced Cytotoxicity in ZR-75-1 Human Breast Cancer Cells . Journal of Natural Products 78:7, pages 1624-1634.
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Ehsan Moghaddam, Boon-Teong Teoh, Sing-Sin Sam, Rafidah Lani, Pouya Hassandarvish, Zamri Chik, Andrew Yueh, Sazaly Abubakar & Keivan Zandi. (2014) Baicalin, a metabolite of baicalein with antiviral activity against dengue virus. Scientific Reports 4:1.
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Wei Dou, Subhajit Mukherjee, Hao Li, Madhukumar Venkatesh, Hongwei Wang, Sandhya Kortagere, Ariel Peleg, Sridhar S. Chilimuri, Zheng-Tao Wang, Ying Feng, Eric R. Fearon & Sridhar Mani. (2012) Alleviation of Gut Inflammation by Cdx2/Pxr Pathway in a Mouse Model of Chemical Colitis. PLoS ONE 7:7, pages e36075.
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