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Journal of Asian Natural Products Research Volume 13, 2011 - Issue 11
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Original Articles

Gambogenic acid inhibits proliferation of A549 cells through apoptosis inducing through up-regulation of the p38 MAPK cascade

Hui Cheng Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&D of Traditional Chinese Medicine, Anhui University of Traditional Chinese Medicine, Hefei, 230038, ChinaView further author information
,
Jing-Jing Su Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&D of Traditional Chinese Medicine, Anhui University of Traditional Chinese Medicine, Hefei, 230038, ChinaView further author information
,
Jian-Ya Peng China Pharmaceutical University, Nanjing, 210009, China
,
Mei Wang Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&D of Traditional Chinese Medicine, Anhui University of Traditional Chinese Medicine, Hefei, 230038, China
,
Xun-Cui Wang Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&D of Traditional Chinese Medicine, Anhui University of Traditional Chinese Medicine, Hefei, 230038, China
,
Feng-Gen Yan Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&D of Traditional Chinese Medicine, Anhui University of Traditional Chinese Medicine, Hefei, 230038, China
,
Xiao-Shan Wang Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&D of Traditional Chinese Medicine, Anhui University of Traditional Chinese Medicine, Hefei, 230038, China
&
Qing-Lin Li Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&D of Traditional Chinese Medicine, Anhui University of Traditional Chinese Medicine, Hefei, 230038, ChinaCorrespondence[email protected]
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Pages 993-1002 | Received 16 Mar 2011, Accepted 11 Jul 2011, Published online: 19 Oct 2011

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Ruifen Su, Xiaoli Wu & Fengmei Ke. (2021) Long Non-Coding RNA HOTAIR Expression and Clinical Significance in Patients with Gestational Diabetes. International Journal of General Medicine 14, pages 9945-9950.
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Zhe Ma, Yuqi Fan, Yumei Wu, Dereje Kebebe, Bing Zhang, Peng Lu, Jiaxin Pi & Zhidong Liu. (2019) Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment. International Journal of Nanomedicine 14, pages 2029-2053.
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Beilei Wang, Weiye Cheng, Caiyun Zhang, Youmei Bao, Liqiong Zha, Jiajia Qian, Lufeng Hong & Weidong Chen. (2019) Self-assembled micelles based on gambogenic acid-phospholipid complex for sustained-release drug delivery. Journal of Microencapsulation 36:6, pages 566-575.
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Tongyuan Lin, Xia Huang, Yanyan Wang, Tingting Zhu, Qing Luo, Xiaoxiao Wang, Kai Zhou, Hao Cheng, Daiyin Peng & Weidong Chen. (2017) Long circulation nanostructured lipid carriers for gambogenic acid: formulation design, characterization, and pharmacokinetic. Xenobiotica 47:9, pages 793-799.
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Articles from other publishers (12)

Yee Lin Phang, Changwu Zheng & Hongxi Xu. (2022) Structural diversity and biological activities of caged Garcinia xanthones: recent updates. Acta Materia Medica 1:1.
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You Qin, Rong-Rong Zhou, Jian Jin, Fei Cheng, Bing-Bing Shen, Hong-Liang Zeng, Dan Wan, Can Zhong, Jing Xie, Jun Shu, Shu-Yun Shi & Shui-Han Zhang. (2021) Indole-based alkaloids from Ophiocordyceps xuefengensis. Phytochemistry 181, pages 112536.
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Tong‐Yuan Lin, Jia‐Li Chang, Yan Xun, Yi Zhao, Wang Peng, Wang Yang, Bai‐Jing Ding & Wei‐Dong Chen. (2020) Folic acid‐modified nonionic surfactant vesicles for gambogenic acid targeting: Preparation, characterization, and in vitro and in vivo evaluation. The Kaohsiung Journal of Medical Sciences 36:5, pages 344-353.
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Huanhuan Liu, Hong Chen, Fuhu Cao, Daiyin Peng, Weidong Chen & Chuanling Zhang. (2019) Amphiphilic Block Copolymer Poly (Acrylic Acid)-B-Polycaprolactone as a Novel pH-sensitive Nanocarrier for Anti-Cancer Drugs Delivery: In-vitro and In-vivo Evaluation. Polymers 11:5, pages 820.
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Lingli Zheng, Xu Han, Yupeng Hu, Xuerong Zhao, Lianhong Yin, Lina Xu, Yan Qi, Youwei Xu, Xu Han, Kexin Liu & Jinyong Peng. (2019) Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis. Pharmacological Research 139, pages 431-439.
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Qianqian Xu, Junsong Guo & Weidong Chen. (2019) Gambogenic acid reverses P-glycoprotein mediated multidrug resistance in HepG2/Adr cells and its underlying mechanism. Biochemical and Biophysical Research Communications 508:3, pages 882-888.
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Xian-Jun Yu, Qun Zhao, Xuan-Bin Wang, Jing-Xuan Zhang & Xiao-Bo Wang. (2016) Gambogenic acid induces proteasomal degradation of CIP2A and sensitizes hepatocellular carcinoma to anticancer agents. Oncology Reports 36:6, pages 3611-3618.
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Ye He, Jie Ding, Yan Lin, Juan Li, Yongguo Shi, Juan Wang, Ya Zhu, Keming Wang & Xuezhen Hu. (2015) Gambogenic acid alters chemosensitivity of breast cancer cells to Adriamycin. BMC Complementary and Alternative Medicine 15:1.
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Qing Luo, Tongyuan Lin, Cai Yuan Zhang, Tingting Zhu, Lei Wang, Zhaojie Ji, Buyun Jia, Tao Ge, Daiyin Peng & Weidong Chen. (2015) A novel glyceryl monoolein-bearing cubosomes for gambogenic acid: Preparation, cytotoxicity and intracellular uptake. International Journal of Pharmaceutics 493:1-2, pages 30-39.
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Jin Pei Chen, Dian Lei Wang, Li Li Yang, Chen Yin Wang & Shan Shan Wang. (2014) Ultra-high-performance liquid chromatography tandem mass spectrometry method for the determination of gambogenic acid in dog plasma and its application to a pharmacokinetic study. Biomedical Chromatography 28:12, pages 1854-1859.
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Wang Mei, Chen Dong, Cheng Hui, Li Bin, Yan Fenggen, Su Jingjing, Peng Cheng, Sun Meiling, Hu Yawen, Wang Xiaoshan, Wang Guanghui, Chen Zhiwu & Li Qinglin. (2014) Gambogenic Acid Kills Lung Cancer Cells through Aberrant Autophagy. PLoS ONE 9:1, pages e83604.
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Lain-Tze Lee, Hui-Ping Tsai, Chun-Chung Wang, Chia-Ni Chang, Wan-Chun Liu, Hui-Chun Hsu, Cheng-Ta Hsieh, Yen-Chun Chen, Hsiang-Wen Tseng, Rung-Jiun Gau, Szu-Hsiu Liu, I-Sen Chen & Munekazu Iinuma. (2013) Guttiferone F from the fruit of Garcinia multiflora and its anti-hepatocellular carcinoma activity. Biomedicine & Preventive Nutrition 3:3, pages 247-252.
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