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Journal of Asian Natural Products Research Volume 14, 2012 - Issue 1
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Original Articles

Uptake characteristics of pinocembrin and its effect on p-glycoprotein at the blood–brain barrier in in vitro cell experiments

Zhi-Hong Yang Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China
,
Xiao Sun Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China
,
Yun Qi Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China
,
Chao Mei Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China
,
Xiao-Bo Sun Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, ChinaCorrespondence[email protected] [email protected]
&
Guan-Hua Du Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
Pages 14-21 | Published online: 20 Jan 2012

Citations (24)

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Wenqi Wang, Xin Feng, Yu Du, Cen Liu, Xinxin Pang, Kunxiu Jiang, Xirui Wang & Yonggang Liu. (2021) Synthesis of Novel Pinocembrin Amino Acid Derivatives and Their Antiaging Effect on Caenorhabditis elegans via the Modulating DAF-16/FOXO. Drug Design, Development and Therapy 15, pages 4177-4193.
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Xue Wang, Jia-Jia Wang, Xin-Yue Suo, Hao-Ran Sun, Bo Zhen, Hua Sun, Jian-Guang Li & Teng-Fei Ji. (2020) Hyperacmosins H-J, three new polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum acmosepalum. Journal of Asian Natural Products Research 22:6, pages 521-530.
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Articles from other publishers (22)

Mehdi Valipour, Maryam Mohammadi & Habib Valipour. (2023) CNS-Active p38α MAPK Inhibitors for the Management of Neuroinflammatory Diseases: Medicinal Chemical Properties and Therapeutic Capabilities. Molecular Neurobiology.
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Deepika Joshi & Priya Sharma. (2023) A Comprehensive Review on Herbal Nanoparticulate System through Intranasal Route for Management of Congenital-Neuro Zika Therapy. Current Bioactive Compounds 19:9.
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Mehdi Valipour. (2023) Therapeutic prospects of naturally occurring p38 MAPK inhibitors tanshinone IIA and pinocembrin for the treatment of SARS‐CoV ‐2‐induced CNS complications . Phytotherapy Research.
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Mahmoud H. Elbatreek, Ismail Mahdi, Wafae Ouchari, Mona F. Mahmoud & Mansour Sobeh. (2023) Current advances on the therapeutic potential of pinocembrin: An updated review. Biomedicine & Pharmacotherapy 157, pages 114032.
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Natalia Cichon, Angela Dziedzic, Leslaw Gorniak, Elzbieta Miller, Michal Bijak, Michal Starosta & Joanna Saluk-Bijak. (2021) Unusual Bioactive Compounds with Antioxidant Properties in Adjuvant Therapy Supporting Cognition Impairment in Age-Related Neurodegenerative Disorders. International Journal of Molecular Sciences 22:19, pages 10707.
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Felix Zulhendri, Conrad O. Perera & Steven Tandean. (2021) Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence. Biomedicines 9:9, pages 1227.
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Xianwei Gao, Shengnan Li, Chao Cong, Yuejiao Wang & Lianwei Xu. (2021) A Network Pharmacology Approach to Estimate Potential Targets of the Active Ingredients of Epimedium for Alleviating Mild Cognitive Impairment and Treating Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-15.
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Derya Kilicaslan, Akif Hakan Kurt & Adem Doğaner. (2020) Protective Effects of Pinocembrin and Pinostrobin against Hydrogen Peroxide-Induced Stress in Retina Pigment Epithelial Cells. Pharmaceutical Chemistry Journal 54:8, pages 788-796.
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Vanessa Shi Li Goh, Chee-Keng Mok & Justin Jang Hann Chu. (2020) Antiviral Natural Products for Arbovirus Infections. Molecules 25:12, pages 2796.
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Andrea Braakhuis. (2019) Evidence on the Health Benefits of Supplemental Propolis. Nutrients 11:11, pages 2705.
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Xiaoling Shen, Yeju Liu, Xiaoya Luo & Zhihong Yang. (2019) Advances in Biosynthesis, Pharmacology, and Pharmacokinetics of Pinocembrin, a Promising Natural Small-Molecule Drug. Molecules 24:12, pages 2323.
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Jason Q.D. Goodger, Samiddhi L. Senaratne, Phillip van der Peet, Rhys Browning, Spencer J. Williams, Dean Nicolle & Ian E. Woodrow. (2019) Eucalyptus subgenus Eucalyptus (Myrtaceae) trees are abundant sources of medicinal pinocembrin and related methylated flavanones. Industrial Crops and Products 131, pages 166-172.
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Borriello, Iannuzzi & Sirangelo. (2019) Pinocembrin Protects from AGE-Induced Cytotoxicity and Inhibits Non-Enzymatic Glycation in Human Insulin. Cells 8:5, pages 385.
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Kumju Youn & Mira Jun. (2019) Biological Evaluation and Docking Analysis of Potent BACE1 Inhibitors from Boesenbergia rotunda. Nutrients 11:3, pages 662.
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Piero Portincasa & Giuseppe Calamita. (2019) Phytocompounds modulating Aquaporins: Clinical benefits are anticipated. Food Chemistry 274, pages 642-650.
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Ghazaleh Kheiri, Mahsa Dolatshahi, Farzaneh Rahmani & Nima Rezaei. (2018) Role of p38/MAPKs in Alzheimer’s disease: implications for amyloid beta toxicity targeted therapy. Reviews in the Neurosciences 30:1, pages 9-30.
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Angela Tesse, Elena Grossini, Grazia Tamma, Catherine Brenner, Piero Portincasa, Raul A. Marinelli & Giuseppe Calamita. (2018) Aquaporins as Targets of Dietary Bioactive Phytocompounds. Frontiers in Molecular Biosciences 5.
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Saikat Dewanjee, Tarun Dua, Niloy Bhattacharjee, Anup Das, Moumita Gangopadhyay, Ritu Khanra, Swarnalata Joardar, Muhammad Riaz, Vincenzo Feo & Muhammad Zia-Ul-Haq. (2017) Natural Products as Alternative Choices for P-Glycoprotein (P-gp) Inhibition. Molecules 22:6, pages 871.
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Xi Lan, Xiaoning Han, Qian Li, Qiang Li, Yufeng Gao, Tian Cheng, Jieru Wan, Wei Zhu & Jian Wang. (2017) Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia. Brain, Behavior, and Immunity 61, pages 326-339.
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Xi Lan, Wenzhu Wang, Qiang Li & Jian Wang. (2015) The Natural Flavonoid Pinocembrin: Molecular Targets and Potential Therapeutic Applications. Molecular Neurobiology 53:3, pages 1794-1801.
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Jason Q. D. Goodger, Samiddhi L. Seneratne, Dean Nicolle & Ian E. Woodrow. (2016) Foliar Essential Oil Glands of Eucalyptus Subgenus Eucalyptus (Myrtaceae) Are a Rich Source of Flavonoids and Related Non-Volatile Constituents. PLOS ONE 11:3, pages e0151432.
Crossref
Rui Liu, Cai-xia Wu, Dan Zhou, Fan Yang, Shuo Tian, Li Zhang, Tian-tai Zhang & Guan-hua Du. (2012) Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis. BMC Medicine 10:1.
Crossref

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