1,464
Views
49
CrossRef citations to date
0
Altmetric
Book Reviews

Natural products as lead compounds in drug discovery

, , &
Pages 764-788 | Received 26 Dec 2012, Accepted 18 Apr 2013, Published online: 22 May 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Tahseen Iqbal, Nuzhat Arshad, Jamshed Hashim, Syed Abid Ali, Binte Zehra, Malik Shoaib Ahmad, Nabila Hassan, Arif Ullah, Syeda Zehra Hamid & Ibanga Okon Isaac. (2022) Natural products based crown ethers: synthesis and their anticancer potential. Journal of Asian Natural Products Research 24:3, pages 268-277.
Read now
Furkan Ahmad, Laxminarain Misra, Vivek Kumar Gupta, Mahendra Pandurang Darokar, Om Prakash, Feroz Khan & Rakesh Shukla. (2016) Synergistic effect of (+)-pinitol from Saraca asoca with β-lactam antibiotics and studies on the in silico possible mechanism. Journal of Asian Natural Products Research 18:2, pages 172-183.
Read now
Yan-Ling Zhang, Ya-Fei Li, Bin Yu, Li-Hong Shan & Hong-Min Liu. (2015) Recent Progress on the Synthesis and Bioactivity of Marine Naturally Occurring Dienamides and Related Derivatives. Synthetic Communications 45:19, pages 2159-2180.
Read now
René Csuk. (2014) Betulinic acid and its derivatives: a patent review (2008 – 2013). Expert Opinion on Therapeutic Patents 24:8, pages 913-923.
Read now
Adriana G Guimarães, Mairim R Serafini & Lucindo J Quintans-Júnior. (2014) Terpenes and derivatives as a new perspective for pain treatment: a patent review. Expert Opinion on Therapeutic Patents 24:3, pages 243-265.
Read now

Articles from other publishers (44)

Jung Ho Han, Eun-Ji Lee, Wonyoung Park, Ki-Tae Ha & Hwan-Suck Chung. (2023) Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases. Frontiers in Pharmacology 14.
Crossref
Akash KUMAR, Jhilam PRAMANIK, Sarvesh RUSTAGI, Sweety BHARTI, Anchal TREHAN, Mehak KATYAL, Sheetal THAKUR, Shafiul HAQUE, Jutishna BORA, Shristi KISHORE & Sumira MALIK. (2023) Insight into the preclinical studies of phytomedicines in cancer theragnostics. Minerva Biotechnology and Biomolecular Research 35:3.
Crossref
Tabasum Ali, Sheikh Tahir Majeed, Rabiya Majeed, Rabiah Bashir, Suhail Ahmad Mir, Ifat Jan, Ghulam Nabi Bader & Khurshid Iqbal Andrabi. (2023) Recent Advances in the Pharmacological Properties and Molecular Mechanisms of Carvacrol. Revista Brasileira de Farmacognosia.
Crossref
Ran Zou, Bao Chen, Jie Sun, Yue-Wei Guo & Baofu Xu. (2023) Recent advances of activation techniques-based discovery of new compounds from marine fungi. Fitoterapia 167, pages 105503.
Crossref
Sangeetha Mohan, M. S. Ajay Krishna, Manasa Chandramouli, Rangappa S. Keri, Siddappa A. Patil, Srikantamurthy Ningaiah & Sasidhar B. Somappa. (2022) Antibacterial natural products from microbial and fungal sources: a decade of advances. Molecular Diversity 27:1, pages 517-541.
Crossref
Nisha Sam Nirmala, Navina Bala Krishnan, Vaishnavi Vivekanandan & Krishnaraj Thirugnanasambantham. 2023. Bioprospecting of Tropical Medicinal Plants. Bioprospecting of Tropical Medicinal Plants 1199 1232 .
Ashok K. Shakya & Rajashri R. Naik. (2022) The Chemotherapeutic Potentials of Compounds Isolated from the Plant, Marine, Fungus, and Microorganism: Their Mechanism of Action and Prospects. Journal of Tropical Medicine 2022, pages 1-17.
Crossref
Pei Dong, Zhaojing Li, Xiaohua Liu, Shunxi Dong & Xiaoming Feng. (2022) Asymmetric synthesis of polycyclic spiroindolines via the Dy-catalyzed cascade reaction of 3-(2-isocyanoethyl)indoles with aziridines . Organic Chemistry Frontiers 9:17, pages 4591-4597.
Crossref
Md.Sarfaraj Hussain, Faizul Azam, Jamal Mezogi, Fatima Abdmalla Enwij, Ghazalla M Benhusein, Anzarul Haque, Mohammad Khalid, Muhammed Arif, Mohammad Mahtab Alam, Irfan Ahmad & Mohd. Saeed. (2022) A simple validated HPTLC method for the analysis of flavonoids and molecular docking studies of novel tri-terpenoid glycoside isolated from Carya illinoinensis bark with potential anti-inflammatory and antinociceptive activities. South African Journal of Botany 147, pages 596-607.
Crossref
Fangqing Zhang, Bing-Tao Ren, Yuqiao Zhou, Yangbin Liu & Xiaoming Feng. (2022) Enantioselective construction of cis -hydroindole scaffolds via an asymmetric inverse-electron-demand Diels–Alder reaction: application to the formal total synthesis of (+)-minovincine . Chemical Science 13:19, pages 5562-5567.
Crossref
Jelena Djordjevic, Stoimir Kolarevic, Jovana Jovanovic-Maric, Mariana Oaldje-Pavlovic, Dusan Sladic, Irena Novakovic & Branka Vukovic-Gacic. (2022) Synthesis and biological activity of alkylthio and arylthio derivatives of tert-butylquinone. Journal of the Serbian Chemical Society 87:11, pages 1245-1258.
Crossref
Shivani Verma & Rajesh Kumar Pathak. 2022. Bioinformatics. Bioinformatics 253 267 .
İmren Esentürk-Güzel, Meltem Ezgi Durgun, Yıldız Özsoy & Sevgi Güngör. 2022. Encyclopedia of Infection and Immunity. Encyclopedia of Infection and Immunity 640 651 .
Sahil Butala, Vasanti Suvarna, Rashmi Mallya & Tabassum Khan. (2021) An insight into cytotoxic activity of flavonoids and sesquiterpenoids from selected plants of Asteraceae species. Chemical Biology & Drug Design 98:6, pages 1116-1130.
Crossref
Olabisi Flora Davies-Bolorunduro, Abraham Ajayi, Isaac Adeyemi Adeleye, Alfinda Novi Kristanti & Nanik Siti Aminah. (2021) Bioprospecting for antituberculosis natural products – A review. Open Chemistry 19:1, pages 1074-1088.
Crossref
Shi Tang, Shumin Ding, Dan Li, Lianjie Li, Haixia Zhao, Minxue Chai & Jian Wang. (2021) Palladium-catalysed imidoylative spirocyclization of 3-(2-isocyanoethyl)indoles. Chemical Communications 57:81, pages 10576-10579.
Crossref
Xiao-Feng Wang, Wen-Bin Cao, Hai-Yan Li, Xiao-Ping Xu & Shun-Jun Ji. (2021) Cascade Reaction of Tryptamine-Derived Isocyanides with Nitrile Oxides: Construction of Oxazine Fused-Spiroindoline Derivatives. The Journal of Organic Chemistry 86:18, pages 12597-12606.
Crossref
Yulei Zhao, Shuai Li, Yuhang Fan, Xuqiang Guo, Xin Jiao, Laijin Tian & Xuejun Sun. (2021) Synthesis of 10 H ‐Indolo[1,2‐ a ]indole Derivatives via Intramolecular Cycloaddition and H‐Migration . European Journal of Organic Chemistry 2021:30, pages 4358-4363.
Crossref
Sunil Kumar, Yi-Hsuan Wang, Po-Jen Chen, Yu-Chia Chang, Hemant K. Kashyap, Ya-Ching Shen, Huang-Ping Yu & Tsong-Long Hwang. (2021) Design and synthesis of β-carboline and combretastatin derivatives as anti-neutrophilic inflammatory agents. Bioorganic Chemistry 111, pages 104846.
Crossref
Nitika Singh, Nagendra Sastry Yarla, Nikhat Jamal Siddiqi, Maria de Lourdes Pereira & Bechan Sharma. (2021) Features, Pharmacological Chemistry, Molecular Mechanism and Health Benefits of Lemon. Medicinal Chemistry 17:3, pages 187-202.
Crossref
Majid M. Heravi & Vahideh Zadsirjan. 2021. Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids. Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids 11 58 .
Conrad V. Simoben, Fidele Ntie-Kang, Dina Robaa & Wolfgang Sippl. (2020) Case studies on computer-based identification of natural products as lead molecules. Physical Sciences Reviews 5:10.
Crossref
Guo‐Shu Chen, Shu‐Jie Chen, Jian Luo, Xiang‐Yu Mao, Albert Sun‐Chi Chan, Raymond Wai‐Yin Sun & Yun‐Lin Liu. (2019) Tandem Cross‐Coupling/Spirocyclization/Mannich‐Type Reactions of 3‐(2‐Isocyanoethyl)indoles with Diazo Compounds toward Polycyclic Spiroindolines. Angewandte Chemie International Edition 59:2, pages 614-621.
Crossref
Guo‐Shu Chen, Shu‐Jie Chen, Jian Luo, Xiang‐Yu Mao, Albert Sun‐Chi Chan, Raymond Wai‐Yin Sun & Yun‐Lin Liu. (2019) Tandem Cross‐Coupling/Spirocyclization/Mannich‐Type Reactions of 3‐(2‐Isocyanoethyl)indoles with Diazo Compounds toward Polycyclic Spiroindolines. Angewandte Chemie 132:2, pages 624-631.
Crossref
. 2020. Principles of Tumors. Principles of Tumors 633 646 .
Eka Gunarti Ningsih, Muhammad Fauzi Hidayat & Usman Sumo Friend Tambunan. 2019. Bioinformatics and Biomedical Engineering. Bioinformatics and Biomedical Engineering 14 24 .
K. Ramanathan, Kanika Verma, Naina Gupta & V. Shanthi. (2017) Discovery of Therapeutic Lead Molecule Against β-Tubulin Using Computational Approach. Interdisciplinary Sciences: Computational Life Sciences 10:4, pages 734-747.
Crossref
Armin Presser, Gunda Lainer, Nadine Kretschmer, Wolfgang Schuehly, Robert Saf, Marcel Kaiser & Marc-Manuel Kalt. (2018) Synthesis of Jacaranone-Derived Nitrogenous Cyclohexadienones and Their Antiproliferative and Antiprotozoal Activities. Molecules 23:11, pages 2902.
Crossref
Dini Hu, Yan Chen, Chenghang Sun, Tao Jin, Guangyi Fan, Qiwen Liao, Kai Meng Mok & Ming-Yuen Simon Lee. (2018) Genome guided investigation of antibiotics producing actinomycetales strain isolated from a Macau mangrove ecosystem. Scientific Reports 8:1.
Crossref
Iyiola Oluwakemi, Chutha Takahashi & Sunisa Siripongvu. (2018) Enhancing Secondary Metabolites (Emphasis on Phenolics and Antioxidants) in Plants through Elicitation and Metabolomics. Pakistan Journal of Nutrition 17:9, pages 411-420.
Crossref
Wesam Kooti, Karo Servatyari, Masoud Behzadifar, Majid Asadi-Samani, Fatemeh Sadeghi, Bijan Nouri & Hadi Zare Marzouni. (2017) Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study. Journal of Evidence-Based Complementary & Alternative Medicine 22:4, pages 982-995.
Crossref
Lia-Mara Ditu & Irina Gheorghe. 2017. Soft Chemistry and Food Fermentation. Soft Chemistry and Food Fermentation 1 19 .
Majid Asadi-Samani, Wesam Kooti, Elahe Aslani & Hedayatollah Shirzad. (2015) A Systematic Review of Iran’s Medicinal Plants With Anticancer Effects. Journal of Evidence-Based Complementary & Alternative Medicine 21:2, pages 143-153.
Crossref
Mohamed Ali-Seyed, Ibrahim Jantan, Kavitha Vijayaraghavan & Syed Nasir Abbas Bukhari. (2016) Betulinic Acid: Recent Advances in Chemical Modifications, Effective Delivery, and Molecular Mechanisms of a Promising Anticancer Therapy. Chemical Biology & Drug Design 87:4, pages 517-536.
Crossref
Swati Pund, Amita Joshi & Vandana Patravale. 2016. Nutraceuticals. Nutraceuticals 481 534 .
Adriana M. do Nascimento, Mateus Gon?alves Soares, Fernanda K. V. da Silva Torchelsen, Jorge A. Viana de Araujo, Paula S. Lage, Mariana C. Duarte, Pedro H. R. Andrade, Tatiana G. Ribeiro, Eduardo A. F. Coelho & Andr?a M. do Nascimento. (2015) Antileishmanial activity of compounds produced by endophytic fungi derived from medicinal plant Vernonia polyanthes and their potential as source of bioactive substances. World Journal of Microbiology and Biotechnology 31:11, pages 1793-1800.
Crossref
Takahiro Morikawa, Shinji Harada & Atsushi Nishida. (2015) Chiral Holmium Complex-Catalyzed Synthesis of Hydrocarbazole from Siloxyvinylindole and Its Application to the Enantioselective Total Synthesis of (−)-Minovincine. The Journal of Organic Chemistry 80:17, pages 8859-8867.
Crossref
Suerialoasan Navanesan, Norhanom Abdul Wahab, Sugumaran Manickam & Kae Shin Sim. (2015) Leptospermum flavescens Constituent-LF1 Causes Cell Death through the Induction of Cell Cycle Arrest and Apoptosis in Human Lung Carcinoma Cells. PLOS ONE 10:8, pages e0135995.
Crossref
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro & Michèle R. Prinsep. (2015) Marine natural products. Natural Product Reports 32:2, pages 116-211.
Crossref
Carla Carolina Munari, Pollyanna Francielli de Oliveira, Luis Fernando Leandro, Leandra Mara Pimenta, Natália Helen Ferreira, Juliana de Carvalho da Costa, Jairo Kenupp Bastos & Denise Crispim Tavares. (2014) In Vivo Assessment of Genotoxic, Antigenotoxic and Anticarcinogenic Activities of Solanum lycocarpum Fruits Glycoalkaloidic Extract. PLoS ONE 9:11, pages e111999.
Crossref
Jabeena Khazir, Darren L. Riley, Lynne A. Pilcher, Pieter De-Maayer & Bilal Ahmad Mir. (2014) Anticancer Agents from Diverse Natural Sources. Natural Product Communications 9:11, pages 1934578X1400901.
Crossref
Nneka N. Ibekwe, John B. Nvau, Peters O. Oladosu, Auwal M. Usman, Kolo Ibrahim, Helena I. Boshoff, Cynthia S. Dowd, Abayomi T. Orisadipe, Olapeju Aiyelaagbe, Akinbo A. Adesomoju, Clifton E. BarryIIIIII & Joseph I. Okogun. (2014) Some Nigerian anti-tuberculosis ethnomedicines: A preliminary efficacy assessment. Journal of Ethnopharmacology 155:1, pages 524-532.
Crossref
Milton SantamariaJr.Jr., Klodyne Dayana Petermann, Silvia Amélia Scudeler Vedovello, Viviane Degan, Adriana Lucato & Cristina Maria Franzini. (2014) Antimicrobial effect of Melaleuca alternifolia dental gel in orthodontic patients. American Journal of Orthodontics and Dentofacial Orthopedics 145:2, pages 198-202.
Crossref
Rainer Breitling, Ana Ceniceros, Andris Jankevics & Eriko Takano. (2013) Metabolomics for Secondary Metabolite Research. Metabolites 3:4, pages 1076-1083.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.