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Journal of Asian Natural Products Research Volume 16, 2014 - Issue 1
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Articles

Polygalasaponin F against rotenone-induced apoptosis in PC12 cells via mitochondria protection pathway

Miao-Miao WuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
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Yu-He YuanState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Jiao ChenTianjin University of Traditional Chinese Medicine, Tianjin, 300193, China
,
Chuang-Jun LiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China;Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China
,
Dong-Ming ZhangState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China;Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China
&
Nai-Hong ChenState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China;Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, ChinaCorrespondence[email protected]
Pages 59-69 | Received 18 Oct 2013, Accepted 06 Nov 2013, Published online: 02 Jan 2014

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Wen-Fen Yan, Qian-Hang Shao, Dong-Ming Zhang, Yu-He Yuan & Nai-Hong Chen. (2015) The molecular mechanism of polygalasaponin F-mediated decreases in TNFα: emphasizing the role of the TLR4-PI3K/AKT-NF-κB pathway. Journal of Asian Natural Products Research 17:6, pages 662-670.
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Articles from other publishers (7)

Li Zhang, Yuan-Yuan Yong, Lan Deng, Jing Wang, Betty Yuen-Kwan Law, Meng-Ling Hu, Jian-Ming Wu, Lu Yu, Vincent Kam-Wai Wong, Chong-Lin Yu, Da-Lian Qin, Xiao-Gang Zhou & An-Guo Wu. (2023) Therapeutic potential of Polygala saponins in neurological diseases. Phytomedicine 108, pages 154483.
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Chong Sun, Xin-Cheng Cao, Zhi-Yang Liu, Chao-Lin Ma & Bao-Ming Li. (2022) Polygalasaponin F protects hippocampal neurons against glutamate-induced cytotoxicity. Neural Regeneration Research 17:1, pages 178.
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Ruoqiu Fu, Haiyan Xing, Xianfeng Wang, Yao Liu, Bin Li, Lin Zhang, Ziwei Li, Dongyu Duan & Jianhong Chen. (2022) Neuroprotective Effects of Tetrahydroxystilbene Glucoside against Rotenone-Induced Toxicity in PC12 Cells. Biological and Pharmaceutical Bulletin 45:1, pages 143-149.
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Wei Xie, Hade Wulin, Guo Shao, Liqin Wei, Ruifang Qi, Baohui Ma, Naihong Chen & Ruili Shi. (2020) Polygalasaponin F inhibits neuronal apoptosis induced by oxygen‐glucose deprivation and reoxygenation through the PI3K/Akt pathway. Basic & Clinical Pharmacology & Toxicology 127:3, pages 196-204.
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Wen-Li Zhou, Jian-Tao Zhang, Wei Xu & Jing-Hui Sun. (2019) Protective effects of polygalasaponin F on oxidative stress and apoptosis-induced ischemic myocardial injury in neonatal rats with hypoxic-ischemic brain damage. NeuroReport 30:17, pages 1148-1156.
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Pan Xu, Shu-ping Xu, Ke-zhu Wang, Cong Lu, Hong-xia Zhang, Rui-le Pan, Chang Qi, Yan-yan Yang, Ying-hui Li & Xin-min Liu. (2016) Cognitive-enhancing effects of hydrolysate of polygalasaponin in SAMP8 mice远志皂苷水解产物对SAMP8 小鼠的益智作用研究. Journal of Zhejiang University-SCIENCE B 17:7, pages 503-514.
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P.C. Nagajyothi, Sang Ju Cha, In Jun Yang, T.V.M. Sreekanth, Kwang Joong Kim & Heung Mook Shin. (2015) Antioxidant and anti-inflammatory activities of zinc oxide nanoparticles synthesized using Polygala tenuifolia root extract. Journal of Photochemistry and Photobiology B: Biology 146, pages 10-17.
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