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Journal of Asian Natural Products Research Volume 16, 2014 - Issue 8
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Polygalasaponin F inhibits secretion of inflammatory cytokines via NF-κB pathway regulation

Wei WeiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, China;Tianjin University of Traditional Chinese Medicine, Tianjin300193, China
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Yu-He YuanState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, China;Tianjin University of Traditional Chinese Medicine, Tianjin300193, China
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Yan-Na GaoState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, China;Tianjin University of Traditional Chinese Medicine, Tianjin300193, China
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Wen-Fen YanState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, China
,
Chuang-Jun LiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, China
,
Dong-Ming ZhangState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, China
&
Nai-Hong ChenState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, ChinaCorrespondence[email protected]
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Pages 865-875 | Received 23 Apr 2014, Accepted 24 Apr 2014, Published online: 01 Aug 2014

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Wen-Fen Yan, Qian-Hang Shao, Dong-Ming Zhang, Yu-He Yuan & Nai-Hong Chen. (2015) The molecular mechanism of polygalasaponin F-mediated decreases in TNFα: emphasizing the role of the TLR4-PI3K/AKT-NF-κB pathway. Journal of Asian Natural Products Research 17:6, pages 662-670.
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Articles from other publishers (4)

Chong Sun, Xin-Cheng Cao, Zhi-Yang Liu, Chao-Lin Ma & Bao-Ming Li. (2022) Polygalasaponin F protects hippocampal neurons against glutamate-induced cytotoxicity. Neural Regeneration Research 17:1, pages 178.
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Wei Xie, Hade Wulin, Guo Shao, Liqin Wei, Ruifang Qi, Baohui Ma, Naihong Chen & Ruili Shi. (2020) Polygalasaponin F inhibits neuronal apoptosis induced by oxygen‐glucose deprivation and reoxygenation through the PI3K/Akt pathway. Basic & Clinical Pharmacology & Toxicology 127:3, pages 196-204.
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Chunlian Tian, Yu Chang, Xin Liu, Zehui Zhang, Yuru Guo, Zhiwei Lan, Peng Zhang & Mingchun Liu. (2020) Anti-inflammatory activity in vitro, extractive process and HPLC-MS characterization of total saponins extract from Tribulus terrestris L. fruits. Industrial Crops and Products 150, pages 112343.
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Yi Ye, Huixian Wang, Jinyuan Liu, Fang Zhao & Peiping Xu. (2019) Polygalasaponin F treats mice with pneumonia induced by influenza virus. Inflammopharmacology 28:1, pages 299-310.
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