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Journal of Asian Natural Products Research Volume 18, 2016 - Issue 6
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Original Articles

Pharmacokinetics of ginsenoside Rg1 in rat medial prefrontal cortex, hippocampus, and lateral ventricle after subcutaneous administration

Wei XueBeijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical Pharmacology, Beijing Hospital, Beijing100730, China
,
Yang LiuDepartment of Pharmacy, Peking University People’s Hospital, Beijing100044, China
,
Wen-Yuan QiBeijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical Pharmacology, Beijing Hospital, Beijing100730, China
,
Yan GaoBeijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical Pharmacology, Beijing Hospital, Beijing100730, China
,
Min LiBeijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical Pharmacology, Beijing Hospital, Beijing100730, China
,
Ai-Xin ShiBeijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical Pharmacology, Beijing Hospital, Beijing100730, China
&
Ke-Xin LiBeijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical Pharmacology, Beijing Hospital, Beijing100730, ChinaCorrespondence[email protected]
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Pages 587-595 | Received 20 Jan 2016, Accepted 06 Apr 2016, Published online: 20 Jun 2016

Citations (16)

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Wei Xue, Yan Gao, Pan-Pan Xie, Yang Liu, Wen-Yuan Qi, Ai-Xin Shi & Ke-Xin Li. (2021) Plasma and intracerebral pharmacokinetics and pharmacodynamics modeling for the acetylcholine releasing effect of ginsenoside Rg1 in mPFC of Aβ model rats. Journal of Asian Natural Products Research 23:3, pages 294-306.
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Yang Liu, Yan Gao, Ke-Xin Li & Wei Xue. (2019) Pharmacokinetics and acetylcholine releasing effects of ginsenoside Rg1 in hippocampus of beta-amyloid model rats. Journal of Asian Natural Products Research 21:8, pages 772-781.
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Articles from other publishers (14)

Ruifeng Zhang, Miao Zeng, Xiaolu Zhang, Yujia Zheng, Nuan Lv, Luming Wang, Jiali Gan, Yawen Li, Xijuan Jiang & Lin Yang. (2023) Therapeutic Candidates for Alzheimer’s Disease: Saponins. International Journal of Molecular Sciences 24:13, pages 10505.
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Zhikun Shi, Hongyu Chen, Xu Zhou, Wei Yang & Yang Lin. (2022) Pharmacological effects of natural medicine ginsenosides against Alzheimer’s disease. Frontiers in Pharmacology 13.
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Lin Chen, Ruimei Li, Feiyan Chen, Hantao Zhang, Zhu Zhu, Shuyi Xu, Yao Cheng & Yunan Zhao. (2022) A possible mechanism to the antidepressant-like effects of 20 (S)-protopanaxadiol based on its target protein 14-3-3 ζ. Journal of Ginseng Research 46:5, pages 666-674.
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Jiao-jiao Wu, Yu Yang, Yan Wan, Jia Xia, Jin-Feng Xu, Li Zhang, Dong Liu, Lu Chen, Fei Tang, Hui Ao & Cheng Peng. (2022) New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer’s disease. Biomedicine & Pharmacotherapy 152, pages 113207.
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Ying Chen, Yan-Yan Li, Shuo Wang, Tiantian Zhou, Nai-hong Chen & Yu-he Yuan. (2022) Ginsenoside Rg1 Plays a Neuroprotective Role in Regulating the Iron-Regulated Proteins and Against Lipid Peroxidation in Oligodendrocytes. Neurochemical Research 47:6, pages 1721-1735.
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Feiyan Chen, Chu Li, Huiying Cao, Hantao Zhang, Cai Lu, Ruimei Li, Zhu Zhu, Lin Chen & Yunan Zhao. (2022) Identification of Adenylate Kinase 5 as a Protein Target of Ginsenosides in Brain Tissues Using Mass Spectrometry-Based Drug Affinity Responsive Target Stability (DARTS) and Cellular Thermal Shift Assay (CETSA) Techniques. Journal of Agricultural and Food Chemistry 70:8, pages 2741-2751.
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Yan Tan, Jiani Zhang, Ke Yang, Zihui Xu, Huawei Zhang, Weihang Chen, Tiantian Peng, Xu Wang, Zhaoheng Liu, Peng Wei, Na Li, Zhenqiang Zhang, Tonghua Liu & Qian Hua. (2022) Anti-Stroke Chinese Herbal Medicines Inhibit Abnormal Amyloid-β Protein Precursor Processing in Alzheimer’s Disease. Journal of Alzheimer's Disease 85:1, pages 261-272.
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Hengyu Li, Hongwei Zhao, Yong Yang, Dongmei Qi, Xiaorui Cheng & Jiafeng Wang. (2021) Identification of Chemical Components of Qi-Fu-Yin and Its Prototype Components and Metabolites in Rat Plasma and Cerebrospinal Fluid via UPLC-Q-TOF-MS. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-27.
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Ting Zhu, Lei Wang, Yicheng Feng, Guibo Sun & Xiaobo Sun. (2021) Classical Active Ingredients and Extracts of Chinese Herbal Medicines: Pharmacokinetics, Pharmacodynamics, and Molecular Mechanisms for Ischemic Stroke. Oxidative Medicine and Cellular Longevity 2021, pages 1-27.
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Dong-Dong Shi, Yu-Hua Huang, Cora Sau Wan Lai, Celia M. Dong, Leon C. Ho, Xiao-Yang Li, Ed X. Wu, Qi Li, Xiao-Min Wang, Yong-Jun Chen, Sookja Kim Chung & Zhang-Jin Zhang. (2019) Ginsenoside Rg1 Prevents Chemotherapy-Induced Cognitive Impairment: Associations with Microglia-Mediated Cytokines, Neuroinflammation, and Neuroplasticity. Molecular Neurobiology 56:8, pages 5626-5642.
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Mehdy Ghaeminia, Ramamoorthy Rajkumar, Hwee-Ling Koh, Gavin S. Dawe & Chay Hoon Tan. (2018) Ginsenoside Rg1 modulates medial prefrontal cortical firing and suppresses the hippocampo-medial prefrontal cortical long-term potentiation. Journal of Ginseng Research 42:3, pages 298-303.
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Dezhi Kong, Xiaolin Tian, Yunshan Li, Saihang Zhang, Yiru Cheng, Lifang Huo, Huanhuan Ma, Zuxiao Yang, Leiming Ren, Mingquan Zhang & Wei Zhang. (2018) Revealing the Inhibitory Effect of Ginseng on Mitochondrial Respiration through Synaptosomal Proteomics. PROTEOMICS 18:11, pages 1700354.
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Yu-Nan ZHAO, Xiao SHAO, Liu-Feng OUYANG, Lin CHEN & Ling GU. (2018) Qualitative detection of ginsenosides in brain tissues after oral administration of high-purity ginseng total saponins by using polyclonal antibody against ginsenosides. Chinese Journal of Natural Medicines 16:3, pages 175-183.
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Xiuqing Zhang, Ting Liu, Xiaohui Fan & Ni Ai. (2017) In silico modeling on ADME properties of natural products: Classification models for blood-brain barrier permeability, its application to traditional Chinese medicine and in vitro experimental validation. Journal of Molecular Graphics and Modelling 75, pages 347-354.
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