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Original Articles

Synthesis and evaluation of coumarin/1,2,4-oxadiazole hybrids as selective BChE inhibitors with neuroprotective activity

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Pages 1090-1103 | Received 14 May 2018, Accepted 20 Jun 2018, Published online: 10 Jul 2018

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Muhammad Faheem, Yusuf S Althobaiti, Abdul Waheed Khan, Aman Ullah, Syed Hussain Ali & Umair Ilyas. (2021) Investigation of 1, 3, 4 Oxadiazole Derivative in PTZ-Induced Neurodegeneration: A Simulation and Molecular Approach. Journal of Inflammation Research 14, pages 5659-5679.
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Articles from other publishers (17)

Yijie Wang, Xu Cheng, Jing Xu, Lin Wang, Shouguo Zhang, Shuchen Liu & Tao Peng. (2023) A new method to synthesize 1,2,4-oxadiazoles by using DMTMM as condensing agent. Tetrahedron Letters 124, pages 154590.
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Shivani Saxena, Rajnish Kumar, Avijit Mazumder, Sunita Kumari, Divya Sharma, Sagar Joshi & Vikas Sharma. (2023) A Review on Synthetic Strategies for Useful Oxadiazole Derivatives in Psychological Disorders. Mini-Reviews in Organic Chemistry 20:4, pages 324-332.
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Ankita Sharma & Sandip B. Bharate. (2023) Synthesis and Biological Evaluation of Coumarin Triazoles as Dual Inhibitors of Cholinesterases and β-Secretase. ACS Omega 8:12, pages 11161-11176.
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Kaan Kucukoglu, Nagihan Faydali, Dilek Bul, Hayrunnisa Nadaroglu, Belgin Sever, Mehlika Dilek Altıntop, Bahadır Ozturk & Ilkay Guzel. (2023) Synthesis, in silico and in vitro evaluation of new 3,5-disubstituted-1,2,4-oxadiazole derivatives as carbonic anhydrase inhibitors and cytotoxic agents. Journal of Molecular Structure 1276, pages 134699.
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Sonali Mehendale Munj & Pooja Bhagwan Patil. (2023) Drug Discovery to Drug Development of BACE1 Inhibitor as Antialzheimer’s: A Review. Current Topics in Medicinal Chemistry 23:2, pages 77-97.
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Abdul Latif N. Shaikh, Abhijit Shinde, Abhijit Chavan, Rajendra Patil, Vivek Bobade & Pravin C. Mhaske. (2022) Synthesis of new 3-(4-methyl-2-arylthiazol-5-yl)-5-aryl-1,2,4-oxadiazole derivatives as potential cytotoxic and antimicrobial agents. European Journal of Medicinal Chemistry Reports 6, pages 100092.
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Yong-Hui Wen, Long Cheng, Tian-Ming Xu, Xing-Hai Liu & Ning-Jie Wu. (2021) Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4-oxadiazole motif. Frontiers of Chemical Science and Engineering 16:7, pages 1090-1100.
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Omnia M. Hendawy. (2022) A comprehensive review of recent advances in the biological activities of 1,2,4‐oxadiazoles. Archiv der Pharmazie 355:7.
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Namy George, Bushra Al Sabahi, Majed AbuKhader, Khalid Al Balushi, Md. Jawaid Akhtar & Shah Alam Khan. (2022) Design, synthesis and in vitro biological activities of coumarin linked 1,3,4-oxadiazole hybrids as potential multi-target directed anti-Alzheimer agents. Journal of King Saud University - Science 34:4, pages 101977.
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Hong-Xu Xie, Yan-Hong Wang, Jin-He Zhang, Juan Zhang, Ying-Nan Zhong, Yong-Xi Ge, Zhi-Qiang Cheng, Cheng-Shi Jiang & Ning Meng. (2022) Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway. Bioorganic Chemistry 120, pages 105606.
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Kishor R. Desai & Bhavin R. Patel. 2022. N-Heterocycles. N-Heterocycles 221 274 .
Asif Husain, Al Balushi K, Md Jawaid Akhtar & Shah Alam Khan. (2021) Coumarin linked heterocyclic hybrids: A promising approach to develop multi target drugs for Alzheimer's disease. Journal of Molecular Structure 1241, pages 130618.
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Tao Lu, Yi Liu, Yan Liu, Hao Chen, Chengang Han, Xiaoye Feng, Hui Zhou & Yanfang Li. (2021) Discovery, biological evaluation and molecular dynamic simulations of butyrylcholinesterase inhibitors through structure-based pharmacophore virtual screening. Future Medicinal Chemistry 13:9, pages 769-784.
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Karol Biernacki, Mateusz Daśko, Olga Ciupak, Konrad Kubiński, Janusz Rachon & Sebastian Demkowicz. (2020) Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery. Pharmaceuticals 13:6, pages 111.
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Cheng-Shi Jiang, Yong-Xi Ge, Zhi-Qiang Cheng, Yin-Yin Wang, Hong-Rui Tao, Kongkai Zhu & Hua Zhang. (2019) Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-Aβ Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation. Molecules 24:14, pages 2568.
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Cheng-Shi Jiang, Yong-Xi Ge, Zhi-Qiang Cheng, Jia-Li Song, Yin-Yin Wang, Kongkai Zhu & Hua Zhang. (2019) Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation. Journal of Computer-Aided Molecular Design 33:5, pages 521-530.
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Zhi-Qiang Cheng, Jia-Li Song, Kongkai Zhu, Juan Zhang, Cheng-Shi Jiang & Hua Zhang. (2018) Total Synthesis of Pulmonarin B and Design of Brominated Phenylacetic Acid/Tacrine Hybrids: Marine Pharmacophore Inspired Discovery of New ChE and Aβ Aggregation Inhibitors. Marine Drugs 16:9, pages 293.
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