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Journal of Asian Natural Products Research Volume 21, 2019 - Issue 12
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Original Articles

Synthesis and in vitro anti-epileptic activities of novel [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one derivatives

Jing DingCollege of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266061, China; View further author information
,
Feng-De CaoCollege of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266061, China; View further author information
,
Yan-Ru GengCollege of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266061, China; View further author information
,
Yuan TianCollege of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266061, China; View further author information
,
Peng LiCollege of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266061, China; View further author information
,
Xiu-Fen LiCollege of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266061, China; View further author information
&
Long-Jiang HuangCollege of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266061, China; ;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, ChinaCorrespondence[email protected]
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Pages 1190-1204 | Received 14 Aug 2018, Accepted 24 Sep 2018, Published online: 28 Dec 2018

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Raj Kamal, Ravinder Kumar, Vipan Kumar, Jitender K. Bhardwaj, Priyanka Saraf, Ajay Kumar, Kritika Pandit, Satwinderjeet Kaur, Prabhakar Chetti & Satyajit Beura. (2021) Diacetoxy iodobenzene mediated regioselective synthesis and characterization of novel [1,2,4]triazolo[4,3-a]pyrimidines: apoptosis inducer, antiproliferative activities and molecular docking studies. Journal of Biomolecular Structure and Dynamics 39:12, pages 4398-4414.
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Articles from other publishers (13)

Xue Yan, Chun Zhang, Li-Xin Gao, Min-Min Liu, Yu-Ting Yang, Li-Jie Yu, Yu-Bo Zhou, Slieman Milaneh, Yun-Long Zhu, Jia Li & Wen-Long Wang. (2023) Novel Imidazo[1,2,4] triazole derivatives: Synthesis, fluorescence, bioactivity for SHP1. European Journal of Medicinal Chemistry, pages 116027.
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Parul Kaushik, Ravinder Kumar, Shiwani Khokhar, Sukhvinder Dhiman & Raj Kamal. (2023) Recent Synthetic and Biological Developments on 1,2,4‐Triazolopyrimidines. ChemistrySelect 8:33.
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Ying Wang, Zheshan Quan & Dachuan Liu. (2023) An Active Group with Potential Anti-seizure Activity: A Review on 1,2,4- Triazoles. Letters in Drug Design & Discovery 20:8, pages 1005-1019.
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Qingfei Meng, Xue Ren, Rui Wang, Yu Han, Xiufen Li, Qin Zhang, Zhenpeng Li, Yuexing Wang, Longjiang Huang & Haibo Yu. (2023) Design, synthesis, anticonvulsant activity and structure-activity relationships of novel 7-Azaindole derivatives. Bioorganic Chemistry 133, pages 106430.
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Mostafa Arab, Hamid Beyzaei & Reza Aryan. (2022) One‐Pot Synthesis of 3‐Amino‐1,2,4‐triazoles Using Choline Chloride‐Urea and Their Antibacterial Activities. ChemistrySelect 7:38.
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Nicole McNamara, Eleanor Saunders, Swapna Varghese, Rebecca Zheng, Kaylene Simpson, Devika M. Varma, Monica M. Johnson, M Shamim Hasan Zahid, Eric M. Bachelder, Kristy M. Ainslie, Joo Hwan No, Dahae Koh, David Shum, Nirmal Das, Binita Patra, Jayasree Roy, Arindam Talukdar, Dipyman Ganguly, Malcolm McConville & Jonathan Baell. (2022) Hit-to-lead optimization of novel phenyl imidazole carboxamides that are active against Leishmania donovani. European Journal of Medicinal Chemistry 240, pages 114577.
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Ying Wang & Dachuan Liu. (2021) An Important Potential Anti-Epileptic/Anticonvulsant Active Group: A Review of 1,2,4-Triazole Groups and Their Action. Drug Research 72:03, pages 131-138.
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Jun Wu, Zhipeng Hou, Yan Wang, Liping Chen, Chengxi Lian, Qingfei Meng, Chaoying Zhang, Xiufen Li, Longjiang Huang & Haibo Yu. (2022) Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of GABAA1 and GABAA4 receptors with potent antiepileptic activity. Bioorganic Chemistry 119, pages 105565.
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Andrei Corbu. 2022. Comprehensive Heterocyclic Chemistry IV. Comprehensive Heterocyclic Chemistry IV 724 754 .
Daniil N. Lyapustin, Evgeny N. Ulomsky, Ilya A. Balyakin, Alexander V. Shchepochkin, Vladimir L. Rusinov & Oleg N. Chupakhin. (2021) Oxidative Aromatization of 4,7-Dihydro-6-nitroazolo[1,5-a]pyrimidines: Synthetic Possibilities and Limitations, Mechanism of Destruction, and the Theoretical and Experimental Substantiation. Molecules 26:16, pages 4719.
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A. V. Astakhov, E. V. Tarasova, A. V. Chernysheva, V. B. Rybakov, Z. A. Starikova & V. M. Chernyshev. (2021) Tautomerism and basicity of carboxylic acid guanyl hydrazides (acylaminoguanidines). Russian Chemical Bulletin 70:8, pages 1509-1522.
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Vladimir А. Polikarchuk, Yuliya V. Chertova, Andrei Yu. Potapov, Irina V. Ledenyova, Yevgeniya А. Kosheleva, Mikhail Yu. Krysin, Oleg А. Kozadyorov, Gennadiy V. Shatalov, Dmitriy Yu. Vandyshev, Khidmet S. Shikhaliev & Chetti Prabhakar. (2020) Novel variants of the multicomponent reaction for the synthesis of 1,2,4-triazolo[1,5-а]pyrimidines and pyrido[3,4-е][1,2,4]triazolo[1,5-а]pyrimidines. Chemistry of Heterocyclic Compounds 56:8, pages 1054-1061.
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Tienan Wang, Shan Yang, Hongyan Li, Aidang Lu, Ziwen Wang, Yingwu Yao & Qingmin Wang. (2019) Discovery, Structural Optimization, and Mode of Action of Essramycin Alkaloid and Its Derivatives as Anti-Tobacco Mosaic Virus and Anti-Phytopathogenic Fungus Agents. Journal of Agricultural and Food Chemistry 68:2, pages 471-484.
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