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Journal of Asian Natural Products Research Volume 6, 2004 - Issue 2
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Original Articles

Oridonin induced A375-S2 cell apoptosis VIA BAX-regulated caspase pathway activation, dependent on the cytochrome C/CASPASE-9 apoptosome

Chun-Ling Zhang China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, 110016, Shenyang, China
,
Li-Jun Wu Department of Phytochemistry, Shenyang Pharmaceutical University, 110016, Shenyang, China
,
Shin-Ichi Tashiro Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University, 194-8543, Tokyo, Japan
,
Satoshi Onodera Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University, 194-8543, Tokyo, Japan
&
Takashi Ikejima China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, 110016, Shenyang, ChinaCorrespondence[email protected]
Pages 127-138 | Received 01 Jan 2003, Accepted 02 Jul 2003, Published online: 15 Aug 2006

Citations (35)

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Hong-Jun Wang, Dan Li, Fan-Yi Yang, Shin-ichi Tashiro, Satoshi Onodera & Takashi Ikejima. (2008) Oridonin induces human melanoma A375-S2 cell death partially through inhibiting insulin-like growth factor 1 receptor signaling. Journal of Asian Natural Products Research 10:8, pages 777-788.
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Li Qiao, Yong-Fu Huang, Jia-Qing Cao, Yu-Zhi Zhou, Xiu-Lan Qi & Yue-Hu Pei. (2008) One new bufadienolide from Chinese drug “Chan'Su”. Journal of Asian Natural Products Research 10:3, pages 224-227.
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Articles from other publishers (33)

Meizhu He, Lijie Xia & Jinyao Li. (2021) Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer. Biomolecules 11:10, pages 1539.
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Yong-Feng Guan, Xiu-Juan Liu, Xiao-Jing Pang, Wen-Bo Liu, Guang -Xi Yu, Yin -Ru Li, Yan-Bing Zhang, Jian Song & Sai-Yang Zhang. (2021) Recent progress of oridonin and its derivatives for cancer therapy and drug resistance. Medicinal Chemistry Research 30:10, pages 1795-1821.
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Xi Liu, Jimin Xu, Jia Zhou & Qiang Shen. (2021) Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance. Genes & Diseases 8:4, pages 448-462.
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Shi-Yu Chen, Yue Gao, Jia-Yi Sun, Xian-Li Meng, Dong Yang, Lin-Hong Fan, Li Xiang & Ping Wang. (2020) Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease. Frontiers in Pharmacology 11.
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Fabrizio Fontana, Michela Raimondi, Alessandro Di Domizio, Roberta M. Moretti, Marina Montagnani Marelli & Patrizia Limonta. (2019) Unraveling the molecular mechanisms and the potential chemopreventive/therapeutic properties of natural compounds in melanoma. Seminars in Cancer Biology 59, pages 266-282.
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Muhammad Torequl Islam, Sajal Biswas, Rajat Bagchi, Md. Roich Khan, Abul Bashar Ripon Khalipha, Razina Rouf, Shaikh Jamal Uddin, Jamil A. Shilpi, Sanaa K. Bardaweel, Dima A. Sabbah & Mohammad S. Mubarak. (2019) Ponicidin as a promising anticancer agent: Its biological and biopharmaceutical profile along with a molecular docking study. Biotechnology and Applied Biochemistry 66:3, pages 434-444.
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Jimin Xu, Eric Wold, Ye Ding, Qiang Shen & Jia Zhou. (2018) Therapeutic Potential of Oridonin and Its Analogs: From Anticancer and Antiinflammation to Neuroprotection. Molecules 23:2, pages 474.
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Mingxing Zheng, Zhibing Zhu, Yongzhao Zhao, Da Yao, Maoqing Wu & Gengyun Sun. (2017) Oridonin promotes G2/M arrest in A549 cells by facilitating ATM activation. Molecular Medicine Reports 15:1, pages 375-379.
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Yang-Yang Dong, Yi-Huang Zhuang, Wen-Jie Cai, Yan Liu & Wen-Bing Zou. (2016) The mitochondrion interfering compound NPC-26 exerts potent anti-pancreatic cancer cell activity in vitro and in vivo. Tumor Biology 37:11, pages 15053-15063.
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Shijie Cao, Meijuan Xia, Yiwei Mao, Qiang Zhang, Paul Donkor, Feng Qiu & Ning Kang. (2016) Combined oridonin with cetuximab treatment shows synergistic anticancer effects on laryngeal squamous cell carcinoma: involvement of inhibition of EGFR and activation of reactive oxygen species-mediated JNK pathway. International Journal of Oncology.
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Brice Ayissi Owona & Herman J. Schluesener. (2015) Molecular Insight in the Multifunctional Effects of Oridonin. Drugs in R&D 15:3, pages 233-244.
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Byul-Bora Choi, Jeong Hae Choi, Sang-Rye Park, Ji-Young Kim, Jin-Woo Hong & Gyoo-Cheon Kim. (2015) Scutellariae radix Induces Apoptosis in Chemoresistant SCC-25 Human Tongue Squamous Carcinoma Cells . The American Journal of Chinese Medicine 43:01, pages 167-181.
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Ying Liu, Jian-Hong Liu, Kuan Chai, Shin-Ichi Tashiro, Satoshi Onodera & Takashi Ikejima. (2013) Inhibition of c-Met promoted apoptosis, autophagy and loss of the mitochondrial transmembrane potential in oridonin-induced A549 lung cancer cells. Journal of Pharmacy and Pharmacology 65:11, pages 1622-1642.
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Duo-te Cai, Hua Jin, Qi-Xing Xiong, Wei-Guang Liu, Zhi-gang Gao, Gui-xiong Gu & Yu-hui Qiu. (2013) ER stress and ASK1-JNK activation contribute to oridonin-induced apoptosis and growth inhibition in cultured human hepatoblastoma HuH-6 cells. Molecular and Cellular Biochemistry 379:1-2, pages 161-169.
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Yu-Jie Wang, Xiao-Ping Niu, Li Yang, Zhen Han & Ying-Jie Ma. (2013) Effects of Celecoxib on Cycle Kinetics of Gastric Cancer Cells and Protein Expression of Cytochrome C and Caspase-9. Asian Pacific Journal of Cancer Prevention 14:4, pages 2343-2347.
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Hiu-Yee Kwan, Zhijun Yang, Wang-Fun Fong, Yong-Mei Hu, Zhi-Ling Yu & Wen-Luan Wendy Hsiao. (2012) The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells. Journal of Gastroenterology 48:2, pages 182-192.
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Christophe Wiart. 2013. Lead Compounds from Medicinal Plants for the Treatment of Cancer. Lead Compounds from Medicinal Plants for the Treatment of Cancer 97 265 .
Z. Liu, L. Ouyang, H. Peng & W.‐Z. Zhang. (2012) Oridonin: targeting programmed cell death pathways as an anti‐tumour agent. Cell Proliferation 45:6, pages 499-507.
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Wen Tan, Jinjian Lu, Mingqing Huang, Yingbo Li, Meiwan Chen, Guosheng Wu, Jian Gong, Zhangfeng Zhong, Zengtao Xu, Yuanye Dang, Jiajie Guo, Xiuping Chen & Yitao Wang. (2011) Anti-cancer natural products isolated from chinese medicinal herbs. Chinese Medicine 6:1.
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Chun-yang Li, En-qin Wang, Yan Cheng & Jin-ku Bao. (2011) Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics. The International Journal of Biochemistry & Cell Biology 43:5, pages 701-704.
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Ning KangJing-Hai ZhangFeng QiuSheng ChenShin-ichi TashiroSatoshi OnoderaTakashi Ikejima. (2010) Induction of G 2 /M Phase Arrest and Apoptosis by Oridonin in Human Laryngeal Carcinoma Cells . Journal of Natural Products 73:6, pages 1058-1063.
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ANGELA M. WONG, YANJUNG ZHANG, KELLY KESLER, MAX DENG, LUCAS BURHENN, DAVID WANG, AUNE MORO, ZHAOPING LI & DAVID HEBER. (2010) Genomic and in vivo evidence of synergy of a herbal extract compared to its most active ingredient: Rabdosia rubescens vs. oridonin. Experimental and Therapeutic Medicine 1:6, pages 1013-1017.
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Xia Xu, Yu Ke, Qi Zhang, Xiaoyu Qi & Hongmin Liu. (2018) DNA Binding and Cleavage Properties of Ponicidin. Tumori Journal 95:3, pages 348-351.
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Yu Du, Nicole F. Villeneuve, Xiao-Jun Wang, Zheng Sun, Weimin Chen, Jixue Li, Hongxiang Lou, Pak Kin Wong & Donna D. Zhang. (2008) Oridonin Confers Protection against Arsenic-Induced Toxicity through Activation of the Nrf2-Mediated Defensive Response. Environmental Health Perspectives 116:9, pages 1154-1161.
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Jinyi Xu, JingYi Yang, Qian Ran, Lei Wang, Jie Liu, Zhixuan Wang, Xiaoming Wu, Weiyi Hua, Shengtao Yuan, Luyong Zhang, Mingqin Shen & Yongfang Ding. (2008) Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates. Bioorganic & Medicinal Chemistry Letters 18:16, pages 4741-4744.
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Jian Huang, Lijun Wu, Shin-ichi Tashiro, Satoshi Onodera & Takashi Ikejima. (2008) Reactive Oxygen Species Mediate Oridonin-Induced HepG2 Apoptosis Through p53, MAPK, and Mitochondrial Signaling Pathways. Journal of Pharmacological Sciences 107:4, pages 370-379.
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Junhui Chen, Shaobin Wang, Dongyang Chen, Guisheng Chang, Qingfeng Xin, Shoujun Yuan & Zhongying Shen. (2007) The inhibitory effect of oridonin on the growth of fifteen human cancer cell lines. Chinese Journal of Clinical Oncology 4:1, pages 16-20.
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Jia-Jun Liu, Ren-Wei Huang, Dong-Jun Lin, Xiang-Yuan Wu, Jun Peng, Xiang-Lin Pan, Qu Lin, Ming Hou, Mao-Hong Zhang & Feng Chen. (2006) Antiproliferation effects of oridonin on HPB-ALL cells and its mechanisms of action. American Journal of Hematology 81:2, pages 86-94.
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Jian Huang, Lijun Wu, Shin-ichi Tashiro, Satoshi Onodera & Takashi Ikejima. (2006) Fibroblast Growth Factor-2 Suppresses Oridonin-Induced L929 Apoptosis Through Extracellular Signal-Regulated Kinase-Dependent and Phosphatidylinositol 3-Kinase-Independent Pathway. Journal of Pharmacological Sciences 102:3, pages 305-313.
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Yan-Qiu Liu, Zhen-Qiang Mu, Song You, Shin-ichi Tashiro, Satoshi Onodera & Takashi Ikejima. (2006) Fas/FasL Signaling Allows Extracelluar-Signal Regulated Kinase to Regulate Cytochrome c Release in Oridonin-Induced Apoptotic U937 Cells. Biological and Pharmaceutical Bulletin 29:9, pages 1873-1879.
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Yan-Qiu Liu, Song You, Chun-Ling Zhang, Shin-ichi Tashiro, Satoshi Onodera & Takashi Ikejima. (2005) Oridonin Enhances Phagocytosis of UV-Irradiated Apoptotic U937 Cells. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 28:3, pages 461-467.
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Chun-Ling Zhang, Li-Jun Wu, Hai-Jun Zuo, Shin-ichi Tashiro, Satoshi Onodera & Takashi Ikejima. (2004) Cytochrome c Release From Oridonin-Treated Apoptotic A375-S2 Cells Is Dependent on p53 and Extracellular Signal-Regulated Kinase Activation. Journal of Pharmacological Sciences 96:2, pages 155-163.
Crossref
Chun-Ling Zhang, Li-Jun Wu, Shin-ichi Tashiro, Satoshi Onodera & Takashi Ikejima. (2004) Oridonin Induces a Caspase-Independent But Mitochondria- and MAPK-Dependent Cell Death in the Murine Fibrosarcoma Cell Line L929. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 27:10, pages 1527-1531.
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