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Original Articles

Labdane-type diterpenes as new cell cycle inhibitors and apoptosis inducers from Vitex trifolia L.

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Pages 95-105 | Received 06 May 2003, Accepted 04 Jul 2003, Published online: 15 Aug 2006

Keep up to date with the latest research on this topic with citation updates for this article.

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Yuan-Yu Zhao, Lian Guo, Lan-Jie Cao, Jian Zhang & Zhi-Qi Yin. (2017) A new iridoid glycoside from the fruits of Vitex rotundifolia. Natural Product Research 31:21, pages 2491-2496.
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Satyam Kumar Agrawal, Madhunika Agrawal, Parduman Raj Sharma, Bishan Datt Gupta, Saroj Arora & Ajit Kumar Saxena. (2011) Induction of Apoptosis in Human Promyelocytic Leukemia HL60 Cells by an Extract From Erythrina suberosa Stem Bark. Nutrition and Cancer 63:5, pages 802-813.
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Qiong Gu, Xue-Mei Zhang, Jun Zhou, Sheng-Xiang Qiu & Ji-Jun Chen. (2008) One new dihydrobenzofuran lignan from Vitex trifolia . Journal of Asian Natural Products Research 10:6, pages 499-502.
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Wen-Xin Li, Cheng-Bin Cui, Bing Cai, Hai-Yan Wang & Xin-Sheng Yao. (2005) Flavonoids from Vitex trifolia L. inhibit cell cycle progression at G2/M phase and induce apoptosis in mammalian cancer cells. Journal of Asian Natural Products Research 7:4, pages 615-626.
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Articles from other publishers (27)

Chun-Xiao Yan, Ya-Wen Wei, Hui Li, Kuo Xu, Run-Xiang Zhai, De-Chuan Meng, Xian-Jun Fu & Xia Ren. (2023) Vitex rotundifolia L. f. and Vitex trifolia L.: A review on their traditional medicine, phytochemistry, pharmacology. Journal of Ethnopharmacology 308, pages 116273.
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Komi Djimabi, Ru-Yue Wang, Bing Li, Xiao-Han Chen, Xu Liu, Mei-Jie Wang, Xiao-Qing Zhan, Feng-Ming Qi, Dong-Qing Fei & Zhan-Xin Zhang. (2022) Diterpenoids with α-glucosidase inhibitory activities from the fruits of Vitex trifolia Linn. Fitoterapia 161, pages 105248.
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Nurkhalida Kamal, Nurul Syahidah Mio Asni, Ivana Nur Allisya Rozlan, Muhammad Aniq Hamzah Mohd Azmi, Noor Wini Mazlan, Ahmed Mediani, Syarul Nataqain Baharum, Jalifah Latip, Suvik Assaw & Ru Angelie Edrada-Ebel. (2022) Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.. Plants 11:15, pages 1944.
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Gang Gong, Yu-Li Shen, Hai-Yue Lan, Jin-Mei Jin, Pei An, Li-Jun Zhang, Li-Li Chen, Wei Peng, Xin Luan & Hong Zhang. (2021) The Cyr61 Is a Potential Target for Rotundifuran, a Natural Labdane-Type Diterpene from Vitex trifolia L., to Trigger Apoptosis of Cervical Cancer Cells. Oxidative Medicine and Cellular Longevity 2021, pages 1-15.
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Hadi Bakhtiari, Ali Gheysarzadeh, Mustafa Ghanadian & Mahmoud Aghaei. (2021) 15-Hydroxy-8(17),13(E)-labdadiene-19-carboxylic acid (HLCA) inhibits proliferation and induces cell cycle arrest and apoptosis in ovarian cancer cells. Life Sciences 267, pages 118981.
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Nwet Nwet Win & Hiroyuki Morita. 2021. Progress in the Chemistry of Organic Natural Products 114. Progress in the Chemistry of Organic Natural Products 114 135 251 .
Kadidiatou O. Ndjoubi, Rajan Sharma & Ahmed A. Hussein. (2020) The Potential of Natural Diterpenes Against Tuberculosis: An Updated Review. Current Pharmaceutical Design 26:24, pages 2909-2932.
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Yanfei Ban, Tianshuang Xia, Rui Jing, Yaoli Guo, Yiya Geng, Qi Ye & Chengjian Zheng. (2020) Vitex Diterpenoids: Structural Diversity and Pharmacological Activity. Current Pharmaceutical Design 26:1, pages 138-159.
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Mya Aye, Hnin Aung, Myint Sein & Chabaco Armijos. (2019) A Review on the Phytochemistry, Medicinal Properties and Pharmacological Activities of 15 Selected Myanmar Medicinal Plants. Molecules 24:2, pages 293.
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Hun Min Song, Gwang Hun Park, Su Bin Park, Hyun-Seok Kim, Ho-Jun Son, Yurry Um & Jin Boo Jeong. (2018) Vitex rotundifolia Fruit Suppresses the Proliferation of Human Colorectal Cancer Cells through Down-regulation of Cyclin D1 and CDK4 via Proteasomal-Dependent Degradation and Transcriptional Inhibition . The American Journal of Chinese Medicine 46:01, pages 191-207.
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Atsuyoshi Nishina, Masaya Itagaki, Daisuke Sato, Hirokazu Kimura, Yasuaki Hirai, Nyunt Phay & Makoto Makishima. (2017) The Rosiglitazone-Like Effects of Vitexilactone, a Constituent from Vitex trifolia L. in 3T3-L1 Preadipocytes. Molecules 22:11, pages 2030.
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Hun Min Song, Gwang Hun Park, Jin Suk Koo, Hyung Jin Jeong & Jin Boo Jeong. (2017) Vitex rotundifolia Fruit Extract Induces Apoptosis Through the Downregulation of ATF3-Mediated Bcl-2 Expression in Human Colorectal Cancer Cells . The American Journal of Chinese Medicine 45:04, pages 901-915.
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K. Elumalai, S. Velmurugan, S. Ravi, V. Kathiravan & G. Adaikala Raj. (2015) Bio-approach: Plant mediated synthesis of ZnO nanoparticles and their catalytic reduction of methylene blue and antimicrobial activity. Advanced Powder Technology 26:6, pages 1639-1651.
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Amberkar Vittal Rao Mohanbabu, Meena Kumari Kamal Kishore, Bangalore Revanna Chandrashekar, Hoskeri Dakappa Pradeepa, Rockson Christopher & Purnanand Banawalikar Nandit. (2015) Evaluation of potential antiamnesic activities of aqueous extract of Vitex trifolia leaves against scopolamine induced amnesia and in normal rats. Journal of Basic and Clinical Physiology and Pharmacology 26:2.
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Neerja Tiwari, Jayprakash Thakur, Dharmendra Saikia & Madan M. Gupta. (2013) Antitubercular diterpenoids from Vitex trifolia. Phytomedicine 20:7, pages 605-610.
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Teng Zhang, Chong Xi Zhang, Wei Dong Xie & Kyung Ho Row. (2013) Vitrifolin A: A Norlabdane Diterpenoid from the Fruits of Vitex trifolia Linn. var. simplicifolia Cham . Journal of the Chinese Chemical Society 60:5, pages 542-545.
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Mariko Matsui, Minou Adib-Conquy, Agnès Coste, Shilpa Kumar-Roiné, Bernard Pipy, Dominique Laurent & Serge Pauillac. (2012) Aqueous extract of Vitex trifolia L. (Labiatae) inhibits LPS-dependent regulation of inflammatory mediators in RAW 264.7 macrophages through inhibition of Nuclear Factor kappa B translocation and expression. Journal of Ethnopharmacology 143:1, pages 24-32.
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Yuan-Jun Chen, Chun-Miao Li, Wei-Wei Ling, Xiao-Chun Wan, Tao Xia, Xian-Feng Du, Zheng-Zhu Zhang & Tie-Jun Ling. (2012) A rearranged labdane-type diterpenoid and other constituents from Vitex negundo var. cannabifolia. Biochemical Systematics and Ecology 40, pages 98-102.
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Louisa G. Mahaira, Chrisiida Tsimplouli, Nikos Sakellaridis, Konstantinos Alevizopoulos, Costas Demetzos, Zhiyong Han, Panayotis Pantazis & Konstantinos Dimas. (2011) The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action. European Journal of Pharmacology 666:1-3, pages 173-182.
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Shokoofe Noori, Zuhair M. Hassan, Mehdi Mohammadi, Zohre Habibi, Nooshin Sohrabi & Saeed Bayanolhagh. (2010) Sclareol modulates the Treg intra-tumoral infiltrated cell and inhibits tumor growth in vivo. Cellular Immunology 263:2, pages 148-153.
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Mariko Matsui, Shilpa Kumar-Roine, H. Taiana Darius, Mireille Chinain, Dominique Laurent & Serge Pauillac. (2009) Characterisation of the anti-inflammatory potential of Vitex trifolia L. (Labiatae), a multipurpose plant of the Pacific traditional medicine. Journal of Ethnopharmacology 126:3, pages 427-433.
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B. K. Manjunatha, S. M. Vidya, V. Krishna, K. L. Mankani, S. D. Jagadeesh Singh & Y. N. Manohara. (2007) Comparative evaluation of wound healing potency of Vitex trifolia L. and Vitex altissima L. . Phytotherapy Research 21:5, pages 457-461.
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Konstantinos Dimas, Sophia Hatziantoniou, Sophia Tseleni, Humaira Khan, Aristidis Georgopoulos, Konstantinos Alevizopoulos, James H. Wyche, Panayotis Pantazis & Costas Demetzos. (2007) Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice. Apoptosis 12:4, pages 685-694.
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. 2007. Ethnopharmacology of Medicinal Plants. Ethnopharmacology of Medicinal Plants 57 153 .
Hong‐Bing Liu, Bing Cai, Cheng‐Bin Cui, Qian‐Qun Gu, Qing‐Chun Zhao & Hua‐Shi Guan. (2006) Pterocaryquinone, a Novel Naphthoquinone Derivative from Pterocarya tonkinesis . Chinese Journal of Chemistry 24:12, pages 1683-1686.
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K. Dimas, M. Papadaki, C. Tsimplouli, S. Hatziantoniou, K. Alevizopoulos, P. Pantazis & C. Demetzos. (2006) Labd-14-ene-8,13-diol (sclareol) induces cell cycle arrest and apoptosis in human breast cancer cells and enhances the activity of anticancer drugs. Biomedicine & Pharmacotherapy 60:3, pages 127-133.
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Xiao-Xian Han, Cheng-Bin Cui, Qian-Qun Gu, Wei-Ming Zhu, Hong-Bing Liu, Jing-Yan Gu & Hiroyuki Osada. (2005) ZHD-0501, a novel naturally occurring staurosporine analog from Actinomadura sp. 007. Tetrahedron Letters 46:36, pages 6137-6140.
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