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Journal of Asian Natural Products Research Volume 7, 2005 - Issue 5
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Silymarin augments human cervical cancer HeLa cell apoptosis via P38/JNK MAPK pathways in serum-free medium

Qing Huang Shenyang Pharmaceutical University, China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang, 110016, China E-mail: [email protected]; Shenyang Pharmaceutical University, Department of Phytochemistry, Shenyang, 110016, China
,
Li-Jun Wu Shenyang Pharmaceutical University, Department of Phytochemistry, Shenyang, 110016, China
,
Shin-Ichi Tashiro Showa Pharmaceutical University, Department of Clinical and Biomedical Sciences, Tokyo, 194-8543, Japan
,
Satoshi Onodera Showa Pharmaceutical University, Department of Clinical and Biomedical Sciences, Tokyo, 194-8543, Japan
,
Lin-Hao Li Shenyang Pharmaceutical University, China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang, 110016, China E-mail: [email protected]
&
Takashi Ikejima Shenyang Pharmaceutical University, China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang, 110016, China E-mail: [email protected]
Pages 701-709 | Published online: 19 Aug 2006

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Chuanpit Ninsontia, Kanittha Pongjit, Chatchai Chaotham & Pithi Chanvorachote. (2011) Silymarin selectively protects human renal cells from cisplatin-induced cell death. Pharmaceutical Biology 49:10, pages 1082-1090.
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Articles from other publishers (21)

Jung Ho Han, Eun-Ji Lee, Wonyoung Park, Ki-Tae Ha & Hwan-Suck Chung. (2023) Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases. Frontiers in Pharmacology 14.
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Nizar A. Khamjan, Saba Beigh, Abdullah Algaissi, Kanu Megha, Mohtashim Lohani, Majid Darraj, Nader Kamli, Faisal Madkhali & Sajad Ahmad Dar. (2023) Natural and synthetic drugs and formulations for intravaginal HPV clearance. Journal of Infection and Public Health 16:9, pages 1471-1480.
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Mehdi Koushki, Reyhaneh Farrokhi Yekta & Nasrin Amiri-Dashatan. (2023) Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid. Journal of Functional Foods 104, pages 105502.
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Karan Wadhwa, Rakesh Pahwa, Manish Kumar, Shobhit Kumar, Prabodh Chander Sharma, Govind Singh, Ravinder Verma, Vineet Mittal, Inderbir Singh, Deepak Kaushik & Philippe Jeandet. (2022) Mechanistic Insights into the Pharmacological Significance of Silymarin. Molecules 27:16, pages 5327.
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Myoung-Jin Kim, Dong-Uk Kim, Ji-Won Choi, Dong-Gu Kim, Ho-Joon Song, Gi-Sang Bae & Sung-Joo Park. (2020) Silymarin Attenuates the Severity of Cerulein-Induced Acute Pancreatitis. Pancreas 49:1, pages 89-95.
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Tahereh Hosseinabadi, Zahra Lorigooini, Maryam Tabarzad, Bahare Salehi, Célia F. Rodrigues, Natália Martins & Javad Sharifi‐Rad. (2019) Silymarin antiproliferative and apoptotic effects: Insights into its clinical impact in various types of cancer. Phytotherapy Research 33:11, pages 2849-2861.
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Basant Sharma, Udit Chaube & Bhoomika M. Patel. (2018) Beneficial Effect of Silymarin in Pressure Overload Induced Experimental Cardiac Hypertrophy. Cardiovascular Toxicology 19:1, pages 23-35.
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Yang Yu, Ming Zhang, Yali Hu, Yali Zhao, Fei Teng, Xiaoyan Lv, Ji Li, Ying Zhang, Grant M. Hatch & Li Chen. (2018) Increased Bioavailable Berberine Protects Against Myocardial Ischemia Reperfusion Injury Through Attenuation of NFκB and JNK Signaling Pathways. International Heart Journal 59:6, pages 1378-1388.
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Zhongming Zhu & Gengyun Sun. (2017) Silymarin mitigates lung impairments in a rat model of acute respiratory distress syndrome. Inflammopharmacology 26:3, pages 747-754.
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Dong-Hoon Won, Lee-Han Kim, Boonsil Jang, In-Hyoung Yang, Hye-Jeong Kwon, Bohwan Jin, Seung Hyun Oh, Ju-Hee Kang, Seong-Doo Hong, Ji-Ae Shin & Sung-Dae Cho. (2018) In vitro and in vivo anti-cancer activity of silymarin on oral cancer. Tumor Biology 40:5, pages 101042831877617.
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Qin Li, Yanhong Feng, Xu Chao, Shuai Shi, Man Liang, Yumei Qiao, Bin Wang, Pin Wang & Zhenning Zhu. (2018) HOTAIR contributes to cell proliferation and metastasis of cervical cancer via targetting miR-23b /MAPK1 axis . Bioscience Reports 38:1.
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Ye Li, Haihong Luo, Nan Xiao, Jianmin Duan, Zhiping Wang & Shuanke Wang. (2018) Long Noncoding RNA SChLAP1 Accelerates the Proliferation and Metastasis of Prostate Cancer via Targeting miR-198 and Promoting the MAPK1 Pathway. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 26:1, pages 131-143.
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Xu Jun. 2016. Cancer Inhibitors from Chinese Natural Medicines. Cancer Inhibitors from Chinese Natural Medicines 17 192 .
Neha, Amteshwar S. Jaggi & Nirmal Singh. 2016. Drug Discovery from Mother Nature. Drug Discovery from Mother Nature 25 44 .
Hun Jung, Nirmal Rajasekaran, Woong Ju & Young Shin. (2015) Human Papillomavirus: Current and Future RNAi Therapeutic Strategies for Cervical Cancer. Journal of Clinical Medicine 4:5, pages 1126-1155.
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Li Fan, Yalin Ma, Ying Liu, Dongping Zheng & Guangrong Huang. (2014) Silymarin induces cell cycle arrest and apoptosis in ovarian cancer cells. European Journal of Pharmacology 743, pages 79-88.
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Sung Il Cho, Ji-Eun Lee & Nam Yong Do. (2014) Protective effect of silymarin against cisplatin-induced ototoxicity. International Journal of Pediatric Otorhinolaryngology 78:3, pages 474-478.
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Nataša Milić, Nataša Milošević, Ljiljana Suvajdžić, Marija Žarkov & Ludovico Abenavoli. (2013) New Therapeutic Potentials of Milk Thistle ( Silybum marianum ) . Natural Product Communications 8:12, pages 1934578X1300801.
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. 2013. Principles and Practice of Phytotherapy. Principles and Practice of Phytotherapy 353 961 .
Gagan Deep & Rajesh Agarwal. (2016) Chemopreventive Efficacy of Silymarin in Skin and Prostate Cancer. Integrative Cancer Therapies 6:2, pages 130-145.
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Reinhard Saller, Jörg Melzer, Jürgen Reichling, Reto Brignoli & Remy Meier. (2007) An Updated Systematic Review of the Pharmacology of Silymarin. Complementary Medicine Research 14:2, pages 70-80.
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