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Abstracts

Studies on the preparation, crystal structure and bioactivity of ginsenoside compound K

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Pages 519-527 | Received 12 Dec 2004, Accepted 14 Mar 2005, Published online: 17 Dec 2010

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Qin YAN, Wei ZHOU, Xingwei LI, Meiqing FENG & Pei ZHOU. (2008) Purification Method Improvement and Characterization of a Novel Ginsenoside-Hydrolyzing β-Glucosidase from Paecilomyces Bainier sp. 229. Bioscience, Biotechnology, and Biochemistry 72:2, pages 352-359.
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Eun-Bi Jeong, Se-A Kim, Kyung-Chul Shin & Deok-Kun Oh. (2020) Biotransformation of Protopanaxadiol-Type Ginsenosides in Korean Ginseng Extract into Food-Available Compound K by an Extracellular Enzyme from Aspergillus niger . Journal of Microbiology and Biotechnology 30:10, pages 1560-1567.
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Jinyao Chen, Wenming Zhu, Weijie Ji, Bin Zhu, Chunyang Guo, Minghui Qi & Guobin Ren. (2019) Crystal structure and physical stability of ginsenoside compound-K solvates. CrystEngComm 21:47, pages 7313-7321.
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Lu Yu, Yuan Chen, Jie Shi, Rufeng Wang, Yingbo Yang, Li Yang, Shujuan Zhao & Zhengtao Wang. (2019) Biosynthesis of rare 20(R)-protopanaxadiol/protopanaxatriol type ginsenosides through Escherichia coli engineered with uridine diphosphate glycosyltransferase genes. Journal of Ginseng Research 43:1, pages 116-124.
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Ji-Hyeon Choi, Kyung-Chul Shin & Deok-Kun Oh. (2018) An L213A variant of β-glycosidase from Sulfolobus solfataricus with increased α-L-arabinofuranosidase activity converts ginsenoside Rc to compound K. PLOS ONE 13:1, pages e0191018.
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Xiao-Jia Chen, Xiao-Jing Zhang, Yan-Mei Shui, Jian-Bo Wan & Jian-Li Gao. (2016) Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites. Evidence-Based Complementary and Alternative Medicine 2016, pages 1-19.
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Yun Jong LeeKye Yong SongEun Young LeeHeun Soo KangYeong Wook Song. (2015) Compound K, a Metabolite of Ginsenosides, Attenuates Collagen-induced Arthritis in Mice. Journal of Rheumatic Diseases 22:3, pages 154.
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Xi-Ding Yang, Yong-Yu Yang, Dong-Sheng Ouyang & Guo-Ping Yang. (2015) A review of biotransformation and pharmacology of ginsenoside compound K. Fitoterapia 100, pages 208-220.
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Su-Kyung Sung, Young-Kyung Rhee, Chang-Won Cho, Young-Chan Kim, OK-Hwan Lee & Hee-Do Hong. (2013) Physicochemical Properties and Antioxidative Activity of Fermented Rhodiola sachalinensis and Korean Red Ginseng Mixture by Lactobacillus acidophilus. The Korean Journal of Food And Nutrition 26:3, pages 358-365.
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YAN ZHENG, HONGMEI NAN, MIAO HAO, CHENGCHENG SONG, YIFA ZHOU & YUFEI GAO. (2013) Antiproliferative effects of protopanaxadiol ginsenosides on human colorectal cancer cells. Biomedical Reports 1:4, pages 555-558.
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Huike Gu, Runyan Li, Yajuan Sun, Shaohua Li, Weibing Dong & Junbo Gong. (2013) Molecular modeling of crystal morphology of ginsenoside compound K solvates and its crystal habit modification by solvent molecules. Journal of Crystal Growth 373, pages 146-150.
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Juan Gao, Wenjing Xu, Qiang Fang, Fei Liang, Rutian Jin, Di Wu, Guihua Tai & Yifa Zhou. (2012) Efficient biotransformation for preparation of pharmaceutically active ginsenoside Compound K by Penicillium oxalicum sp. 68. Annals of Microbiology 63:1, pages 139-149.
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J.-G. Hou, J.-J. Xue, M.-Q. Sun, C.-Y. Wang, L. Liu, D.-L. Zhang, M.-R. Lee, L.-J. Gu, C.-L. Wang, Y.-B. Wang, Y. Zheng, W. Li & C.-K. Sung. (2012) Highly selective microbial transformation of major ginsenoside Rb1 to gypenoside LXXV by Esteya vermicola CNU120806. Journal of Applied Microbiology 113:4, pages 807-814.
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Se-Hwa Kim, Jin-Woo Min, Lin-Hu Quan, Sung-Young Lee, Dong-Uk Yang & Deok-Chun Yang. (2012) Enzymatic Transformation of Ginsenoside Rb1 by Lactobacillus pentosus Strain 6105 from Kimchi. Journal of Ginseng Research 36:3, pages 291-297.
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박상헌, 이정민, 양정은 & 신헌섭. (2012) Effects of Ginsenoside Enriched in Compound K by Biotransformation on HHDPC and HaCaT Cell Growth. Journal of Investigative Cosmetology 8:2, pages 99-106.
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Youl Her, Young-Chul Lee, Jin-Hwan Oh, Yoon-E Choi, Chang-Woo Lee, Jin-Suk Kim, Hwan Mook Kim & Ji-Won Yang. (2012) An application of β-glycosidase to transformation of ginsenosides for the effective production of specific ginsenosides with biological efficacy. Biotechnology and Bioprocess Engineering 17:3, pages 538-546.
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Jin-Ying Piao, Yeon-Ju Kim, Lin-Hu Quan, Dong-Uk Yang, Jin-Woo Min, Seon-Heui Son, Sang-Mok Kim & Deok-Chun Yang. (2011) Bioconversion of Ginsenoside Rb1 to Compound K using Leuconostoc lactis DC201. Korean Journal of Plant Resources 24:6, pages 712-718.
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Li Ye, Chao-Qun Zhou, Wei Zhou, Pei Zhou, Dao-Feng Chen, Xiao-Hui Liu, Xun-Long Shi & Mei-Qing Feng. (2010) Biotransformation of ginsenoside Rb1 to ginsenoside Rd by highly substrate-tolerant Paecilomyces bainier 229-7. Bioresource Technology 101:20, pages 7872-7876.
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Qin Yan, Wei Zhou, XunLong Shi, Pei Zhou, DianWen Ju & MeiQing Feng. (2010) Biotransformation pathways of ginsenoside Rb1 to compound K by β-glucosidases in fungus Paecilomyces Bainier sp. 229. Process Biochemistry 45:9, pages 1550-1556.
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. (2008) Conversion of Ginsenoside Rd to Compound K by Crude Enzymes Extracted from Lactobacillus brevis LH8. Journal of Ginseng Research 32:3, pages 226-231.
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Wei Zhou, Jiyang Li, Xinwei Li, Qin Yan & Pei Zhou. (2008) Development and validation of a reversed-phase HPLC method for quantitative determination of ginsenosides Rb1, Rd, F2, and compound K during the process of biotransformation of ginsenoside Rb1. Journal of Separation Science 31:6-7, pages 921-925.
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