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Original Articles

Three major urinary metabolites of sinomenine in rats

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Pages 13-18 | Received 28 Mar 2005, Accepted 30 Jun 2005, Published online: 28 Feb 2007

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Read on this site (1)

Xiang-Xiang Zhao, Cheng Peng, Hong Zhang & Lu-Ping Qin. (2012) Sinomenium acutum: A review of chemistry, pharmacology, pharmacokinetics, and clinical use. Pharmaceutical Biology 50:8, pages 1053-1061.
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Articles from other publishers (17)

Ke Fang, Shaoyu Ren & Qian Zhang. (2023) Identification and characterization of the metabolites of sinomenine using liquid chromatography combined with benchtop Orbitrap mass spectrometry and nuclear magnetic resonance spectroscopy. Rapid Communications in Mass Spectrometry 38:3.
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Dan Li, Zhangfeng Zhong, Chung‐Nga Ko, Tiantian Tian & Chao Yang. (2023) From mundane to classic: Sinomenine as a multi‐therapeutic agent. British Journal of Pharmacology.
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Lulu Yu, Xunjia Qian, Yiheng Feng, Yujian Yin, Xiao-Dan Zhang, Qianqian Wei, Liyun Wang, Weiwei Rong, Jie-Jia Li, Jun-Xu Li & Qing Zhu. (2023) Investigation of preclinical pharmacokinetics of N-demethylsinomenine, a potential novel analgesic candidate, using an UPLC-MS/MS quantification method. Frontiers in Chemistry 11.
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Siwei Wang, Lvzhuo Zhang, Yanhua Zhou, Zhenzhen Liu, Zushan Zhou & Jiangrong Huang. (2023) A review on pharmacokinetics of sinomenine and its anti-inflammatory and immunomodulatory effects. International Immunopharmacology 119, pages 110227.
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Hiroto Kataoka, Kanae Ura & Tetsuya Saita. (2023) Development of a Simple and Sensitive Enzyme-linked Immunosorbent Assay for Sinomenineシノメニンの簡便で高感度な酵素免疫測定法の開発. YAKUGAKU ZASSHI 143:2, pages 153-158.
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Antoinette Keita, Romain Duval & François-Hugues Porée. 2023.
Mengyu Qian, Xia Gao, Xialin Chen, Jiajia Wang, Huifang Gao, Qi Tang, Liang Cao & Wei Xiao. (2022) Metabolic characteristics and pharmacokinetic differences of Qiwei Tongbi oral liquid in rheumatoid arthritis rats. Biomedical Chromatography 36:7.
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Kuo Yu, Ying Sun, Lu Xue, Jingtao He, Fangyi Li, Maojing Yin, Zheng Li, Xiaohui Yan, Jialiang Guo, Guoqiang Li & Chunhua Wang. (2022) Compounds with NO Inhibitory Effect from the Rattan Stems of Sinomenium acutum , a Kind of Chinese Folk Medicine for Treating Rheumatoid Arthritis . Chemistry & Biodiversity 19:6.
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Zhiyong Zhou, Nanqing Qiu, Yuntao Ou, Qianqian Wei, Wenting Tang, Mingcong Zheng, Yaluan Xing, Jie-Jia Li, Yong Ling, Junxu Li & Qing Zhu. (2021) N-Demethylsinomenine, an active metabolite of sinomenine, attenuates chronic neuropathic and inflammatory pain in mice. Scientific Reports 11:1.
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Jerome P. L. Ng, Paolo Coghi, Betty Yuen Kwan Law, Liang Liu & Vincent Kam Wai Wong. (2020) The present and future synthetic strategies of structural modifications of sinomenine. Organic Chemistry Frontiers 7:24, pages 4089-4107.
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Qiang Li, Wenbin Zhou, Yuyan Wang, Fang Kou, Chunming Lyu & Hai Wei. (2020) Metabolic mechanism and anti-inflammation effects of sinomenine and its major metabolites N-demethylsinomenine and sinomenine-N-oxide. Life Sciences 261, pages 118433.
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Tianle Gao, Tiansheng Shi, Zsuzsanna Wiesenfeld-Hallin, Tao Li, Jian-Dong Jiang & Xiao-Jun Xu. (2019) Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain. European Journal of Pharmacology 854, pages 101-108.
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Yuntao Ou, Man Su, Yong Ling, Qianqian Wei, Fei Pan, Jiejia Li, Jun-Xu Li & Qing Zhu. (2018) Anti-allodynic effects of N -demethylsinomenine, an active metabolite of sinomenine, in a mouse model of postoperative pain. European Journal of Pharmacology 823, pages 105-109.
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Tianle Gao, Tiansheng Shi, Zsuzsanna Wiesenfeld-Hallin, Camilla I. Svensson & Xiao-Jun Xu. (2015) Sinomenine alleviates mechanical hypersensitivity in mice with experimentally induced rheumatoid arthritis. Scandinavian Journal of Pain 7:1, pages 9-14.
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Tianle Gao, Tiansheng Shi, Dan-Qiao Wang, Zsuzsanna Wiesenfeld-Hallin & Xiao-Jun Xu. (2014) Repeated sinomenine administration alleviates chronic neuropathic pain-like behaviours in rodents without producing tolerance. Scandinavian Journal of Pain 5:4, pages 249-255.
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Roger Joyeau, Mariane Planchon, Jenna Abessolo, Kevin Aissa, Caroline Bance & Didier Buisson. (2013) Combinatorial approach to the selection of active microorganisms in biotransformation: Application to sinomenine. Journal of Molecular Catalysis B: Enzymatic 85-86, pages 65-70.
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Peng Teng, Hai-Liang Liu, Zhang-Shuang Deng, Zhi-Bing Shi, Yun-Mian He, Li-Li Feng, Qiang Xu & Jian-Xin Li. (2011) Synthesis and biological evaluation of unique stereodimers of sinomenine analogues as potential inhibitors of NO production. Bioorganic & Medicinal Chemistry 19:10, pages 3096-3104.
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