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Journal of Asian Natural Products Research Volume 10, 2008 - Issue 1
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Original Articles

Oridonin induces human epidermoid carcinoma A431 cell apoptosis through tyrosine kinase and mitochondrial pathway

DAN Li China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, 110016, China
,
Department of Phytochemistry, Shenyang Pharmaceutical University, Shenyang, 110016, China
,
LI-JUN Wu Department of Phytochemistry, Shenyang Pharmaceutical University, Shenyang, 110016, China
,
SHIN-ICHI Tashiro Department of Clinical and Biomedical Science, Showa Pharmaceutical University, Tokyo, 194-8543, Japan
,
SATOSHI Onodera Department of Clinical and Biomedical Science, Showa Pharmaceutical University, Tokyo, 194-8543, Japan
&
TAKASHI Ikejima China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaCorrespondence[email protected]
Pages 77-87 | Received 23 Aug 2006, Accepted 26 Jan 2007, Published online: 03 Dec 2007

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Sheikh Rayees, Ajay Kumar, Shafaq Rasool, Peerzada Kaiser, Naresh Kumar Satti, Payare Lal Sangwan, Surjeet Singh, Rakesh Kamal Johri & Gurdarshan Singh. (2013) Ethanolic Extract of (AS-1) Inhibits IgE-mediated Allergic Response in RBL-2H3 Cells. Immunological Investigations 42:6, pages 470-480.
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Yang Yu, Si-Miao Fan, Yuan-Chao Ye, Shin-ichi Tashiro, Satoshi Onodera & Takashi Ikejima. (2012) The tyrphostin AG1478 augments oridonin-induced A431 cell apoptosis by blockage of JNK MAPK and enhancement of oxidative stress. Free Radical Research 46:11, pages 1393-1405.
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Articles from other publishers (21)

Rui Li, Xiao-Rong Sun, Xiao-Ting He, Xue-Mei Zhou, Xue-Wen Wu, Rui-Han Zhang, Xing-Jie Zhang, Xiao-Li Li & Wei-Lie Xiao. (2023) 16,17-dinor-abietane diterpenoids from Casearia kurzii. Fitoterapia 168, pages 105519.
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Listiana Oktavia, Asrul Muhamad Fuad, Seni Kurnia Senjaya & Yuliawati Yuliyawati. (2023) Naturally Occurring Compounds as Potential Inhibitors of Epidermal Growth Factor Receptors (EGFRs). Combinatorial Chemistry & High Throughput Screening 26:6, pages 1093-1107.
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Tanzida Zubair & Debasish Bandyopadhyay. (2023) Small Molecule EGFR Inhibitors as Anti-Cancer Agents: Discovery, Mechanisms of Action, and Opportunities. International Journal of Molecular Sciences 24:3, pages 2651.
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Xinying Wang, Ming Gao, Zihan Wang, Weiqi Cui, Jingxian Zhang, Weijie Zhang, Yu Xia, Bo Wei, Youcai Tang & Xia Xu. (2021) Hepatoprotective effects of oridonin against bisphenol A induced liver injury in rats via inhibiting the activity of xanthione oxidase. Science of The Total Environment 770, pages 145301.
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Yuan Liang, Tiehua Zhang & Jie Zhang. (2020) Natural tyrosine kinase inhibitors acting on the epidermal growth factor receptor: Their relevance for cancer therapy. Pharmacological Research 161, pages 105164.
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Vijaybabu KPunnagai K2. (2019) In-vitro Anti-proliferative Effects of Ethanolic Extract of Vanilla Planifolia Leaf Extract against A431 Human Epidermoid Carcinoma Cells. Biomedical & Pharmacology Journal 12:3, pages 1141-1146.
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Wei Zheng, Chun-Yan Zhou, Xin-Qing Zhu, Xue-Jian Wang, Zi-Yao Li, Xiao-Chi Chen, Feng Chen, Xiang-Yu Che & Xin Xie. (2018) Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death. Biomedicine & Pharmacotherapy 106, pages 175-182.
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Jiang Pi, Hua Jin, Jinhuan Jiang, Fen Yang, Huaihong Cai, Peihui Yang, Jiye Cai & Zheng W. Chen. (2017) Single molecule force spectroscopy for in-situ probing oridonin inhibited ROS-mediated EGF-EGFR interactions in living KYSE-150 cells. Pharmacological Research 119, pages 479-489.
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Shengtao Xu, Guangyu Wang, Yan Lin, Yanju Zhang, Lingling Pei, Hong Yao, Mei Hu, Yangyi Qiu, Zhangjian Huang, Yihua Zhang & Jinyi Xu. (2016) Novel anticancer oridonin derivatives possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Design, synthesis, biological evaluation and nitric oxide release studies. Bioorganic & Medicinal Chemistry Letters 26:12, pages 2795-2800.
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Qiu-Xiang Wu, Shuang-Xue Yuan, Chun-Mei Ren, Yu Yu, Wen-Juan Sun, Bai-Cheng He & Ke Wu. (2016) Oridonin upregulates PTEN through activating p38�MAPK and inhibits proliferation in human colon cancer cells. Oncology Reports.
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Brice Ayissi Owona & Herman J. Schluesener. (2015) Molecular Insight in the Multifunctional Effects of Oridonin. Drugs in R&D 15:3, pages 233-244.
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Faya M. Millimouno, Jia Dong, Liu Yang, Jiang Li & Xiaomeng Li. (2014) Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature. Cancer Prevention Research 7:11, pages 1081-1107.
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Shi-Yong Gao, Jun Li, Xiao-Ying Qu, Nan Zhu & Yu-Bin Ji. (2014) Downregulation of Cdk1 and CyclinB1 Expression Contributes to Oridonin-induced Cell Cycle Arrest at G 2 /M Phase and Growth Inhibition in SGC-7901 Gastric Cancer Cells . Asian Pacific Journal of Cancer Prevention 15:15, pages 6437-6441.
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Liang-Mou Kuo, Chan-Yen Kuo, Chen-Yu Lin, Min-Fa Hung, Jiann-Jong Shen & Tsong-Long Hwang. (2014) Intracellular Glutathione Depletion by Oridonin Leads to Apoptosis in Hepatic Stellate Cells. Molecules 19:3, pages 3327-3344.
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Wei Tian & Si-yu Chen. (2013) Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin. Chinese Journal of Integrative Medicine 19:4, pages 315-320.
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Yang Yu, Si Miao Fan, Jun Ke Song, Shin-ichi Tashiro, Satoshi Onodera & Takashi Ikejima. (2012) Hydroxyl Radical (·OH) Played a Pivotal Role in Oridonin-Induced Apoptosis and Autophagy in Human Epidermoid Carcinoma A431 Cells. Biological and Pharmaceutical Bulletin 35:12, pages 2148-2159.
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Wen Tan, Jinjian Lu, Mingqing Huang, Yingbo Li, Meiwan Chen, Guosheng Wu, Jian Gong, Zhangfeng Zhong, Zengtao Xu, Yuanye Dang, Jiajie Guo, Xiuping Chen & Yitao Wang. (2011) Anti-cancer natural products isolated from chinese medicinal herbs. Chinese Medicine 6:1.
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S.-H. Sung, S.-H. Park, S.-Y. Song, S.-J. Lee, H.-W. Lee, S.-H. Kim, M. A Lee, I.-S. Yoon, D.-D. Kim, S. Kang & J.-H. Sung. (2011) Epidermal regeneration by ent-16α, 17-dihydroxy-kauran-19-oic acid isolated from Siegesbeckia pubescens. Cell Proliferation 44:6, pages 527-536.
Crossref
Kashif Jilani, Syed M. Qadri, Christine Zelenak & Florian Lang. (2011) Stimulation of suicidal erythrocyte death by oridonin. Archives of Biochemistry and Biophysics 511:1-2, pages 14-20.
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Sui Chen, Jiarong Liu & Handong Zhang. (2009) Efficacy of rabdosia rubescens in the treatment of gingivitis. Journal of Huazhong University of Science and Technology [Medical Sciences] 29:5, pages 659-663.
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Jinyi Xu, JingYi Yang, Qian Ran, Lei Wang, Jie Liu, Zhixuan Wang, Xiaoming Wu, Weiyi Hua, Shengtao Yuan, Luyong Zhang, Mingqin Shen & Yongfang Ding. (2008) Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates. Bioorganic & Medicinal Chemistry Letters 18:16, pages 4741-4744.
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