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Original Articles

Acute neurovascular unit protective action of pinocembrin against permanent cerebral ischemia in rats

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Pages 551-558 | Received 23 May 2007, Accepted 07 Jul 2007, Published online: 12 May 2008

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Lanan Wassy Soromou, Lanxiang Jiang, Miaomiao Wei, Na Chen, Meixia Huo, Xiao Chu, Weiting Zhong, Qianchao Wu, Abdourahmane Baldé, Xuming Deng & Haihua Feng. (2014) Protection of mice against lipopolysaccharide-induced endotoxic shock by pinocembrin is correlated with regulation of cytokine secretion. Journal of Immunotoxicology 11:1, pages 56-61.
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Zhi-Hong Yang, Xiao Sun, Yun Qi, Chao Mei, Xiao-Bo Sun & Guan-Hua Du. (2012) Uptake characteristics of pinocembrin and its effect on p-glycoprotein at the blood–brain barrier in in vitro cell experiments. Journal of Asian Natural Products Research 14:1, pages 14-21.
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Mei Gao, Shen-Yin Zhu, Chu-Bing Tan, Bei Xu, Wen-Cui Zhang & Guan-Hua Du. (2010) Pinocembrin protects the neurovascular unit by reducing inflammation and extracellular proteolysis in MCAO rats. Journal of Asian Natural Products Research 12:5, pages 407-418.
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Qiang Su, Yuhan Sun, Ziliang Ye, Huafeng Yang, Binghui Kong & Lang Li. (2018) Pinocembrin protects endothelial cells from oxidized LDL-induced injury. Cytokine 111, pages 475-480.
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Jinhao Tao, Chen Shen, Yanchun Sun, Weiming Chen & Gangfeng Yan. (2018) Neuroprotective effects of pinocembrin on ischemia/reperfusion-induced brain injury by inhibiting autophagy. Biomedicine & Pharmacotherapy 106, pages 1003-1010.
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Xu Yang, Xin Wang, Xiao-Yu Chen, Hai-Yu Ji, Yan Zhang & An-Jun Liu. (2018) Pinocembrin–Lecithin Complex: Characterization, Solubilization, and Antioxidant Activities. Biomolecules 8:2, pages 41.
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Marwa M. Said, Samar S. Azab, Noha M. Saeed & Ebtehal El-Demerdash. (2018) Antifibrotic Mechanism of Pinocembrin: Impact on Oxidative Stress, Inflammation and TGF-β /Smad Inhibition in Rats. Annals of Hepatology 17:2, pages 307-317.
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YinZhong Ma, Li Li, LingLei Kong, ZhiMei Zhu, Wen Zhang, JunKe Song, Junlei Chang & GuanHua Du. (2018) Pinocembrin Protects Blood-Brain Barrier Function and Expands the Therapeutic Time Window for Tissue-Type Plasminogen Activator Treatment in a Rat Thromboembolic Stroke Model. BioMed Research International 2018, pages 1-13.
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Bing Pei & Jian Sun. (2018) Pinocembrin alleviates cognition deficits by inhibiting inflammation in diabetic mice. Journal of Neuroimmunology 314, pages 42-49.
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Marcos Roberto de Oliveira, Alessandra Peres, Clarissa Severino Gama & Simone Morelo Dal Bosco. (2016) Pinocembrin Provides Mitochondrial Protection by the Activation of the Erk1/2-Nrf2 Signaling Pathway in SH-SY5Y Neuroblastoma Cells Exposed to Paraquat. Molecular Neurobiology 54:8, pages 6018-6031.
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Kelsey Murphy & Joshua Park. (2017) Can Co-Activation of Nrf2 and Neurotrophic Signaling Pathway Slow Alzheimer’s Disease?. International Journal of Molecular Sciences 18:6, pages 1168.
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Taiwo Olayemi Elufioye, Tomayo Ireti Berida & Solomon Habtemariam. (2017) Plants-Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms. Evidence-Based Complementary and Alternative Medicine 2017, pages 1-27.
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Xi Lan, Wenzhu Wang, Qiang Li & Jian Wang. (2015) The Natural Flavonoid Pinocembrin: Molecular Targets and Potential Therapeutic Applications. Molecular Neurobiology 53:3, pages 1794-1801.
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Guoying Cao, Pengyue Ying, Bei Yan, Wei Xue, Kexin Li, Aixin Shi, Taohua Sun, Jiling Yan & Xin Hu. (2015) Pharmacokinetics, safety, and tolerability of single and multiple-doses of pinocembrin injection administered intravenously in healthy subjects. Journal of Ethnopharmacology 168, pages 31-36.
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Xiaohua Jin, Qian Liu, Lili Jia, Meng Li & Xuan Wang. (2014) Pinocembrin Attenuates 6-OHDA-induced Neuronal Cell Death Through Nrf2/ARE Pathway in SH-SY5Y Cells. Cellular and Molecular Neurobiology 35:3, pages 323-333.
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Muhammed A. Saad, Rania M. Abdel Salam, Sanaa A. Kenawy & Amina S. Attia. (2015) Pinocembrin attenuates hippocampal inflammation, oxidative perturbations and apoptosis in a rat model of global cerebral ischemia reperfusion. Pharmacological Reports 67:1, pages 115-122.
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Peng-Fei Wang, Yu Zhou, Huang Fang, Sen Lin, Yan-Chun Wang, Yong Liu, Jun Xia, Guy D. Eslick & Qing-Wu Yang. (2015) Treatment of acute cerebral ischemia using animal models: a meta-analysis. Translational Neuroscience 6:1, pages 47-58.
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Dawei Zhang, Bo Huang, Chengjie Xiong & Zhou Yue. (2015) Pinocembrin inhibits matrix metalloproteinase expression in chondrocytes. IUBMB Life 67:1, pages 36-41.
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Bei Yan, Guoying Cao, Taohua Sun, Xi Zhao, Xin Hu, Jiling Yan, Yueying Peng, Aixin Shi, Yang Li, Wei Xue, Min Li, Kexin Li & Yingfa Liu. (2014) Determination of pinocembrin in human plasma by solid-phase extraction and LC/MS/MS: application to pharmacokinetic studies. Biomedical Chromatography 28:12, pages 1601-1606.
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FANRUI MENG, YUEHUA WANG, RUI LIU, MEI GAO & GUANHUA DU. (2014) Pinocembrin alleviates memory impairment in transient global cerebral ischemic rats. Experimental and Therapeutic Medicine 8:4, pages 1285-1290.
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Gang Zhao, Wen Zhang, Li Li, Song Wu & Guanhua Du. (2014) Pinocembrin Protects the Brain against Ischemia-Reperfusion Injury and Reverses the Autophagy Dysfunction in the Penumbra Area. Molecules 19:10, pages 15786-15798.
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Lei Ye, Jianwei Gong, Yonghua Wang & Xiling Sun. (2014) Pharmacological Activities of Sijunzi Decoction Which Are Related to Its Antioxidant Properties. Journal of Chemistry 2014, pages 1-10.
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Li Li, Xiao-Bin Pang, Bai-Nian Chen, Li Gao, Le Wang, Shou-Bao Wang, Su-Bo Wang, De-Pei Liu & Guan-Hua Du. (2013) Pinocembrin inhibits angiotensin II-induced vasoconstriction via suppression of the increase of [Ca2+]i and ERK1/2 activation through blocking AT1R in the rat aorta. Biochemical and Biophysical Research Communications 435:1, pages 69-75.
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Li LI, Hai-Guang YANG, Tian-Yi YUAN, Yan ZHAO & Guan-Hua DU. (2013) Rho kinase inhibition activity of pinocembrin in rat aortic rings contracted by angiotensin II. Chinese Journal of Natural Medicines 11:3, pages 258-263.
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Shou-Bao WANG, Xiao-Bin PANG, Mei GAO, Lian-Hua FANG & Guan-Hua DU. (2013) Pinocembrin protects rats against cerebral ischemic damage through soluble epoxide hydrolase and epoxyeicosatrienoic acids. Chinese Journal of Natural Medicines 11:3, pages 207-213.
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Qun Lu & Jian-Guo Jiang. (2013) Response to Comment on Isolation and Identification of Compounds from Penthorum chinense Pursh with Antioxidant and Antihepatocarcinoma Properties: Bioactivities of Pinocembrine Group and Its Derivatives Are Noteworthy. Journal of Agricultural and Food Chemistry 61:6, pages 1417-1417.
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Jin-hui Li, Jing Lu & Hong Zhang. (2013) Functional Recovery after Scutellarin Treatment in Transient Cerebral Ischemic Rats: A Pilot Study with 18 F-Fluorodeoxyglucose MicroPET . Evidence-Based Complementary and Alternative Medicine 2013, pages 1-9.
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Azhar Rasul, Faya Martin Millimouno, Wafa Ali Eltayb, Muhammad Ali, Jiang Li & Xiaomeng Li. (2013) Pinocembrin: A Novel Natural Compound with Versatile Pharmacological and Biological Activities. BioMed Research International 2013, pages 1-9.
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Bo-yu Li, Yu-he Yuan, Jin-feng Hu, Qing Zhao, Dong-ming Zhang & Nai-hong Chen. (2011) Protective effect of Bu-7, a flavonoid extracted from Clausena lansium, against rotenone injury in PC12 cells. Acta Pharmacologica Sinica 32:11, pages 1321-1326.
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