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Original Articles

Scutellarin protects against lipopolysaccharide-induced acute lung injury via inhibition of NF-κB activation in mice

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Pages 175-184 | Received 03 Jul 2009, Accepted 16 Sep 2009, Published online: 26 Mar 2010

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Xiaoxue Zhang, Renpeng Ji, Huijun Sun, Jinyong Peng, Xiaodong Ma, ChangYuan Wang, Yufeng Fu, Liuchi Bao & Yue Jin. (2018) Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway. Free Radical Research 52:2, pages 198-211.
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Articles from other publishers (19)

Hao-Lun Chen, Li Yang, Xiao-Li-Na Zhang, Qiu-Ye Jia, Zhao-Da Duan, Juan-juan Li, Li-yang Zheng, Teng-teng Liu, Zhi Qi, Yun Yuan & Chun-Yun Wu. (2023) Scutellarin Acts via MAPKs Pathway to Promote M2 Polarization of Microglial Cells. Molecular Neurobiology 60:8, pages 4304-4323.
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Natalie Vivien Gunter & Siau Hui Mah. 2023. Handbook of Dietary Flavonoids. Handbook of Dietary Flavonoids 1 73 .
Ruiyun Li, Yanru Zhu, Miao Yu, Ting Liu, Yunli Zhao & Zhiguo Yu. (2022) Study on the mechanism of anti-acute lung injury of Shuanghuanglian oral liquid based on identification of transitional components in blood and network pharmacology. Journal of Chromatography B 1212, pages 123498.
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Li Zhang, Qiaohua Yan, Wei Zhang, Xiaoyuan Li, Xiu Zhang, Shijing Du, Xiaoping Hua, Juchun Lin, Gang Shu, Guangneng Peng, Zhenghuai Tan & Hualin Fu. (2022) Enhancement of the functionality of attenuating acute lung injury by a microemulsion formulation with volatile oil of Angelicae Sinensis Radix and Ligusticum Chuanxiong Rhizoma encapsulated. Biomedicine & Pharmacotherapy 156, pages 113888.
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Jingyuan Zhu, Anoop Sainulabdeen, Krystal Akers, Vishnu Adi, Jeffrey R. Sims, Eva Yarsky, Yi Yan, Yu Yu, Hiroshi Ishikawa, Christopher K. Leung, Gadi Wollstein, Joel S. Schuman, Wenbin Wei & Kevin C. Chan. (2021) Oral Scutellarin Treatment Ameliorates Retinal Thinning and Visual Deficits in Experimental Glaucoma. Frontiers in Medicine 8.
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Yu-Qiong He, Can-Can Zhou, Lu-Yao Yu, Liang Wang, Jiu-ling Deng, Yu-Long Tao, Feng Zhang & Wan-Sheng Chen. (2021) Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms. Pharmacological Research 163, pages 105224.
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Jiezhou Ye, Bo Zeng, Meiyan Zhong, Hongchun Li, Lihui Xu, Junxiang Shu, Yaofeng Wang, Fan Yang, Chunsu Zhong, Xunjia Ye, Xianhui He & Dongyun Ouyang. (2021) Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling. Acta Pharmaceutica Sinica B 11:1, pages 112-126.
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Hao-Lun Chen, Wen-Ji Jia, Hong-E Li, Hong Han, Fan Li, Xiao-Li-Na Zhang, Juan-Juan Li, Yun Yuan & Chun-Yun Wu. (2019) Scutellarin Exerts Anti-Inflammatory Effects in Activated Microglia/Brain Macrophage in Cerebral Ischemia and in Activated BV-2 Microglia Through Regulation of MAPKs Signaling Pathway. NeuroMolecular Medicine 22:2, pages 264-277.
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Juan Nie, Hong-Mei Yang, Chao-Yue Sun, Yan-Lu Liu, Jian-Yi Zhuo, Zhen-Biao Zhang, Xiao-Ping Lai, Zi-Ren Su & Yu-Cui Li. (2018) Scutellarin Enhances Antitumor Effects and Attenuates the Toxicity of Bleomycin in H22 Ascites Tumor-Bearing Mice. Frontiers in Pharmacology 9.
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Yi Liu, Yan-Yun Jing, Chen-Ying Zeng, Chen-Guang Li, Li-Hui Xu, Liang Yan, Wen-Jing Bai, Qing-Bing Zha, Dong-Yun Ouyang & Xian-Hui He. (2018) Scutellarin Suppresses NLRP3 Inflammasome Activation in Macrophages and Protects Mice against Bacterial Sepsis. Frontiers in Pharmacology 8.
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Jun Li, Shu Zhang, Rui Zhou, Jian Zhang & Zong-Fang Li. (2017) Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. World Journal of Gastroenterology 23:20, pages 3615.
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Shuai Zhao, Yu Sun, Xiaolei Li, Jingcheng Wang, Lianqi Yan, Zhen Zhang, Daxin Wang, Jihang Dai, Jun He & Shuguang Wang. (2016) Scutellarin inhibits RANKL-mediated osteoclastogenesis and titanium particle-induced osteolysis via suppression of NF-κB and MAPK signaling pathway. International Immunopharmacology 40, pages 458-465.
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Dian-Wei Wu, Xiao-Dan Yu, Jian-Hui Xie, Zu-Qing Su, Ji-Yan Su, Li-Rong Tan, Xiao-Qi Huang, Jian-Nan Chen & Zi-Ren Su. (2013) Inactivation of jack bean urease by scutellarin: Elucidation of inhibitory efficacy, kinetics and mechanism. Fitoterapia 91, pages 60-67.
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Kaihui Lu, Miaomiao Han, Hui Lin Ting, Zeyu Liu & Dawei Zhang. (2013) Scutellarin from Scutellaria baicalensis Suppresses Adipogenesis by Upregulating PPARα in 3T3-L1 Cells . Journal of Natural Products 76:4, pages 672-678.
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Xingyong Chen, Xiaogeng Shi, Xu Zhang, Huixin Lei, Simei Long, Huanxing Su, Zhong Pei & Ruxun Huang. (2013) Scutellarin Attenuates Hypertension-Induced Expression of Brain Toll-Like Receptor 4/Nuclear Factor Kappa B. Mediators of Inflammation 2013, pages 1-9.
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Chen Hanqing, Zhang Xiping, Ou Jingmin, Jiang Jun & Wu Dijiong. (2011) Research on Scutellarin Parenteral Solution’s Protective Effects in Rats with Severe Acute Pancreatitis and Multiple Organ Injuries. Inflammation 35:3, pages 1005-1014.
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Haiqiang Zhou, Difei Bian, Xiaolan Jiao, Zhifeng Wei, Haofang Zhang, Yufeng Xia, Yisheng He & Yue Dai. (2011) Paeoniflorin protects against lipopolysaccharide-induced acute lung injury in mice by alleviating inflammatory cell infiltration and microvascular permeability. Inflammation Research 60:10, pages 981-990.
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S. Wang, H. Wang, H. Guo, L. Kang, X. Gao & L. Hu. (2011) Neuroprotection of Scutellarin is mediated by inhibition of microglial inflammatory activation. Neuroscience 185, pages 150-160.
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Zhenwei Pan, Weiming Zhao, Xiangying Zhang, Bing Wang, Jinghao Wang, Xuelin Sun, Xuantong Liu, Shuya Feng, Baofeng Yang & Yanjie Lu. (2011) Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGFβ1 expression and activation of p38-MAPK and ERK1/2. British Journal of Pharmacology 162:3, pages 688-700.
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