Metabolic Activation of Dibenzo[a,l]Pyrene by Cytochrome P450 Enzymes to Stable DNA Adducts Occurs Exclusively Through the Formation of the (−)-trans−(11R, 12R)-Diol

Andreas Luch Institute of Toxicology and Environmental Hygiene, Technical University of Munich, D-80636, Munich, Germany; Departments of Environmental & Molecular Toxicology and Biochemistry & Biophysics, Oregon State University, Agricultural and Life Sciences 1011, Corvallis, OR, 97331, USA

Wolfgang Schober Institute of Toxicology and Environmental Hygiene, Technical University of Munich, D-80636, Munich, Germany

Helmut Greim Institute of Toxicology and Environmental Hygiene, Technical University of Munich, D-80636, Munich, Germany; GSF–National Research Center for Environment and Health, Institute of Toxicology, D-85764, Neuherberg, Germany

Johannes Doehmer Institute of Toxicology and Environmental Hygiene, Technical University of Munich, D-80636, Munich, Germany

Jürgen Jacob Biochemical Institute of Environmental Carcinogens, D-22927, Grosshansdorf, Germany

Albrecht Seidel Biochemical Institute of Environmental Carcinogens, D-22927, Grosshansdorf, Germany

William M. Baird Departments of Environmental & Molecular Toxicology and Biochemistry & Biophysics, Oregon State University, Agricultural and Life Sciences 1011, Corvallis, OR, 97331, USA

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Jürgen Jacob. (2008) THE SIGNIFICANCE OF POLYCYCLIC AROMATIC HYDROCARBONS AS ENVIRONMENTAL CARCINOGENS. 35 YEARS RESEARCH ON PAH—A RETROSPECTIVE. Polycyclic Aromatic Compounds 28:4-5, pages 242-272.
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Fei Li, Weifeng Zhu & Frank J. Gonzalez. (2017) Potential role of CYP1B1 in the development and treatment of metabolic diseases. Pharmacology & Therapeutics 178, pages 18-30.
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Robert Landsiedel, Eric Fabian, Tewes Tralau & Andreas Luch. (2011) Chemical toxicity testing in vitro using cytochrome P450–expressing cell lines, such as human CYP1B1. Nature Protocols 6:5, pages 677-688.
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Brinda Mahadevan, Andreas Luch, Jennifer Atkin, Melanie Haynes, Tuan Nguyen & William M. Baird. (2007) Inhibition of human cytochrome p450 1b1 further clarifies its role in the activation of dibenzo[ a , l ]pyrene in cells in culture . Journal of Biochemical and Molecular Toxicology 21:3, pages 101-109.
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Metabolic Activation of Dibenzo[a,l]Pyrene by Cytochrome P450 Enzymes to Stable DNA Adducts Occurs Exclusively Through the Formation of the (−)-trans−(11R, 12R)-Diol

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Metabolic Activation of Dibenzo[a,l]Pyrene by Cytochrome P450 Enzymes to Stable DNA Adducts Occurs Exclusively Through the Formation of the (−)-trans−(11R, 12R)-Diol

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