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Review Article

Characteristics, Biological Properties and Analytical Methods of Piperine: A Review

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Pages 62-77 | Published online: 27 Feb 2019

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Tianjing Ren & Zhong Zuo. (2019) Role of piperine in CNS diseases: pharmacodynamics, pharmacokinetics and drug interactions. Expert Opinion on Drug Metabolism & Toxicology 15:10, pages 849-867.
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Articles from other publishers (32)

Jiayi Sun, Biqi Tang, Chi-Tang Ho & Muwen Lu. (2023) Piperine Attenuates Bmal1 -Mediated Glucose Metabolism Disorder in a Trpv1 -Dependent Manner in HepG2 Cells . Journal of Agricultural and Food Chemistry.
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Sagar Joshi, Salahuddin, Avijit Mazumder, Rajnish Kumar, Km Shabana, Sonakshi Tyagi, Kavita Rana, Mohamed Jawed AhsanMohammad Shahar Yar, Arvind Arya & Navneet Khurana. (2023) Significant Advancement in Various Synthetic Strategies and Pharmacotherapy of Piperine Derivatives: A Review. Current Topics in Medicinal Chemistry 23:25, pages 2394-2415.
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Phiwayinkosi V. Dludla, Ilenia Cirilli, Fabio Marcheggiani, Sonia Silvestri, Patrick Orlando, Ndivhuwo Muvhulawa, Marakiya T. Moetlediwa, Bongani B. Nkambule, Sithandiwe E. Mazibuko-Mbeje, Nokulunga Hlengwa, Sidney Hanser, Duduzile Ndwandwe, Jeanine L. Marnewick, Albertus K. Basson & Luca Tiano. (2023) Bioactive Properties, Bioavailability Profiles, and Clinical Evidence of the Potential Benefits of Black Pepper (Piper nigrum) and Red Pepper (Capsicum annum) against Diverse Metabolic Complications. Molecules 28:18, pages 6569.
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Chaohua Zhang, Zhiqiang Niu, Zhiliang He, Yunshuang Ding, Guiping Wu, Haifeng Wu, Weijun Chen, Conghui Dong, Zan Ye, Fenglin Gu & Weicheng Hu. (2023) Molecular interaction of soybean protein and piperine by computational docking analyses. Food Hydrocolloids, pages 109249.
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Wen Zhang, Fuli Zhu, Yi Huang, Xiangli He, Jie Li, Jin Huang & Lei Ma. (2023) Design and Synthesis of Isobavachalcone Derivatives as Potential Dihydroorotate Dehydrogenase Inhibitors. ChemistrySelect 8:26.
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Sharmistha Das, Payel Paul, Debabrata Ghosh Dastidar, Poulomi Chakraborty, Sudipta Chatterjee, Sarita Sarkar, Debasish Maiti & Prosun Tribedi. (2022) Piperine Exhibits Potential Antibiofilm Activity Against Pseudomonas aeruginosa by Accumulating Reactive Oxygen Species, Affecting Cell Surface Hydrophobicity and Quorum Sensing. Applied Biochemistry and Biotechnology 195:5, pages 3229-3256.
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Flávio Augusto Sanches Politi, Suzana Gonçalves Carvalho, Camila Fernanda Rodero, Kaio Pini dos Santos, Andréia Bagliotti Meneguin, Rodrigo Sorrechia, Leila Aparecida Chiavacci & Marlus Chorilli. (2023) Piperine-loaded nanoparticles incorporated into hyaluronic acid/sodium alginate-based membranes for the treatment of inflammatory skin diseases. International Journal of Biological Macromolecules 227, pages 736-748.
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Charles Lwamba, Saied A. Aboushanab, Ranga Rao Ambati & Elena G. Kovaleva. (2023) Innovative Green Approach for Extraction of Piperine from Black Pepper Based on Response Surface Methodology. Sustainable Chemistry 4:1, pages 40-53.
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Mariana Matias, Adriana O. Santos, Samuel Silvestre & Gilberto Alves. (2023) Fighting Epilepsy with Nanomedicines—Is This the Right Weapon?. Pharmaceutics 15:2, pages 306.
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Rengasamy Balakrishnan, Shofiul Azam, In-Su Kim & Dong-Kug Choi. (2023) Neuroprotective Effects of Black Pepper and Its Bioactive Compounds in Age-Related Neurological Disorders. Aging and disease 14:3, pages 750.
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Xiaojin Peng, Ning Liu, Mingxia Wang, Bing Liang, Chunte Feng, Renshuai Zhang, Xufu Wang, Xiaokun Hu, Huiyan Gu & Dongming Xing. (2022) Recent advances of kinetic model in the separation of essential oils by microwave-assisted hydrodistillation. Industrial Crops and Products 187, pages 115418.
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Xia Hu, Di Wu, Lan Tang, Jing Zhang, Zhen Zeng, Fang Geng & Hui Li. (2022) Binding mechanism and antioxidant activity of piperine to hemoglobin. Food Chemistry 394, pages 133558.
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Arumugam Priya & Shunmugiah Karutha Pandian. (2022) Biofilm and hyphal inhibitory synergistic effects of phytoactives piperine and cinnamaldehyde against Candida albicans . Medical Mycology 60:8.
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Ting-Yang Hsieh, Yi Chang & Su-Jane Wang. (2022) Piperine Provides Neuroprotection against Kainic Acid-Induced Neurotoxicity via Maintaining NGF Signalling Pathway. Molecules 27:9, pages 2638.
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Lele Zhang, Jifa Zhang, Jiaxing Wang, Changyu Ren, Pan Tang, Liang Ouyang & Yuxi Wang. (2022) Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: Current development and future perspectives. European Journal of Medicinal Chemistry 232, pages 114176.
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Galih Aji Kuncoro Jati, Nazzun Assihhah, Anas Ardiana Wati & Siti Isrina Oktavia Salasia. (2022) Immunosuppression by piperine as a regulator of the NLRP3 inflammasome through MAPK/NF-κB in monosodium urate-induced rat gouty arthritis. Veterinary World, pages 288-298.
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Dimas Rahadian Aji Muhammad. (2022) Nanoencapsulation: A New Way of Using Herbs and Spices in Food and Its Related Products. Reviews in Agricultural Science 10:0, pages 288-303.
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Sharmistha Das, Payel Paul, Sudipta Chatterjee, Poulomi Chakraborty, Ranojit K. Sarker, Amlan Das, Debasish Maiti & Prosun Tribedi. (2021) Piperine exhibits promising antibiofilm activity against Staphylococcus aureus by accumulating reactive oxygen species (ROS). Archives of Microbiology 204:1.
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Dongdong Wang, Lu Zhang, Jiansheng Huang, K. Himabindu, Devesh Tewari, Jarosław O. Horbańczuk, Suowen Xu, Zhu Chen & Atanas G. Atanasov. (2021) Cardiovascular protective effect of black pepper (Piper nigrum L.) and its major bioactive constituent piperine. Trends in Food Science & Technology 117, pages 34-45.
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Xiaojin Peng, Xiaoyu Sui, Jialei Li, Tingting Liu & Lei Yang. (2021) Development of a novel functionality for a highly efficient imidazole-based ionic liquid non-aqueous solvent system for the complete extraction of target alkaloids from Phellodendron amurense Rupr. under ultrasound-assisted conditions. Industrial Crops and Products 168, pages 113596.
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Leonildo A. Ferreira, Josiane T. Silva, Raissa G. Alves, Kelley C.B. Oliveira & Eduardo N. dos Santos. (2021) Spicing up olefin cross metathesis with the renewables estragole and methyl sorbate. Applied Catalysis A: General 620, pages 118173.
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Zhao Li, Iftikhar Ali, Jinqian Yu, Li Cui, Heng Zhu, Wenya Ma, Ge Li & Daijie Wang. (2021) Efficient separation of N-Alkylamides from Piper longum L. using off-line two-dimensional coupled with gradient high-speed counter-current chromatography. LWT 140, pages 110817.
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Mohd Nazri Zayapor, Aminah Abdullah & Wan Aida Wan Mustapha. (2021) The antioxidant analysis and α-glucosidase inhibition activities of spices and herbs (22 species) in Asian traditional beverages. Journal of Food Measurement and Characterization 15:2, pages 1703-1718.
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Sharna-kay Daley & Geoffrey A. Cordell. (2021) Biologically Significant and Recently Isolated Alkaloids from Endophytic Fungi. Journal of Natural Products 84:3, pages 871-897.
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Sophia Mayr, Krzysztof B. Beć, Justyna Grabska, Elisabeth Schneckenreiter & Christian W. Huck. (2021) Near-infrared spectroscopy in quality control of Piper nigrum: A comparison of performance of benchtop and handheld spectrometers. Talanta 223, pages 121809.
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Kourosh Cheraghipour, Marjan Beiranvand, Masoomeh Zivdari, Sana Amiri, Leila Masoori, Morteza Nourmohammadi, Ali Safar Maken Ali, Saber Abbaszadeh, Kobra Moradpour & Abdolrazagh Marzban. (2021) In vitro potential effect of Pipper longum methanolic extract against protoscolices of hydatid cysts. Experimental Parasitology 221, pages 108051.
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Jong-Rak Park, Hyun-Hee Kang, Jong-Ku Cho, Kwang-Deog Moon & Young-Jun Kim. (2020) Application of Non-Destructive Rapid Determination of Piperine in Piper nigrum L. (Black Pepper) Using NIR and Multivariate Statistical Analysis: A Promising Quality Control Tool. Foods 9:10, pages 1437.
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Vishal Sharad Chaudhari, Roshan M. Borkar, Upadhyayula Suryanarayana Murty & Subham Banerjee. (2020) Analytical method development and validation of reverse-phase high-performance liquid chromatography (RP-HPLC) method for simultaneous quantifications of quercetin and piperine in dual-drug loaded nanostructured lipid carriers. Journal of Pharmaceutical and Biomedical Analysis 186, pages 113325.
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Zehui Liu, Qian Hu, Wanyan Wang, Sisi Lu, Dang Wu, Shuyin Ze, Jiacheng He, Ying Huang, Wuyan Chen, Yechun Xu, Weiqiang Lu & Jin Huang. (2020) Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase. Biochemical Pharmacology 177, pages 114000.
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Shuai Chen, Qike Li, David Julian McClements, Yahong Han, Lei Dai, Like Mao & Yanxiang Gao. (2020) Co-delivery of curcumin and piperine in zein-carrageenan core-shell nanoparticles: Formation, structure, stability and in vitro gastrointestinal digestion. Food Hydrocolloids 99, pages 105334.
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Toshiyuki MizumotoFusako NakanoYuzo Nishizaki, Naoko Masumoto & Naoki Sugimoto. (2019) Quantitative Analysis of Piperine and the Derivatives in Long Pepper Extract by HPLC Using Relative Molar Sensitivity相対モル感度を利用したヒハツ抽出物中のピペリン類のHPLC定量分析. Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 60:5, pages 134-143.
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Qin Lingli. (2019) Advance on delivery nanocarriers of piperine: nanoparticles. E3S Web of Conferences 131, pages 01002.
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