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Research Article

Thyroid-Associated Ophthalmopathy: Clinical Features, Pathogenesis, and Management

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Pages 523-549 | Published online: 29 Sep 2008

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Read on this site (11)

Yonghoon Lee, Minji Kim & Anat Galor. (2022) Beyond dry eye: how co-morbidities influence disease phenotype in dry eye disease. Clinical and Experimental Optometry 105:2, pages 177-185.
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Hasan Kiziltoprak, Mustafa Koc, Kemal Tekin, Rumeysa Hekimoglu, Merve Inanc, Aslıhan Araslı Yılmaz, Selin Elmaoğulları & Zehra Aycan. (2020) Local Ocular Surface Alterations in Children with Hashimoto’s Thyroiditis. Ocular Immunology and Inflammation 28:5, pages 791-797.
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Hooshang Lahooti, Daniele Cultrone, Senarath Edirimanne, John P Walsh, Leigh Delbridge, Patrick Cregan, Bernard Champion & Jack R Wall. (2015) Novel single-nucleotide polymorphisms in the calsequestrin-1 gene are associated with Graves’ ophthalmopathy and Hashimoto’s thyroiditis. Clinical Ophthalmology 9, pages 1731-1740.
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Hao Wang, Li-Shuang Zhu, Jin-Wei Cheng, Ji-Ping Cai, You Li, Xiao-Ye Ma & Rui-Li Wei. (2015) Meta-analysis of Association Between the +49A/G Polymorphism of Cytotoxic T-Lymphocyte Antigen-4 and Thyroid Associated Ophthalmopathy. Current Eye Research 40:12, pages 1195-1203.
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Hooshang Lahooti, Kishan R Parmar & Jack R Wall. (2010) Pathogenesis of thyroid-associated ophthalmopathy: does autoimmunity against calsequestrin and collagen XIII play a role?. Clinical Ophthalmology 4, pages 417-425.
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Erick D Bothun, Ryan A Scheurer, Andrew R Harrison & Michael S Lee. (2009) Update on thyroid eye disease and management. Clinical Ophthalmology 3, pages 543-551.
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Bamini Gopinath, Leon Wescombe, Bao Nguyen & Jack R. Wall. (2009) Can Autoimmunity Against Calsequestrin Explain the Eye and Eyelid Muscle Inflammation of Thyroid Eye Disease?. Orbit 28:4, pages 256-261.
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Bao Nguyen, Bamini Gopinath, Junichi Tani, Leon Wescombe & Jack R. Wall. (2008) Peripheral blood T lymphocyte sensitisation against calsequestrin and flavoprotein in patients with Graves' ophthalmopathy. Autoimmunity 41:5, pages 372-376.
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Bamini Gopinath, Cherie-Lee Adams, Reilly Musselman, Junichi Tani & Jack R. Wall. (2007) Antibodies against Calsequestrin and Type XIII Collagen are Good Markers for Chronic Upper Eyelid Retraction. Ocular Immunology and Inflammation 15:2, pages 81-88.
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T.R. Mizen M.D.. (2003) Thyroid eye disease. Seminars in Ophthalmology 18:4, pages 243-247.
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Articles from other publishers (32)

Volkan Yeter, Nurullah Koçak, Mustafa Subaşı & Utku Parlak. (2023) Choroidal vascularity index in thyroid-associated ophthalmopathy. Canadian Journal of Ophthalmology 58:1, pages 27-33.
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Ramy Rashad, Raquel Pinto, Emily Li, Mahsa Sohrab & Alberto G. Distefano. (2022) Thyroid Eye Disease. Life 12:12, pages 2084.
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Volkan Yeter, Nurullah Koçak, Mehmet Tayfun Arslan & Elif Kiliç Kan. (2021) Blood Count-derived Immunoinflammatory Markers in Thyroidassociated Ophthalmopathy. Korean Journal of Ophthalmology 35:3, pages 198-206.
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Mahmoud Sakr. 2020. Diagnosing and Managing Hashimoto’s Disease. Diagnosing and Managing Hashimoto’s Disease 241 247 .
Mahmoud Sakr. 2020. Diagnosing and Managing Hashimoto’s Disease. Diagnosing and Managing Hashimoto’s Disease 141 157 .
Frank H. P. Lai, Tiara W. U. Iao, Danny S. C. Ng, Alvin L. Young, Joy Leung, Alvin Au, Simon T. C. Ko & Kelvin K. L. Chong. (2019) Choroidal thickness in thyroid‐associated orbitopathy. Clinical & Experimental Ophthalmology 47:7, pages 918-924.
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Yeseul KimJin Kwon ChungSi Hyung Lee. (2019) Thyroid Abnormality and Dry Eye Syndrome: a Cross-sectional Study from the Republic of Korea. Journal of the Korean Ophthalmological Society 60:8, pages 725.
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A.S. Siebuhr, C.S. Thudium & M.A. Karsdal. 2019. Biochemistry of Collagens, Laminins and Elastin. Biochemistry of Collagens, Laminins and Elastin 115 120 .
Sangeetha Thirumazhisi Sachithanandam. (2016) ISOLATED AGGER NASI MUCOCOELE: A FACTOR FOR RECURRENCE?. Journal of Evidence Based Medicine and Healthcare 3:38, pages 1915-1918.
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A.S. Siebuhr & M.A. Karsdal. 2016. Biochemistry of Collagens, Laminins and Elastin. Biochemistry of Collagens, Laminins and Elastin 87 91 .
Jack R. Wall, Hooshang Lahooti, Emily J. Hibbert & Bernard Champion. (2015) Relationship between Clinical and Immunological Features of Thyroid Autoimmunity and Ophthalmopathy during Pregnancy. Journal of Thyroid Research 2015, pages 1-6.
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Emrah Kan, Elif Kılıçkan, Gulçin Ecemiş, Emrullah Beyazyildiz & Ramis Çolak. (2014) Presence of Dry Eye in Patients with Hashimoto’s Thyroiditis. Journal of Ophthalmology 2014, pages 1-4.
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István Gáti, Olof Danielsson, Hajnalka Merkli & Endre Pál. (2012) External Ophthalmoplegia Associated With Hashimoto’s Thyroiditis and Recovered on Corticosteroid Treatment. The American Journal of the Medical Sciences 344:2, pages 151-152.
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Ai Yoshihara, Jaeduk Yoshimura Noh, Ayako Nakachi, Hidemi Ohye, Shiori Sato, Kenichi Sekiya, Yuka Kosuga, Miho Suzuki, Masako Matsumoto, Yo Kunii, Natsuko Watanabe, Koji Mukasa, Yoichi Inoue, Kunihiko Ito & Koichi Ito. (2011) Severe thyroid-associated orbitopathy in Hashimoto's thyroiditis. Report of 2 cases. Endocrine Journal 58:5, pages 343-348.
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Hilman TjiangHooshang LahootiTom McCorquodaleKishan R. ParmarJack R. Wall. (2010) Eye and Eyelid Abnormalities Are Common in Patients with Hashimoto's Thyroiditis. Thyroid 20:3, pages 287-290.
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A.J. Lowery & M.J. Kerin. (2009) Graves' ophthalmopathy: The case for thyroid surgery. The Surgeon 7:5, pages 290-296.
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Hannu Järveläinen, Annele Sainio, Markku Koulu, Thomas N. Wight & Risto Penttinen. (2009) Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy. Pharmacological Reviews 61:2, pages 198-223.
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Timothy J. Doherty & Michael W. Nicolle. 2009. Brocklehurst's Textbook of Geriatric Medicine and Gerontology. Brocklehurst's Textbook of Geriatric Medicine and Gerontology 520 532 .
Christine E. Burness & Pamela J. Shaw. 2008. Neurology and General Medicine. Neurology and General Medicine 357 381 .
Tomasz Bednarczuk, Bamini Gopinath, Rafal Ploski & Jack R. Wall. (2007) Susceptibility genes in Graves? ophthalmopathy: searching for a needle in a haystack?. Clinical Endocrinology 67:1, pages 3-19.
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Bamini GopinathReilly MusselmanCherie-Lee AdamsJunichi TaniNicole BeardJack R. Wall. (2006) Study of Serum Antibodies Against Three Eye Muscle Antigens and the Connective Tissue Antigen Collagen XIII in Patients with Graves' Disease With and Without Ophthalmopathy: Correlation With Clinical Features. Thyroid 16:10, pages 967-974.
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B Gopinath, R Musselman, N Beard, S El-Kaissi, J Tani, C-L Adams & J R Wall. (2006) Antibodies targeting the calcium binding skeletal muscle protein calsequestrin are specific markers of ophthalmopathy and sensitive indicators of ocular myopathy in patients with Graves’ disease. Clinical and Experimental Immunology 145:1, pages 56-62.
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Sara P Modjtahedi, Bobeck S Modjtahedi, Ahmad M Mansury, Dinesh Selva, Raymond S Douglas, Robert A Goldberg & Igal Leibovitch. (2006) Pharmacological Treatments for Thyroid Eye Disease. Drugs 66:13, pages 1685-1700.
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A. De Bellis, D. Sansone, C. Coronella, M. Conte, S. Iorio, S. Perrino, M. Battaglia, G. Bellastella, J. R. Wall, A. Bellastella & A. Bizzarro. (2005) Serum antibodies to collagen XIII: a further good marker of active Graves' ophthalmopathy. Clinical Endocrinology 62:1, pages 24-29.
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Michael J Wearne & Silvia Wengrowicz. 2005. Evidence‐based Ophthalmology. Evidence‐based Ophthalmology 115 117 .
S. El-Kaissi, A. G. Frauman & J. R. Wall. (2004) Thyroid-associated ophthalmopathy: a practical guide to classification, natural history and management. Internal Medicine Journal 34:8, pages 482-491.
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T. Mizokami, M. Salvi & Jack R. Wall. (2014) Eye muscle antibodies in Graves’ ophthalmopathy: Pathogenic or secondary epiphenomenon?. Journal of Endocrinological Investigation 27:3, pages 221-229.
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HENRY J. KAMINSKI, ZHUYI LI, CHELLIAH RICHMONDS, ROBERT L. RUFF & LINDA KUSNER. (2003) Susceptibility of Ocular Tissues to Autoimmune Diseases. Annals of the New York Academy of Sciences 998:1, pages 362-374.
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Masayo Yamada, Audrey Li, Cheng-Hsien Chang & Jack Wall. 2002. Thyroid Eye Disease. Thyroid Eye Disease 223 233 .
HENRY J. KAMINSKI, CHELLIAH R. RICHMONDS, LINDA L. KUSNER & HIROSHI MITSUMOTO. (2006) Differential Susceptibility of the Ocular Motor System to Disease. Annals of the New York Academy of Sciences 956:1, pages 42-54.
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Matthias Kaspar, Curtis Archibald, Anna Maria De Bellis, Audrey Wu Li, Masayo Yamada, Cheng-Hsien Chang, George Kahaly & Jack Ronald Wall. (2002) Eye Muscle Antibodies and Subtype of Thyroid-Associated Ophthalmopathy. Thyroid 12:3, pages 187-191.
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